Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 16,076–16,100 of 27,380 studies, newest first · page 644 of 1096.
May 2016 25
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2016-05-10
A retrospective population based cohort study of access to specialist palliative care in the last year of life: who is still missing out a decade on?
71/100 ✓ Peer-reviewed End-of-life care BMC palliative care
Key finding: There is small but significant increase in access to specialist palliative care services in Western Australia, specifically in patients dying with non-cancer conditions. +4 more findings
Full summary, score breakdown and related studies → Original source
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2016-05-10
Cognition and gait in older people
36/100 ✓ Peer-reviewed Prevention trials Maturitas
Key finding: Structural and functional assays highlight the shared anatomic control of cognitive and gait function, mostly in the prefrontal cortices. +4 more findings
Full summary, score breakdown and related studies → Original source
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2016-05-10
Prevalence of dementia subtypes in United States Medicare fee-for-service beneficiaries, 2011-2013
59/100 ✓ Peer-reviewed Getting a diagnosis Alzheimer's & dementia : the journal of the Alzheimer's Association
Key finding: This study is the first to document concurrent prevalence of primary dementia subtypes among this US population.
Full summary, score breakdown and related studies → Original source
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2016-05-09
Optical coherence tomography and neurodegeneration: are eyes the windows to the brain?
38/100 ✓ Peer-reviewed Brain scans and imaging Expert review of neurotherapeutics
Key finding: Central nervous system (CNS) pathologies have ocular manifestations due to direct and/or retrograde degeneration of the visual pathways, most often related to a direct injury to the optic nerve, retinal ganglion cells and/or its surrounding cells.
Full summary, score breakdown and related studies → Original source
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2016-05-09
Triggering Receptor Expressed on Myeloid Cells 2 Deficiency Alters Acute Macrophage Distribution and Improves Recovery after Traumatic Brain Injury
44/100 ✓ Peer-reviewed TREM2 and immune genetics Journal of neurotrauma
Key finding: There is increasing evidence that persons exposed to TBI have increased risk of the development of multiple neurodegenerative conditions, including Alzheimer disease (AD). +3 more findings
Full summary, score breakdown and related studies → Original source
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2016-05-07
Impaired protein degradation in FTLD and related disorders
38/100 ✓ Peer-reviewed Disease mechanisms Ageing research reviews
Key finding: FTD-linked mutations in genes encoding three autophagy adaptor proteins, p62/SQSTM1, ubiquilin 2 and optineurin, indicate that impaired autophagy might cause FTD.
Full summary, score breakdown and related studies → Original source
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2016-05-07
Impaired fasting glucose is associated with increased regional cerebral amyloid
45/100 ✓ Peer-reviewed Genetics Neurobiology of aging
Key finding: The Alzheimer's disease risk gene apolipoprotein E epsilon 4 (APOE ε4) is associated with increased cerebral amyloid. +3 more findings
Full summary, score breakdown and related studies → Original source
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2016-05-06
Default mode network differences between rigidity- and tremor-predominant Parkinson's disease
38/100 ✓ Peer-reviewed Brain scans and imaging Cortex; a journal devoted to the study of the nervous system and behavior
Key finding: There was decreased activity in the left inferior parietal cortex (IPC) and the left posterior cingulate cortex (PCC) within the DMN between PDAR and both HC and PDT subjects, even after controlling for multiple comparisons, but not between PDT and HC. +4 more findings
Full summary, score breakdown and related studies → Original source
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2016-05-06
New relationships and intimacy in long-term care: The views of relatives of residents with dementia and care home staff
33/100 ✓ Peer-reviewed Health systems and care delivery Dementia
Key finding: The views of care home staff and relatives had similarities in general terms regarding the problems arising around expressions of sexuality in care homes: indicting that a light-hearted or non-physical connection between residents is deemed acceptable, but the moment it becomes a sexual relationship then decision making becomes more complicated. +4 more findings
Full summary, score breakdown and related studies → Original source
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2016-05-06
Common neurodegenerative pathways in obesity, diabetes, and Alzheimer's disease
53/100 ✓ Peer-reviewed Risk factors Biochimica et biophysica acta. Molecular basis of disease
Key finding: Damage to the blood brain barrier (BBB) as seen with aging can lead to infiltration of immune cells into the brain, leading to the exacerbation of central inflammation. +4 more findings
Full summary, score breakdown and related studies → Original source
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2016-05-06
What is the association between sedentary behaviour and cognitive function? A systematic review
65/100 ✓ Peer-reviewed Prevention and risk British journal of sports medicine
Key finding: 8 studies examined the association of sedentary behaviour with cognitive function. 6 studies reported significant negative associations between sedentary behaviour and cognitive function. 8 different measures of sedentary behaviour and 13 different measures of cognitive function were used across all eight studies. +4 more findings
Full summary, score breakdown and related studies → Original source
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2016-05-05
Apolipoprotein E lipoprotein particles inhibit amyloid-β uptake through cell surface heparan sulphate proteoglycan
38/100 ✓ Peer-reviewed Genetics Molecular neurodegeneration
Key finding: In this study, we show that apoE lipoprotein particles from conditioned media of immortalized astrocytes isolated from human APOE-targeted replacement (TR) mice significantly suppress cellular Aβ42 and Aβ40 uptake through cell surface HSPG. +4 more findings
Full summary, score breakdown and related studies → Original source
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2016-05-05
The Health and Well-Being of Older Adults with Dual Sensory Impairment (DSI) in Four Countries
43/100 ✓ Peer-reviewed Risk factors PloS one
