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Validation of a polygenic risk score for dementia in black and white individuals
Marden JR, Walter S, Tchetgen Tchetgen EJ, Kawachi I, Glymour MM.. Brain and behavior, 2014-07-18
Topic: Risk, prevention and care in population studies
Objective To determine whether a polygenic risk score for Alzheimer's disease (AD) predicts dementia probability and memory functioning in non-Hispanic black (NHB) and non-Hispanic white (NHW) participants from a sample not used in previous genome-wide association studies. Methods Non-Hispanic white and NHB Health and Retirement Study (HRS) participants provided genetic information and either a composite memory score (n = 10,401) or a dementia probability score (n = 7690). Dementia probability score was estimated for participants' age 65+ from 2006 to 2010, while memory score was available for participants age 50+. We calculated AD genetic risk scores (AD-GRS) based on 10 polymorphisms confirmed to predict AD, weighting alleles by beta coefficients reported in AlzGene meta-analyses. We used pooled logistic regression to estimate the association of the AD-GRS with dementia probability and generalized linear models to estimate its effect on memory score. Results Each 0.10 unit change in the AD-GRS was associated with larger relative effects on dementia among NHW aged 65+ (OR = 2.22; 95% CI: 1.79, 2.74; P Conclusion This analysis provides evidence for differential relative effects of the GRS on dementia probability and memory score among NHW and NHB in a new, national data set.
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APA 7th
Marden, JR., Walter, S., Tchetgen Tchetgen, E. J., Kawachi, I., & Glymour, M. M. (2014). Validation of a polygenic risk score for dementia in black and white individuals. Brain and behavior. https://doi.org/10.1002/brb3.248
Vancouver
Marden JR, Walter S, Tchetgen Tchetgen EJ, Kawachi I, Glymour MM. Validation of a polygenic risk score for dementia in black and white individuals. Brain and behavior. 2014. doi:10.1002/brb3.248. PMID: 25328845.
BibTeX
@article{marden2014-25328845,
author = {Marden, JR. and Walter, S. and Tchetgen Tchetgen, E. J. and Kawachi, I. and Glymour, M. M.},
title = {{Validation of a polygenic risk score for dementia in black and white individuals}},
journal = {Brain and behavior},
year = {2014},
doi = {10.1002/brb3.248},
pmid = {25328845},
url = {https://doi.org/10.1002/brb3.248}
}
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Key findings
- Results Each 0.10 unit change in the AD-GRS was associated with larger relative effects on dementia among NHW aged 65+ (OR = 2.22; 95% CI: 1.79, 2.74; P < 0.001) than NHB (OR=1.33; 95% CI: 1.00, 1.77; P = 0.047), although additive effect estimates were similar.
Why it matters
This study tested whether a genetic risk score for Alzheimer's disease predicted dementia and memory in black and white participants. It found that the genetic score had different relative effects in the two groups, but it does not provide a treatment or cure.
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Study details
- Study designmeta-analysis
- Participants10,401
- Effect sizeOR = 2.22
- Evidence strengthHigh
How this study scored 70/100
Published in a peer-reviewed journal, and it is a meta-analysis pooling many studies.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Brain and behavior) |
| Journal's citation record | 1 / 4 | Brain and Behavior: journal h-index 92 (OpenAlex, 2026-10-29) |
| Study design | 12 / 12 | A meta-analysis pooling many studies |
| Strength of evidence | 5 / 5 | Rated “high” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2014 — within 20 year(s) of the newest study here |
| Sample size | 4 / 4 | 10,401 participants |
| Effect reported | 3 / 3 | Effect reported with a statistic (interval, p-value, ratio or similar) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomized / blinded | 0 / 2 | A review of other studies — randomization is not credited here |
| Times cited | 4 / 7 | Cited 75 times (OpenAlex, 2026-10-10) |
| Citations per year | 2 / 5 | 5.4 citations a year over 14 year(s) since 2014 |
| Impact for its field and year | 3 / 6 | Cited 3.4× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 3 / 6 | Cited by 11 other studies in this library |
| Still being cited | 1 / 4 | Cited 14 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 3 / 4 | Last-listed author M. Maria Glymour: h-index 83 (OpenAlex, whole career) |
| Institution's track record | 3 / 3 | Harvard University: institution h-index 3,235 (OpenAlex) |
| Multicenter collaboration | 1 / 3 | OpenAlex lists 2 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 25328845) |
| Free to read | 2 / 2 | Free to read |
| Total | 70 / 100 | — |
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