Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 17,826–17,850 of 27,380 studies, newest first · page 714 of 1096.
June 2014 7
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2014-06-01
Early identification of palliative care needs by family physicians: A qualitative study of barriers and facilitators from the perspective of family physicians, community nurses, and patients
43/100 ✓ Peer-reviewed End-of-life care Palliative medicine
Key finding: The current practice of palliative care in Belgium is far from the presently considered ideal palliative care approaches.
Full summary, score breakdown and related studies → Original source
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2014-06-01
Diabetes Mellitus and Blood-Brain Barrier Dysfunction: An Overview
36/100 ✓ Peer-reviewed Disease mechanisms Journal of pharmacovigilance
Key finding: The underlying causes of diabetes-induced CNS complications are multifactorial and are relatively little understood although it is now evident that blood-brain barrier (BBB) damage plays a significant role in diabetes-dependent CNS disorders. +3 more findings
Full summary, score breakdown and related studies → Original source
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2014-06-01
A Shelter of Others by Charles Dodd White (review)
22/100 ✓ Peer-reviewed Risk factors Appalachian heritage
Key finding: As Deputy Gibbs’ father says, “I know it’s hard to find people in this world,” he said. +4 more findings
Full summary, score breakdown and related studies → Original source
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2014-06-01
Relationship of hearing loss and dementia: a prospective, population-based study
64/100 ✓ Peer-reviewed Prevention and risk Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
Key finding: At baseline, 4,463 subjects were without dementia, 836 of whom had HL. +2 more findings
Full summary, score breakdown and related studies → Original source
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2014-06-01
Effects of galantamine and galantamine combined with nimodipine on cognitive speed and quality of life in mixed dementia: a 24-week, randomized, placebo-controlled exploratory trial (the REMIX study)
56/100 ✓ Peer-reviewed Treatments Arquivos de neuro-psiquiatria
Key finding: Twenty-one patients received at least one drug dose (9 GAL/NIM and 12 GAL/PLA). +2 more findings
Full summary, score breakdown and related studies → Original source
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2014-06-01
MAPT STUDY: A MULTIDOMAIN APPROACH FOR PREVENTING ALZHEIMER'S DISEASE: DESIGN AND BASELINE DATA
59/100 ✓ Peer-reviewed Treatments The journal of prevention of Alzheimer's disease
Key finding: AV45 PET scans were performed in 271 individuals and preliminary results showed that 38.0% had a cortical SUVR > 1.17, which gave an indication of significant brain amyloïd deposit.
Full summary, score breakdown and related studies → Original source
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2014-06-01
Amyloid PET/MRI in the differential diagnosis of dementia
34/100 ✓ Peer-reviewed Biomarkers Clinical nuclear medicine
Key finding: The potential of brain imaging has grown rapidly with new modalities, hybrid combinations of existing modalities, and novel metabolic tracers. +3 more findings
Full summary, score breakdown and related studies → Original source
May 2014 18
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2014-05-29
Temsirolimus attenuates tauopathy in vitro and in vivo by targeting tau hyperphosphorylation and autophagic clearance
36/100 ✓ Peer-reviewed Disease mechanisms Neuropharmacology
Key finding: Recent findings suggested that temsirolimus also provided beneficial effects in animal models of Huntington's disease and spinocerebellar ataxia type 3, two neurodegenerative diseases caused by accumulation of aberrant proteins within brain. +3 more findings
Full summary, score breakdown and related studies → Original source
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2014-05-29
Depression and dementia: cause, consequence or coincidence?
56/100 ✓ Peer-reviewed How common it is Maturitas
Key finding: Overall there is convincing evidence to support both the notion that early life depression can act as a risk factor for later life dementia, and that later life depression can be seen as a prodrome to dementia. +1 more finding
Full summary, score breakdown and related studies → Original source
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2014-05-28
Multimorbidity and long-term care dependency--a five-year follow-up
60/100 ✓ Peer-reviewed Digital health tools BMC geriatrics
Key finding: The results should form the basis for future health policy decisions on the treatment of patients with multiple chronic diseases and also show the need to introduce new ways of providing long-term care to this population. +2 more findings
Full summary, score breakdown and related studies → Original source
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2014-05-28
Delirium diagnostic and classification challenges in palliative care: subsyndromal delirium, comorbid delirium-dementia, and psychomotor subtypes
36/100 ✓ Peer-reviewed End-of-life care Journal of pain and symptom management
Key finding: Challenges in the diagnosis and classification of delirium in people with advanced disease are compounded by the generalized disturbance of central nervous system function that occurs in the seriously ill, often with comorbid illness, including dementia.
