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Newest studies

Every summary in our library, newest first, as a dated timeline.

What "newest" means here

The most recent study in this library is dated 2026-11-01 (Paths of Aging Minds: Health Journeys of Older Adults with Mild Cognitive Impairment). This is our summary library, not a news wire — it is added to in batches, so the newest entry may not be the newest paper published anywhere.

Entries are sorted strictly by publication date, newest first. 26489 of the 27380 entries carry a full day-level date. 65 have no date recorded at all and are placed by publication year, at the start of that year; those are marked "no date recorded" below so you can see where the ordering is a best effort rather than a fact.

Prefer a reader? Subscribe to the Atom feed. Want them sorted by subject or by score instead? Browse the research library.

Showing 16,451–16,475 of 27,380 studies, newest first · page 659 of 1096.

January 2016 11

  1. 2016-01-01

    Timely Diagnosis for Alzheimer's Disease: A Literature Review on Benefits and Challenges

    ✓ Peer-reviewed Getting a diagnosis Journal of Alzheimer's disease : JAD

    Key finding: Despite its potential benefits, few published studies have explored the advantages or risks of a timely diagnosis of AD.

    Full summary, score breakdown and related studies → Original source

  2. 2016-01-01

    The risk of overweight/obesity in mid-life and late life for the development of dementia: a systematic review and meta-analysis of longitudinal studies

    ✓ Peer-reviewed Getting a diagnosis Age and ageing

    Key finding: Scope it has been suggested that overweight/obesity as a risk factor for incident dementia differs between mid-life and later life. +1 more finding

    Full summary, score breakdown and related studies → Original source

  3. 2016-01-01

    Can anxiety damage the brain?

    ✓ Peer-reviewed Prevention and risk Current opinion in psychiatry

    Key finding: Recent findings Anxiety disorders are associated with alterations in fear neurocircuitry such that 'bottom-up' processes in the amygdala which respond to threat are exaggerated, and regulation of these processes by the prefrontal cortex (PFC) and hippocampus is impaired. +1 more finding

    Full summary, score breakdown and related studies → Original source

  4. 2016-01-01

    Dietary exposure to an environmental toxin triggers neurofibrillary tangles and amyloid deposits in the brain

    ✓ Peer-reviewed Prevention and risk Proceedings. Biological sciences

    Key finding: In replicated experiments, we found that chronic dietary exposure to a cyanobacterial toxin present in the traditional Chamorro diet, β-N-methylamino-l-alanine (BMAA), triggers the formation of both NFT and β-amyloid deposits similar in structure and density to those found in brain tissues of Chamorros who died with ALS/PDC. +2 more findings

    Full summary, score breakdown and related studies → Original source

  5. 2016-01-01

    Relearning of Activities of Daily Living: A Comparison of the Effectiveness of Three Learning Methods in Patients with Dementia of the Alzheimer Type

    ✓ Peer-reviewed Treatments The journal of nutrition, health & aging

    Key finding: The participants had to relearn three IADLs. +4 more findings

    Full summary, score breakdown and related studies → Original source

  6. 2016-01-01

    Association Between Olfactory Dysfunction and Amnestic Mild Cognitive Impairment and Alzheimer Disease Dementia

    ✓ Peer-reviewed Genetics JAMA neurology

    Key finding: Among the 1430 cognitively normal participants included, the mean (SD) age was 79.5 (5.3) years, 49.4% were men, the mean duration of education was 14.3 years, and 25.4% were APOE ε4 carriers. +4 more findings

    Full summary, score breakdown and related studies → Original source

  7. 2016-01-01

    A Survey of Knowledge and Views Concerning Genetic and Amyloid PET Status Disclosure

    ✓ Peer-reviewed Biomarkers Alzheimer's & dementia (New York, N. Y.)

    Key finding: These results suggest that stakeholders in AD prevention research generally wish to know biological test information about their risk for developing AD to assist in making life plans. +4 more findings

    Full summary, score breakdown and related studies → Original source

  8. 2016-01-01

    Amyloid PET Screening for Enrichment of Early-Stage Alzheimer Disease Clinical Trials: Experience in a Phase 1b Clinical Trial

    ✓ Peer-reviewed Biomarkers Alzheimer disease and associated disorders

    Key finding: Comparison of visual readings with quantitative results identified 21 discordant cases (92% agreement).

