Newest studies

Impact of regional white matter hyperintensity patterns on cognitive trajectories in NACC

50/100 ✓ Peer-reviewed Vascular contributions Alzheimer s & Dementia

Key finding: Compared to those with low WMH burden, participants in the mild occipital and high parieto-occipital clusters had faster memory decline; mild fronto-parietal and high parieto-occipital clusters showed faster executive decline; and mild and high fronto-parietal and high parieto-occipital clusters had faster language decline. +4 more findings

• Brain Scans

Full summary, score breakdown and related studies → Original source

Effectiveness of the In-Hospital Information Technology System-Based Delirium Management Intervention Program in Medically Hospitalized Patients with Dementia: A Retrospective Case–Control Study

39/100 ✓ Peer-reviewed Clinical safety Journal of Multidisciplinary Healthcare

Key finding: The intervention group showed a significantly lower delirium incidence (34% versus 18%, p =0.010) and earlier detection of delirium after hospitalization (3.2 versus 2.2 days, p =0.035). +4 more findings

• Care Services
• Digital Tools

Full summary, score breakdown and related studies → Original source

Prevention of cognitive impairment and dementia in people with Parkinson's disease: A call-to-action

38/100 ✓ Peer-reviewed Prevention trials Journal of Parkinson s Disease

Key finding: The main pillars of a strategic agenda for this purpose include: (i) regular assessment of cognitive state, overall risk, and risk factors for cognitive decline; (ii) risk communication and education concerning modifiable risk factors with standardized procedures; (iii) risk reduction with multi-domain interventions for secondary prevention; and (iv) cognitive enhancement with cognitive and physical training for tertiary prevention.

• Prevention
• Other Dementias
• Risk Factors

Full summary, score breakdown and related studies → Original source

Towards optimizing the diagnosis of Lewy body dementia: Lessons from the NACC

37/100 ✓ Peer-reviewed Long-term cohort studies Alzheimer s & Dementia

Key finding: Diagnosis of LBD had high specificity but low sensitivity, with fewer than half of autopsy-confirmed cases having received an LBD diagnosis. +3 more findings

• Diagnosis
• Other Dementias

Full summary, score breakdown and related studies → Original source

Evaluating cognitive impairment among a geriatric population in India using the Indian Council of Medical Research (ICMR)–multilingual dementia research and assessment (MUDRA) toolbox

46/100 ✓ Peer-reviewed Cognitive tests and assessment Indian Journal of Psychiatry

Key finding: Among 1013 participants, 847 screened positive on MoCA (70.4% mild, 13.2% moderate) for cognitive impairment and were assessed further for other domains of ICMR-MUDRA toolbox. +4 more findings

Full summary, score breakdown and related studies → Original source

Impact of cerebral small vessel disease on cognitive outcomes in early age at onset MCI and dementia: Findings from the DIASPORA study

41/100 ✓ Peer-reviewed Cognitive tests and assessment Alzheimer s & Dementia

Key finding: Montreal Cognitive Assessment (MoCA), Mini-Mental State Examination (MMSE), Neuropsychiatric Inventory Questionnaire (NPI-Q), and Clinical Dementia Rating (CDR) scale plus National Alzheimer's Coordinating Center-Frontotemporal Lobar Degeneration module (NACC-FTLD). +4 more findings

• Diagnosis
• Other Dementias

Full summary, score breakdown and related studies → Original source

MMSE-Based Dementia Prediction: Deep vs. Traditional Models

35/100 ✓ Peer-reviewed Cognitive tests and assessment Life

Key finding: These findings suggest that deep learning not only enhances predictive accuracy but also offers interpretable insights aligned with clinical reasoning, underscoring its potential utility as a reliable tool for early dementia diagnosis.

