Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 18,051–18,075 of 27,380 studies, newest first · page 723 of 1096.
February 2014 25
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2014-02-11
Biomarker evidence of axonal injury in neuroasymptomatic HIV-1 patients
55/100 ✓ Peer-reviewed Inflammation and the immune system PloS one
Key finding: Increased CSF NFL indicates ongoing axonal injury in many neuroasymptomatic patients. +1 more finding
Full summary, score breakdown and related studies → Original source
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2014-02-11
Network dysfunction after traumatic brain injury
47/100 ✓ Peer-reviewed Brain scans and imaging Nature reviews. Neurology
Key finding: Damage to the structural connectivity of these networks produces predictable abnormalities of network function and cognitive control. +4 more findings
Full summary, score breakdown and related studies → Original source
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2014-02-10
Delirium risk prediction, healthcare use and mortality of elderly adults in the emergency department
45/100 ✓ Peer-reviewed Clinical safety Journal of the American Geriatrics Society
Key finding: This risk prediction rule may help identify a group of individuals in the ED at high risk of developing delirium who should undergo screening, but it requires external validation. +1 more finding
Full summary, score breakdown and related studies → Original source
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2014-02-10
Physiological and functional consequences of caregiving for relatives with dementia
51/100 ✓ Peer-reviewed Caregiving International psychogeriatrics
Key finding: There is accumulating evidence that chronic dementia caregiver stress increases their vulnerability to disease and diminishes their ability to provide optimal care. +1 more finding
Full summary, score breakdown and related studies → Original source
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2014-02-08
Working memory improvement with non-invasive brain stimulation of the dorsolateral prefrontal cortex: a systematic review and meta-analysis
64/100 ✓ Peer-reviewed Risk factors Brain and cognition
Key finding: However, such experiments have yielded mixed results, possibly due to small sample sizes and heterogeneity of outcomes. +4 more findings
Full summary, score breakdown and related studies → Original source
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2014-02-07
The influences of age on olfaction: a review
40/100 ✓ Peer-reviewed Prevention and risk Frontiers in psychology
Key finding: Such dysfunction significantly influences physical well-being and quality of life, nutrition, the enjoyment of food, as well as everyday safety. +2 more findings
Full summary, score breakdown and related studies → Original source
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2014-02-06
Development and testing of a decision aid on goals of care for advanced dementia
43/100 ✓ Peer-reviewed End-of-life care Journal of the American Medical Directors Association
Key finding: The decision-support intervention piloted in this study was feasible and relevant for surrogate decision-makers of persons with advanced dementia in NHs, and it improved quality of communication between SDM and NH providers.
Full summary, score breakdown and related studies → Original source
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2014-02-06
Molecular imaging of Alzheimer disease pathology
48/100 ✓ Peer-reviewed Biomarkers AJNR. American journal of neuroradiology
Key finding: Large cohort studies with longitudinal follow-up in cognitively normal individuals and patients with mild cognitive impairment and Alzheimer disease indicate that β-amyloid deposition can be detected many years before the onset of symptoms with molecular imaging, and its progression can be followed longitudinally.
Full summary, score breakdown and related studies → Original source
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2014-02-05
Triggering receptor expressed on myeloid cells 2 variants are rare in Parkinson's disease in a Han Chinese cohort
54/100 ✓ Peer-reviewed TREM2 and immune genetics Neurobiology of aging
Key finding: Recent studies have reported that a rare nonsynonymous variant rs75932628-T in the TREM2 gene is associated with increased risk of Alzheimer's disease and Parkinson's disease (PD) in European-descended populations. +1 more finding
Full summary, score breakdown and related studies → Original source
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2014-02-05
Amyloid beta: multiple mechanisms of toxicity and only some protective effects?
40/100 ✓ Peer-reviewed Disease mechanisms Oxidative medicine and cellular longevity
Key finding: In contrast, Aβ has also shown some interesting neuroprotective and physiological properties under certain experimental conditions, suggesting that both physiological and pathological roles of Aβ may depend on several factors.
Full summary, score breakdown and related studies → Original source
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2014-02-04
Network dysfunction in Alzheimer's disease and frontotemporal dementia: implications for psychiatry
36/100 ✓ Peer-reviewed Brain scans and imaging Biological psychiatry
Key finding: Structural and functional connectivity methods are changing how researchers conceptualize and explore neuropsychiatric disease. +4 more findings
Full summary, score breakdown and related studies → Original source
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2014-02-03
Ageing and Parkinson's disease: why is advancing age the biggest risk factor?
40/100 ✓ Peer-reviewed Disease mechanisms Ageing research reviews
Key finding: In this review we focus specifically on the neuronal population associated with the motor symptoms of Parkinson's disease, the dopaminergic neurons of the substantia nigra, and try to understand how ageing puts these neurons at risk to the extent that a slight change in protein metabolism or mitochondrial function can push the cells over the edge leading to catastrophic cell death and many of the symptoms seen in Parkinson's disease.
