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Specific Resting-State Brain Networks in Mesial Temporal Lobe Epilepsy
Mona Maneshi, Shahabeddin Vahdat, Firas Fahoum, Christophe Grova, Jean Gotman. Frontiers in Neurology, 2014-07-14
Topic: Brain proteins, microglia and lab models
We studied with functional magnetic resonance imaging (fMRI) differences in resting-state networks between patients with mesial temporal lobe epilepsy (MTLE) and healthy subjects. To avoid any a priori hypothesis, we use a data-driven analysis assessing differences between groups independently of structures involved. Shared and specific independent component analysis (SSICA) is an exploratory method based on independent component analysis, which performs between-group network comparison. It extracts and classifies components (networks) in those common between groups and those specific to one group. Resting fMRI data were collected from 10 healthy subjects and 10 MTLE patients. SSICA was applied multiple times with altered initializations and different numbers of specific components. This resulted in many components specific to patients and to controls. Spatial clustering identified the reliable resting-state networks among all specific components in each group. For each reliable specific network, power spectrum analysis was performed on reconstructed time-series to estimate connectivity in each group and differences between groups. Two reliable networks, corresponding to statistically significant clusters robustly detected with clustering were labeled as specific to MTLE and one as specific to the control group. The most reliable MTLE network included hippocampus and amygdala bilaterally. The other MTLE network included the postcentral gyri and temporal poles. The control-specific network included bilateral precuneus, anterior cingulate, thalamus, and parahippocampal gyrus. Results indicated that the two MTLE networks show increased connectivity in patients, whereas the control-specific network shows decreased connectivity in patients. Our findings complement results from seed-based connectivity analysis (1). The pattern of changes in connectivity between mesial temporal lobe structures and other areas may help us understand the cognitive impairments often reported in patients with MTLE.
Key findings
- Two reliable networks, corresponding to statistically significant clusters robustly detected with clustering were labeled as specific to MTLE and one as specific to the control group.
- Results indicated that the two MTLE networks show increased connectivity in patients, whereas the control-specific network shows decreased connectivity in patients.
- Our findings complement results from seed-based connectivity analysis (1).
Why it matters
This small imaging study compared resting-state brain networks in 10 patients with mesial temporal lobe epilepsy and 10 healthy subjects. It is not about Alzheimer's disease and does not test any treatment, cure or prevention for it.
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Study details
- Evidence strengthLow
How this study scored 38/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Frontiers in Neurology) |
| Journal's citation record | 2 / 4 | Frontiers in Neurology: journal h-index 162 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2014 — within 20 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 3 / 7 | Cited 33 times (OpenAlex, 2026-10-10) |
| Citations per year | 1 / 5 | 2.4 citations a year over 14 year(s) since 2014 |
| Impact for its field and year | 2 / 6 | Cited 2.0× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 1 / 4 | Cited 6 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 4 / 4 | Last-listed author Jean Gotman: h-index 102 (OpenAlex, whole career) |
| Institution's track record | 1 / 3 | McGill University: institution h-index 1,373 (OpenAlex) |
| Multi-centre collaboration | 1 / 3 | OpenAlex lists 3 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 25071712) |
| Free to read | 2 / 2 | Free to read |
| Total | 38 / 100 | — |
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Read the original
- DOI: 10.3389/fneur.2014.00127
- PubMed: 25071712
- Original source →
- Free full text: Frontiers in Neurology →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
APA 7th
Maneshi, M., Vahdat, S., Fahoum, F., Grova, C., & Gotman, J. (2014). Specific Resting-State Brain Networks in Mesial Temporal Lobe Epilepsy. Frontiers in Neurology. https://doi.org/10.3389/fneur.2014.00127
Vancouver
Maneshi M, Vahdat S, Fahoum F, Grova C, Gotman J. Specific Resting-State Brain Networks in Mesial Temporal Lobe Epilepsy. Frontiers in Neurology. 2014. doi:10.3389/fneur.2014.00127. PMID: 25071712.
BibTeX
@article{maneshi2014-25071712,
author = {Maneshi, Mona and Vahdat, Shahabeddin and Fahoum, Firas and Grova, Christophe and Gotman, Jean},
title = {{Specific Resting-State Brain Networks in Mesial Temporal Lobe Epilepsy}},
journal = {Frontiers in Neurology},
year = {2014},
doi = {10.3389/fneur.2014.00127},
pmid = {25071712},
url = {https://doi.org/10.3389/fneur.2014.00127}
}
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