Newest studies

Epidemiology of stroke and transient ischemic attacks: Current knowledge and perspectives

41/100 ✓ Peer-reviewed Prevention and risk Revue neurologique

Key finding: Current epidemiological data indicate that 16.9 million people suffer a stroke each year, which represents a global incidence of 258/100,000/year, with marked differences between high- and low-income countries, and an age-adjusted incidence 1.5 times higher in men than in women. +1 more finding

• Prevention

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Why has therapy development for dementia failed in the last two decades?

51/100 ✓ Peer-reviewed Brain tissue and pathology Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: Also low has been the number of pipeline drugs in development, compared to other therapy areas. +3 more findings

• Treatments

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Unfolded Protein Response and Macroautophagy in Alzheimer's, Parkinson's and Prion Diseases

38/100 ✓ Peer-reviewed Disease mechanisms Molecules (Basel, Switzerland)

Key finding: Alzheimer's disease (AD), Parkinson's disease (PD) and prion diseases (PrDs) have different clinical manifestations of neurodegeneration, however, all share an accumulation of misfolded pathological proteins associated with perturbations in unfolded protein response and macroautophagy.

• Other Dementias

Full summary, score breakdown and related studies → Original source

Melanopsin retinal ganglion cell loss in Alzheimer disease

43/100 ✓ Peer-reviewed Brain scans and imaging Annals of neurology

Key finding: We show variable degrees of rest-activity circadian dysfunction in AD patients. +4 more findings

• Brain Biology

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Maltreatment Exposure, Brain Structure, and Fear Conditioning in Children and Adolescents

47/100 ✓ Peer-reviewed Hippocampus size on brain scans Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology

Key finding: Amygdala and hippocampal volume were reduced among children with maltreatment exposure and were negatively associated with SCR to the CS+ during early conditioning in the total sample, although these associations were negative only among non-maltreated children and were positive among maltreated children. +1 more finding

• Brain Scans

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Genome-Wide Scan Informed by Age-Related Disease Identifies Loci for Exceptional Human Longevity

67/100 ✓ Peer-reviewed Genetics PLoS Genetics

Key finding: We developed a new statistical framework to find genetic variants associated with extreme longevity. +4 more findings

• Genetics

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Neuroinflammation and Depression: Microglia Activation, Extracellular Microvesicles and microRNA Dysregulation

40/100 ✓ Peer-reviewed Risk factors Frontiers in cellular neuroscience

Key finding: Patients with chronic inflammation are often associated with the emergence of depression symptoms, while diagnosed depressed patients show increased levels of circulating cytokines. +3 more findings

• Brain Biology

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Type 2 Diabetes as a Risk Factor for Dementia in Women Compared With Men: A Pooled Analysis of 2.3 Million People Comprising More Than 100,000 Cases of Dementia

87/100 ✓ Peer-reviewed Risk factors Diabetes care

Key finding: Study-level data from 14 studies, 2,310,330 individuals, and 102,174 dementia case patients were included. +2 more findings

• Risk Factors

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Depressive symptoms increase the risk of progression to dementia in subjects with mild cognitive impairment: systematic review and meta-analysis

59/100 ✓ Peer-reviewed Prevention and risk International journal of geriatric psychiatry

Key finding: Our results provide additional evidence that depressive symptoms determine an additive risk effect to the progression to dementia in subjects with MCI. +4 more findings

• Early Stage

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Neurovascular dysfunction and neurodegeneration in dementia and Alzheimer's disease

49/100 ✓ Peer-reviewed Prevention and risk Biochimica et biophysica acta

Key finding: Vascular insults can initiate a cascade of molecular events leading to neurodegeneration, cognitive impairment, and dementia. +4 more findings

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Comparing three methods of computerised cognitive training for older adults with subclinical cognitive decline

62/100 ✓ Peer-reviewed Prevention trials Neuropsychological rehabilitation

Key finding: Initial evidence suggests that techniques incorporating motivational strategies to enhance treatment engagement may provide more benefit than computerised training alone. +3 more findings

• Lifestyle
• Digital Tools

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Astrocytes: a central element in neurological diseases

40/100 ✓ Peer-reviewed Inflammation and the immune system Acta neuropathologica

Key finding: As this concept is changing, so is also the perceived role of astrocytes in the healthy and diseased brain and spinal cord. +4 more findings

• Brain Biology

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Depression and frailty in later life: a systematic review

67/100 ✓ Peer-reviewed Clinical safety Clinical interventions in aging

Key finding: The prospective relationship between depressive symptomatology and increased risk of incident frailty was robust, while the opposite relationship was less conclusive.