Full summary, score breakdown and related studies → Original source
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2014-02-03
Pesticides exposure as etiological factors of Parkinson's disease and other neurodegenerative diseases--a mechanistic approach
36/100 ✓ Peer-reviewed Risk factors Toxicology letters
Key finding: The role of pesticide exposure in neurodegenerative disease has long been suspected, but the specific causative agents and the mechanisms underlying are not fully understood. +4 more findings
Full summary, score breakdown and related studies → Original source
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2014-02-03
Incidence of idiopathic normal pressure hydrocephalus (iNPH): a 10-year follow-up study of a rural community in Japan
42/100 ✓ Peer-reviewed Disparities Journal of the neurological sciences
Key finding: The estimated incidence of iNPH in a community was higher than those estimated by previous studies where they collected patients at hospitals.
Full summary, score breakdown and related studies → Original source
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2014-02 month only
Ocular motor disorders
38/100 ✓ Peer-reviewed Brain scans and imaging Current opinion in neurology
Key finding: Studying eye movements can provide insight into how the normal brain works, how diseases affect eye movements, and how eye movement abnormalities can be used to study diseases and/or their treatments.
Full summary, score breakdown and related studies → Original source
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2014-02-01
Patient and physician factors associated with pulmonary function testing for COPD: a population study
40/100 ✓ Peer-reviewed Digital health tools Chest
Key finding: Only about one-third of individuals with COPD in Ontario, Canada, received PFT to confirm their diagnosis; age, comorbidity, and physician factors appear to influence its use.
Full summary, score breakdown and related studies → Original source
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2014-02-01
Assessing potential glycemic overtreatment in persons at hypoglycemic risk
62/100 ✓ Peer-reviewed Digital health tools JAMA internal medicine
Key finding: We also assessed the rates in patients with other significant medical, neurologic, or mental comorbid illness. +2 more findings
Full summary, score breakdown and related studies → Original source
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2014-02-01
SIRT1 in neurodevelopment and brain senescence
36/100 ✓ Peer-reviewed Risk factors Neuron
Key finding: During neuronal development, the SIR2 ortholog SIRT1 is structurally important, promoting axonal elongation, neurite outgrowth, and dendritic branching. +4 more findings
Full summary, score breakdown and related studies → Original source
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2014-02-01
Environmental enrichment and brain repair: harnessing the therapeutic effects of cognitive stimulation and physical activity to enhance experience-dependent plasticity
36/100 ✓ Peer-reviewed Prevention trials Neuropathology and applied neurobiology
Key finding: Whilst environmental enrichment is of course a relative term, dependent on the nature of control environmental conditions, epidemiological studies suggest that EE has direct clinical relevance to a range of neurological and psychiatric disorders. +1 more finding
Full summary, score breakdown and related studies → Original source
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2014-02-01
Incretin mimetics as pharmacologic tools to elucidate and as a new drug strategy to treat traumatic brain injury
43/100 ✓ Peer-reviewed Drug development Alzheimer's & dementia : the journal of the Alzheimer's Association
Key finding: Indeed, nearly one third (30.5%) of all injury-related deaths in the USA are associated with TBI, which will soon outpace many common diseases as the major cause of death and disability. +4 more findings
Full summary, score breakdown and related studies → Original source
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2014-02-01
The incretin hormones glucagonlike peptide 1 and glucose-dependent insulinotropic polypeptide are neuroprotective in mouse models of Alzheimer's disease
40/100 ✓ Peer-reviewed Drug development Alzheimer's & dementia : the journal of the Alzheimer's Association
Key finding: We found that liraglutide, lixisenatide, and D-Ala2-GIP cross the blood-brain barrier and prevent the impairment in memory formation and synaptic plasticity, increase synapse numbers, reduce amyloid plaque load and soluble amyloid-β levels, reduce oxidative stress and the chronic inflammation response in the brain, enhance the proliferation of neuronal progenitor cells, and increase neurogenesis in the dentate gyrus.
Full summary, score breakdown and related studies → Original source
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2014-02-01
The nature, significance, and glucagon-like peptide-1 analog treatment of brain insulin resistance in Alzheimer's disease
40/100 ✓ Peer-reviewed Drug development Alzheimer's & dementia : the journal of the Alzheimer's Association
Key finding: Many of its pathologic features and cognitive deficits may be due in part to brain insulin resistance recently demonstrated in the insulin receptor→insulin receptor substrate-1 (IRS-1) signaling pathway. +2 more findings
Full summary, score breakdown and related studies → Original source
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2014-02-01
ApoE and Aβ in Alzheimer's disease: accidental encounters or partners?
36/100 ✓ Peer-reviewed Genetics Neuron
Key finding: Although earlier work suggests that different affinities of apoE isoforms to Aβ might account for their effects on Aβ clearance, recent studies indicate that apoE also competes with Aβ for cellular uptake through apoE receptors.
Full summary, score breakdown and related studies → Original source
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2014-02-01
Associations between serum cholesterol levels and cerebral amyloidosis
57/100 ✓ Peer-reviewed Vascular contributions JAMA neurology
Key finding: Elevated cerebral Aβ level was associated with cholesterol fractions in a pattern analogous to that found in coronary artery disease. +4 more findings
Full summary, score breakdown and related studies → Original source
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2014-02-01
Hippocampal sclerosis after febrile status epilepticus: the FEBSTAT study
48/100 ✓ Peer-reviewed Hippocampus size on brain scans Annals of neurology
Key finding: Hippocampal T2 hyperintensity after FSE represents acute injury often evolving to a radiological appearance of HS after 1 year. +2 more findings
Full summary, score breakdown and related studies → Original source
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