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55/100

✓ Peer-reviewed alzhub usefulness score 55 out of 100. Brain scans and imaging

Topic: Brain proteins, microglia and lab models

Importance Cerebrovascular disease (CVD) and Alzheimer disease are significant causes of cognitive impairment in the elderly. However, few studies have evaluated the relationship between CVD and β-amyloid burden in living humans or their synergistic effects on cognition. Thus, there is a need for better understanding of mild cognitive impairment (MCI) before clinical deterioration begins. Objective To determine the synergistic effects of β-amyloid burden and CVD on cognition in patients with subcortical vascular MCI (svMCI). Design, setting, and participants A cross-sectional study was conducted using a hospital-based sample at a tertiary referral center. We prospectively recruited 95 patients with svMCI; 67 of these individuals participated in the study. Forty-five patients with amnestic MCI (aMCI) were group matched with those with svMCI by the Clinical Dementia Rating Scale Sum of Boxes. Main outcomes and measures We measured β-amyloid burden using positron emission tomography with carbon 11-labeled Pittsburgh Compound B (PiB). Cerebrovascular disease was quantified as white matter hyperintensity volume detected by magnetic resonance imaging fluid-attenuated inversion recovery. Detailed neuropsychological tests were performed to determine the level of patients' cognitive impairment. Results On evaluation, 22 of the svMCI group (33%) and 28 of the aMCI group (62%) were found to be PiB positive. The mean PiB retention ratio was lower in patients with svMCI than in those with aMCI. In svMCI, the PiB retention ratio was associated with cognitive impairments in multiple domains, including language, visuospatial, memory, and frontal executive functions, but was associated only with memory dysfunction in aMCI. A significant interaction between PiB retention ratio and white matter hyperintensity volume was found to affect visuospatial function in patients with svMCI. Conclusions and relevance Most patients with svMCI do not exhibit substantial amyloid burden, and CVD does not increase β-amyloid burden as measured by amyloid imaging. However, in patients with svMCI, amyloid burden and white matter hyperintensity act synergistically to impair visuospatial function. Therefore, our findings highlight the need for accurate biomarkers, including neuroimaging tools, for early diagnosis and the need to relate these biomarkers to cognitive measurements for effective use in the clinical setting.

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APA 7th

Lee, M. J., Seo, S. W., Na, D. L., Kim, C., Park, J. H., Kim, G. H., et al. (2014). Synergistic effects of ischemia and β-amyloid burden on cognitive decline in patients with subcortical vascular mild cognitive impairment. JAMA psychiatry. https://doi.org/10.1001/jamapsychiatry.2013.4506

Vancouver

Lee MJ, Seo SW, Na DL, Kim C, Park JH, Kim GH, et al. Synergistic effects of ischemia and β-amyloid burden on cognitive decline in patients with subcortical vascular mild cognitive impairment. JAMA psychiatry. 2014. doi:10.1001/jamapsychiatry.2013.4506. PMID: 24554306.

BibTeX

@article{lee2014-24554306,
  author  = {Lee, M. J. and Seo, S. W. and Na, D. L. and Kim, C. and Park, J. H. and Kim, G. H. and Kim, C. H. and Noh, Y. and others},
  title   = {{Synergistic effects of ischemia and β-amyloid burden on cognitive decline in patients with subcortical vascular mild cognitive impairment}},
  journal = {JAMA psychiatry},
  year    = {2014},
  doi     = {10.1001/jamapsychiatry.2013.4506},
  pmid    = {24554306},
  url     = {https://doi.org/10.1001/jamapsychiatry.2013.4506}
}

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Key findings

Importance Cerebrovascular disease (CVD) and Alzheimer disease are significant causes of cognitive impairment in the elderly.
Results On evaluation, 22 of the svMCI group (33%) and 28 of the aMCI group (62%) were found to be PiB positive.
In svMCI, the PiB retention ratio was associated with cognitive impairments in multiple domains, including language, visuospatial, memory, and frontal executive functions, but was associated only with memory dysfunction in aMCI.
A significant interaction between PiB retention ratio and white matter hyperintensity volume was found to affect visuospatial function in patients with svMCI.
Therefore, our findings highlight the need for accurate biomarkers, including neuroimaging tools, for early diagnosis and the need to relate these biomarkers to cognitive measurements for effective use in the clinical setting.

Why it matters

In this cross-sectional study of patients with subcortical vascular mild cognitive impairment and amnestic mild cognitive impairment, amyloid burden was associated with cognitive impairment in multiple domains in the vascular group but only with memory dysfunction in the amnestic group, and a significant interaction was found. The study describes how vascular disease and amyloid burden relate to cognition and does not test any treatment, cure or prevention.

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Study details

Study designcross-sectional
Participants95
Evidence strengthLow

How this study scored 55/100

Published in a leading specialty journal, and it is a snapshot of people at one point in time. Scored zero for effect reported and randomized / blinded because the record does not state it.

Component	Points	Why
Journal tier	9 / 10	Tier 2 — leading specialty journal (JAMA psychiatry)
Journal's citation record	3 / 4	JAMA Psychiatry: journal h-index 256 (OpenAlex, 2026-10-29)
Study design	4 / 12	A snapshot of people at one point in time
Strength of evidence	1 / 5	Rated “low” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	1 / 5	2014 — within 20 year(s) of the newest study here
Sample size	1 / 4	95 participants
Effect reported	0 / 3	No effect size reported — scores zero (not stated in the record — scored 0)
Studied in people	3 / 3	Studied in people (participant count stated)
Randomized / blinded	0 / 2	No randomization or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	5 / 7	Cited 102 times (OpenAlex, 2026-10-10)
Citations per year	2 / 5	7.3 citations a year over 14 year(s) since 2014
Impact for its field and year	4 / 6	Cited 9.2× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	0 / 6	No other study in this library cites it
Still being cited	1 / 4	Cited 13 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	4 / 4	Last-listed author Michael Walter Weiner: h-index 171 (OpenAlex, whole career)
Institution's track record	2 / 3	University College London: institution h-index 2,029 (OpenAlex)
Multicenter collaboration	3 / 3	OpenAlex lists 20 institution(s) in 4 countries
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 24554306)
Free to read	0 / 2	Behind a paywall — scores zero
Total	55 / 100	—

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