Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 15,301–15,325 of 27,380 studies, newest first · page 613 of 1096.
February 2017 25
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2017-02-22
Prolonged sleep duration as a marker of early neurodegeneration predicting incident dementia
62/100 ✓ Peer-reviewed Long-term cohort studies Neurology
Key finding: We observed 234 cases of all-cause dementia over 10 years of follow-up. +3 more findings
Full summary, score breakdown and related studies → Original source
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2017-02-22
Brain injury with diabetes mellitus: evidence, mechanisms and treatment implications
42/100 ✓ Peer-reviewed Prevention and risk Expert review of clinical pharmacology
Key finding: Brain injury is associated with acute and chronic hyperglycaemia, insulin resistance, hyperinsulinemia, diabetic ketoacidosis (DKA) and hypoglycaemic events in diabetic patients.
Full summary, score breakdown and related studies → Original source
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2017-02-21
Care home leadership: action is needed
30/100 ✓ Peer-reviewed Health systems and care delivery Age and Ageing
Key finding: As a result, the similarities of older people in residential care to those in nursing care homes greatly outweigh the differences and arguably strengthen the case for RN input to all care home residents.
Full summary, score breakdown and related studies → Original source
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2017-02-21
Enhanced neural activation with blueberry supplementation in mild cognitive impairment
63/100 ✓ Peer-reviewed Prevention and risk Nutritional neuroscience
Key finding: Preclinical studies have shown that blueberry supplementation can improve cognitive performance and neural function in aged animals and have identified associations between anthocyanins and such benefits. +2 more findings
Full summary, score breakdown and related studies → Original source
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2017-02-20
A novel GLP-1/GIP dual receptor agonist protects from 6-OHDA lesion in a rat model of Parkinson's disease
38/100 ✓ Peer-reviewed Drug development Neuropharmacology
Key finding: We previously showed that the novel dual agonist (DA-JC1) was effective in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of PD. +1 more finding
Full summary, score breakdown and related studies → Original source
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2017-02-20
Tau PET imaging: present and future directions
41/100 ✓ Peer-reviewed Brain scans and imaging Molecular neurodegeneration
Key finding: In this review, we summarize recent findings on the most promising tau PET tracers to date, discuss what has been learnt from these findings, and offer some suggestions for the next steps that need to be achieved in a near future.
Full summary, score breakdown and related studies → Original source
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2017-02-18
Living near major roads and the incidence of dementia, Parkinson's disease, and multiple sclerosis: a population-based cohort study
71/100 ✓ Peer-reviewed Prevention and risk The Lancet
Key finding: Living less than 50 meters from a major road was linked to a 7% higher risk of dementia (HR 1.07) compared with living more than 300 meters away +3 more findings
Full summary, score breakdown and related studies → Original source
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2017-02-17
Effectiveness of person-centered care on people with dementia: a systematic review and meta-analysis
79/100 ✓ Peer-reviewed Caregiving Clinical interventions in aging
Key finding: Nineteen interventional studies, including 3,985 participants, were identified. +1 more finding
Full summary, score breakdown and related studies → Original source
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2017-02-17
Evidence for benefit of statins to modify cognitive decline and risk in Alzheimer's disease
66/100 ✓ Peer-reviewed Drug development Alzheimer's research & therapy
Key finding: These results indicate that the use of statins may benefit all AD patients with potentially greater therapeutic efficacy in those homozygous for ApoE4. +4 more findings
Full summary, score breakdown and related studies → Original source
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2017-02-17
Tau and β-Amyloid Are Associated with Medial Temporal Lobe Structure, Function, and Memory Encoding in Normal Aging
38/100 ✓ Peer-reviewed Brain scans and imaging The Journal of neuroscience : the official journal of the Society for Neuroscience
Key finding: Normal aging is associated with a decline in episodic memory and also with aggregation of the β-amyloid (Aβ) and tau proteins and atrophy of medial temporal lobe (MTL) structures crucial to memory formation. +4 more findings
Full summary, score breakdown and related studies → Original source
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2017-02-17
Early-onset and delayed-onset poststroke dementia - revisiting the mechanisms
45/100 ✓ Peer-reviewed Prevention and risk Nature reviews. Neurology
Key finding: However, results from clinical trials completed in the past 10-15 years have been disappointing. +2 more findings
Full summary, score breakdown and related studies → Original source
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2017-02-16
Design and rationale of the EBBINGHAUS trial: A phase 3, double-blind, placebo-controlled, multicenter study to assess the effect of evolocumab on cognitive function in patients with clinically evident cardiovascular disease and receiving statin background lipid-lowering therapy-A cognitive study of patients enrolled in the FOURIER trial
72/100 ✓ Peer-reviewed Cognitive tests and assessment Clinical cardiology
Key finding: Key additional exclusion criteria for EBBINGHAUS were dementia, cognitive impairment, or other significant mental or neurological disorder.
