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Apolipoprotein E Allele and Hearing Thresholds in Older Adults
David J Mener, Joshua Betz, Kristine Yaffe, Tamara B Harris, Elizabeth P Helzner, Suzanne Satterfield, Denise K Houston, Elsa S Strotmeyer et al.. American journal of Alzheimer's disease and other dementias, 2014-06-06
Topic: Genetics and APOE
Compared to participants with no APOE-E4 alleles, participants with 1 allele had better thresholds at 4.0 kHz (β = -2.72 dB, P = .013) and 8.0 kHz (β = -3.05 kHz, P = .006), and participants with 2 alleles had better hearing thresholds at 1.0 kHz (β = -8.56 dB, P = .021). Our results suggest that APOE-E4 allele status may be marginally associated with better hearing thresholds in older adults.
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APA 7th
Mener, D. J., Betz, J., Yaffe, K., Harris, T. B., Helzner, E. P., Satterfield, S., et al. (2016). Apolipoprotein E Allele and Hearing Thresholds in Older Adults. American journal of Alzheimer's disease and other dementias. https://doi.org/10.1177/1533317514537549
Vancouver
Mener DJ, Betz J, Yaffe K, Harris TB, Helzner EP, Satterfield S, et al. Apolipoprotein E Allele and Hearing Thresholds in Older Adults. American journal of Alzheimer's disease and other dementias. 2016. doi:10.1177/1533317514537549. PMID: 24906966.
BibTeX
@article{mener2016-24906966,
author = {Mener, David J and Betz, Joshua and Yaffe, Kristine and Harris, Tamara B and Helzner, Elizabeth P and Satterfield, Suzanne and Houston, Denise K and Strotmeyer, Elsa S and others},
title = {{Apolipoprotein E Allele and Hearing Thresholds in Older Adults}},
journal = {American journal of Alzheimer's disease and other dementias},
year = {2016},
doi = {10.1177/1533317514537549},
pmid = {24906966},
url = {https://doi.org/10.1177/1533317514537549}
}
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Key findings
- Compared to participants with no APOE-E4 alleles, participants with 1 allele had better thresholds at 4.0 kHz (β = -2.72 dB, P = .013) and 8.0 kHz (β = -3.05 kHz, P = .006), and participants with 2 alleles had better hearing thresholds at 1.0 kHz (β = -8.56 dB, P = .021).
- Our results suggest that APOE-E4 allele status may be marginally associated with better hearing thresholds in older adults.
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Study details
- Study designcross-sectional
- Participants1,833
- Evidence strengthLow
How this study scored 55/100
Published in a peer-reviewed journal, and it is a snapshot of people at one point in time. Scored zero for effect reported and randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record, multi-centre collaboration and free to read, so those were left out: it earned 31 of the 56 points we could judge it on, which is 55 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (American journal of Alzheimer's disease and other dementias) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 4 / 12 | A snapshot of people at one point in time |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2016 — within 20 year(s) of the newest study here |
| Sample size | 3 / 4 | 1,833 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 24906966) |
| Free to read | — / 2 | Access not recorded — left out of this score |
| Points | 31 / 56 | Scored on 10 of 20 parts. We have no data for the rest, so they are left out: 31 of the 56 points we could judge it on is 55 out of 100. |
| Total | 55 / 100 | — |
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