Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 16,826–16,850 of 27,380 studies, newest first · page 674 of 1096.
July 2015 25
-
2015-07-07
Reelin protects against amyloid β toxicity in vivo
36/100 ✓ Peer-reviewed Disease mechanisms Science signaling
Key finding: We have previously shown that the presence of ApoE4 renders neurons unresponsive to Reelin by impairing the recycling of the receptors, thereby decreasing its protective effects against amyloid β (Aβ) oligomer-induced synaptic toxicity in vitro. +2 more findings
Full summary, score breakdown and related studies → Original source
-
2015-07-03
Olfactory identification deficits and increased mortality in the community
74/100 ✓ Peer-reviewed Risk factors Annals of neurology
Key finding: Impaired odor identification, particularly in the anosmic range, is associated with increased mortality in older adults even after controlling for dementia and medical comorbidity. +2 more findings
Full summary, score breakdown and related studies → Original source
-
2015-07-03
Dealing with behavioral and psychological symptoms of dementia: a general overview
40/100 ✓ Peer-reviewed Prevention trials Psychology research and behavior management
Key finding: Potential nonpharmacological interventions for BPSD are: cognitive training/stimulation, rehabilitative care, activities of daily living, music therapy, massage/touch, physical activity, education/training of professionals, and education and psychosocial support of informal caregivers. +4 more findings
Full summary, score breakdown and related studies → Original source
-
2015-07-02
Neuroprotective effects of lixisenatide and liraglutide in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease
36/100 ✓ Peer-reviewed Drug development Neuroscience
Key finding: In addition, the GLP-1 mimetic exendin-4 has shown protective effects in animal models of Parkinson's disease (PD), and a clinical trial in PD patients showed promising first results. +2 more findings
Full summary, score breakdown and related studies → Original source
-
2015-07-02
Sialic acid (SA)-modified selenium nanoparticles coated with a high blood-brain barrier permeability peptide-B6 peptide for potential use in Alzheimer's disease
36/100 ✓ Peer-reviewed Treatments Acta biomaterialia
Key finding: Laser-scanning confocal microscopy, flow cytometry analysis and inductively coupled plasma-atomic emission spectroscopy ICP-AES revealed high cellular uptake of B6-SA-SeNPs by cerebral endothelial cells (bEnd.3). +2 more findings
Full summary, score breakdown and related studies → Original source
-
2015-07-02
Nursing home and end-of-life care in Parkinson disease
66/100 ✓ Peer-reviewed Disparities Neurology
Key finding: A large proportion of the Medicare PD population resides in an LTCF. +1 more finding
Full summary, score breakdown and related studies → Original source
-
2015-07-02
Visualization of regional tau deposits using (3)H-THK5117 in Alzheimer brain tissue
43/100 ✓ Peer-reviewed Brain scans and imaging Acta neuropathologica communications
Key finding: Saturation and competition binding studies of (3)H-THK5117 in post-mortem AD brain tissue showed the presence of multiple binding sites. +1 more finding
Full summary, score breakdown and related studies → Original source
-
2015-07-02
When DLB, PD, and PSP masquerade as MSA: an autopsy study of 134 patients
60/100 ✓ Peer-reviewed Getting a diagnosis Neurology
Key finding: The diagnostic accuracy for MSA was suboptimal in this autopsy study. +2 more findings
Full summary, score breakdown and related studies → Original source
-
2015-07-02
The behavioural/dysexecutive variant of Alzheimer's disease: clinical, neuroimaging and pathological features
60/100 ✓ Peer-reviewed Getting a diagnosis Brain : a journal of neurology
Key finding: Patients with behavioural Alzheimer's disease showed worse memory scores than behavioural variant frontotemporal dementia and did not differ from typical Alzheimer's disease, while executive function composite scores were lower compared to behavioural variant frontotemporal dementia and typical Alzheimer's disease. +2 more findings
Full summary, score breakdown and related studies → Original source
-
2015-07-01
DT‐01‐04: The efficacy of RVT‐101, a 5‐ht6 receptor antagonist, as an adjunct to donepezil in adults with mild‐to‐moderate Alzheimer's disease: Completer analysis of a phase 2b study
52/100 ✓ Peer-reviewed Treatments Alzheimer s & Dementia
Key finding: We present the results of an analysis of observed data from a randomized, double-blind, placebo-controlled Phase 2b study. +3 more findings
Full summary, score breakdown and related studies → Original source
-
2015-07-01
DT‐01‐03: Efficacy and safety of gantenerumab in prodromal Alzheimer's disease: Results from scarlet road—a global, multicenter trial
55/100 ✓ Peer-reviewed Treatments Alzheimer s & Dementia
Key finding: Biomarker results are presented separately. +2 more findings
Full summary, score breakdown and related studies → Original source
-
2015-07-01
O4‐04‐05: Aducanumab (BIIB037), an anti‐amyloid beta monoclonal antibody, in patients with prodromal or mild Alzheimer's disease: Interim results of a randomized, double‐blind, placebo‐controlled, phase 1b study
43/100 ✓ Peer-reviewed Treatments Alzheimer s & Dementia
Key finding: Interim analyses included: (1) subjects in all arms who completed the Week 26 visit, and (2) subjects in all arms who completed the Week 54 visit (results for placebo, 1, 3 and 10 mg/kg aducanumab at Week 54 available here, results for 6 mg/kg at Week 54 will be presented).