Full summary, score breakdown and related studies → Original source
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2017-02-16
Soluble TREM2 induces inflammatory responses and enhances microglial survival
54/100 ✓ Peer-reviewed TREM2 and immune genetics The Journal of experimental medicine
Key finding: A soluble form of TREM2 (sTREM2) derived from proteolytic cleavage of the cell surface receptor is increased in the preclinical stages of AD and positively correlates with the amounts of total and phosphorylated tau in the cerebrospinal fluid. +3 more findings
Full summary, score breakdown and related studies → Original source
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2017-02-16
From mild cognitive impairment to subjective cognitive decline: conceptual and methodological evolution
52/100 ✓ Peer-reviewed Mild cognitive impairment Neuropsychiatric disease and treatment
Key finding: Evidence from cross-sectional and longitudinal studies has shown that MCI is associated with an increased risk of positive AD biomarkers and an increased annual conversion rate of 5%-17% to AD. +2 more findings
Full summary, score breakdown and related studies → Original source
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2017-02-16
Cognitive impairment and dementia: a new emerging complication of type 2 diabetes-The diabetologist's perspective
45/100 ✓ Peer-reviewed Prevention and risk Acta diabetologica
Key finding: Given the frequency with which T2D and AD occur, the notion that people with T2D may be at increased risk for AD has large societal consequences, and understanding the mechanistic links between these diseases is imperative for the development of effective AD prevention and treatment strategies. +3 more findings
Full summary, score breakdown and related studies → Original source
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2017-02-15
Association between tau deposition and antecedent amyloid-β accumulation rates in normal and early symptomatic individuals
52/100 ✓ Peer-reviewed Brain scans and imaging Brain
Key finding: In this study, we first assessed the patterns of brain tau tangle accumulation (measured with the positron emission tomography tracer 18F-AV-1451) associated with well-established Alzheimer's disease factors in a cohort including cognitively healthy elderly individuals and individuals at early symptomatic stages of Alzheimer's disease. +2 more findings
Full summary, score breakdown and related studies → Original source
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2017-02-15
Approach to atypical Alzheimer's disease and case studies of the major subtypes
43/100 ✓ Peer-reviewed Risk factors CNS spectrums
Key finding: Our knowledge of atypical clinical phenotypes of AD comes from clinicopathologic studies, but with the growing use of in vivo molecular biomarkers of amyloid and tau pathology, we are beginning to recognize that these syndromes may not be as rare as once thought. +4 more findings
Full summary, score breakdown and related studies → Original source
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2017-02-15
Multicenter Validation of an MMSE-MoCA Conversion Table
51/100 ✓ Peer-reviewed Cognitive tests and assessment Journal of the American Geriatrics Society
Key finding: Accumulating evidence points to the superiority of the MoCA over the MMSE as a cognitive screening tool. +3 more findings
Full summary, score breakdown and related studies → Original source
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2017-02-14
Evaluation of glymphatic system activity with the diffusion MR technique: diffusion tensor image analysis along the perivascular space (DTI-ALPS) in Alzheimer's disease cases
45/100 ✓ Peer-reviewed Brain scans and imaging Japanese journal of radiology
Key finding: Activity of the glymphatic system may be evaluated with diffusion images. +1 more finding
Full summary, score breakdown and related studies → Original source
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2017-02-14
n-3 Fatty acids, Mediterranean diet and cognitive function in normal aging: A systematic review
66/100 ✓ Peer-reviewed Prevention trials Experimental gerontology
Key finding: Studies suggest that n-3 fatty acids in the diet and adherence to the MedDiet are beneficial in slowing age-related cognitive decline. +4 more findings
Full summary, score breakdown and related studies → Original source
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2017-02-14
Deconstructing empathy: Neuroanatomical dissociations between affect sharing and prosocial motivation using a patient lesion model
47/100 ✓ Peer-reviewed Long-term cohort studies Neuropsychologia
Key finding: We used a neurodegenerative disease (NDG) lesion model to examine the neural correlates of these two aspects of real-world empathic responding. +3 more findings
Full summary, score breakdown and related studies → Original source
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2017-02-14
Nutrition and dementia care: developing an evidence-based model for nutritional care in nursing homes
39/100 ✓ Peer-reviewed Digital health tools BMC geriatrics
Key finding: This collaboratively developed, person-centred model can support the design of new education and training tools and be readily translated into existing programmes. +1 more finding
Full summary, score breakdown and related studies → Original source
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2017-02-13
Human astrocytes in the diseased brain
41/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Brain research bulletin
Key finding: These findings, together with the discovery that human astrocytes display contrasting characteristics with their rodent counterparts, point to a role for astrocytes in higher cognitive functions.
Full summary, score breakdown and related studies → Original source
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2017-02-13
Resveratrol and Grape Extract-loaded Solid Lipid Nanoparticles for the Treatment of Alzheimer's Disease
41/100 ✓ Peer-reviewed Disease mechanisms Molecules (Basel, Switzerland)
Key finding: Here, we provide evidence that grape skin and grape seed extracts increase the inhibition effect on Aβ aggregation. +4 more findings
Full summary, score breakdown and related studies → Original source
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2017-02-13
Targeting the HDAC2/HNF-4A/miR-101b/AMPK Pathway Rescues Tauopathy and Dendritic Abnormalities in Alzheimer's Disease
38/100 ✓ Peer-reviewed Disease mechanisms Molecular therapy : the journal of the American Society of Gene Therapy
Key finding: Previous studies have shown that HDAC2 expression is strongly increased in Alzheimer's disease (AD), a major neurodegenerative disorder and the most common form of dementia. +1 more finding
Full summary, score breakdown and related studies → Original source
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