Newest studies

Time-varying impact of comorbidities on mortality after liver transplantation: a national cohort study using linked clinical and administrative data

60/100 ✓ Peer-reviewed Digital health tools BMJ open

Key finding: The impact of comorbidities present at the time of transplantation changes with time after transplantation. +4 more findings

Full summary, score breakdown and related studies → Original source

Association between air pollutants and dementia risk in the elderly

60/100 ✓ Peer-reviewed Risk factors Alzheimer's & dementia (Amsterdam, Netherlands)

Key finding: Long-term exposure to the highest tertile of PM10 or ozone was significantly associated with an increased risk of AD and VaD. +1 more finding

• Risk Factors

Full summary, score breakdown and related studies → Original source

Amyloid burden is associated with self-reported sleep in nondemented late middle-aged adults

36/100 ✓ Peer-reviewed Brain scans and imaging Neurobiology of aging

Key finding: To determine whether sleep is associated with early signs of AD neuropathology (amyloid deposition) in late midlife, we imaged brain amyloid deposits using positron emission tomography with [C-11]Pittsburgh Compound B (PiB), and assessed sleep with the Epworth Sleepiness Scale and the Medical Outcomes Study Sleep Scale in 98 cognitively healthy adults (aged 62.4 ± 5.7 years) from the Wisconsin Registry for Alzheimer's Prevention. +1 more finding

• Lifestyle

Full summary, score breakdown and related studies → Original source

Neurodegeneration. C9ORF72 repeat expansions in mice cause TDP-43 pathology, neuronal loss, and behavioral deficits

57/100 ✓ Peer-reviewed Lewy body dementia Science (New York, N.Y.)

Key finding: Efforts to combat neurodegeneration associated with "c9FTD/ALS" are hindered by a lack of animal models recapitulating disease features.

• Brain Biology
• Other Dementias

Full summary, score breakdown and related studies → Original source

Decreased levels of guanosine 3′, 5′‐monophosphate (c GMP ) in cerebrospinal fluid ( CSF ) are associated with cognitive decline and amyloid pathology in A lzheimer's disease

46/100 ✓ Peer-reviewed Mild cognitive impairment Neuropathology and Applied Neurobiology

Key finding: c GMP , and not c AMP levels, were significantly lower in the CSF of patients diagnosed with mild AD when compared with nondemented controls. +4 more findings

• Biomarkers

Full summary, score breakdown and related studies → Original source

Cerebrospinal Fluid Biomarkers in Familial Forms of Alzheimer's Disease and Frontotemporal Dementia

38/100 ✓ Peer-reviewed Tau biomarkers Dementia and geriatric cognitive disorders

Key finding: In conclusion, the biomarker profile of inherited AD is quite similar between carriers of different mutations as well as similar to the profile found in sporadic AD, whereas familial FTD does not seem to have a clear biomarker profile.

• Biomarkers
• Genetics
• Other Dementias

Full summary, score breakdown and related studies → Original source

A web-based psychoeducational program for informal caregivers of patients with Alzheimer's disease: a pilot randomized controlled trial

71/100 ✓ Peer-reviewed Caregiving Journal of medical Internet research

Key finding: In this study, quantitative results were inconclusive owing to small sample size. +4 more findings

• Clinical Trials
• Caregiving

Full summary, score breakdown and related studies → Original source

Complement C1q-C3-associated synaptic changes in multiple sclerosis hippocampus

47/100 ✓ Peer-reviewed Inflammation and the immune system Annals of neurology

Key finding: Multiple sclerosis (MS) is a demyelinating disease of the central nervous system, leading to memory impairment in up to 65% of patients. +3 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source

Preventive methylene blue treatment preserves cognition in mice expressing full-length pro-aggregant human Tau

40/100 ✓ Peer-reviewed Drug development Acta neuropathologica communications

Key finding: Our data support the use of Tau aggregation inhibitors as potential drugs for the treatment of AD and other tauopathies and highlights the need for preventive treatment before onset of cognitive impairments.

• Treatments
• Brain Biology

Full summary, score breakdown and related studies → Original source

Olfaction and Aging: A Mini-Review

43/100 ✓ Peer-reviewed Mild cognitive impairment Gerontology

Key finding: Smell dysfunction significantly influences physical well-being, quality of life, nutritional status as well as everyday safety and is associated with increased mortality. +2 more findings

• Early Stage

Full summary, score breakdown and related studies → Original source

Sevoflurane and Isoflurane induce structural changes in brain vascular endothelial cells and increase blood-brain barrier permeability: Possible link to postoperative delirium and cognitive decline

36/100 ✓ Peer-reviewed Clinical safety Brain research

Key finding: Quantitative immunohistochemistry revealed increased BBB permeability in older animals treated with Sevoflurane, but not Isoflurane. +2 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source

DAP12 Stabilizes the C-terminal Fragment of the Triggering Receptor Expressed on Myeloid Cells-2 (TREM2) and Protects against LPS-induced Pro-inflammatory Response

47/100 ✓ Peer-reviewed Risk genes beyond APOE The Journal of biological chemistry

Key finding: Previous studies have suggested that TREM2/DAP12 signaling pathway reduces inflammatory responses and promotes phagocytosis of apoptotic neurons. +3 more findings

• Genetics
• Brain Biology

Full summary, score breakdown and related studies → Original source

Cognitive performance and cerebrospinal fluid biomarkers of neurodegeneration: a study of patients with bipolar disorder and healthy controls

45/100 ✓ Peer-reviewed Biomarkers PloS one

Key finding: The purpose of the present study was to investigate if cerebrospinal fluid (CSF) biomarkers of neurodegeneration are associated with cognition in bipolar disorder and healthy controls, respectively. +3 more findings

