Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 24,051–24,075 of 27,380 studies, newest first · page 963 of 1096.
July 2004 9
-
2004-07-01
Mild cognitive impairment, amnestic type: an epidemiologic study
63/100 ✓ Peer-reviewed How common it is Neurology
Key finding: In this community-based sample, 3 to 4% of nondemented persons met MCI operational criteria; despite increased risk of progressing to dementia, a substantial proportion also remained stable or reverted to normal during follow-up. +2 more findings
Full summary, score breakdown and related studies → Original source
-
2004-07-01
Pathways to dementia diagnosis: evidence for cross-ethnic differences
40/100 ✓ Peer-reviewed Disparities Alzheimer disease and associated disorders
Key finding: Help-seeking was most often initiated by family members or formal care providers (ie, healthcare providers or social workers), usually in outpatient primary care settings but also elsewhere (eg, social service agencies, hospitals). +1 more finding
Full summary, score breakdown and related studies → Original source
-
2004-07-01
Predicting the rate of cognitive decline in aging and early Alzheimer disease
54/100 ✓ Peer-reviewed Brain scans and imaging Neurology
Key finding: Percent total HSI, ventricular, and total CSF volume measures can independently predict the rate of cognitive decline and improve the predictive power of statistical models that use only clinical data. +3 more findings
Full summary, score breakdown and related studies → Original source
-
2004-07-01
White matter lesions impair frontal lobe function regardless of their location
57/100 ✓ Peer-reviewed Brain scans and imaging Neurology
Key finding: The frontal lobes are most severely affected by SIVD. +3 more findings
Full summary, score breakdown and related studies → Original source
-
2004-07-01
Nonsteroidal anti-inflammatory drugs for the prevention of Alzheimer's disease: a systematic review
62/100 ✓ Peer-reviewed Prevention and risk Neuroepidemiology
Key finding: Based on analysis of prospective and nonprospective studies, NSAID exposure was associated with decreased risk of Alzheimer's disease. +2 more findings
Full summary, score breakdown and related studies → Original source
-
2004-07-01
Metaanalysis of randomized trials of the efficacy and safety of donepezil, galantamine, and rivastigmine for the treatment of Alzheimer disease
53/100 ✓ Peer-reviewed Treatments The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry
Key finding: All three drugs showed beneficial effects on cognitive tests, as compared with placebo. +3 more findings
Full summary, score breakdown and related studies → Original source
-
2004-07-01
Transgenic mice overexpressing amyloid beta protein are an incomplete model of Alzheimer disease
42/100 ✓ Peer-reviewed Genetics Experimental neurology
Key finding: The abundant amyloid deposits in tg mice were in a consolidated state as revealed by strong Congo red birefringence. +3 more findings
Full summary, score breakdown and related studies → Original source
-
2004-07-01
Memory impairment, but not cerebrovascular disease, predicts progression of MCI to dementia
55/100 ✓ Peer-reviewed Genetics Neurology
Key finding: Within a heterogenous group of MCI patients, including many with clinically significant CVD, baseline memory and executive performance significantly predicted likelihood to develop dementia. +4 more findings
Full summary, score breakdown and related studies → Original source
-
2004-07-01
Analysis of European mitochondrial haplogroups with Alzheimer disease risk
49/100 ✓ Peer-reviewed Genetics Neuroscience letters
Key finding: Males classified as haplogroup U showed an increase in risk (OR = 2.30; 95% CI, 1.03-5.11; P = 0.04) of AD relative to the most common haplogroup H, while females demonstrated a significant decrease in risk with haplogroup U (OR = 0.44 ; 95% CI, 0.24-0.80; P = 0.007). +2 more findings
Full summary, score breakdown and related studies → Original source
June 2004 16
-
2004-06-30
Cognitive dysfunction and dementia in Parkinson's disease
46/100 ✓ Peer-reviewed Caregiving Journal of neural transmission (Vienna, Austria : 1996)
Key finding: It is thought to be the result of a combination of both subcortical and cortical changes. +1 more finding
Full summary, score breakdown and related studies → Original source
-
2004-06-25
HIV secreted protein Tat prevents long-term potentiation in the hippocampal CA1 region
38/100 ✓ Peer-reviewed Disease mechanisms Brain research
Key finding: Tat 1-72delta31-61, which lacks the neurotoxic domain of Tat, had no significant effect on LTP.