• Diagnosis
• Early Stage
• Digital Tools

Full summary, score breakdown and related studies → Original source

Gamma sensory stimulation in mild Alzheimer's dementia: An open‐label extension study

57/100 ✓ Peer-reviewed Cognitive tests and assessment Alzheimer s & Dementia

Key finding: No adverse events occurred over the study period. +4 more findings

• Diagnosis
• Biomarkers

Full summary, score breakdown and related studies → Original source

GLP-1 Receptor Agonists Reduce Dementia and Alzheimer Disease Risk in Patients with Diabetes and Advanced CKD: Real-World Evidence from TriNetX

47/100 ✓ Peer-reviewed Drug development Journal of the American Society of Nephrology

Key finding: GLP-1RA use was associated with lower risk of dementia (HR 0.80, 95% CI 0.71–0.91) and Alzheimer’s disease (HR 0.76, 95% CI 0.59–0.98) compared to DPP4is. +4 more findings

• Risk Factors
• Other Dementias

Full summary, score breakdown and related studies → Original source

SORL1 as a Putative Candidate Gene for a Novel Recessive Form of Complicated Hereditary Spastic Paraplegia: Insights from a Deep Functional Study

26/100 ✓ Peer-reviewed Risk genes beyond APOE Clinical and Translational Neuroscience

Key finding: Sequencing revealed a biallelic SORL1 splice donor variant (c.1211 + 1G > A). +4 more findings

• Genetics
• Brain Biology

Full summary, score breakdown and related studies → Original source

Electroencephalography‐based signatures of cognitive resilience in individuals with stable mild cognitive impairment despite carrying a high‐risk for progression to dementia

38/100 ✓ Peer-reviewed Mild cognitive impairment Alzheimer s & Dementia Translational Research & Clinical Interventions

Key finding: Compared with sMCI-resilient subjects, cMCI individuals exhibited increased frontal delta power, reduced posterior alpha power, and an elevated delta/alpha ratio in the right temporal region, consistent with cortical dysfunction. +4 more findings

• Early Stage

Full summary, score breakdown and related studies → Original source

Polypharmacy and risk of dementia progression in older adults with mild cognitive impairment: A longitudinal cohort study

48/100 ✓ Peer-reviewed Mild cognitive impairment Alzheimer s & Dementia Translational Research & Clinical Interventions

Key finding: Cox regression analysis revealed that polypharmacy was significantly associated with a reduced risk of MCI progression to dementia (hazard ratio [HR] = 0.49, 95% confidence interval [CI]: 0.31 to 0.78) after adjusting for covariates. +4 more findings

• Early Stage
• Risk Factors
• Prevention

Full summary, score breakdown and related studies → Original source

COVID-19 infection associated with increased risk of new-onset vascular dementia in adults ≥50 years

37/100 ✓ Peer-reviewed Lewy body dementia npj Dementia

Key finding: We observed adults aged 50 years and older from the UK Biobank over a median observational period exceeding two years following COVID-19 infection. +4 more findings

• Other Dementias
• Risk Factors

Full summary, score breakdown and related studies → Original source

A review of studies on vascular dementia and iron metabolism

32/100 ✓ Peer-reviewed Lewy body dementia Science Progress

Key finding: Vascular dementia (VaD) is recognized as the second most prevalent form of dementia after Alzheimer's disease, with its pathogenesis intricately associated with cerebrovascular pathologies, including chronic hypoperfusion, oxidative stress, and neuroinflammation. +1 more finding

• Other Dementias
• Brain Biology

Full summary, score breakdown and related studies → Original source

Plasma p‐tau217 and Aβ42/40 as markers of Aβ pathology in the Lewy body continuum

43/100 ✓ Peer-reviewed Lewy body dementia Alzheimer s & Dementia

Key finding: Higher plasma p-tau217, lower Aβ42/40, and their interaction were associated with greater Aβ-PET uptake. +4 more findings

• Other Dementias
• Brain Biology
• Biomarkers

Full summary, score breakdown and related studies → Original source

White matter hyperintensities precede other biomarkers in GRN frontotemporal dementia

48/100 ✓ Peer-reviewed Lewy body dementia Alzheimer s & Dementia

Key finding: Symptomatic GRN carriers showed elevated WMHs, primarily in the frontal lobe, while no significant increase was observed in symptomatic C9orf72 or MAPT carriers. +4 more findings

