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Newest studies

Every summary in our library, newest first, as a dated timeline.

What "newest" means here

The most recent study in this library is dated 2026-11-01 (Paths of Aging Minds: Health Journeys of Older Adults with Mild Cognitive Impairment). This is our summary library, not a news wire — it is added to in batches, so the newest entry may not be the newest paper published anywhere.

Entries are sorted strictly by publication date, newest first. 26489 of the 27380 entries carry a full day-level date. 65 have no date recorded at all and are placed by publication year, at the start of that year; those are marked "no date recorded" below so you can see where the ordering is a best effort rather than a fact.

Prefer a reader? Subscribe to the Atom feed. Want them sorted by subject or by score instead? Browse the research library.

Showing 23,201–23,225 of 27,380 studies, newest first · page 929 of 1096.

April 2006 2

  1. 2006-04-01

    Predictors of conversion to dementia of probable Alzheimer type in patients with mild cognitive impairment

    ✓ Peer-reviewed Genetics Current Alzheimer research

    Key finding: There is a substantial body of literature dealing with predictors of dementia in patients with MCI. +2 more findings

    Full summary, score breakdown and related studies → Original source

  2. 2006-04-01

    Altered brain white matter integrity in healthy carriers of the APOE epsilon4 allele: a risk for AD?

    ✓ Peer-reviewed Genetics Neurology

    Key finding: Although the mechanism underlying vulnerability of white matter tracts in APOE epsilon4 carriers is still unknown, these findings suggest that increased genetic risk for developing Alzheimer disease is associated with changes in microscopic white matter integrity well before the onset of dementia. +2 more findings

    Full summary, score breakdown and related studies → Original source

March 2006 23

  1. 2006-03-29

    The aging hippocampus: a multi-level analysis in the rat

    ✓ Peer-reviewed Hippocampus size on brain scans Neuroscience

    Key finding: Aging was associated with functional deficits on hippocampus-dependent memory tasks, accompanied by structural alterations observed both in vivo (magnetic resonance imaging-hippocampal volume) and postmortem (dentate gyrus neuronal density and neurogenesis). +1 more finding

    Full summary, score breakdown and related studies → Original source

  2. 2006-03-29

    Locus coeruleus neurofibrillary degeneration in aging, mild cognitive impairment and early Alzheimer's disease

    ✓ Peer-reviewed Cognitive tests and assessment Neurobiology of aging

    Key finding: The AD brain is also associated with a degeneration of the noradrenergic projections arising from the nucleus locus coeruleus (LC), but the time course of this lesion is poorly understood. +3 more findings

    Full summary, score breakdown and related studies → Original source

  3. 2006-03-27

    Apolipoprotein E4: a causative factor and therapeutic target in neuropathology, including Alzheimer's disease

    ✓ Peer-reviewed Genetics Proceedings of the National Academy of Sciences of the United States of America

    Key finding: Importantly, apoE4 displays domain interaction (an interaction between the N- and C-terminal domains of the protein that results in a compact structure) and molten globule formation (the formation of stable, reactive intermediates with potentially pathological activities). +1 more finding

    Full summary, score breakdown and related studies → Original source

  4. 2006-03-24

    Brain ferritin iron may influence age- and gender-related risks of neurodegeneration

    ✓ Peer-reviewed Risk factors Neurobiology of aging

    Key finding: This is the first demonstration of gender differences in brain ferritin iron levels. +3 more findings

    Full summary, score breakdown and related studies → Original source

  5. 2006-03-22

    Attainment of treatment goals by people with Alzheimer's disease receiving galantamine: a randomized controlled trial

    ✓ Peer-reviewed Treatments CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne

    Key finding: Although cholinesterase inhibitors have produced statistically significant treatment effects, their clinical meaningfulness in Alzheimer's disease is disputed. +3 more findings

    Full summary, score breakdown and related studies → Original source

  6. 2006-03-22

    BDNF serum and CSF concentrations in Alzheimer's disease, normal pressure hydrocephalus and healthy controls

