alzhub.org
Get help now — free helplines

You can call any of these for free. You do not need a diagnosis, an appointment, or a crisis to call — questions and plain exhaustion are reasons enough.

  • Alzheimer's Association 24/7 Helpline 800-272-3900 24 hours a day, 365 days a year Free, confidential support and information for people with dementia, caregivers, families and the public. Master's-level clinicians. Also Spanish.
  • 988 Suicide & Crisis Lifeline 988 24/7 Call or text 988, or chat at 988lifeline.org. For anyone in emotional distress or a mental-health crisis, including caregivers.
  • Alzheimer's Foundation of America (AFA) Helpline 866-232-8484 9:00 am - 9:00 pm ET, seven days a week Licensed social workers providing support, info and referrals. Also text message and web chat. Text: 646-586-5283

In a medical emergency, call 911. More numbers, and what each line does, on the help page.

Newest studies

Every summary in our library, newest first, as a dated timeline.

What "newest" means here

The most recent study in this library is dated 2026-11-01 (Paths of Aging Minds: Health Journeys of Older Adults with Mild Cognitive Impairment). This is our summary library, not a news wire — it is added to in batches, so the newest entry may not be the newest paper published anywhere.

Entries are sorted strictly by publication date, newest first. 26489 of the 27380 entries carry a full day-level date. 65 have no date recorded at all and are placed by publication year, at the start of that year; those are marked "no date recorded" below so you can see where the ordering is a best effort rather than a fact.

Prefer a reader? Subscribe to the Atom feed. Want them sorted by subject or by score instead? Browse the research library.

Showing 17,176–17,200 of 27,380 studies, newest first · page 688 of 1096.

February 2015 25

  1. 2015-02-25

    Tau Positron Emission Tomography (PET) Imaging: Past, Present, and Future

    ✓ Peer-reviewed Brain scans and imaging Journal of medicinal chemistry

    Key finding: Alzheimer's disease (AD) is a chronic neurodegenerative disorder and the most common cause of dementia among the elderly population. +3 more findings

    Full summary, score breakdown and related studies → Original source

  2. 2015-02-25

    Spatially distinct atrophy is linked to β-amyloid and tau in preclinical Alzheimer disease

    ✓ Peer-reviewed Brain scans and imaging Neurology

    Key finding: Spatially distinct neurodegeneration is associated with Aβ and tau pathology in preclinical AD. +4 more findings

    Full summary, score breakdown and related studies → Original source

  3. 2015-02-24

    Disease-Associated Mutations of TREM2 Alter the Processing of N-Linked Oligosaccharides in the Golgi Apparatus

    ✓ Peer-reviewed TREM2 and immune genetics Traffic (Copenhagen, Denmark)

    Key finding: Mutations of Q33X, Y38C and T66M cause Nasu-Hakola disease (NHD) which is characterized by early onset of dementia and bone cysts. +3 more findings

    Full summary, score breakdown and related studies → Original source

  4. 2015-02-23

    Cross-sectional comparison of small animal [18F]-florbetaben amyloid-PET between transgenic AD mouse models

    ✓ Peer-reviewed Brain scans and imaging PloS one

    Key finding: We correlated methoxy-X04 staining of β-amyloid with PET results, and undertook ex vivo autoradiography for further validation of a partial volume effect correction (PVEC) of PET data.

    Full summary, score breakdown and related studies → Original source

  5. 2015-02-23

    From admission to death: prevalence and course of pain, agitation, and shortness of breath, and treatment of these symptoms in nursing home residents with dementia

    ✓ Peer-reviewed End-of-life care Journal of the American Medical Directors Association

    Key finding: Pain and agitation were common and frequently persisted in residents with dementia during nursing home stay, but symptom management intensified only at the end of life. +3 more findings

    Full summary, score breakdown and related studies → Original source

  6. 2015-02-23

    Different cerebrospinal fluid levels of Alzheimer-type biomarker Aβ42 between general paresis and asymptomatic neurosyphilis