Key finding: Raising awareness of this unique disability is imperative to insure that individuals receive the necessary rehabilitation and supportive services to improve their level of independence and quality of life. +1 more finding
Full summary, score breakdown and related studies → Original source
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2016-05-05
Discovery of 6-(Fluoro-(18)F)-3-(1H-pyrrolo[2,3-c]pyridin-1-yl)isoquinolin-5-amine ([(18)F]-MK-6240): A Positron Emission Tomography (PET) Imaging Agent for Quantification of Neurofibrillary Tangles (NFTs)
36/100 ✓ Peer-reviewed Brain scans and imaging Journal of medicinal chemistry
Key finding: Neurofibrillary tangles (NFTs) made up of aggregated tau protein have been identified as the pathologic hallmark of several neurodegenerative diseases including Alzheimer's disease. +2 more findings
Full summary, score breakdown and related studies → Original source
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2016-05-05
Kinetics of the Tau PET Tracer 18F-AV-1451 (T807) in Subjects with Normal Cognitive Function, Mild Cognitive Impairment, and Alzheimer Disease
47/100 ✓ Peer-reviewed Brain scans and imaging Journal of nuclear medicine : official publication, Society of Nuclear Medicine
Key finding: We report kinetic modeling results of dynamic acquisition data from 0 to 100 min after injection with the tau PET tracer 18 F-AV-1451 in 19 subjects. +1 more finding
Full summary, score breakdown and related studies → Original source
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2016-05-05
Long-Term Population-Based Cerebral Ischemic Event and Cognitive Outcomes of Direct Oral Anticoagulants Compared With Warfarin Among Long-term Anticoagulated Patients for Atrial Fibrillation
51/100 ✓ Peer-reviewed Prevention and risk The American journal of cardiology
Key finding: The use of DOACs compared with warfarin was associated with a reduced risk of long-term adverse outcomes: death (p = 0.09), stroke/TIA (p <0.0001), major bleed (p <0.0001), and bleed (p = 0.14). +3 more findings
Full summary, score breakdown and related studies → Original source
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2016-05-04
Cholinesterase Inhibitor Utilization: The Impact of Provincial Drug Policy on Discontinuation
54/100 ✓ Peer-reviewed Treatments Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research
Key finding: Patients who started ChEI therapy after the introduction of the coverage policy had a significantly longer persistence. +4 more findings
Full summary, score breakdown and related studies → Original source
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2016-05-04
A Multimodal Structural and Functional Neuroimaging Study of Amnestic Mild Cognitive Impairment
46/100 ✓ Peer-reviewed Brain scans and imaging The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry
Key finding: Patients with aMCI showed significant gray matter volumetric reductions in bilateral parahippocampal gyri as well as multiple other brain regions including frontal, temporal, and parietal cortices. +2 more findings
Full summary, score breakdown and related studies → Original source
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2016-05-04
Tau: From research to clinical development
40/100 ✓ Peer-reviewed Brain scans and imaging Alzheimer's & dementia : the journal of the Alzheimer's Association
Key finding: Tau pathology is recognized as the key driver of disease progression in Alzheimer's and other neurodegenerative diseases. +4 more findings
Full summary, score breakdown and related studies → Original source
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2016-05-03
Pharmacologic Treatment of Insomnia Disorder: An Evidence Report for a Clinical Practice Guideline by the American College of Physicians
47/100 ✓ Peer-reviewed Clinical safety Annals of internal medicine
Key finding: Data synthesis Eszopiclone, zolpidem, and suvorexant improved short-term global and sleep outcomes compared with placebo, although absolute effect sizes were small (low- to moderate-strength evidence). +3 more findings
Full summary, score breakdown and related studies → Original source
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2016-05-02
sTREM2 cerebrospinal fluid levels are a potential biomarker for microglia activity in early-stage Alzheimer's disease and associate with neuronal injury markers
60/100 ✓ Peer-reviewed TREM2 and immune genetics EMBO molecular medicine
Key finding: Loss-of-function mutations of TREM2 are associated with increased risk of Alzheimer's disease (AD). +3 more findings
Full summary, score breakdown and related studies → Original source
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2016-05-01
The American Psychiatric Association Practice Guideline on the Use of Antipsychotics to Treat Agitation or Psychosis in Patients With Dementia
40/100 ✓ Peer-reviewed Clinical safety American Journal of Psychiatry
Key finding: Author(s): Reus, Victor I; Fochtmann, Laura J; Eyler, A Evan; Hilty, Donald M; Horvitz-Lennon, Marcela; Jibson, Michael D; Lopez, Oscar L; Mahoney, Jane; Pasic, Jagoda; Tan, Zaldy S; Wills, Cheryl D; Rhoads, Richard; Yager, Joel
Full summary, score breakdown and related studies → Original source
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2016-05-01
Pericytes of the neurovascular unit: key functions and signaling pathways
40/100 ✓ Peer-reviewed Inflammation and the immune system Nature neuroscience
Key finding: CNS pericytes are uniquely positioned in the neurovascular unit between endothelial cells, astrocytes and neurons. +4 more findings
Full summary, score breakdown and related studies → Original source
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2016-05-01
Association of Antipsychotic Use With Mortality Risk in Patients With Parkinson Disease
69/100 ✓ Peer-reviewed Clinical safety JAMA neurology
Key finding: The use of APs by patients with dementia in the general population is associated with increased mortality, but whether this risk extends to patients with PD remains unknown. +4 more findings
Full summary, score breakdown and related studies → Original source
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2016-05-01
Healthy cognitive aging and dementia prevention
64/100 ✓ Peer-reviewed Prevention trials The American psychologist
Key finding: Behavioral prevention strategies can help maintain high levels of cognition and functional integrity, and can reduce the social, medical, and economic burden associated with cognitive aging and age-associated neurodegenerative diseases.
Full summary, score breakdown and related studies → Original source
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