Newest studies

The genetic landscape of Alzheimer disease: clinical implications and perspectives

53/100 ✓ Peer-reviewed Genetics Genetics in medicine : official journal of the American College of Medical Genetics

Key finding: The search for the genetic factors contributing to Alzheimer disease (AD) has evolved tremendously throughout the years. +4 more findings

• Genetics

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GGGGCC repeat expansion in C9orf72 compromises nucleocytoplasmic transport

58/100 ✓ Peer-reviewed Lewy body dementia Nature

Key finding: Consistent with these results, we found morphological abnormalities in the architecture of the nuclear envelope in cells expressing expanded G4C2 repeats in vitro and in vivo.

• Other Dementias
• Brain Biology

Full summary, score breakdown and related studies → Original source

The C9orf72 repeat expansion disrupts nucleocytoplasmic transport

57/100 ✓ Peer-reviewed Lewy body dementia Nature

Key finding: Nuclear import is impaired as a result of HRE expression in the fly model and in C9orf72 iPSC-derived neurons, and these deficits are rescued by small molecules and antisense oligonucleotides targeting the HRE G-quadruplexes.

• Other Dementias

Full summary, score breakdown and related studies → Original source

Phenome-wide analysis of genome-wide polygenic scores

53/100 ✓ Peer-reviewed Genetics Molecular Psychiatry

Key finding: For example, education GPS explained variation in adolescents' behavior problems (~0.6%) and in educational achievement (~2%) but psychiatric GPS were associated with neither.

• Genetics

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Gait Monitoring for Early Neurological Disorder Detection Using Sensors in a Smartphone: Validation and a Case Study of Parkinsonism

36/100 ✓ Peer-reviewed Cognitive tests and assessment Telemedicine Journal and e-Health

Key finding: On average, the accuracy of our step length estimation was about 98%. +2 more findings

• Digital Tools

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Precortical Phase of Alzheimer's Disease (AD)-Related Tau Cytoskeletal Pathology

36/100 ✓ Peer-reviewed Drug development Brain pathology (Zurich, Switzerland)

Key finding: These investigations revealed consistent AT8 immunoreactive tau cytoskeletal pathology in a subset of these subcortical nuclei in the Braak and Braak AD stage 0 individuals and in all of these subcortical nuclei in the Braak and Braak AD stage I individuals.

Full summary, score breakdown and related studies → Original source

The keystone of Alzheimer pathogenesis might be sought in Aβ physiology

36/100 ✓ Peer-reviewed Disease mechanisms Neuroscience

Key finding: However, several evidences suggest that this hypothesis is not sufficient to explain AD pathogenesis, especially considering that most of the clinical trials aimed to decrease Aβ levels have been unsuccessful.

• Brain Biology

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Silencing of TREM2 exacerbates tau pathology, neurodegenerative changes, and spatial learning deficits in P301S tau transgenic mice

48/100 ✓ Peer-reviewed TREM2 and immune genetics Neurobiology of aging

Key finding: As a novel susceptibility gene for these 2 diseases, triggering receptor expressed on myeloid cells 2 (TREM2) gene encodes an immune receptor that is uniquely expressed by microglia. +3 more findings

• Genetics
• Brain Biology

Full summary, score breakdown and related studies → Original source

Evidence of neurodegeneration in obstructive sleep apnea: Relationship between obstructive sleep apnea and cognitive dysfunction in the elderly

42/100 ✓ Peer-reviewed Prevention and risk Journal of neuroscience research

Key finding: Rodent and clinical studies suggest that OSA impairs the structural integrity of several brain regions, including the medial temporal lobe. +1 more finding

• Prevention
• Brain Biology
• Risk Factors

Full summary, score breakdown and related studies → Original source

Vascular dysfunction in the pathogenesis of Alzheimer's disease--A review of endothelium-mediated mechanisms and ensuing vicious circles

46/100 ✓ Peer-reviewed Brain tissue and pathology Neurobiology of disease

Key finding: Alzheimer's disease (AD) accounts for the largest proportion (65-70%) of dementia cases in the older population. +3 more findings

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Citalopram for the Treatment of Agitation in Alzheimer Dementia: Genetic Influences

54/100 ✓ Peer-reviewed Treatments Journal of geriatric psychiatry and neurology

Key finding: Treatment outcomes in CitAD showed modest, although statistically significant, influence of genetic variation at HTR2A and HTR2C loci. +2 more findings

• Treatments
• Genetics
• Clinical Trials

Full summary, score breakdown and related studies → Original source

Structural imaging of hippocampal subfields in healthy aging and Alzheimer's disease

50/100 ✓ Peer-reviewed Getting a diagnosis Neuroscience

Key finding: The present review provides an overview of the methodological developments that allow the assessment of hippocampal subfield morphology in vivo, and summarizes the results of studies looking at the effects of AD and normal aging on these structures. +2 more findings

