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Toward onset prevention of cognitive decline in adults with Down syndrome (the TOP-COG study): study protocol for a randomized controlled trial
Cooper SA, Caslake M, Evans J, Hassiotis A, Jahoda A, McConnachie A, Morrison J, Ring H et al.. Trials, 2014-06-03
Topic: Risk, prevention and care in population studies
Plain-language summary
The intervention is oral simvastatin 40 mg at night for 12 months, versus placebo.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Cooper, S. A., Caslake, M., Evans, J., Hassiotis, A., Jahoda, A., McConnachie, A., et al. (2014). Toward onset prevention of cognitive decline in adults with Down syndrome (the TOP-COG study): study protocol for a randomized controlled trial. Trials. https://doi.org/10.1186/1745-6215-15-202
Vancouver
Cooper SA, Caslake M, Evans J, Hassiotis A, Jahoda A, McConnachie A, et al. Toward onset prevention of cognitive decline in adults with Down syndrome (the TOP-COG study): study protocol for a randomized controlled trial. Trials. 2014. doi:10.1186/1745-6215-15-202. PMID: 24888381.
BibTeX
@article{cooper2014-24888381,
author = {Cooper, S. A. and Caslake, M. and Evans, J. and Hassiotis, A. and Jahoda, A. and McConnachie, A. and Morrison, J. and Ring, H. and others},
title = {{Toward onset prevention of cognitive decline in adults with Down syndrome (the TOP-COG study): study protocol for a randomized controlled trial}},
journal = {Trials},
year = {2014},
doi = {10.1186/1745-6215-15-202},
pmid = {24888381},
url = {https://doi.org/10.1186/1745-6215-15-202}
}
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Key findings
- The intervention is oral simvastatin 40 mg at night for 12 months, versus placebo.
Why it matters
This is a study protocol, so no results are available yet. It will test whether 12 months of oral simvastatin 40 mg at night can prevent cognitive decline in adults with Down syndrome.
New to this subject? Start with our plain-English guide: Treatments →
Study details
- Study designrandomized controlled trial
- Evidence strengthHigh
How this study scored 57/100
Published in a peer-reviewed journal, and it is a randomized controlled trial. Scored zero for sample size and effect reported because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Trials) |
| Journal's citation record | 1 / 4 | Trials: journal h-index 132 (OpenAlex, 2026-10-29) |
| Study design | 11 / 12 | A randomized controlled trial |
| Strength of evidence | 5 / 5 | Rated “high” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2014 — within 20 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (pubmed indexes it as a clinical or observational study) |
| Randomized / blinded | 1 / 2 | Randomized (as stated in the record) |
| Times cited | 3 / 7 | Cited 18 times (OpenAlex, 2026-10-10) |
| Citations per year | 1 / 5 | 1.3 citations a year over 14 year(s) since 2014 |
| Impact for its field and year | 2 / 6 | Cited 2.5× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 1 / 6 | Cited by 2 other studies in this library |
| Still being cited | 0 / 4 | Cited 1 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 3 / 4 | Last-listed author Frank Sullivan: h-index 70 (OpenAlex, whole career) |
| Institution's track record | 2 / 3 | University College London: institution h-index 2,029 (OpenAlex) |
| Multicenter collaboration | 2 / 3 | OpenAlex lists 7 institution(s) in 2 countries |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 24888381) |
| Free to read | 2 / 2 | Free to read |
| Total | 57 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
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