Full summary, score breakdown and related studies → Original source
-
2004-06-25
Proteomic characterization of postmortem amyloid plaques isolated by laser capture microdissection
45/100 ✓ Peer-reviewed Genetics The Journal of biological chemistry
Key finding: We identified a total of 488 proteins co-isolated with the plaques, and we found multiple phosphorylation sites on the neurofilament intermediate chain, implicating the complexity and diversity of cellular processes involved in the plaque formation. +3 more findings
Full summary, score breakdown and related studies → Original source
-
2004-06-24
Stroke risk profile predicts white matter hyperintensity volume: the Framingham Study
51/100 ✓ Peer-reviewed How common it is Stroke
Key finding: FSRP and several cardiovascular risk factors were related to both WMHV measured continuously and to a categorical designation of large volumes of WMH. +2 more findings
Full summary, score breakdown and related studies → Original source
-
2004-06-24
Screening for cognitive impairment among older people in black and minority ethnic groups
38/100 ✓ Peer-reviewed Disparities Age and ageing
Key finding: This gives rise to a substantially higher risk of mistaken diagnosis of dementia. +1 more finding
Full summary, score breakdown and related studies → Original source
-
2004-06-21
Regional distribution of white matter hyperintensities in vascular dementia, Alzheimer's disease and healthy aging
41/100 ✓ Peer-reviewed Cognitive tests and assessment Dementia and geriatric cognitive disorders
Key finding: White matter hyperintensities (WMH) on MRI scans indicate lesions of the subcortical fiber system. +3 more findings
Full summary, score breakdown and related studies → Original source
-
2004-06-13
Apolipoprotein E promotes astrocyte colocalization and degradation of deposited amyloid-beta peptides
52/100 ✓ Peer-reviewed Genetics Nature medicine
Key finding: We have previously shown that apolipoprotein E (Apoe) promotes the formation of amyloid in brain and that astrocyte-specific expression of APOE markedly affects the deposition of amyloid-beta peptides (Abeta) in a mouse model of Alzheimer disease.
Full summary, score breakdown and related studies → Original source
-
2004-06-09
Gene regulation and DNA damage in the ageing human brain
41/100 ✓ Peer-reviewed Disease mechanisms Nature
Key finding: These genes play central roles in synaptic plasticity, vesicular transport and mitochondrial function. +4 more findings
Full summary, score breakdown and related studies → Original source
-
2004-06-03
Neurodegenerative disorders associated with diabetes mellitus
42/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Journal of molecular medicine (Berlin, Germany)
Key finding: More than 20 syndromes among the significant and increasing number of degenerative diseases of neuronal tissues are known to be associated with diabetes mellitus, increased insulin resistance and obesity, disturbed insulin sensitivity, and excessive or impaired insulin secretion. +1 more finding
Full summary, score breakdown and related studies → Original source
-
2004-06-01
Hsp70 Reduces α-Synuclein Aggregation and Toxicity
40/100 ✓ Peer-reviewed Brain tissue and pathology Journal of Biological Chemistry
Key finding: Introducing the molecular chaperone Hsp70 into the in vivo model by breeding alpha-synuclein transgenic mice with Hsp70-overexpressing mice led to a significant reduction in both the high molecular weight and detergent-insoluble alpha-synuclein species. +2 more findings
Full summary, score breakdown and related studies → Original source
-
2004-06 month only
Review of donepezil, rivastigmine, galantamine and memantine for the treatment of dementia in Alzheimer's disease in adults with Down syndrome: implications for the intellectual disability population
38/100 ✓ Peer-reviewed Treatments International journal of geriatric psychiatry
Key finding: The management of dementia in Alzheimer's disease has dramatically changed since the development of anti-dementia drugs. +4 more findings
Full summary, score breakdown and related studies → Original source
-
2004-06-01
Plasma homocysteine levels and risk of Alzheimer disease
64/100 ✓ Peer-reviewed Costs and economics Neurology
Key finding: High homocysteine levels were not associated with AD and were not related to a decrease in memory scores over time. +3 more findings
Full summary, score breakdown and related studies → Original source
-
2004-06-01
Insulin resistance syndrome in children
36/100 ✓ Peer-reviewed Disparities The Journal of clinical endocrinology and metabolism
Key finding: The natural history includes small for gestational age birth weight, excessive weight gains during childhood, premature pubarche, an allergic diathesis, acanthosis nigricans, striae compounded by gynecomastia, hypertriglyceridemia, hepatic steatosis, premature atherosclerosis, hypertension, polycystic ovarian syndrome, and focal glomerulonephritis appearing increasingly through adolescence into adulthood. +4 more findings
Full summary, score breakdown and related studies → Original source
-
2004-06-01
Validation of a 26-point telephone version of the Mini-Mental State Examination
52/100 ✓ Peer-reviewed Risk factors Journal of geriatric psychiatry and neurology
Key finding: Hearing impairment and education level did not significantly affect telephone-based performance.
Full summary, score breakdown and related studies → Original source
-
2004-06-01
Glycogen synthase kinase 3: a drug target for CNS therapies
36/100 ✓ Peer-reviewed Drug development Journal of neurochemistry
Key finding: The most exciting of the possibilities of GSK3 lies within the treatment of Alzheimer's disease (AD) where abnormal increases in GSK3 levels and activity have been associated with neuronal death, paired helical filament tau formation and neurite retraction as well as a decline in cognitive performance.
Full summary, score breakdown and related studies → Original source
-
2004-06-01
Long-term donepezil treatment in 565 patients with Alzheimer's disease (AD2000): randomised double-blind trial
69/100 ✓ Peer-reviewed Treatments Lancet (London, England)
Key finding: Cognition averaged 0.8 MMSE (mini-mental state examination) points better (95% CI 0.5-1.2; p<0.0001) and functionality 1.0 BADLS points better (0.5-1.6; p<0.0001) with donepezil over the first 2 years. +2 more findings
Full summary, score breakdown and related studies → Original source
Browse the library by subject, with the full score breakdown →