Newest studies

Shared genetic architecture between brain iron deposition and Alzheimer's disease

16/100 ⚠ Preprint — not yet peer-reviewed Genetics medRxiv (preprint)

Key finding: We identified 116 independent genome-wide significant loci associated with brain iron (r2<0.1; p <5 x 10-8) and validated these signals in an independent cohort using polygenic scores, which explained between 8.9% and 25.4% of variance in regional iron. +3 more findings

• Genetics

Scored 27 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Population-Scale Integration of Spatial Omics Networks for Clinical Prediction and Biological Discovery by SPIN

16/100 ⚠ Preprint — not yet peer-reviewed How common it is medRxiv (preprint)

Key finding: In the SEA-AD MERFISH transcriptomics cohort, SPIN framework achieved an accuracy of 0.81 for dementia-status prediction and revealed gene-gene co-expression subnetworks with clear biological relevance, such as glutamatergic synapses- and neurogenesis-related subnetworks.

Scored 26 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Ibuprofen modulates inflammatory and autophagy-associated pathways linked to neurodegenerative pathology in APOE-context-dependent cellular models

32/100 ✓ Peer-reviewed Genetics Journal of Neuroinflammation

Key finding: Our results showing that Ibuprofen decreases the known mechanism of IL-1β to drive the synthesis of each of the aggregates diagnostic of Alzheimers and Parkinsons while simultaneously boosting autophagy for their clearance provides for a vision of one day with Ibuprofen or some more perfect foil these dread diseases may be prevented.

• Genetics
• Brain Biology

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Plasma phosphorylated tau 217 concentrations, APOE genotype, and timing of cognitive impairment in individuals across diverse racial and ethnic groups: a pooled analysis of prospective cohort studies

59/100 ✓ Peer-reviewed Biomarkers The Lancet. Neurology

Key finding: Plasma p-tau217 concentrations, considered together with APOE genotype, might help stratify risk and estimate the timing of future cognitive impairment in asymptomatic individuals who are at increased risk for Alzheimer's disease, such as those with a family history of dementia or known APOE-ε4 carrier status. +4 more findings

• Genetics
• Biomarkers
• Health Equity

Full summary, score breakdown and related studies → Original source

Early strong anticholinergic initiation and 30-day mortality in older inpatients with dementia: a target trial emulation

16/100 ⚠ Preprint — not yet peer-reviewed How common it is Research Square

Key finding: Rare confirmed initiation prevented a clinically interpretable admission-time strategy estimate. +2 more findings

• Side Effects

Scored 37 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Specification dependence of EEG theta/alpha ratio associations with cognitive impairment: a multiverse analysis

16/100 ⚠ Preprint — not yet peer-reviewed Lewy body dementia bioRxiv

Key finding: The theta/alpha ratio is a promising but specification-dependent marker of cognitive impairment, contingent particularly on ICA and spectral power quantification. +3 more findings

• Other Dementias
• Diagnosis

Scored 27 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Neuropsychiatric Adverse-Event Reporting With Brexpiprazole Across Approved Indications: A Disproportionality Analysis Using the FDA Adverse Event Reporting System (FAERS)

16/100 ⚠ Preprint — not yet peer-reviewed Clinical safety Research Square

Key finding: Brexpiprazole was associated with a distinct neuropsychiatric adverse-event reporting pattern in Alzheimer’s disease compared with psychiatric indications, with the most consistent signals observed for delirium, falls, and agitation. +4 more findings

• Treatments
• Side Effects

Scored 26 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Multi-Omics Analysis Reveals Molecular Responses of Alkaloid Content Variations in Lycoris radiata Across Different Locations

16/100 ⚠ Preprint — not yet peer-reviewed Disease mechanisms Research Square

Key finding: Untargeted metabolomics revealed highly region-specific accumulation patterns of key alkaloids, such as galanthamine and lycorine. +4 more findings

Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Neuroprotective potential of Acetylcholinesterase Inhibitors from Natural Sources in Combating Neurodegenerative Diseases

16/100 ⚠ Preprint — not yet peer-reviewed Disease mechanisms ScienceOpen Preprints

Key finding: Neurodegeneration is distinguished by primary neuronal loss rather than damage secondary to external insults. +4 more findings

• Brain Biology

Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Plasma Fibrinogen Correlates with Aβ Clearance of monocytes and AD Biomarkers in Cognitively Normal Individuals

16/100 ⚠ Preprint — not yet peer-reviewed Biomarkers Research Square

Key finding: After adjusting for confounders, plasma fibrinogen levels were significantly positively correlated with Aβ42 (γ = 0.616, P = 0.005), the Aβ42/Aβ40 ratio (γ = 0.478, P = 0.038), and T-tau (γ = 0.544, P = 0.016), and negatively correlated with monocyte count (γ = -0.479, P = 0.038) and uptake of Aβ42 by monocytes (γ = -0.569, P = 0.011). +1 more finding

• Biomarkers
• Early Stage
• Brain Biology

Scored 27 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Elecsys pT181p immunoassay: Clinical performance for ruling out amyloid pathology

61/100 ✓ Peer-reviewed Biomarkers Alzheimer's & dementia (Amsterdam, Netherlands)

Key finding: At a care setting-agnostic cutoff of 0.934 pg/ml, high negative predictive value (NPV) (93.8%) and acceptable positive predictive value (PPV) (46.6%) were observed against amyloid-positron emission tomography (PET). +3 more findings

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A positive Alzheimer's blood biomarker is not a diagnosis: the presence-primacy-permission framework for plasma p-tau217

45/100 ✓ Peer-reviewed Biomarkers Annals of medicine and surgery (2012)

Key finding: Separate documentation of the biomarker result, syndrome, etiologic attribution, and actionability may reduce premature diagnostic closure while preserving the clinical value of p-tau217.

