Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 17,476–17,500 of 27,380 studies, newest first · page 700 of 1096.
November 2014 25
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2014-11-27
Bilingualism and cognition
34/100 ✓ Peer-reviewed Risk factors Bilingualism Language and Cognition
Key finding: To understand the variability and inconsistencies in results with bilingualism, I analyze concepts of executive function and cognitive reserve and examine the range of factors (such as active video game playing, education, musical training, and aerobic exercise) that are known to correlate with or to improve executive function. +1 more finding
Full summary, score breakdown and related studies → Original source
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2014-11-26
Peptide Vaccines for Hypertension and Diabetes Mellitus
38/100 ✓ Peer-reviewed Risk factors Vaccines
Key finding: In our therapeutic vaccines against hypertension, the target is angiotensin II (Ang II) and induced anti-Ang II antibodies could efficiently ameliorate high blood pressure. +4 more findings
Full summary, score breakdown and related studies → Original source
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2014-11-25
Preventing delirium: should non-pharmacological, multicomponent interventions be used? A systematic review and meta-analysis of the literature
79/100 ✓ Peer-reviewed Clinical safety Age and ageing
Key finding: A total of 21,788 citations were screened, and seven studies of diverse quality were included in the review, comprising 1,691 participants. +2 more findings
Full summary, score breakdown and related studies → Original source
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2014-11-22
Medical genetics-based drug repurposing for Alzheimer's disease
38/100 ✓ Peer-reviewed Drug development Brain research bulletin
Key finding: In vitro and in vivo experiments revealed that four drugs, all of which are angiotensin-converting enzyme (ACE) inhibitors, had potential to treat AD.
Full summary, score breakdown and related studies → Original source
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2014-11-21
Cognitive intervention through a training program for picture book reading in community-dwelling older adults: a randomized controlled trial
67/100 ✓ Peer-reviewed Prevention trials BMC geriatrics
Key finding: The intervention effect was found in delayed verbal memory. +3 more findings
Full summary, score breakdown and related studies → Original source
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2014-11-21
Prevalence of mixed pathologies in the aging brain
48/100 ✓ Peer-reviewed Lewy body dementia Alzheimer's research & therapy
Key finding: In summary, community-based neuropathology studies have shown that complex constellations of underlying pathologies may lead to cognitive decline, and that the number of possible combinations increases in the aging brain.
Full summary, score breakdown and related studies → Original source
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2014-11-20
Multimodal neuroimaging feature learning for multiclass diagnosis of Alzheimer's disease
36/100 ✓ Peer-reviewed Digital health tools IEEE transactions on bio-medical engineering
Key finding: Compared to the previous state-of-the-art workflows, our method is capable of fusing multimodal neuroimaging features in one setting and has the potential to require less labeled data.
Full summary, score breakdown and related studies → Original source
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2014-11-20
Multimodality imaging of Alzheimer disease and other neurodegenerative dementias
40/100 ✓ Peer-reviewed Biomarkers Journal of nuclear medicine : official publication, Society of Nuclear Medicine
Key finding: Neurodegenerative diseases, such as Alzheimer disease, result in cognitive decline and dementia and are a leading cause of mortality in the growing elderly population. +1 more finding
Full summary, score breakdown and related studies → Original source
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2014-11-19
Metabotropic P2Y1 receptor signalling mediates astrocytic hyperactivity in vivo in an Alzheimer's disease mouse model
40/100 ✓ Peer-reviewed Genetics Nature communications
Key finding: We find that astrocytic hyperactivity, consisting of single-cell transients and calcium waves, is most pronounced in reactive astrogliosis around plaques and is sometimes associated with local blood flow changes. +1 more finding
Full summary, score breakdown and related studies → Original source
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2014-11-19
Obesity and cognitive decline: role of inflammation and vascular changes
48/100 ✓ Peer-reviewed How common it is Frontiers in neuroscience
Key finding: Numerous studies have demonstrated that both obesity and metabolic disorders are associated with poorer cognitive performance, cognitive decline, and dementia.
Full summary, score breakdown and related studies → Original source
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2014-11-18
Models of β-amyloid induced Tau-pathology: the long and "folded" road to understand the mechanism
40/100 ✓ Peer-reviewed Treatments Molecular neurodegeneration
Key finding: This may require a better in depth understanding of the cascade. +4 more findings
Full summary, score breakdown and related studies → Original source
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2014-11-18
Hippocampal structural and functional changes associated with electroconvulsive therapy response
62/100 ✓ Peer-reviewed Hippocampus size on brain scans Translational psychiatry
Key finding: Longitudinal changes in functional connectivity of hippocampal regions and volumes of hippocampal subfields were compared with reductions in ratings of depressive symptoms. +1 more finding
Full summary, score breakdown and related studies → Original source
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2014-11-18
Computerized cognitive training in cognitively healthy older adults: a systematic review and meta-analysis of effect modifiers
81/100 ✓ Peer-reviewed Prevention trials PLoS medicine
Key finding: The overall effect size (Hedges' g, random effects model) for CCT versus control was small and statistically significant, g = 0.22 (95% CI 0.15 to 0.29). +3 more findings
Full summary, score breakdown and related studies → Original source
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2014-11-15
Self-rated and informant-rated everyday function in comparison to objective markers of Alzheimer's disease
53/100 ✓ Peer-reviewed Mild cognitive impairment Alzheimer's & dementia : the journal of the Alzheimer's Association
Key finding: This study examined the relationship between self- versus informant-report of functional ability, and how those reports relate to objective disease measures across the disease spectrum (i.e. cognitively normal, MCI, Alzheimer's disease). +1 more finding
Full summary, score breakdown and related studies → Original source
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2014-11-15
Independent comparison of CogState computerized testing and a standard cognitive battery with neuroimaging
38/100 ✓ Peer-reviewed Biomarkers Alzheimer's & dementia : the journal of the Alzheimer's Association
Key finding: Inexpensive, non-invasive tools for assessing Alzheimer-type pathophysiologies are needed.