    ✓ Peer-reviewed Tau biomarkers European journal of neurology

    Key finding: Neurosyphilis is a neurological disease that involves infection of the central nervous system with Treponema pallidum. +3 more findings

    Full summary, score breakdown and related studies → Original source

  7. 2015-02-21

    Thinner changes of the retinal nerve fiber layer in patients with mild cognitive impairment and Alzheimer's disease

    ✓ Peer-reviewed Mild cognitive impairment BMC neurology

    Key finding: Our data indicate that the retinal nerve fiber layer degeneration is paralleled with dementia progression. +3 more findings

    Full summary, score breakdown and related studies → Original source

  8. 2015-02-20

    Modifiable predictors of dementia in mild cognitive impairment: a systematic review and meta-analysis

    ✓ Peer-reviewed Prevention and risk The American journal of psychiatry

    Key finding: Diabetes increased the risk of conversion to dementia. +1 more finding

    Full summary, score breakdown and related studies → Original source

  9. 2015-02-19

    The human CHRNA7 and CHRFAM7A genes: A review of the genetics, regulation, and function

    ✓ Peer-reviewed Genetics Neuropharmacology

    Key finding: The duplication is human specific, occurring neither in primates nor in rodents. +4 more findings

    Full summary, score breakdown and related studies → Original source

  10. 2015-02-19

    Pathological tau disrupts ongoing network activity

    ✓ Peer-reviewed Disease mechanisms Neuron

    Key finding: Using in vivo intracellular and extracellular recordings, we measured ongoing activity of neocortical pyramidal cells during various arousal states in the rTg4510 mouse model of tauopathy, prior to significant cell death, when only a fraction of the neurons show pathological tau. +1 more finding

    Full summary, score breakdown and related studies → Original source

  11. 2015-02-19

    Low cardiac index is associated with incident dementia and Alzheimer disease: the Framingham Heart Study

    ✓ Peer-reviewed Long-term cohort studies Circulation

    Key finding: Cross-sectional epidemiological and clinical research suggests that lower cardiac index is associated with abnormal brain aging, including smaller brain volumes, increased white matter hyperintensities, and worse cognitive performances. +3 more findings

    Full summary, score breakdown and related studies → Original source

  12. 2015-02-19

    Montreal Cognitive Assessment 5-minute protocol is a brief, valid, reliable, and feasible cognitive screen for telephone administration

    ✓ Peer-reviewed Cognitive tests and assessment Stroke

    Key finding: The National Institute of Neurological Disorders and Stroke-Canadian Stroke Network Vascular Cognitive Impairment Harmonization working group proposed a brief cognitive protocol for screening of vascular cognitive impairment. +3 more findings

    Full summary, score breakdown and related studies → Original source

  13. 2015-02-18

    Compromised MAPK signaling in human diseases: an update

    ✓ Peer-reviewed Inflammation and the immune system Archives of toxicology

    Key finding: The p38 MAPK pathway contributes to neuroinflammation mediated by glial cells including microglia and astrocytes, and it has also been associated with anticancer drug resistance in colon and liver cancer.

    Full summary, score breakdown and related studies → Original source

  14. 2015-02-18

    Can physicians conceive of performing euthanasia in case of psychiatric disease, dementia or being tired of living?

    ✓ Peer-reviewed Disparities Journal of medical ethics

    Key finding: This study shows that a minority of Dutch physicians find it conceivable that they would grant a request for EAS from a patient with psychiatric disease, dementia or a patient who is tired of living. +1 more finding

    Full summary, score breakdown and related studies → Original source

  15. 2015-02-17

    Effect of stress and peripheral immune activation on astrocyte activation in transgenic bioluminescent Gfap‐luc mice

    ✓ Peer-reviewed Inflammation and the immune system Glia

    Key finding: However, stressed animals showed a reduced response to a subsequent systemic LPS injection, suggesting that the immune system is compromised in these animals.

