Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 16,676–16,700 of 27,380 studies, newest first · page 668 of 1096.
September 2015 25
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2015-09-14
Convergent Genetic and Expression Datasets Highlight TREM2 in Parkinson's Disease Susceptibility
67/100 ✓ Peer-reviewed TREM2 and immune genetics Molecular neurobiology
Key finding: A recent study indicated no evidence of the involvement of this variant in Parkinson's disease (PD). +3 more findings
Full summary, score breakdown and related studies → Original source
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2015-09-11
Individually modifiable risk factors to ameliorate cognitive aging: a systematic review and meta-analysis
64/100 ✓ Peer-reviewed Prevention trials Climacteric : the journal of the International Menopause Society
Key finding: A number of health and lifestyle factors are thought to contribute to cognitive decline associated with age but cannot be easily modified by the individual patient. +2 more findings
Full summary, score breakdown and related studies → Original source
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2015-09-11
Longitudinal study of normal cognition in Parkinson disease
68/100 ✓ Peer-reviewed Mild cognitive impairment Neurology
Key finding: The cumulative incidence of cognitive impairment was 8.5% at year 1, increasing to 47.4% by year 6. +1 more finding
Full summary, score breakdown and related studies → Original source
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2015-09-11
A randomized, double-blind, placebo-controlled trial of resveratrol for Alzheimer disease
81/100 ✓ Peer-reviewed Treatments Neurology
Key finding: Resveratrol was safe and well-tolerated. +3 more findings
Full summary, score breakdown and related studies → Original source
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2015-09-10
What Are Physicians' Reasons for Not Referring People with Life-Limiting Illnesses to Specialist Palliative Care Services? A Nationwide Survey
50/100 ✓ Peer-reviewed End-of-life care PloS one
Key finding: Specialist palliative care is not initiated in almost half of the people for whom it could be beneficial, most frequently because physicians deem regular caregivers to be sufficiently skilled in addressing palliative care needs.
Full summary, score breakdown and related studies → Original source
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2015-09-09
The pattern of amyloid accumulation in the brains of adults with Down syndrome
43/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Alzheimer's & dementia : the journal of the Alzheimer's Association
Key finding: PIB binding in DS, first appearing in striatum, began around age 40 and was strongly associated with dementia and cognitive decline. +1 more finding
Full summary, score breakdown and related studies → Original source
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2015-09-09
Serum amyloid-beta levels are increased in patients with obstructive sleep apnea syndrome
40/100 ✓ Peer-reviewed Biomarkers Scientific reports
Key finding: A critical link between amyloid-beta (Aβ) and hypoxia has been demonstrated in in vitro and animal studies but has not yet been proven in humans. +2 more findings
Full summary, score breakdown and related studies → Original source
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2015-09-09
A neuroradiologist's guide to arterial spin labeling MRI in clinical practice
55/100 ✓ Peer-reviewed Vascular contributions Neuroradiology
Key finding: In the workup of dementia patients, ASL is proposed as a diagnostic alternative to PET. +4 more findings
Full summary, score breakdown and related studies → Original source
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2015-09-09
Development of a model for integrated care at the end of life in advanced dementia: A whole systems UK-wide approach
47/100 ✓ Peer-reviewed End-of-life care Palliative medicine
Key finding: Use of in-depth data, consensus methods and theoretical understanding of the intervention components produced an evidence-based intervention for further testing in end-of-life care in advanced dementia.
Full summary, score breakdown and related studies → Original source
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2015-09-09
Trajectories of decline in cognition and daily functioning in preclinical dementia
46/100 ✓ Peer-reviewed Cognitive tests and assessment Alzheimer's & dementia : the journal of the Alzheimer's Association
Key finding: Although preclinical dementia is characterized by decline in cognition and daily functioning, little is known on their temporal sequence. +3 more findings
Full summary, score breakdown and related studies → Original source
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2015-09-09
The effects of light therapy on sleep problems: A systematic review and meta-analysis
66/100 ✓ Peer-reviewed Risk factors Sleep medicine reviews
Key finding: Although bright light therapy seems a promising treatment for sleep problems, research shows inconclusive results. +3 more findings
Full summary, score breakdown and related studies → Original source
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2015-09-09
Detailed comparison of amyloid PET and CSF biomarkers for identifying early Alzheimer disease
72/100 ✓ Peer-reviewed Biomarkers Neurology
Key finding: The best CSF measures for identifying MCI-AD were Aβ42/total tau (t-tau) and Aβ42/hyperphosphorylated tau (p-tau) (area under the curve [AUC] 0.93-0.94). +2 more findings
Full summary, score breakdown and related studies → Original source
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2015-09-08
Western diet is associated with a smaller hippocampus: a longitudinal investigation
79/100 ✓ Peer-reviewed Hippocampus size on brain scans BMC medicine
Key finding: Lower intakes of nutrient-dense foods and higher intakes of unhealthy foods are each independently associated with smaller left hippocampal volume. +2 more findings
Full summary, score breakdown and related studies → Original source
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2015-09-08