Full summary, score breakdown and related studies → Original source
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2014-05-28
Homocysteine exacerbates β-amyloid pathology, tau pathology, and cognitive deficit in a mouse model of Alzheimer disease with plaques and tangles
45/100 ✓ Peer-reviewed Risk genes beyond APOE Annals of neurology
Key finding: High level of homocysteine (Hcy) is a recognized risk factor for developing Alzheimer disease (AD). +3 more findings
Full summary, score breakdown and related studies → Original source
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2014-05-28
[Effects of a neuropsychology program based on mindfulness on Alzheimer's disease: randomized double-blind clinical study]
50/100 ✓ Peer-reviewed Treatments Revista espanola de geriatria y gerontologia
Key finding: The mindfulness based neuropsychological program showed better cognitive and functional stability, as well as significant improvement in the psychopathological condition of mild to moderate Alzheimer' patients. +2 more findings
Full summary, score breakdown and related studies → Original source
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2014-05-27
Does physical activity prevent cognitive decline and dementia?: A systematic review and meta-analysis of longitudinal studies
72/100 ✓ Peer-reviewed Prevention trials BMC public health
Key finding: Longitudinal observational studies show an association between higher levels of physical activity and a reduced risk of cognitive decline and dementia. +3 more findings
Full summary, score breakdown and related studies → Original source
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2014-05-24
Disease progression model for Clinical Dementia Rating-Sum of Boxes in mild cognitive impairment and Alzheimer's subjects from the Alzheimer's Disease Neuroimaging Initiative
47/100 ✓ Peer-reviewed Long-term cohort studies Neuropsychiatric disease and treatment
Key finding: The objective of this analysis was to develop a nonlinear disease progression model, using an expanded set of covariates that captures the longitudinal Clinical Dementia Rating Scale-Sum of Boxes (CDR-SB) scores. +3 more findings
Full summary, score breakdown and related studies → Original source
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2014-05-23
Circulating miRNAs as biomarkers for neurodegenerative disorders
40/100 ✓ Peer-reviewed Disease mechanisms Molecules (Basel, Switzerland)
Key finding: The brain's ability to compensate for these dysfunctions occurs over a long period of time and results in late clinical manifestation of symptoms, when successful pharmacological intervention is no longer feasible.
Full summary, score breakdown and related studies → Original source
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2014-05-23
Crucial role of calbindin-D28k in the pathogenesis of Alzheimer's disease mouse model
47/100 ✓ Peer-reviewed Risk genes beyond APOE Cell death and differentiation
Key finding: Although marked reductions of CB expression have been observed in the brains of mice and humans with Alzheimer disease (AD), it is unknown whether these changes contribute to AD-related dysfunction. +3 more findings
Full summary, score breakdown and related studies → Original source
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2014-05-22
Natural course of care dependency in residents of long-term care facilities: prospective follow-up study
66/100 ✓ Peer-reviewed End-of-life care BMC geriatrics
Key finding: The majority of residents were stable in their care dependency status over two subsequent 6-month periods. +1 more finding
Full summary, score breakdown and related studies → Original source
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2014-05-22
Susceptibility of the conventional criteria for mild cognitive impairment to false-positive diagnostic errors
56/100 ✓ Peer-reviewed Long-term cohort studies Alzheimer's & dementia : the journal of the Alzheimer's Association
Key finding: Four subtypes emerged: (1) dysnomic (n = 153), (2) dysexecutive (n = 102), (3) amnestic (n = 288), and (4) cluster-derived normal (n = 282) who performed within normal limits on cognitive testing. +3 more findings
Full summary, score breakdown and related studies → Original source
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2014-05-21
Retinal alterations in mild cognitive impairment and Alzheimer's disease: an optical coherence tomography study
51/100 ✓ Peer-reviewed Mild cognitive impairment Journal of neurology
Key finding: In the analysis of variance we saw that RNFL was thinner in MCI patients compared with controls, and it was also thinner in AD patients compared with MCI patients and controls.
Full summary, score breakdown and related studies → Original source
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2014-05-20
The low-density lipoprotein receptor-related protein 1 and amyloid-β clearance in Alzheimer's disease
49/100 ✓ Peer-reviewed Brain tissue and pathology Frontiers in aging neuroscience
Key finding: Perturbation in Aβ clearance, rather than Aβ production, is likely the cause of sporadic, late-onset AD, which accounts for the majority of AD cases. +3 more findings
Full summary, score breakdown and related studies → Original source
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2014-05-20
The role of FUS gene variants in neurodegenerative diseases
49/100 ✓ Peer-reviewed Lewy body dementia Nature reviews. Neurology
Key finding: Additionally, abnormal aggregation of FUS protein has been reported in multiple neurodegenerative diseases, including ALS, FTLD and the polyglutamine diseases, suggesting a role for FUS in the pathogenesis of these neurodegenerative diseases. +4 more findings
Full summary, score breakdown and related studies → Original source
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2014-05-19
Cognitive impairment in older patients with breast cancer before systemic therapy: is there an interaction between cancer and comorbidity?
47/100 ✓ Peer-reviewed Caregiving Journal of clinical oncology : official journal of the American Society of Clinical Oncology
Key finding: There were no overall differences between patients with breast cancer and controls before systemic treatment, but there may be pretreatment cognitive impairment within subgroups of patient cases with greater tumor or comorbidity burden. +4 more findings
Full summary, score breakdown and related studies → Original source
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2014-05-18
Advancing research diagnostic criteria for Alzheimer's disease: the IWG-2 criteria
66/100 ✓ Peer-reviewed Getting a diagnosis The Lancet Neurology
This Position Paper evaluates the strengths and limitations of the International Working Group research diagnostic criteria and proposes advances to improve the diagnostic framework for Alzheimer's disease.
Full summary, score breakdown and related studies → Original source
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2014-05-17
Alzheimer's disease risk genes and mechanisms of disease pathogenesis
57/100 ✓ Peer-reviewed TREM2 and immune genetics Biological psychiatry
Key finding: More recent advances in understanding of the human genome-technologic advances in methods to analyze millions of polymorphisms in thousands of subjects-have revealed new genes associated with AD risk, including ABCA7, BIN1, CASS4, CD33, CD2AP, CELF1, CLU, CR1, DSG2, EPHA1, FERMT2, HLA-DRB5-DBR1, INPP5D, MS4A, MEF2C, NME8, PICALM, PTK2B, SLC24H4-RIN3, SORL1, and ZCWPW1. +3 more findings
Full summary, score breakdown and related studies → Original source
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