    Full summary, score breakdown and related studies → Original source

  16. 2015-02-17

    Aging‐like changes in the transcriptome of irradiated microglia

    ✓ Peer-reviewed Inflammation and the immune system Glia

    Key finding: Although necessary for improving survival outcomes, cranial irradiation also results in cognitive decline in long‐term survivors. +3 more findings

    Full summary, score breakdown and related studies → Original source

  17. 2015-02-17

    Neuroinflammation and Aβ Accumulation Linked To Systemic Inflammation Are Decreased By Genetic PKR Down-Regulation

    ✓ Peer-reviewed Inflammation and the immune system Scientific Reports

    Key finding: Previous works have suggested that systemic inflammation could contribute to neuroinflammation and enhanced Aβ cerebral concentrations. +2 more findings

    Full summary, score breakdown and related studies → Original source

  18. 2015-02-17

    Comfort goal of care and end-of-life outcomes in dementia: A prospective study

    ✓ Peer-reviewed End-of-life care Palliative medicine

    Key finding: We found that family satisfaction with care is related to a comfort care goal shortly after admission, but quality of dying did not. +4 more findings

    Full summary, score breakdown and related studies → Original source

  19. 2015-02-17

    In vivo imaging of tau pathology using multi-parametric quantitative MRI

    ✓ Peer-reviewed Disease mechanisms NeuroImage

    Key finding: However the descent into dementia is not defined by macroscopic brain matter loss alone: non-invasive imaging measurements sensitive to protein accumulation, white matter integrity and cerebral haemodynamics probe distinct aspects of AD pathophysiology and may serve as superior biomarkers for assessing drug efficacy. +4 more findings

    Full summary, score breakdown and related studies → Original source

  20. 2015-02-17

    Translating Evidence-Based Dementia Caregiving Interventions into Practice: State-of-the-Science and Next Steps

    ✓ Peer-reviewed Caregiving The Gerontologist

    Key finding: We suggest that as caregiver interventions are tested external to service contexts, a translational phase is required.

    Full summary, score breakdown and related studies → Original source

  21. 2015-02-17

    White matter hyperintensities, cognitive impairment and dementia: an update

    ✓ Peer-reviewed Brain scans and imaging Nature reviews. Neurology

    Key finding: Over the past three decades, research has shown that the presence and extent of white matter hyperintense signals on MRI are important for clinical outcome, in terms of cognitive and functional impairment. +1 more finding

    Full summary, score breakdown and related studies → Original source

  22. 2015-02-17

    Prevalence and prognosis of Alzheimer's disease at the mild cognitive impairment stage

    ✓ Peer-reviewed Getting a diagnosis Brain : a journal of neurology

    Key finding: Their 3-year progression rate to Alzheimer's disease-type dementia was 50% compared to 21% for subjects without prodromal Alzheimer's disease. +2 more findings

    Full summary, score breakdown and related studies → Original source

  23. 2015-02-17

    Age-related hearing impairment-a risk factor and frailty marker for dementia and AD

    ✓ Peer-reviewed Prevention and risk Nature reviews. Neurology

    Key finding: ARHI is an important frailty marker, and several factors related to physical frailty could be associated with cognitive impairment. +1 more finding

    Full summary, score breakdown and related studies → Original source

  24. 2015-02-16

    A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases

    ✓ Peer-reviewed Risk factors Nature medicine

    Key finding: MCC950 blocked canonical and noncanonical NLRP3 activation at nanomolar concentrations. +4 more findings

    Full summary, score breakdown and related studies → Original source

  25. 2015-02-16

    Cognitive function in patients with diabetes mellitus: guidance for daily care

    ✓ Peer-reviewed Risk factors The Lancet. Neurology

    Key finding: Diabetes mellitus is associated with an increase in the risk of dementia and the proportion of patients who convert from mild cognitive impairment (MCI) to dementia. +1 more finding

    Full summary, score breakdown and related studies → Original source

Browse the library by subject, with the full score breakdown →