• Brain Scans
• Early Stage

Full summary, score breakdown and related studies → Original source

Analysis of entropies based on empirical mode decomposition in amnesic mild cognitive impairment of diabetes mellitus

39/100 ✓ Peer-reviewed Risk factors Journal of Innovative Optical Health Sciences

Key finding: Compared to other entropies, FEn had a higher classification accuracy, sensitivity and specificity of 68%, 67.1% and 71.9%, respectively. +1 more finding

• Early Stage
• Risk Factors
• Diagnosis

Full summary, score breakdown and related studies → Original source

Default mode network connectivity in patients with idiopathic normal pressure hydrocephalus

38/100 ✓ Peer-reviewed Brain scans and imaging Journal of neurosurgery

Key finding: Both ROI-based and voxel-based analyses revealed reduced DMN connectivity in patients with iNPH. +4 more findings

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GBA Variants are associated with a distinct pattern of cognitive deficits in Parkinson's disease

56/100 ✓ Peer-reviewed Cognitive tests and assessment Movement disorders : official journal of the Movement Disorder Society

Key finding: Loss-of-function mutations in the GBA gene are associated with more severe cognitive impairment in PD, but the nature of these deficits is not well understood and whether common GBA polymorphisms influence cognitive performance in PD is not yet known. +3 more findings

• Genetics

Full summary, score breakdown and related studies → Original source

Amyloid Precursor Protein (APP) Metabolites APP Intracellular Fragment (AICD), Aβ42, and Tau in Nuclear Roles

45/100 ✓ Peer-reviewed Risk genes beyond APOE The Journal of biological chemistry

Key finding: Consequently, intense research has focused upon deciphering their physiological roles to understand their altered state in Alzheimer disease pathophysiology. +2 more findings

• Brain Biology
• Digital Tools

Full summary, score breakdown and related studies → Original source

Using the Delphi expert consensus method in mental health research

50/100 ✓ Peer-reviewed How common it is The Australian and New Zealand journal of psychiatry

Key finding: The Delphi method has a wide range of potential uses in mental health research.

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Dementia in western Europe: epidemiological evidence and implications for policy making

55/100 ✓ Peer-reviewed Prevention and risk The Lancet. Neurology

Key finding: Dementia is receiving increasing attention from governments and politicians. +4 more findings

• Prevention
• Policy

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Meta-analysis of modifiable risk factors for Alzheimer's disease

64/100 ✓ Peer-reviewed Drug development Journal of neurology, neurosurgery, and psychiatry

Key finding: Effective interventions in diet, medications, biochemical exposures, psychological condition, pre-existing disease and lifestyle may decrease new incidence of AD. +3 more findings

• Treatments
• Risk Factors
• Prevention

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Cognitive Frailty: A Systematic Review of Epidemiological and Neurobiological Evidence of an Age-Related Clinical Condition

57/100 ✓ Peer-reviewed Mild cognitive impairment Rejuvenation research

Key finding: Frailty reflects a nonspecific state of vulnerability and a multi-system physiological change with increased risk for adverse health outcomes in older age. +2 more findings

• Early Stage

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Advance care planning in dementia

38/100 ✓ Peer-reviewed End-of-life care Nursing standard (Royal College of Nursing (Great Britain) : 1987)

Key finding: It is important to support people with dementia in developing an advance care plan, since they may lose the capacity to make decisions associated with this early in the disease process. +1 more finding

• End-of-Life Care

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Stress effects on the hippocampus: a critical review

40/100 ✓ Peer-reviewed Hippocampus size on brain scans Learning & memory (Cold Spring Harbor, N.Y.)

Key finding: Neurally, animal studies have revealed that stress alters ensuing synaptic plasticity and firing properties of hippocampal neurons. +1 more finding

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Transitioning From Community-Based to Institutional Long-term Care: Comparing 1915(c) Waiver and PACE Enrollees

35/100 ✓ Peer-reviewed Risk factors The Gerontologist

Key finding: Compared with waiver enrollees, PACE enrollees had 31% lower risk of long-term NH admission (p < .001). +2 more findings

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The cognitive profile of ALS: a systematic review and meta-analysis update

69/100 ✓ Peer-reviewed Caregiving Journal of neurology, neurosurgery, and psychiatry

Key finding: All cognitive domains, except visuoperceptive functions, showed significant effect sizes compared to controls. +1 more finding

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GWAS of longitudinal amyloid accumulation on18F-florbetapir PET in Alzheimer’s disease implicates microglial activation geneIL1RAP

59/100 ✓ Peer-reviewed Genetics Brain

Key finding: In independent cohorts rs12053868-G was associated with accelerated cognitive decline and lower cortical 11C-PBR28 PET signal, a marker of microglial activation. +1 more finding

• Genetics
• Brain Biology
• Brain Scans

Full summary, score breakdown and related studies → Original source