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[Biomarkers in Alzheimer's disease]
García-Ribas G, López-Sendón Moreno JL, García-Caldentey J.. Revista de neurologia, 2014-04-01
Topic: Amyloid, tau and blood-test diagnosis
The new diagnostic criteria for Alzheimer's disease (AD) include brain imaging and cerebrospinal fluid (CSF) biomarkers, with the aim of increasing the certainty of whether a patient has an ongoing AD neuropathologic process or not. Three CSF biomarkers, Aß42, total tau, and phosphorylated tau, reflect the core pathological features of AD. It is already known that these pathological processes of AD starts decades before the first symptoms, so these biomarkers may provide means of early disease detection.
Key findings
- Three CSF biomarkers, Aß42, total tau, and phosphorylated tau, reflect the core pathological features of AD.
- It is already known that these pathological processes of AD starts decades before the first symptoms, so these biomarkers may provide means of early disease detection.
- At least three stages of AD could be identified: preclinical AD, mild cognitive impairment due to AD, and dementia due to AD.
- In this review, we aim to summarize the CSF biomarker data available for each of these stages.
Why it matters
This review summarizes how three spinal fluid biomarkers reflect the core pathology of Alzheimer's disease and can detect it before symptoms appear. It covers diagnosis and staging and does not describe any treatment or cure.
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Study details
- Evidence strengthLow
How this study scored 27/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Revista de neurologia) |
| Journal's citation record | 0 / 4 | Revista de Neurología: journal h-index 51 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2014 — within 20 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 2 / 7 | Cited 14 times (OpenAlex, 2026-10-10) |
| Citations per year | 1 / 5 | 1.0 citations a year over 14 year(s) since 2014 |
| Impact for its field and year | 2 / 6 | Cited 1.1× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 0 / 4 | Cited 1 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 1 / 4 | Last-listed author Juan García Caldentey: h-index 18 (OpenAlex, whole career) |
| Institution's track record | 0 / 3 | Hospital Universitario Ramón y Cajal: institution h-index 417 (OpenAlex) |
| Multi-centre collaboration | 0 / 3 | OpenAlex lists 1 institution(s) in 1 country — scores zero (affiliation lists can be incomplete) |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 24677154) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 27 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
May need a subscription OpenAlex found no free copy of the full text (checked 6 Feb 1020), so the publisher may charge for it. The PubMed abstract is free.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
APA 7th
García-Ribas, G., López-Sendón Moreno, J. L., & García-Caldentey, J. (2014). [Biomarkers in Alzheimer's disease]. Revista de neurologia. https://doi.org/10.33588/rn.5807.2013394
Vancouver
García-Ribas G, López-Sendón Moreno JL, García-Caldentey J. [Biomarkers in Alzheimer's disease]. Revista de neurologia. 2014. doi:10.33588/rn.5807.2013394. PMID: 24677154.
BibTeX
@article{garciaribas2014-24677154,
author = {García-Ribas, G. and López-Sendón Moreno, J. L. and García-Caldentey, J.},
title = {{[Biomarkers in Alzheimer's disease]}},
journal = {Revista de neurologia},
year = {2014},
doi = {10.33588/rn.5807.2013394},
pmid = {24677154},
url = {https://doi.org/10.33588/rn.5807.2013394}
}
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