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Marked gender differences in progression of mild cognitive impairment over 8 years
Lin KA, Choudhury KR, Rathakrishnan BG, Marks DM, Petrella JR, Doraiswamy PM, Alzheimer's Disease Neuroimaging Initiative.. Alzheimer's & dementia (New York, N. Y.), 2015-09-01
Topic: Risk, prevention and care in population studies
Introduction This study examined whether, among subjects with mild cognitive impairment (MCI), women progressed at faster rates than men. Methods We examine longitudinal rates of change from baseline in 398 MCI subjects (141 Females, 257 Males) in the Alzheimer's Disease Neuroimaging Initiative-1 (ADNI-1), followed for up to 8 years (mean 4.1±2.5 years) using mixed effects models incorporating all follow ups (mean 8±4 visits). Results Women progressed at faster rates than men on ADAS-Cog (p=0.001) and CDR-SB (p=0.003). Quadratic fit for change over time was significant for both ADAS-Cog (p=0.001) and CDR-SB (p=0.004), and the additional acceleration in women was 100% for ADAS-Cog and 143% for CDR-SB. The variability of change was greater in women. The gender effect was greater in ApoE4 carriers. Discussion Women with MCI have greater longitudinal rates of cognitive and functional progression than men. Studies to confirm and uncover potential mechanisms appear to be warranted.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Lin, K. A., Choudhury, K. R., Rathakrishnan, B. G., Marks, D. M., Petrella, JR., Doraiswamy, P. M., et al. (2015). Marked gender differences in progression of mild cognitive impairment over 8 years. Alzheimer's & dementia (New York, N. Y.). https://doi.org/10.1016/j.trci.2015.07.001
Vancouver
Lin KA, Choudhury KR, Rathakrishnan BG, Marks DM, Petrella JR, Doraiswamy PM, et al. Marked gender differences in progression of mild cognitive impairment over 8 years. Alzheimer's & dementia (New York, N. Y.). 2015. doi:10.1016/j.trci.2015.07.001. PMID: 26451386.
BibTeX
@article{lin2015-26451386,
author = {Lin, K. A. and Choudhury, K. R. and Rathakrishnan, B. G. and Marks, D. M. and Petrella, JR. and Doraiswamy, P. M. and {Alzheimer's Disease Neuroimaging Initiative}},
title = {{Marked gender differences in progression of mild cognitive impairment over 8 years}},
journal = {Alzheimer's \& dementia (New York, N. Y.)},
year = {2015},
doi = {10.1016/j.trci.2015.07.001},
pmid = {26451386},
url = {https://doi.org/10.1016/j.trci.2015.07.001}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record names 7 authors; APA and Vancouver show the first six, BibTeX and the downloads carry all of them. Check the citation against the original before you use it.
Key findings
- Results Women progressed at faster rates than men on ADAS-Cog (p=0.001) and CDR-SB (p=0.003).
- Quadratic fit for change over time was significant for both ADAS-Cog (p=0.001) and CDR-SB (p=0.004), and the additional acceleration in women was 100% for ADAS-Cog and 143% for CDR-SB.
Why it matters
Among 398 people with mild cognitive impairment followed for up to 8 years, women declined faster than men on cognitive and functional measures, and the effect was greater in ApoE4 carriers. This identifies a difference in progression rates, but the study does not test any treatment, cure, or prevention.
Study details
- Study designlongitudinal study
- Evidence strengthModerate
Limitations
The abstract does not report whether this sex difference held after accounting for other factors that differ between men and women, such as age, education, or APOE genotype, so it's not clear how much of the difference is attributable to sex itself.
How this study scored 60/100
Published in a leading specialty journal, and it is a longitudinal study following the same people over time. Scored zero for sample size, effect reported, studied in people and randomised / blinded because the record does not state it. We have no data on senior author's track record, so that was left out: it earned 58 of the 96 points we could judge it on, which is 60 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 9 / 10 | Tier 2 — leading specialty journal (Alzheimer's & dementia (New York, N. Y.)) |
| Journal's citation record | 1 / 4 | Alzheimer s & Dementia Translational Research & Clinical Interventions: journal h-index 84 (OpenAlex, 2026-10-29) |
| Study design | 7 / 12 | A longitudinal study following the same people over time |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2015 — within 20 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 6 / 7 | Cited 397 times (OpenAlex, 2026-10-10) |
| Citations per year | 4 / 5 | 30.5 citations a year over 13 year(s) since 2015 |
| Impact for its field and year | 4 / 6 | Cited 14.8× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 3 / 6 | Cited by 24 other studies in this library |
| Still being cited | 3 / 4 | Cited 123 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | 2 / 3 | Duke University: institution h-index 1,541 (OpenAlex) |
| Multi-centre collaboration | 1 / 3 | OpenAlex lists 2 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 26451386) |
| Free to read | 2 / 2 | Free to read |
| Points | 58 / 96 | Scored on 19 of 20 parts. We have no data for the rest, so they are left out: 58 of the 96 points we could judge it on is 60 out of 100. |
| Total | 60 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.1016/j.trci.2015.07.001
- PubMed: 26451386
- Original source →
- Free full text: Alzheimer s & Dementia Translational Research & Clinical Interventions →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
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