Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 17,776–17,800 of 27,380 studies, newest first · page 712 of 1096.
June 2014 25
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2014-06-28
Type 3 diabetes is sporadic Alzheimer׳s disease: mini-review
45/100 ✓ Peer-reviewed Risk factors European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology
Key finding: Because the fundamental abnormalities in AD represent effects of brain insulin resistance and deficiency, and the molecular and biochemical consequences overlap with Type 1 and Type 2 diabetes, we suggest the term "Type 3 diabetes" to account for the underlying abnormalities associated with AD-type neurodegeneration.
Full summary, score breakdown and related studies → Original source
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2014-06-27
Exploring Alzheimer molecular pathology in Down's syndrome cerebrospinal fluid
46/100 ✓ Peer-reviewed Tau biomarkers Neuro-degenerative diseases
Key finding: Individuals with Down's syndrome (DS) develop early Alzheimer's disease (AD) with β-amyloid (Aβ) plaque pathology. +3 more findings
Full summary, score breakdown and related studies → Original source
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2014-06-27
Lewy body compared with Alzheimer dementia is associated with decreased functional connectivity in resting state networks
45/100 ✓ Peer-reviewed Brain scans and imaging Psychiatry research
Key finding: Resting state functional connectivity was affected in the default mode, salience, executive and basal ganglia networks in DLB subjects compared with AD and controls. +3 more findings
Full summary, score breakdown and related studies → Original source
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2014-06-27
Prevention of diseases after menopause
50/100 ✓ Peer-reviewed Prevention and risk Climacteric : the journal of the International Menopause Society
Key finding: For healthy women aged 50-59 years, estrogen therapy decreases coronary heart disease and all-cause mortality; this interpretation is entirely consistent with results from other randomized, controlled trials and observational studies.
Full summary, score breakdown and related studies → Original source
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2014-06-25
GABAergic neurotransmission and new strategies of neuromodulation to compensate synaptic dysfunction in early stages of Alzheimer's disease
40/100 ✓ Peer-reviewed Disease mechanisms Frontiers in cellular neuroscience
Key finding: In turn, neurotransmission imbalance will result in altered network activity that might be responsible of cognitive deficits in AD. +1 more finding
Full summary, score breakdown and related studies → Original source
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2014-06-25
Global epidemiology of dementia: Alzheimer's and vascular types
51/100 ✓ Peer-reviewed How common it is BioMed research international
Key finding: Studies that evaluated the immigration effect of the Japanese and blacks to USA evidenced that acculturation increases the relative proportion of AD cases compared to VaD. +1 more finding
Full summary, score breakdown and related studies → Original source
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2014-06-24
Matrix metalloproteinases and their multiple roles in Alzheimer's disease
40/100 ✓ Peer-reviewed Disease mechanisms BioMed research international
Key finding: Elevated brain levels of MMP-3 might result in increased MMP-9 activity and indirectly facilitate tau aggregation.
Full summary, score breakdown and related studies → Original source
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2014-06-24
Epidemiologic studies of modifiable factors associated with cognition and dementia: systematic review and meta-analysis
74/100 ✓ Peer-reviewed How common it is BMC public health
Key finding: Higher Hcy levels, lower educational attainment, and decreased physical activity were particularly strong predictors of incident AD. +2 more findings
Full summary, score breakdown and related studies → Original source
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2014-06-23
Comparison of sertraline, venlafaxine and desipramine effects on depression, cognition and the daily living activities in Alzheimer patients
58/100 ✓ Peer-reviewed Treatments Pharmacopsychiatry
Key finding: The effects of antidepressants on mood, cognition and the daily activities of Alzheimer patients are ambiguous.
Full summary, score breakdown and related studies → Original source
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2014-06-22
Calculating cognitive decline in delirium
30/100 ✓ Peer-reviewed Risk factors Age and Ageing
Key finding: The 101 CADIS patients demonstrated several new findings: (i) the mean delay between symptom onset and admission was 1.4 days; (ii) for daily attention tests, 5-digit span forward improved to baseline in a mean of 1.3 days, whereas 6-digit span improved in a mean of 5.7 days; (iii) Delirium index, a 7-question instrument for monitoring delirium [2–3] improved to baseline in a mean of 5.8 days.
Full summary, score breakdown and related studies → Original source
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2014-06-21
Cardiovascular risk factors and frontotemporal dementia: a case-control study
41/100 ✓ Peer-reviewed Risk factors Translational neurodegeneration
Key finding: A significant difference was observed for Diabetes Mellitus (39% vs. 22.6% p 0.001).
Full summary, score breakdown and related studies → Original source
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2014-06-21
Nerve growth factor metabolic dysfunction in Alzheimer's disease and Down syndrome
36/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Trends in pharmacological sciences
Key finding: Individuals with Down syndrome (DS) are at increased risk of developing AD in adulthood as a result of chromosome 21 trisomy and triplication of the amyloid precursor protein (APP) gene.
