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Lack of genetic association between TREM2 and Alzheimer's disease in East Asian population: a systematic review and meta-analysis
Huang M, Wang D, Xu Z, Xu Y, Xu X, Ma Y, Xia Z.. American journal of Alzheimer's disease and other dementias, 2015-09-01
Topic: Amyloid, tau and blood-test diagnosis
Purpose Large-scale genome-wide association studies have identified TREM2 variants to be significantly associated with Alzheimer's disease (AD) in caucasian population. The goal of this systematic study and meta-analysis was to assess the association between Triggering receptor expressed on myeloid cells 2 (TREM2) variants and AD in East Asian population. Methods In this study, literatures were searched in PubMed, MEDLINE, EMBASE, and the Cochrane library to screen citations from January 1990 to June 2014. Data analysis was done by using the Stata 12 software. Results Twelve studies were considered for analysis. A total of 13 535 patients with AD and 22 976 healthy controls were studied. The results showed that rs75932628 variant was significantly associated with AD in caucasian population (P Conclusion In our study, we found that TREM2 variant is likely not associated with AD in East Asian population.
Key findings
- Purpose Large-scale genome-wide association studies have identified TREM2 variants to be significantly associated with Alzheimer's disease (AD) in caucasian population.
- Results Twelve studies were considered for analysis.
- The results showed that rs75932628 variant was significantly associated with AD in caucasian population (P Conclusion In our study, we found that TREM2 variant is likely not associated with AD in East Asian population.
Why it matters
Pooling 12 studies with 13 535 patients with Alzheimer's and 22 976 healthy controls, this meta-analysis found that the TREM2 variant rs75932628 was linked to Alzheimer's in Caucasian populations. In East Asian populations, the authors conclude TREM2 variants are likely not associated with the disease, a reminder that genetic risk findings may not carry across ancestries.
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Study details
- Study designmeta-analysis
- Participants535
- Evidence strengthHigh
How this study scored 55/100
Published in a peer-reviewed journal, and it is a meta-analysis pooling many studies. Scored zero for effect reported because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (American journal of Alzheimer's disease and other dementias) |
| Journal's citation record | 1 / 4 | American Journal of Alzheimer s Disease & Other Dementias®: journal h-index 93 (OpenAlex, 2026-10-29) |
| Study design | 12 / 12 | A meta-analysis pooling many studies |
| Strength of evidence | 5 / 5 | Rated “high” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2015 — within 20 year(s) of the newest study here |
| Sample size | 2 / 4 | 535 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | A review of other studies — randomisation is not credited here |
| Times cited | 3 / 7 | Cited 25 times (OpenAlex, 2026-10-10) |
| Citations per year | 1 / 5 | 1.9 citations a year over 13 year(s) since 2015 |
| Impact for its field and year | 2 / 6 | Cited 2.2× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 2 / 6 | Cited by 6 other studies in this library |
| Still being cited | 1 / 4 | Cited 4 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 1 / 4 | Last-listed author Xia Zheng: h-index 16 (OpenAlex, whole career) |
| Institution's track record | 1 / 3 | Zhejiang University: institution h-index 1,040 (OpenAlex) |
| Multi-centre collaboration | 1 / 3 | OpenAlex lists 3 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 25852195) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 55 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.1177/1533317515577128
- PubMed: 25852195
- Original source →
- Free full text: American Journal of Alzheimer s Disease & Other Dementias® →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record names 7 authors; APA and Vancouver show the first six, BibTeX and the downloads carry all of them. Check the citation against the original before you use it.
APA 7th
Huang, M., Wang, D., Xu, Z., Xu, Y., Xu, X., Ma, Y., et al. (2015). Lack of genetic association between TREM2 and Alzheimer's disease in East Asian population: a systematic review and meta-analysis. American journal of Alzheimer's disease and other dementias. https://doi.org/10.1177/1533317515577128
Vancouver
Huang M, Wang D, Xu Z, Xu Y, Xu X, Ma Y, et al. Lack of genetic association between TREM2 and Alzheimer's disease in East Asian population: a systematic review and meta-analysis. American journal of Alzheimer's disease and other dementias. 2015. doi:10.1177/1533317515577128. PMID: 25852195.
BibTeX
@article{huang2015-25852195,
author = {Huang, M. and Wang, D. and Xu, Z. and Xu, Y. and Xu, X. and Ma, Y. and Xia, Z.},
title = {{Lack of genetic association between TREM2 and Alzheimer's disease in East Asian population: a systematic review and meta-analysis}},
journal = {American journal of Alzheimer's disease and other dementias},
year = {2015},
doi = {10.1177/1533317515577128},
pmid = {25852195},
url = {https://doi.org/10.1177/1533317515577128}
}
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