Tauopathies as clinicopathological entities
36/100 ✓ Peer-reviewed Disease mechanisms Parkinsonism & related disorders
Key finding: Further, staging efforts in human autopsy cases suggest a sequential distribution of tau aggregation in the central nervous system that could reflect this observed cell-to-cell transmission of pathogenic tau species in animal models. +4 more findings
Full summary, score breakdown and related studies → Original source
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2015-09-07
Redox- and non-redox-metal-induced formation of free radicals and their role in human disease
36/100 ✓ Peer-reviewed Disease mechanisms Archives of toxicology
Key finding: The depletion of zinc may enhance DNA damage by impairing DNA repair mechanisms. +4 more findings
Full summary, score breakdown and related studies → Original source
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2015-09-07
Measuring sleep quality in older adults: a comparison using subjective and objective methods
50/100 ✓ Peer-reviewed Caregiving Frontiers in aging neuroscience
Key finding: Given the aging population-and the impending economic burden associated with increasing numbers of dementia patients-there is pressing need to improve sleep quality among older adults. +3 more findings
Full summary, score breakdown and related studies → Original source
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2015-09-07
Relationship between the Montreal Cognitive Assessment and Mini-mental State Examination for assessment of mild cognitive impairment in older adults
65/100 ✓ Peer-reviewed Getting a diagnosis BMC geriatrics
Key finding: MoCA and MMSE were more similar for dementia cases, but MoCA distributes MCI cases across a broader score range with less ceiling effect. +3 more findings
Full summary, score breakdown and related studies → Original source
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2015-09-04
TREM2 in CNS homeostasis and neurodegenerative disease
50/100 ✓ Peer-reviewed TREM2 and immune genetics Molecular neurodegeneration
Key finding: The innate immune receptor and its adaptor protein—triggering receptor expressed on myeloid cells 2 (TREM2) and DNAX-activating protein of 12 kDa (DAP12)—possess the ability to modulate critical cellular functions via crosstalk with diverse signaling pathways. +3 more findings
Full summary, score breakdown and related studies → Original source
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2015-09-03
A novel multi-tissue RNA diagnostic of healthy ageing relates to cognitive health status
67/100 ✓ Peer-reviewed Genetics Genome biology
Key finding: One hundred and fifty probe-sets form an accurate classifier of young versus older muscle tissue and this healthy ageing RNA classifier performed consistently in independent cohorts of human muscle, skin and brain tissue (n = 594, AUC = 0.83-0.96) and thus represents a biomarker for biological age. +4 more findings
Full summary, score breakdown and related studies → Original source
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2015-09-03
Autosomal dominant Parkinson's disease caused by SNCA duplications
36/100 ✓ Peer-reviewed Brain scans and imaging Parkinsonism & related disorders
Key finding: We found that over half of the reported cases with SNCA duplication had early-onset parkinsonism and non-motor features, such as dysautonomia, rapid eye movement sleep behavior disorder (RBD), hallucinations (usually visual) and cognitive deficits leading to dementia.
Full summary, score breakdown and related studies → Original source
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2015-09-03
Monomeric C-reactive protein--a key molecule driving development of Alzheimer's disease associated with brain ischaemia?
40/100 ✓ Peer-reviewed Clinical safety Scientific reports
Key finding: IHC study of human AD/stroke patients revealed co-localization of mCRP with Aβ plaques, tau-like fibrils and IRS-1/P-Tau positive neurons and high mCRP-levels spreading from infarcted core regions matched reduced expression of Aβ/Tau. mCRP may be responsible for promoting dementia after ischaemia and mCRP clearance could inform therapeutic avenues to reduce the risk of future dementia.
Full summary, score breakdown and related studies → Original source
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2015-09-03
Prudent diet may attenuate the adverse effects of Western diet on cognitive decline
62/100 ✓ Peer-reviewed Cognitive tests and assessment Alzheimer's & dementia : the journal of the Alzheimer's Association
Key finding: The influence of mixed dietary patterns on cognitive changes is unknown. +3 more findings
Full summary, score breakdown and related studies → Original source
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2015-09-03
Social robots in advanced dementia
50/100 ✓ Peer-reviewed Cognitive tests and assessment Frontiers in aging neuroscience
Key finding: Pilot studies applying a humanoid robot (NAO), a pet robot (PARO) and a real animal (DOG) in therapy sessions of patients with dementia in a nursing home and a day care center. +3 more findings
Full summary, score breakdown and related studies → Original source
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2015-09-03
A Semiautomated Method for Quantification of F 18 Florbetapir PET Images
39/100 ✓ Peer-reviewed Brain scans and imaging Journal of nuclear medicine : official publication, Society of Nuclear Medicine
Key finding: PET amyloid imaging is increasingly used in research trials related to Alzheimer disease and has potential as a quantitative biomarker.
Full summary, score breakdown and related studies → Original source
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2015-09-03
Current Developments in Dementia Risk Prediction Modelling: An Updated Systematic Review
66/100 ✓ Peer-reviewed Prevention and risk PloS one
Key finding: In total, 1,234 articles were identified from the search; 21 articles met inclusion criteria. +4 more findings
Full summary, score breakdown and related studies → Original source
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