Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 17,951–17,975 of 27,380 studies, newest first · page 719 of 1096.
March 2014 25
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2014-03-24
Perspectives on future Alzheimer therapies: amyloid-β protofibrils - a new target for immunotherapy with BAN2401 in Alzheimer's disease
40/100 ✓ Peer-reviewed Treatments Alzheimer's research & therapy
Key finding: Data from recent clinical AD trials indicate that a treatment effect by immunotherapy is possible, providing hope for a new generation of drugs. +3 more findings
Full summary, score breakdown and related studies → Original source
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2014-03-23
TDP-43 is a key player in the clinical features associated with Alzheimer's disease
40/100 ✓ Peer-reviewed Brain scans and imaging Acta neuropathologica
Key finding: TDP-positive subjects were 10× more likely to be cognitively impaired at death compared to TDP-negative subjects. +1 more finding
Full summary, score breakdown and related studies → Original source
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2014-03-22
IVIg protects the 3xTg-AD mouse model of Alzheimer's disease from memory deficit and Aβ pathology
40/100 ✓ Peer-reviewed Biomarkers Journal of neuroinflammation
Key finding: The memory-enhancing effect of IVIg reported here suggests that Aβ oligomers, effector T cells and the fractalkine pathway are potential pharmacological targets of IVIg in AD. +2 more findings
Full summary, score breakdown and related studies → Original source
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2014-03-22
Luteolin protects against high fat diet-induced cognitive deficits in obesity mice
43/100 ✓ Peer-reviewed Inflammation and the immune system Behavioural brain research
Key finding: We showed that adding luteolin in high-fat diet can significantly reduce body weight gain, food intake and plasma cytokines as well as improving glucose metabolism of mice on HFD. +3 more findings
Full summary, score breakdown and related studies → Original source
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2014-03-22
Late-Onset Alzheimer's Disease Genes and the Potentially Implicated Pathways
43/100 ✓ Peer-reviewed TREM2 and immune genetics Current genetic medicine reports
Key finding: In addition to APOE , recent large genome-wide association studies have identified variation in over 20 loci that contribute to disease risk: CR1, BIN1, INPP5D, MEF2C, TREM2, CD2AP, HLA - DRB1/HLA - DRB5, EPHA1, NME8, ZCWPW1, CLU, PTK2B, PICALM, SORL1, CELF1, MS4A4/MS4A6E, SLC24A4/RIN3,FERMT2, CD33, ABCA7, CASS4 . +3 more findings
Full summary, score breakdown and related studies → Original source
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2014-03-21
EphA4 activation of c-Abl mediates synaptic loss and LTP blockade caused by amyloid-β oligomers
40/100 ✓ Peer-reviewed Disease mechanisms PloS one
Key finding: According to this results, the EphA4 antagonistic peptide KYL and c-Abl inhibitor STI prevented i) dendritic spine reduction, ii) the blocking of LTP induction and iii) neuronal apoptosis caused by AβOs. +1 more finding
Full summary, score breakdown and related studies → Original source
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2014-03-21
Aberrant brain functional connectivity related to insulin resistance in type 2 diabetes: a resting-state fMRI study
49/100 ✓ Peer-reviewed Brain scans and imaging Diabetes care
Key finding: Type 2 diabetic patients develop aberrant functional connectivity of the PCC, which is associated with insulin resistance in selected brain regions. +2 more findings
Full summary, score breakdown and related studies → Original source
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2014-03-21
Atherosclerosis and Alzheimer--diseases with a common cause? Inflammation, oxysterols, vasculature
45/100 ✓ Peer-reviewed Genetics BMC geriatrics
Key finding: Both ATH and AD involve inflammation, macrophage infiltration, and occlusion of the vasculature.
Full summary, score breakdown and related studies → Original source
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2014-03-20
Apolipoprotein E, amyloid-beta, and neuroinflammation in Alzheimer's disease
38/100 ✓ Peer-reviewed Genetics Neuroscience bulletin
Key finding: These discrepancies may result from the differences in models, cell types, experimental conditions, and inflammatory stimuli used. +1 more finding
Full summary, score breakdown and related studies → Original source
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2014-03-20
Prevalence of dementia in nursing home and community-dwelling older adults in Germany
48/100 ✓ Peer-reviewed Digital health tools Aging clinical and experimental research
Key finding: More than half of nursing home residents suffer from dementia, which is about 19-fold higher than the prevalence in insured living in the community.
Full summary, score breakdown and related studies → Original source
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2014-03-20
Comorbidity of dementia: a cross-sectional study of primary care older patients
62/100 ✓ Peer-reviewed Brain scans and imaging BMC psychiatry
Key finding: The analysis of the comorbidities associated with an index disease (e.g., dementia) must not be exclusively based on prevalence rates, but rather on methodologies that allow the discovery of non-random associations between diseases. +3 more findings
Full summary, score breakdown and related studies → Original source
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2014-03-20
Amyloid PET imaging in Alzheimer's disease: a comparison of three radiotracers
43/100 ✓ Peer-reviewed Brain scans and imaging European journal of nuclear medicine and molecular imaging
Key finding: Despite differing white and grey matter retention characteristics, cortical retention for each (18)F tracer was highly correlated with that of PiB, enabling conversion of thresholds across tracer measurement scales with a high level of internal consistency. +1 more finding
Full summary, score breakdown and related studies → Original source
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2014-03-20
Genome-wide meta-analysis of homocysteine and methionine metabolism identifies five one carbon metabolism loci and a novel association of ALDH1L1 with ischemic stroke
66/100 ✓ Peer-reviewed Long-term cohort studies PLoS genetics
Key finding: The FOCM is the sole source of de novo methyl group synthesis, impacting many biological and epigenetic pathways. +3 more findings
Full summary, score breakdown and related studies → Original source
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2014-03-20
Diabetes and elevated hemoglobin A1c levels are associated with brain hypometabolism but not amyloid accumulation
63/100 ✓ Peer-reviewed Biomarkers Journal of nuclear medicine : official publication, Society of Nuclear Medicine
Key finding: These factors should be investigated in longitudinal studies for their role in detecting onset of symptoms in AD.