Full summary, score breakdown and related studies → Original source
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2014-06-20
Widespread grey matter pathology dominates the longitudinal cerebral MRI and clinical landscape of amyotrophic lateral sclerosis
59/100 ✓ Peer-reviewed Caregiving Brain : a journal of neurology
Key finding: Longitudinal analysis revealed progressive and widespread changes in the grey matter, notably including the basal ganglia. +3 more findings
Full summary, score breakdown and related studies → Original source
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2014-06-19
The hubs of the human connectome are generally implicated in the anatomy of brain disorders
78/100 ✓ Peer-reviewed Brain scans and imaging Brain : a journal of neurology
Key finding: Recent studies also suggest that hubs have higher metabolic demands and longer-distance connections than other brain regions, and therefore could be considered biologically costly. +4 more findings
Full summary, score breakdown and related studies → Original source
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2014-06-17
Learning to remember: cognitive training-induced attenuation of age-related memory decline depends on sex and cognitive demand, and can transfer to untrained cognitive domains
52/100 ✓ Peer-reviewed Prevention trials Neurobiology of aging
Key finding: Aging is associated with progressive changes in learning and memory. +3 more findings
Full summary, score breakdown and related studies → Original source
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2014-06-17
Upregulation of SET expression by BACE1 and its implications in Down syndrome
32/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Molecular neurobiology
Key finding: In this study, by using Two-dimensional sodium dodecyl sulfate polyacrylamide gel electrophoresis (2D SDS-PAGE) and LC-MS/MS proteomic profiling analysis, we found that the SET oncogene protein (SET) expression was associated with BACE1 but not BACE2. +3 more findings
Full summary, score breakdown and related studies → Original source
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2014-06-17
Elevated risk of type 2 diabetes for development of Alzheimer disease: a key role for oxidative stress in brain
47/100 ✓ Peer-reviewed Risk factors Biochimica et biophysica acta
Key finding: Aβ is associated with the formation of reactive oxygen (ROS) and nitrogen (RNS) species, and induces calcium-dependent excitotoxicity, impairment of cellular respiration, and alteration of synaptic functions associated with learning and memory. +2 more findings
Full summary, score breakdown and related studies → Original source
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2014-06-16
A mitochondrial origin for frontotemporal dementia and amyotrophic lateral sclerosis through CHCHD10 involvement
55/100 ✓ Peer-reviewed How common it is Brain : a journal of neurology
Key finding: The multiple mitochondrial DNA deletions found in skeletal muscle revealed a mitochondrial DNA instability disorder. +1 more finding
Full summary, score breakdown and related studies → Original source
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2014-06-15
Inflammation, defective insulin signaling, and mitochondrial dysfunction as common molecular denominators connecting type 2 diabetes to Alzheimer disease
48/100 ✓ Peer-reviewed Risk factors Diabetes
Key finding: T2D patients have significantly increased risk of developing AD and vice versa. +1 more finding
Full summary, score breakdown and related studies → Original source
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2014-06-15
Brain changes underlying cognitive dysfunction in diabetes: what can we learn from MRI?
48/100 ✓ Peer-reviewed Caregiving Diabetes
Key finding: Diabetes is associated with cognitive dysfunction and an increased risk of dementia. +1 more finding
Full summary, score breakdown and related studies → Original source
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2014-06-14
Vascular cognitive impairment in dementia
38/100 ✓ Peer-reviewed Vascular contributions Maturitas
Key finding: In light of this understanding, the cognitive impairment associated with cerebrovascular disease is an increasingly important and recognised area of the medicine of older people. +2 more findings
Full summary, score breakdown and related studies → Original source
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2014-06-13
Hippocampal atrophy in major depression: a function of childhood maltreatment rather than diagnosis?
36/100 ✓ Peer-reviewed Hippocampus size on brain scans Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
Key finding: Reduced hippocampal volumes are probably the most frequently reported structural neuroimaging finding associated with major depressive disorder (MDD). +3 more findings
Full summary, score breakdown and related studies → Original source
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2014-06-13
Cerebrospinal fluid β-amyloid and phospho-tau biomarker interactions affecting brain structure in preclinical Alzheimer disease
56/100 ✓ Peer-reviewed Brain scans and imaging Annals of neurology
Key finding: Our data suggest that interactions between biomarkers in AD result in a 2-phase phenomenon of pathological cortical thickening associated with low CSF Aβ, followed by atrophy once CSF p-tau becomes abnormal. +2 more findings
Full summary, score breakdown and related studies → Original source
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2014-06-13
Symptom onset in autosomal dominant Alzheimer disease: a systematic review and meta-analysis
75/100 ✓ Peer-reviewed Genetics Neurology
Key finding: Significant proportions of the observed variance in age at symptom onset in ADAD can be explained by family history and mutation type, providing empirical support for use of these data to estimate onset in clinical research. +1 more finding
Full summary, score breakdown and related studies → Original source
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2014-06-12
Dementia and cognitive impairment: epidemiology, diagnosis, and treatment
48/100 ✓ Peer-reviewed Getting a diagnosis Clinics in geriatric medicine
Key finding: Symptoms of memory loss are caused by a range of cognitive abilities or a general cognitive decline, and not just memory. +3 more findings
Full summary, score breakdown and related studies → Original source
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