• Biomarkers
• Diagnosis

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Predicting Conversion from SCD to MCI: A Machine Learning Study

16/100 ⚠ Preprint — not yet peer-reviewed Genetics medRxiv (preprint)

Key finding: The combined set achieved the highest AUC at the 2-year horizon only (0.884). +4 more findings

• Early Stage
• Digital Tools

Scored 35 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Sex Differences in the Associations between Education, Neuropathology, and Cognition

16/100 ⚠ Preprint — not yet peer-reviewed How common it is medRxiv (preprint)

Key finding: In female participants, higher education was associated with lower Thal amyloid phase, diffuse plaques, neuritic plaques, and Braak stage ({beta} range, -0.097 to -0.071; qFDR<.026); none was significant among male participants. +4 more findings

• Brain Biology

Scored 39 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Education and Alzheimer Disease Genetic Risk in Associations of GLP-1 Receptor Agonists With Dementia Among Adults With Type 2 Diabetes

16/100 ⚠ Preprint — not yet peer-reviewed Drug development medRxiv

Key finding: We estimated associations of educational attainment and Alzheimer disease genetic risk with treatment initiation and incident dementia and compared GLP-1 receptor agonist initiators with initiators of non-sodium-glucose cotransporter 2 inhibitor second-line therapies, with a separate sodium-glucose cotransporter 2 inhibitor compa +3 more findings

• Risk Factors
• Treatments
• Genetics

Scored 40 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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A 2-Level Stacking Ensemble Framework for Multi-Class Alzheimer’s Disease Diagnosis Using CNN Feature Extractors and SVM-XGBoost Classifiers

16/100 ⚠ Preprint — not yet peer-reviewed Long-term cohort studies Research Square

Key finding: The improvement was found to be statistically significant using McNemar's test (χ²=98.0865, p < 0.0001) comparing Full Ensemble and Shashi Model. +1 more finding

• Brain Scans

Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Risk factors for Dementia Public Stigma in Zhejiang Province, China: A Cross-Sectional Study

16/100 ⚠ Preprint — not yet peer-reviewed Getting a diagnosis Research Square

Key finding: Dementia public stigma was associated with education, dementia knowledge, media exposure, chronic diseases, and contact experience with people living with dementia. +4 more findings

Scored 37 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Bee Venom-Loaded Nanoliposomes as an Antioxidant and Erythroprotective Delivery Platform for In Vitro Controlled Release and Improved Gastrointestinal Stability

16/100 ⚠ Preprint — not yet peer-reviewed Disease mechanisms Preprints.org

Key finding: Bee venom (BV) contains bioactive peptides with potent antioxidant, anti-inflammatory, and neuroprotective properties, yet its direct therapeutic use is limited by cytotoxicity, instability, and uncontrolled release.

• Brain Biology

Scored 24 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Synergistic Nano-Architectures: How Date Seed Phytochemicals and Cellulose Matrices Template Silver Nanoparticles for Multifunctional Therapy

16/100 ⚠ Preprint — not yet peer-reviewed Treatments Research Square

Key finding: Biological evaluations demonstrated potent, wide-ranging therapeutic potential. +3 more findings

• Treatments

Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Synaptic vesicle glycoprotein 2A PET imaging in parkinsonian α-synucleinopathies: a systematic review

48/100 ✓ Peer-reviewed Disease mechanisms Journal of neurology

Key finding: In PDD/DLB, abnormalities appeared broader and more cortical, with evidence of association between cortical SV2A binding and cognitive performance. +4 more findings

• Brain Scans
• Other Dementias
• Brain Biology

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Instrumental activities of daily living in older adults with epilepsy: A cross-sectional and longitudinal multicenter study

50/100 ✓ Peer-reviewed Risk factors Epilepsia

Key finding: Multivariable Firth penalized logistic regression identified factors associated with baseline functional impairment. +4 more findings

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Online Peer Support Use Among Informal Caregivers of People Living With Alzheimer Disease or Related Dementias: National Cross-Sectional Web-Based Survey

16/100 ⚠ Preprint — not yet peer-reviewed Caregiving medRxiv (preprint)

Key finding: Prior work suggests that perceived value may shape online support use, yet practical and trust-related barriers may still impede uptake even when beliefs are favorable. +4 more findings

• Caregiving
• Digital Tools

Scored 27 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Machine learning-derived Alzheimer's disease dimensions: neuroanatomical, cognitive, clinical, functional, and genetic risk heterogeneity signatures

16/100 ⚠ Preprint — not yet peer-reviewed Genetics medRxiv (preprint)

Key finding: Compared to Dimension 2, Dimension 1 had more severe cognitive and clinical impairment, greater functional impairment, elevated APOE {varepsilon}4 carrier burden, and higher polygenic risk for AD (p < 0.05). +3 more findings

• Genetics
• Early Stage
• Digital Tools

Scored 27 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Implementation and Evaluation of the Harmonized Cognitive Assessment Protocol in an Arabic-Speaking Population: The Lebanon Study on Aging and Health (LSAHA)

16/100 ⚠ Preprint — not yet peer-reviewed Getting a diagnosis medRxiv (preprint)

Key finding: CFA results demonstrated good to excellent model fit across general and domain-specific cognition.

• Diagnosis

Scored 30 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Alzheimer's Polygenic Risk Scores Are Not Interchangeable: Evidence from 1,752 Models

16/100 ⚠ Preprint — not yet peer-reviewed Genetics medRxiv (preprint)

Key finding: ResultsPRS results were not consistent across methodologies (Spearmans {rho}: -0.49 to 1), with >95% of individuals having PRS in both the top and bottom risk deciles.

• Genetics

Scored 20 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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