    Full summary, score breakdown and related studies → Original source

  9. 2016-01-01

    CSF Aβ42/Aβ40 and Aβ42/Aβ38 ratios: better diagnostic markers of Alzheimer disease

    ✓ Peer-reviewed Biomarkers Annals of clinical and translational neurology

    Key finding: The CSF Aβ42/Aβ40 and Aβ42/Aβ38 ratios are significantly better than CSF Aβ42 to detect brain amyloid deposition in prodromal AD and to differentiate AD dementia from non-AD dementias. +4 more findings

    Full summary, score breakdown and related studies → Original source

  10. 2016-01-01

    Association of Cerebrospinal Fluid Neurofilament Light Concentration With Alzheimer Disease Progression

    ✓ Peer-reviewed Biomarkers JAMA neurology

    Key finding: Cerebrospinal fluid NFL concentration (median [interquartile range]) was higher in the AD dementia group (1479 [1134-1842] pg/mL), stable MCI group (no progression to AD during follow-up; 1182 [923-1687] pg/mL), and progressive MCI group (MCI with progression to AD dementia during follow-up; 1336 [1061-1693] pg/mL) compared with control participants (1047 [809-1265] pg/mL) (P Conclusions and relevance Cerebrospinal fluid NFL concentration is increased by the early clinical stage of AD and is associated with cognitive deterioration and structural brain changes over time. +1 more finding

    Full summary, score breakdown and related studies → Original source

  11. 2016 year only

    Incidence of Dementia over Three Decades in the Framingham Heart Study

    ✓ Peer-reviewed How common it is New England Journal of Medicine

    Key finding: 5-year cumulative dementia hazard fell from 3.6% to 2.0% across four successive study epochs +3 more findings

    Full summary, score breakdown and related studies → Original source

December 2015 14

  1. 2015-12-31

    The GLP-1 receptor agonist liraglutide reduces pathology-specific tau phosphorylation and improves motor function in a transgenic hTauP301L mouse model of tauopathy

    ✓ Peer-reviewed Drug development Brain research

    Key finding: Stereological analyses demonstrated that hTauP301L mice exhibited hindbrain-dominant neuronal accumulation of phosphorylated tau closely correlated to the severity of clasping behavior. +2 more findings

    Full summary, score breakdown and related studies → Original source

  2. 2015-12-30

    New insights on the role of microglia in synaptic pruning in health and disease

    ✓ Peer-reviewed Genetics Current opinion in neurobiology

    Key finding: Synapse loss is a significant correlate of cognitive decline that serves as a critical hallmark of AD and other neurodegenerative diseases; however, mechanisms underlying synaptic vulnerability remain elusive.

    Full summary, score breakdown and related studies → Original source

  3. 2015-12-30

    Density of GFAP-immunoreactive astrocytes is decreased in left hippocampi in major depressive disorder

    ✓ Peer-reviewed Hippocampus size on brain scans Neuroscience

    Key finding: Pathology in astrocytes may contribute significantly to this reduced volume and to the involvement of the hippocampus in MDD. +3 more findings

    Full summary, score breakdown and related studies → Original source

  4. 2015-12-29

    Randomized double-blind placebo-controlled multicenter trial of Yokukansan for neuropsychiatric symptoms in Alzheimer's disease

    ✓ Peer-reviewed Clinical trials Geriatrics & gerontology international

    Key finding: Four-week changes in NPI-Q total scores did not differ significantly between the treatment and placebo groups. +4 more findings

    Full summary, score breakdown and related studies → Original source

  5. 2015-12-29

    Cognitive Effects of Intentional Weight Loss in Elderly Obese Individuals With Mild Cognitive Impairment

    ✓ Peer-reviewed Prevention and risk The Journal of clinical endocrinology and metabolism

    Key finding: Intentional weight loss through diet was associated with cognitive improvement in patients with MCI. +3 more findings