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Tau positron emission tomographic imaging in aging and early Alzheimer disease

61/100 ✓ Peer-reviewed Getting a diagnosis Annals of neurology

Key finding: These findings suggest that (18)F T807 PET could have value as a biomarker that reflects both the progression of AD tauopathy and the emergence of clinical impairment. +2 more findings

• Brain Scans

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Vascular cognitive impairment and dementia

42/100 ✓ Peer-reviewed Prevention and risk Biochimica et biophysica acta

Key finding: Vascular contributions to cognitive impairment are receiving heightened attention as potentially modifiable factors for dementias of later life. +3 more findings

• Prevention

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Discriminative and prognostic potential of cerebrospinal fluid phosphoTau/tau ratio and neurofilaments for frontotemporal dementia subtypes

50/100 ✓ Peer-reviewed Biomarkers Alzheimer's & dementia (Amsterdam, Netherlands)

Key finding: CSF p/t-tau ratio and NfL levels are strongly driven by ALS status.

• Biomarkers
• Other Dementias

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Obesity, diabetes, and leptin resistance promote tau pathology in a mouse model of disease

36/100 ✓ Peer-reviewed Disease mechanisms Neuroscience

Key finding: Obesity and type 2 diabetes mellitus (T2DM) convey an increased risk for developing dementia. +2 more findings

• Brain Biology
• Risk Factors

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Frontal white matter hyperintensities, clasmatodendrosis and gliovascular abnormalities in ageing and post-stroke dementia

43/100 ✓ Peer-reviewed Inflammation and the immune system Brain : a journal of neurology

Key finding: White matter hyperintensities as seen on brain T2-weighted magnetic resonance imaging are associated with varying degrees of cognitive dysfunction in stroke, cerebral small vessel disease and dementia. +4 more findings

• Brain Scans
• Brain Biology

Full summary, score breakdown and related studies → Original source

Combined Plasma and Cerebrospinal Fluid Signature for the Prediction of Midterm Progression From Mild Cognitive Impairment to Alzheimer Disease

58/100 ✓ Peer-reviewed Long-term cohort studies JAMA neurology

Key finding: A reliable method of detecting Alzheimer disease (AD) in its prodromal state is needed for patient stratification in clinical trials or for personalizing existing or potential upcoming therapies. +3 more findings

• Biomarkers
• Early Stage

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The first NINDS/NIBIB consensus meeting to define neuropathological criteria for the diagnosis of chronic traumatic encephalopathy

61/100 ✓ Peer-reviewed Getting a diagnosis Acta neuropathologica

Key finding: The results demonstrated that there was good agreement among the neuropathologists who reviewed the cases (Cohen's kappa, 0.67) and even better agreement between reviewers and the diagnosis of CTE (Cohen's kappa, 0.78). +1 more finding

• Diagnosis
• Other Dementias
• Brain Biology

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Longitudinal Predictors of Institutionalization in Old Age

66/100 ✓ Peer-reviewed Prevention and risk PloS one

Key finding: This is relevant as the number of old people (a) living alone and (b) suffering from dementia is expected to increase rapidly in the next decades. +1 more finding

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MicroRNA deregulation and chemotaxis and phagocytosis impairment in Alzheimer's disease

41/100 ✓ Peer-reviewed TREM2 and immune genetics Alzheimer's & dementia (Amsterdam, Netherlands)

Key finding: The chemokine/chemokine receptor CCL2/CCR2 axis was impaired in BDMs from AD and MCI patients, causing a deficit in cell migration. +3 more findings

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Hospice Use, Hospitalization, and Medicare Spending at the End of Life

38/100 ✓ Peer-reviewed End-of-life care The journals of gerontology. Series B, Psychological sciences and social sciences

Key finding: Hospice use over 2 weeks was associated with decreased hospital days (1-5 days overall, with greater decreases for longer hospice use) for all beneficiaries; spending was $900-$5,000 less for hospice use of 31-90 days for most beneficiaries not in nursing homes, except beneficiaries with Alzheimer's. +3 more findings

• End-of-Life Care
• Policy
• Care Services

Full summary, score breakdown and related studies → Original source

Selectively Disrupted Functional Connectivity Networks in Type 2 Diabetes Mellitus

45/100 ✓ Peer-reviewed Brain scans and imaging Frontiers in aging neuroscience

Key finding: We found that patients with T2DM exhibited cognitive function declines and functional connectivity disruptions within the default mode network, left frontal parietal network, and sensorimotor network. +2 more findings

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Brain-derived neurotrophic factor and its clinical implications

40/100 ✓ Peer-reviewed Risk factors Archives of medical science : AMS

Key finding: Decreased levels of BDNF are associated with neurodegenerative diseases with neuronal loss, such as Parkinson's disease, Alzheimer's disease, multiple sclerosis and Huntington's disease.

Full summary, score breakdown and related studies → Original source