Full summary, score breakdown and related studies → Original source
-
2015-07 month only
[(18)F]Florbetaben: a review in β-amyloid PET imaging in cognitive impairment
38/100 ✓ Peer-reviewed Brain scans and imaging CNS drugs
Key finding: Visual assessment of regional and whole brain [(18)F]florbetaben PET images detected brain β-amyloid with high sensitivity and specificity, with good inter-reader agreement, in a phase III study in patients with various levels of cognitive function when compared with postmortem histopathological assessment.
Full summary, score breakdown and related studies → Original source
-
2015-07-01
Motor-Cognitive Dual-Task Training in Persons With Neurologic Disorders: A Systematic Review
57/100 ✓ Peer-reviewed Digital health tools Journal of neurologic physical therapy : JNPT
Key finding: The inclusion criteria of the studies reviewed limited the diagnostic groups included. +2 more findings
Full summary, score breakdown and related studies → Original source
-
2015-07-01
Trajectory of Cognitive Decline After Incident Stroke
59/100 ✓ Peer-reviewed Disparities JAMA
Key finding: Incident stroke was associated with an acute decline in cognitive function and also accelerated and persistent cognitive decline over 6 years. +4 more findings
Full summary, score breakdown and related studies → Original source
-
2015-07-01
The Use of Cholinesterase Inhibitors Across All Stages of Alzheimer's Disease
64/100 ✓ Peer-reviewed End-of-life care Drugs & aging
Key finding: Based on the results of randomized controlled trials and several meta-analyses, ChEIs appear to show modest but statistically significant improvements on several measures, including cognition and global functioning. +2 more findings
Full summary, score breakdown and related studies → Original source
-
2015-07-01
Protective Effects of Physical Exercise in Alzheimer's Disease and Parkinson's Disease: A Narrative Review
40/100 ✓ Peer-reviewed Prevention trials Journal of clinical neurology (Seoul, Korea)
Key finding: Research has shown that the neuroprotective mechanisms induced by PE are linked to an increased production of superoxide dismutase, endothelial nitric oxide synthase, brain-derived neurotrophic factor, nerve growth factor, insulin-like growth factor, and vascular endothelial growth factor, and a reduction in the production of free radicals in brain areas such as the hippocampus, which is particularly involved in memory.
Full summary, score breakdown and related studies → Original source
-
2015-07-01
The Alzheimer's Disease Neuroimaging Initiative 2 PET Core: 2015
50/100 ✓ Peer-reviewed Brain scans and imaging Alzheimer's & dementia : the journal of the Alzheimer's Association
Key finding: The PET Core has demonstrated a variety of methods for the standardization of biomarkers such as florbetapir PET in a multicenter setting. +3 more findings
Full summary, score breakdown and related studies → Original source
-
2015-07-01
Genetic studies of quantitative MCI and AD phenotypes in ADNI: Progress, opportunities, and plans
55/100 ✓ Peer-reviewed Genetics Alzheimer's & dementia : the journal of the Alzheimer's Association
Key finding: Numerous genetic susceptibility and protective markers for AD and disease biomarkers have been identified and replicated using ADNI data and have heavily implicated immune, mitochondrial, cell cycle/fate, and other biological processes. +1 more finding
Full summary, score breakdown and related studies → Original source
-
2015-07-01
Alzheimer's Disease Neuroimaging Initiative 2 Clinical Core: Progress and plans
55/100 ✓ Peer-reviewed Cognitive tests and assessment Alzheimer's & dementia : the journal of the Alzheimer's Association
Key finding: Plans for the next phase of the ADNI project include maintaining longitudinal follow-up of the normal and mild cognitive impairment cohorts, augmenting specific clinical cohorts, and incorporating novel computerized cognitive assessments and patient-reported outcomes.
Full summary, score breakdown and related studies → Original source
-
2015-07-01
The Alzheimer's Disease Neuroimaging Initiative 2 Biomarker Core: A review of progress and plans
40/100 ✓ Peer-reviewed Biomarkers Alzheimer's & dementia : the journal of the Alzheimer's Association
Key finding: Further studies will refine this model and enable the use of biomarkers studied in ADNI clinically and in disease-modifying therapeutic trials. +1 more finding
Full summary, score breakdown and related studies → Original source
-
2015-07-01
Cognitive and Brain Profiles Associated with Current Neuroimaging Biomarkers of Preclinical Alzheimer's Disease
36/100 ✓ Peer-reviewed Hippocampus size on brain scans The Journal of neuroscience : the official journal of the Society for Neuroscience
Key finding: The FDG-positive subgroup showed only hypometabolism, predominantly in AD-sensitive areas extending to the whole neocortex, compared with the FDG-negative subgroup. +4 more findings
Full summary, score breakdown and related studies → Original source
-
2015-07-01
Availability and Primary Health Care Orientation of Dementia-Related Services in Rural Saskatchewan, Canada
47/100 ✓ Peer-reviewed End-of-life care Home health care services quarterly
Key finding: Data were collected from 71 rural Home Care Assessors via cross-sectional survey. +4 more findings
Full summary, score breakdown and related studies → Original source
-
2015-07-01
Place of Death: Trends Over the Course of a Decade: A Population-Based Study of Death Certificates From the Years 2001 and 2011
47/100 ✓ Peer-reviewed End-of-life care Deutsches Arzteblatt international
Key finding: Most people in Germany die in institutions; the most common place of death is still the hospital, where more than half of all deaths take place. +1 more finding
Full summary, score breakdown and related studies → Original source
-
2015-07-01
Tools to Promote Shared Decision Making in Serious Illness: A Systematic Review
67/100 ✓ Peer-reviewed End-of-life care JAMA internal medicine
Key finding: Seventeen randomized clinical trials tested decision tools in serious illness. +1 more finding
Full summary, score breakdown and related studies → Original source
Browse the library by subject, with the full score breakdown →