Full summary, score breakdown and related studies → Original source
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2014-11-14
Oligomeric Aβ-induced synaptic dysfunction in Alzheimer's disease
40/100 ✓ Peer-reviewed Treatments Molecular neurodegeneration
Key finding: Compelling evidence suggests that soluble amyloid-β peptide (Aβ) oligomers induce synaptic loss in AD. +2 more findings
Full summary, score breakdown and related studies → Original source
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2014-11-12
Polyunsaturated fatty acids and their metabolites in brain function and disease
36/100 ✓ Peer-reviewed Risk factors Nature reviews. Neuroscience
Key finding: These include the polyunsaturated fatty acids (PUFAs) arachidonic acid and docosahexaenoic acid, which are largely esterified to the phospholipid cell membrane. +4 more findings
Full summary, score breakdown and related studies → Original source
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2014-11-11
Dementia drug consumption in the Basque Country between 2006 and 2011
41/100 ✓ Peer-reviewed Treatments Neurologia (Barcelona, Spain)
Key finding: Consumption increased by 49.72% between 2006 and 2011. +4 more findings
Full summary, score breakdown and related studies → Original source
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2014-11-11
'The clocks that time us'--circadian rhythms in neurodegenerative disorders
36/100 ✓ Peer-reviewed Risk factors Nature reviews. Neurology
Key finding: Clinical studies and experiments in animal models of neurodegenerative disorders have revealed the progressive nature of circadian dysfunction throughout the course of neurodegeneration, and suggest strategies for the restoration of circadian rhythmicity involving behavioural and pharmacological interventions that target the sleep-wake cycle.
Full summary, score breakdown and related studies → Original source
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2014-11-11
TREM2 Protein Expression Changes Correlate with Alzheimer's Disease Neurodegenerative Pathologies in Post-Mortem Temporal Cortices
45/100 ✓ Peer-reviewed TREM2 and immune genetics Brain pathology (Zurich, Switzerland)
Key finding: Several studies have shown that TREM2 gene variant rs75932628-T increased the risks for Alzheimer's disease (AD), Parkinson's disease, frontotemporal dementia and amyotrophic lateral sclerosis. +3 more findings
Full summary, score breakdown and related studies → Original source
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2014-11-11
The overlap between vascular disease and Alzheimer's disease--lessons from pathology
56/100 ✓ Peer-reviewed Lewy body dementia BMC medicine
Key finding: The most frequent vascular pathologies in the aging brain and in AD are cerebral amyloid angiopathy and small vessel disease. +4 more findings
Full summary, score breakdown and related studies → Original source
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2014-11-11
Incidence of and risk factors for Alzheimer's disease and mild cognitive impairment in Korean elderly
43/100 ✓ Peer-reviewed Disparities Dementia and geriatric cognitive disorders
Key finding: Strategies to control modifiable risk factors should be implemented to decrease the incidence of AD. +2 more findings
Full summary, score breakdown and related studies → Original source
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2014-11-10
Functional connectivity dynamics: modeling the switching behavior of the resting state
36/100 ✓ Peer-reviewed Brain scans and imaging NeuroImage
Key finding: Most computational studies, however, did not address the prominent non-stationarity in resting state FC, which may result in large intra- and inter-subject variability and thus preclude an accurate individual predictability.
Full summary, score breakdown and related studies → Original source
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2014-11-10
Activation of the Wnt/β-catenin pathway represses the transcription of the β-amyloid precursor protein cleaving enzyme (BACE1) via binding of T-cell factor-4 to BACE1 promoter
42/100 ✓ Peer-reviewed Risk genes beyond APOE FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Key finding: In this study, activation of the Wnt pathway by overexpression of the agonist Wnt3a or β-catenin or by inhibition of glycogen kinase synthase-3 in N2a cells resulted in a reduction in Aβ levels and in the activity and expression of BACE1 (β-APP cleaving enzyme). +3 more findings
Full summary, score breakdown and related studies → Original source
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2014-11-08
The need for palliative care in Ireland: a population-based estimate of palliative care using routine mortality data, inclusive of nonmalignant conditions
40/100 ✓ Peer-reviewed End-of-life care Journal of pain and symptom management
Key finding: Future palliative care policy decisions in Ireland must consider the rapidly aging Irish population with the accompanying increase in deaths from cancer, dementia, and neurodegenerative disease and associated palliative care need.
Full summary, score breakdown and related studies → Original source
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