    ✓ Peer-reviewed Cognitive tests and assessment Journal of psychiatric research

    Key finding: Recent findings have suggested an involvement of brain-derived neurotrophic factor (BDNF) in the pathogenesis of AD. +3 more findings

    Full summary, score breakdown and related studies → Original source

  7. 2006-03-21

    Mitochondria are a direct site of A beta accumulation in Alzheimer's disease neurons: implications for free radical generation and oxidative damage in disease progression

    ✓ Peer-reviewed Disease mechanisms Human molecular genetics

    Key finding: In a recent global gene expression study of APP transgenic mice, we found elevated expression of mitochondrial genes, which we hypothesize represents a compensatory response because of mitochondrial oxidative damage caused by the over-expression of mutant APP and/or amyloid beta (Abeta). +4 more findings

    Full summary, score breakdown and related studies → Original source

  8. 2006-03-20

    Early-onset behavioral and synaptic deficits in a mouse model of Alzheimer's disease

    ✓ Peer-reviewed Risk genes beyond APOE Proceedings of the National Academy of Sciences of the United States of America

    Key finding: However, total amyloid levels did not significantly increase until approximately 18 months of age, at which time significant increases in reactive astrocytes and microglia could be observed. +1 more finding

    Full summary, score breakdown and related studies → Original source

  9. 2006-03-20

    Mild cognitive impairment (MCI) in medical practice: a critical review of the concept and new diagnostic procedure. Report of the MCI Working Group of the European Consortium on Alzheimer's Disease

    ✓ Peer-reviewed Mild cognitive impairment Journal of neurology, neurosurgery, and psychiatry

    Key finding: Identifying patients at a high risk for progression to dementia and establishing more specific and adapted therapeutic strategies at an early stage, together with more structured overall management, is made possible by the diagnostic procedure proposed.

    Full summary, score breakdown and related studies → Original source

  10. 2006-03-20

    A diagnostic formulation for anosognosia in Alzheimer's disease

    ✓ Peer-reviewed Caregiving Journal of neurology, neurosurgery, and psychiatry

    Key finding: Anosognosia in those with Alzheimer's disease is manifested as poor awareness of deficits in iADL and bADL, depressive changes and behavioural disinhibition. +1 more finding

    Full summary, score breakdown and related studies → Original source

  11. 2006-03-16

    Effect of enhanced psychosocial care on antipsychotic use in nursing home residents with severe dementia: cluster randomised trial

    ✓ Peer-reviewed Clinical trials BMJ (Clinical research ed.)

    Key finding: Promotion of person centred care and good practice in the management of patients with dementia with behavioural symptoms provides an effective alternative to neuroleptics. +1 more finding

    Full summary, score breakdown and related studies → Original source

  12. 2006-03-16

    Interleukin-1 mediates Alzheimer and Lewy body pathologies

    ✓ Peer-reviewed Risk genes beyond APOE Journal of neuroinflammation

    Key finding: Clinical and neuropathological overlap between Alzheimer's (AD) and Parkinson's disease (PD) is now well recognized. +3 more findings

    Full summary, score breakdown and related studies → Original source

  13. 2006-03-15

    Down regulation of trk but not p75NTR gene expression in single cholinergic basal forebrain neurons mark the progression of Alzheimer's disease

    ✓ Peer-reviewed Mild cognitive impairment Journal of neurochemistry

    Key finding: Using single cell expression profiling methods coupled with custom-designed cDNA arrays and validation with real-time quantitative PCR (qPCR) and in situ hybridization, individual cholinergic NB neurons displayed a significant down regulation of trkA, trkB, and trkC expression during the progression of AD. +2 more findings

    Full summary, score breakdown and related studies → Original source

  14. 2006-03-14

    Structural and functional variations in human apolipoprotein E3 and E4

    ✓ Peer-reviewed Genetics The Journal of biological chemistry

    Key finding: The low density lipoprotein (LDL) receptor binding ability, determined by a competition binding assay of 3H-LDL to the LDL receptor of HepG2 cells, showed that apoE4 proteins with N-terminal (apoE4-(72-299)), C-terminal (apoE4-(1-231)), or complete C-terminal truncation (apoE4-(1-191)) maintained greater receptor binding abilities than their apoE3 counterparts. +1 more finding