• Other Dementias
• Biomarkers

Full summary, score breakdown and related studies → Original source

Risk Factors for Dementia in a Sample of Patients From a Quaternary Care Hospital Network in the United Arab Emirates

49/100 ✓ Peer-reviewed Risk factors Alzheimer Disease & Associated Disorders

Key finding: A total of 281 dementia patients (mean age 74.9 ± 9.2 y, 46.3% females) and 281 age-matched controls (mean age 74.3 ± 4.6 y, 55.9% females) were included. +3 more findings

• Risk Factors

Full summary, score breakdown and related studies → Original source

Factors associated with: problems of using exploratory multivariable regression to identify causal risk factors

41/100 ✓ Peer-reviewed Risk factors BMJ Medicine

Key finding: Where mutually adjusted regression coefficients are significant, the exposures are labelled as risk factors for the outcome. +3 more findings

• Risk Factors

Full summary, score breakdown and related studies → Original source

Cardiovascular risk factors and the allostatic interoceptive network in dementia

51/100 ✓ Peer-reviewed Risk factors Cardiovascular Research

Key finding: We recruited 1501 participants (304 with FTLD, 512 with AD, and 685 healthy controls) from the Multi-Partner Consortium to Expand Dementia Research in Latin America (ReDLat). +4 more findings

• Risk Factors

Full summary, score breakdown and related studies → Original source

Explainable and externally validated machine learning for neurocognitive diagnosis via ECGs

37/100 ✓ Peer-reviewed Digital health tools General Psychiatry

Key finding: Significant predictive performance was observed for several neurocognitive disorders. +4 more findings

• Digital Tools
• Diagnosis

Full summary, score breakdown and related studies → Original source

Acceptability and feasibility of a sensor-instrumented ‘SmartSocks’ wearable prototype to detect agitation in people with dementia

35/100 ✓ Peer-reviewed Digital health tools International Psychogeriatrics

Key finding:

• Digital Tools

Full summary, score breakdown and related studies → Original source

Classification of AD and bvFTD using neuropsychological and neuropsychiatric variables: a machine learning study

46/100 ✓ Peer-reviewed Digital health tools Alzheimer s & Dementia

Key finding: Among 1616 participants (AD = 1498, bvFTD = 118), all algorithms achieved high accuracy (80% to 90%) and discriminatory ability (AUC = 0.89 to 0.95). +4 more findings

• Digital Tools

Full summary, score breakdown and related studies → Original source

Combined with multimodal medical imaging and artificial intelligence for early diagnosis of Parkinson's disease

40/100 ✓ Peer-reviewed Digital health tools Frontiers in Neurology

Key finding: Epidemiological data show that both PD incidence rate and prevalence rate show a significant age-dependent growth trend [3]. +4 more findings

• Digital Tools
• Brain Scans
• Diagnosis

Full summary, score breakdown and related studies → Original source

Advancing early and equitable detection of dementia: key learnings/challenges, recent innovations, and future directions

42/100 ✓ Peer-reviewed Disparities The Gerontologist

Key finding: Systemic under-detection and its contributions to persistent population-level suffering underscore the importance of early detection of dementia as a key public health issue. +4 more findings

• Health Equity

Full summary, score breakdown and related studies → Original source

Population intervention models of racial ethnic disparities in cognitive outcomes from cardiometabolic risk factors – HABS-HD

44/100 ✓ Peer-reviewed Disparities Alzheimer s Research & Therapy

Key finding: NHB Hispanic, and NHW participants prevalences were APOE ε4 (32.2%, 27.4%, 17.6%), diabetes (26.1%, 35.0%, 13.9%), hypertension (79.0%, 63.6%, 58.2%), obesity (56.8%, 50.3%, 38.5%), and tobacco dependence (12.9%, 7.5%, 3.9%). +4 more findings

• Health Equity
• Risk Factors

Full summary, score breakdown and related studies → Original source