• Biomarkers

Full summary, score breakdown and related studies → Original source

APOE effect on Alzheimer's disease biomarkers in older adults with significant memory concern

41/100 ✓ Peer-reviewed Genetics Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: SMC ε4+ showed greater amyloid deposition than SMC ε4-, but no hypometabolism or medial temporal lobe (MTL) atrophy. +2 more findings

• Genetics
• Biomarkers

Full summary, score breakdown and related studies → Original source

Drug repositioning for diabetes based on 'omics' data mining

46/100 ✓ Peer-reviewed Drug development PloS one

Key finding: We analyzed data from genome wide association studies (GWAS), proteomics and metabolomics studies and revealed a total of 992 proteins as potential anti-diabetic targets in human. +3 more findings

• Treatments
• Genetics
• Risk Factors

Full summary, score breakdown and related studies → Original source

Whole-genome sequencing reveals important role for TBK1 and OPTN mutations in frontotemporal lobar degeneration without motor neuron disease

40/100 ✓ Peer-reviewed Genetics Acta neuropathologica

Key finding: Frontotemporal lobar degeneration with TAR DNA-binding protein 43 inclusions (FTLD-TDP) is the most common pathology associated with frontotemporal dementia (FTD). +1 more finding

• Genetics
• Other Dementias
• Brain Biology

Full summary, score breakdown and related studies → Original source

The role of tau in the pathological process and clinical expression of Huntington's disease

53/100 ✓ Peer-reviewed Disease mechanisms Brain : a journal of neurology

Key finding: Recently the microtubule associated protein tau, MAPT, which is associated with several neurodegenerative disorders, has been implicated in Huntington's disease. +3 more findings

• Brain Biology
• Genetics
• Other Dementias

Full summary, score breakdown and related studies → Original source

Beta-amyloid deposition in chronic traumatic encephalopathy

57/100 ✓ Peer-reviewed Disease mechanisms Acta neuropathologica

Key finding: Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease associated with repetitive mild traumatic brain injury. +4 more findings

• Brain Biology
• Other Dementias
• Genetics

Full summary, score breakdown and related studies → Original source

Glucose indices are associated with cognitive and structural brain measures in young adults

57/100 ✓ Peer-reviewed Long-term cohort studies Neurology

Key finding: The sample included dementia-free participants (mean age 40 ± 9 years; 53% women) of the Framingham Heart Study third-generation cohort with cognitive testing of memory, abstract reasoning, visual perception, attention, and executive function (n = 2,126). +3 more findings

Full summary, score breakdown and related studies → Original source

Existing Pittsburgh Compound-B positron emission tomography thresholds are too high: statistical and pathological evaluation

63/100 ✓ Peer-reviewed Getting a diagnosis Brain : a journal of neurology

Key finding: When compared to post-mortem amyloid burden, low proposed thresholds were more sensitive than high thresholds (sensitivities: distribution volume ratiolow 81.0%, standard uptake value ratiolow 83.3%; distribution volume ratiohigh 61.9%, standard uptake value ratiohigh 62.5%) for CERAD moderate-to-frequent neuritic plaques, with similar specificity (distribution volume ratiolow 95.8%; standard uptake value ratiolow, distribution volume ratiohigh and standard uptake value ratiohigh 100.0%). +1 more finding

Full summary, score breakdown and related studies → Original source

Cortical microinfarcts on 3T MRI: Clinical correlates in memory-clinic patients

52/100 ✓ Peer-reviewed Cognitive tests and assessment Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: This is the first study to assess cerebral microinfarcts (CMIs) on 3 tesla (3T) magnetic resonance imaging (MRI) in a memory clinic population. +3 more findings

• Brain Scans

Full summary, score breakdown and related studies → Original source

Age- and education-adjusted normative data for the Montreal Cognitive Assessment (MoCA) in older adults age 70-99

47/100 ✓ Peer-reviewed Cognitive tests and assessment Neuropsychology, development, and cognition. Section B, Aging, neuropsychology and cognition

Key finding: Given the rapidly increasing number of older adults and associated risk of dementia, this study aims to provide appropriate age- and education-adjusted norms for the MoCA. +3 more findings

• Diagnosis

Full summary, score breakdown and related studies → Original source

Social relationships and risk of dementia: A systematic review and meta-analysis of longitudinal cohort studies

69/100 ✓ Peer-reviewed How common it is Ageing research reviews

Key finding: Low social participation (RR: 1.41 (95% CI: 1.13-1.75)), less frequent social contact (RR: 1.57 (95% CI: 1.32-1.85)), and more loneliness (RR: 1.58 (95% CI: 1.19-2.09)) were statistically significant associated with incident dementia. +3 more findings

• Risk Factors

Full summary, score breakdown and related studies → Original source

Sphingolipid metabolism correlates with cerebrospinal fluid Beta amyloid levels in Alzheimer's disease

38/100 ✓ Peer-reviewed Tau biomarkers PloS one

Key finding: In CSF from AD compared with cognitively normal participants: a) total sphingomyelin levels were lower in nanoparticles and supernatant fluid; b) levels of ceramide species were lower in nanoparticles and higher in supernatant fluid; c) three sphingomyelin species were reduced in the nanoparticle fraction. +2 more findings

• Biomarkers

Full summary, score breakdown and related studies → Original source

Amyloid-β and α-synuclein cerebrospinal fluid biomarkers and cognition in early Parkinson's disease

38/100 ✓ Peer-reviewed Tau biomarkers Parkinsonism & related disorders

Key finding: In the PD group, 13 had normal cognition, 4 had subjective and 14 mild cognitive impairment. +4 more findings

• Biomarkers

Full summary, score breakdown and related studies → Original source