    Full summary, score breakdown and related studies → Original source

  15. 2006-03-14

    An automated labeling system for subdividing the human cerebral cortex on MRI scans into gyral based regions of interest

    ✓ Peer-reviewed Brain scans and imaging NeuroImage

    Key finding: When compared with the manual ROIs, the automated ROIs were highly accurate, with an average ICC of 0.835 across all of the ROIs, and a mean distance error of less than 1 mm. +2 more findings

    Full summary, score breakdown and related studies → Original source

  16. 2006-03-13

    Antihypertensive medication use and incident Alzheimer disease: the Cache County Study

    ✓ Peer-reviewed Drug development Archives of neurology

    Key finding: These data suggest that AH medications, and specifically potassium-sparing diuretics, are associated with reduced incidence of AD. +4 more findings

    Full summary, score breakdown and related studies → Original source

  17. 2006-03-08

    24(S)-hydroxycholesterol participates in a liver X receptor-controlled pathway in astrocytes that regulates apolipoprotein E-mediated cholesterol efflux

    ✓ Peer-reviewed Genetics The Journal of biological chemistry

    Key finding: Similar results were obtained using the synthetic liver X receptor (LXR) agonist GW683965A, suggesting involvement of an LXR-controlled signaling pathway. +3 more findings

    Full summary, score breakdown and related studies → Original source

  18. 2006-03-07

    Diffusion tensor imaging in early Alzheimer's disease

    ✓ Peer-reviewed Brain scans and imaging Psychiatry research

    Key finding: Although AD pathology mainly affects cortical grey matter, previous magnetic resonance imaging (MRI) studies showed that changes also exist in the white matter (WM). +1 more finding

    Full summary, score breakdown and related studies → Original source

  19. 2006-03-06

    Functional connectivity of the fusiform gyrus during a face-matching task in subjects with mild cognitive impairment

    ✓ Peer-reviewed Mild cognitive impairment Brain : a journal of neurology

    Key finding: The results demonstrate that functional connectivity can be an effective marker for the detection of changes in brain function in MCI subjects.

    Full summary, score breakdown and related studies → Original source

  20. 2006-03-02

    Complex activities of daily living in mild cognitive impairment: conceptual and diagnostic issues

    ✓ Peer-reviewed Cognitive tests and assessment Age and ageing

    Key finding: The impact of cognitive impairment on activities of daily living (ADL) is being used as a major criterion for differentiating between mild cognitive impairment (MCI) and dementia. +3 more findings

    Full summary, score breakdown and related studies → Original source

  21. 2006-03-01

    Cognitive executive function in Down's syndrome

    ✓ Peer-reviewed Down syndrome and Alzheimer's The British journal of clinical psychology

    Key finding: It is suggested that impaired executive function in Down's syndrome is due to abnormal development of the prefrontal cortex in Down's syndrome. +2 more findings

    Full summary, score breakdown and related studies → Original source

  22. 2006-03-01

    A specific amyloid-beta protein assembly in the brain impairs memory

    ⚠ Retracted — do not rely on it Brain tissue and pathology Nature

    Key finding: We found that memory deficits in middle-aged Tg2576 mice are caused by the extracellular accumulation of a 56-kDa soluble amyloid-beta assembly, which we term Abeta*56 (Abeta star 56). +1 more finding

    Full summary, score breakdown and related studies → Original source

  23. 2006-03-01

    Perivascular nerves and the regulation of cerebrovascular tone

    ✓ Peer-reviewed Vascular contributions Journal of applied physiology (Bethesda, Md. : 1985)

    Key finding: Recently, new insights into our understanding of how neural input regulate cerebrovascular tone resulted in the rediscovery of the functional "neurovascular unit."

    Full summary, score breakdown and related studies → Original source

Browse the library by subject, with the full score breakdown →