Full summary, score breakdown and related studies → Original source
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2014-03-19
Association of type 2 diabetes with brain atrophy and cognitive impairment
57/100 ✓ Peer-reviewed Hippocampus size on brain scans Neurology
Key finding: Midlife onset of diabetes may affect late-life cognition through loss of brain volume. +1 more finding
Full summary, score breakdown and related studies → Original source
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2014-03-19
Genotype patterns at CLU, CR1, PICALM and APOE, cognition and Mediterranean diet: the PREDIMED-NAVARRA trial
72/100 ✓ Peer-reviewed Prevention trials Genes & nutrition
Key finding: A significant interaction (p = 0.041) between CLU-rs11136000 and the MedDiet intervention on the MMSE was found with a beneficial effect of MedDiet among carriers of the T minor allele (B = 0.97, 95 % CI 0.45-1.49). +3 more findings
Full summary, score breakdown and related studies → Original source
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2014-03-19
Human cognitive function and the obesogenic environment
41/100 ✓ Peer-reviewed Risk factors Physiology & behavior
Key finding: Evidence is accumulating which suggests that, in addition to leading to unprecedented rates of obesity, the current food environment is contributing to the development of cognitive impairment and dementia. +2 more findings
Full summary, score breakdown and related studies → Original source
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2014-03-19
REST and stress resistance in ageing and Alzheimer's disease
61/100 ✓ Peer-reviewed Lewy body dementia Nature
Key finding: A functional orthologue of REST, Caenorhabditis elegans SPR-4, also protects against oxidative stress and amyloid β-protein toxicity. +4 more findings
Full summary, score breakdown and related studies → Original source
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2014-03-19
Social representation and practices related to dementia in Hai District of Tanzania
49/100 ✓ Peer-reviewed Digital health tools BMC public health
Key finding: Knowledge about dementia is low and the symptoms are accepted as a problem of old age. +3 more findings
Full summary, score breakdown and related studies → Original source
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2014-03-18
Can a novel computerized cognitive screening test provide additional information for early detection of Alzheimer's disease?
40/100 ✓ Peer-reviewed Cognitive tests and assessment Alzheimer's & dementia : the journal of the Alzheimer's Association
Key finding: Compared with ERP, MRI, or neuropsychological tests alone, the VR-DOT could provide additional predictive information in a low-cost, computerized, and noninvasive way. +2 more findings
Full summary, score breakdown and related studies → Original source
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2014-03-18
End-of-life care in general practice: A cross-sectional, retrospective survey of 'cancer', 'organ failure' and 'old-age/dementia' patients
57/100 ✓ Peer-reviewed End-of-life care Palliative medicine
Key finding: The results highlight the need to integrate palliative care with optimal disease management in primary practice and to initiate advance care planning early in the chronic disease trajectory to enable all patients to live as well as possible with progressive illness and die with dignity and comfort. +1 more finding
Full summary, score breakdown and related studies → Original source
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2014-03-17
Management of neuropsychiatric symptoms of dementia in clinical settings: recommendations from a multidisciplinary expert panel
51/100 ✓ Peer-reviewed Caregiving Journal of the American Geriatrics Society
Key finding: NPS are associated with poor outcomes for individuals with dementia and caregivers, including excess morbidity and mortality, greater healthcare use, and earlier nursing home placement, as well as caregiver stress, depression, and difficulty with employment. +1 more finding
Full summary, score breakdown and related studies → Original source
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2014-03-15
Anxiety is not associated with the risk of dementia or cognitive decline: the Rotterdam Study
47/100 ✓ Peer-reviewed Long-term cohort studies The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry
Key finding: We studied whether anxiety symptoms and anxiety disorders are associated with the risk of dementia and cognition. +3 more findings
Full summary, score breakdown and related studies → Original source
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2014-03-13
Quality end-of-life care for dementia: What have family carers told us so far? A narrative synthesis
40/100 ✓ Peer-reviewed End-of-life care Palliative medicine
Key finding: It is difficult to define what constitutes high-quality end-of-life care for people with dementia from the perspective of family carers. +4 more findings
Full summary, score breakdown and related studies → Original source
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2014-03-13
Impact of differential attrition on the association of education with cognitive change over 20 years of follow-up: the ARIC neurocognitive study
63/100 ✓ Peer-reviewed Long-term cohort studies American journal of epidemiology
Key finding: Evaluating cognitive change is more ideal than evaluating cognitive performance at a single time point, because it should be less susceptible to confounding. +3 more findings
Full summary, score breakdown and related studies → Original source
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