    Full summary, score breakdown and related studies → Original source

  6. 2015-12-28

    Amyloid positron emission tomography and cognitive reserve

    ✓ Peer-reviewed Brain scans and imaging World journal of radiology

    Key finding: CR phenomenon contributed to explain the disjunction between the degree of neurodegeneration and the clinical phenotype of AD. +4 more findings

    Full summary, score breakdown and related studies → Original source

  7. 2015-12-24

    Use of Angiotensin-Converting Enzyme Inhibitors, Angiotensin Receptor Blockers, and Risk of Dementia in Heart Failure

    ✓ Peer-reviewed Health systems and care delivery American Journal of Alzheimer s Disease & Other Dementias®

    Key finding: Using the time-dependent Cox model, the adjusted dementia rate ratios (95% confidence-interval) among current and former users were 0.90(0.70-1.16) and 0.89 (0.71-1.10), respectively. +2 more findings

    Full summary, score breakdown and related studies → Original source

  8. 2015-12-24

    Neurogranin and YKL-40: independent markers of synaptic degeneration and neuroinflammation in Alzheimer's disease

    ✓ Peer-reviewed Cognitive tests and assessment Alzheimer's research & therapy

    Key finding: Neuroinflammation and synaptic degeneration are major neuropathological hallmarks in Alzheimer's disease (AD). +2 more findings

    Full summary, score breakdown and related studies → Original source

  9. 2015-12-22

    The Triggering Receptor Expressed on Myeloid Cells 2: A Molecular Link of Neuroinflammation and Neurodegenerative Diseases

    ✓ Peer-reviewed TREM2 and immune genetics The Journal of biological chemistry

    Key finding: Homozygous mutations in TREM2 or DAP12 cause Nasu-Hakola disease, which is characterized by bone abnormalities and dementia. +2 more findings

    Full summary, score breakdown and related studies → Original source

  10. 2015-12-21

    Air pollution, a rising environmental risk factor for cognition, neuroinflammation and neurodegeneration: The clinical impact on children and beyond

    ✓ Peer-reviewed Risk factors Revue neurologique

    Key finding: Diffuse neuroinflammation, damage to the neurovascular unit, and the production of autoantibodies to neural and tight-junction proteins are worrisome findings in children chronically exposed to concentrations above the current standards for ozone and fine particulate matter (PM2.5), and may constitute significant risk factors for the development of Alzheimer's disease later in life.

    Full summary, score breakdown and related studies → Original source

  11. 2015-12-21

    Ultra-fast magnetic resonance encephalography of physiological brain activity - Glymphatic pulsation mechanisms?

    ✓ Peer-reviewed Tau biomarkers Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism

    Key finding: Our findings using critically sampled magnetic resonance encephalography open a new view into cerebral fluid dynamics.

    Full summary, score breakdown and related studies → Original source

  12. 2015-12-21

    Comparative analysis of cerebrospinal fluid biomarkers in the differential diagnosis of neurodegenerative dementia

    ✓ Peer-reviewed Biomarkers Alzheimer's & dementia : the journal of the Alzheimer's Association

    Key finding: Combining the biomarker panel allows differentiating between various types of neurodegenerative dementias and contributes to a better understanding of their pathophysiological processes.

    Full summary, score breakdown and related studies → Original source

  13. 2015-12-21

    Early detection of Alzheimer's disease using MRI hippocampal texture

    ✓ Peer-reviewed Hippocampus size on brain scans Human brain mapping

    Key finding: Cognitive impairment in patients with Alzheimer's disease (AD) is associated with reduction in hippocampal volume in magnetic resonance imaging (MRI). +2 more findings

    Full summary, score breakdown and related studies → Original source

  14. 2015-12-21

    Tau missorting and spastin-induced microtubule disruption in neurodegeneration: Alzheimer Disease and Hereditary Spastic Paraplegia

    ✓ Peer-reviewed Down syndrome and Alzheimer's Molecular neurodegeneration

    Key finding: Genetic evidence from AD and Down Syndrome (Trisomy 21), and animal models thereof, suggests that aberrant production of Aβ is upstream of Tau aggregation, but also points to Tau as a critical effector in the pathological process. +1 more finding

    Full summary, score breakdown and related studies → Original source

Browse the library by subject, with the full score breakdown →