Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 16,651–16,675 of 27,380 studies, newest first · page 667 of 1096.
September 2015 25
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2015-09-30
The Vallecas Project: A Cohort to Identify Early Markers and Mechanisms of Alzheimer's Disease
58/100 ✓ Peer-reviewed Digital health tools Frontiers in aging neuroscience
Key finding: We have established a valuable homogeneous single-center cohort which, by identifying groups of variables associated with high risk of MCI or dementia conversion, should help to clarify the early physiopathological mechanisms of AD and should provide avenues for prompt diagnosis and AD prevention. +1 more finding
Full summary, score breakdown and related studies → Original source
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2015-09-29
Astrocytic estrogen receptors and impaired neurotrophic responses in a rat model of perimenopause
36/100 ✓ Peer-reviewed Biomarkers Frontiers in aging neuroscience
Key finding: These findings are relevant to impairments of spatial learning and of hippocampal long-term potentiation during the onset of IR in middle-aged rats, and to perimenopausal factors mediating the higher risk of women for Alzheimer disease.
Full summary, score breakdown and related studies → Original source
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2015-09-28
CD33 modulates TREM2: convergence of Alzheimer loci
60/100 ✓ Peer-reviewed Risk genes beyond APOE Nature neuroscience
Key finding: The NME8 locus influenced PTK2B and the CD33 risk allele led to greater TREM2 expression. +1 more finding
Full summary, score breakdown and related studies → Original source
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2015-09-28
Dementia in older people admitted to hospital: a regional multi-hospital observational study of prevalence, associations and case recognition
47/100 ✓ Peer-reviewed Disparities Age and ageing
Key finding: Previous studies have indicated a prevalence of dementia in older admissions of ∼42% in a single London teaching hospital, and 21% in four Queensland hospitals.
Full summary, score breakdown and related studies → Original source
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2015-09-25
A potential endophenotype for Alzheimer's disease: cerebrospinal fluid clusterin
38/100 ✓ Peer-reviewed Tau biomarkers Neurobiology of aging
Key finding: CSF, but not plasma, CLU levels were significantly associated with AD status and CSF tau/amyloid-beta ratio, and highly correlated with CSF apolipoprotein E (APOE) levels. +2 more findings
Full summary, score breakdown and related studies → Original source
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2015-09-25
Anti-Aβ Autoantibodies in Amyloid Related Imaging Abnormalities (ARIA): Candidate Biomarker for Immunotherapy in Alzheimer's Disease and Cerebral Amyloid Angiopathy
40/100 ✓ Peer-reviewed Treatments Frontiers in neurology
Key finding: Amyloid-related imaging abnormalities (ARIA) represent the major severe side effect of amyloid-beta (Aβ) immunotherapy for Alzheimer's disease (AD). +3 more findings
Full summary, score breakdown and related studies → Original source
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2015-09-25
EEG characteristics in "eyes-open" versus "eyes-closed" conditions: Small-world network architecture in healthy aging and age-related brain degeneration
44/100 ✓ Peer-reviewed Mild cognitive impairment Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology
Key finding: In resting state condition, aMCI small-world architecture presents midway topological properties between AD subjects and healthy controls, confirming the hypothesis that aMCI is an intermediate step along the disease progression.
Full summary, score breakdown and related studies → Original source
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2015-09-25
ESPEN guidelines on nutrition in dementia
48/100 ✓ Peer-reviewed Caregiving Clinical nutrition (Edinburgh, Scotland)
Key finding: Nutritional care and support should be an integral part of dementia management. +1 more finding
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2015-09-25
Validating novel tau positron emission tomography tracer [F-18]-AV-1451 (T807) on postmortem brain tissue
57/100 ✓ Peer-reviewed Getting a diagnosis Annals of neurology
Key finding: Our data suggest that [F-18]-AV-1451 holds promise as a surrogate marker for the detection of brain tau pathology in the form of tangles and paired helical filament-tau-containing neurites in Alzheimer brains but also point to its relatively lower affinity for lesions primarily made of straight tau filaments in non-Alzheimer tauopathy cases and to the existence of some [F-18]-AV-1451 off-target binding. +2 more findings
Full summary, score breakdown and related studies → Original source
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2015-09-23
Magnesium in Prevention and Therapy
40/100 ✓ Peer-reviewed Risk factors Nutrients
Key finding: Imbalances in magnesium status-primarily hypomagnesemia as it is seen more common than hypermagnesemia-might result in unwanted neuromuscular, cardiac or nervous disorders. +1 more finding
Full summary, score breakdown and related studies → Original source
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2015-09-21
Cognitive impairment in Parkinson's disease and dementia with Lewy bodies
36/100 ✓ Peer-reviewed Prevention trials Parkinsonism & related disorders
Key finding: Compared to the many treatments available for motor symptoms, relatively few systematic studies exist to guide the treatment of cognitive impairment in PD, and even less in DLB. +1 more finding
Full summary, score breakdown and related studies → Original source
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2015-09-21
Critical role of acetylation in tau-mediated neurodegeneration and cognitive deficits
59/100 ✓ Peer-reviewed Lewy body dementia Nature medicine
Key finding: The acetyl-mimicking mutant K174Q slows tau turnover and induces cognitive deficits in vivo. +4 more findings
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2015-09-17
End of life care interventions for people with dementia in care homes: addressing uncertainty within a framework for service delivery and evaluation
40/100 ✓ Peer-reviewed End-of-life care BMC palliative care
Key finding: For people with dementia living and dying in care homes, EoL interventions need to provide strategies that can accommodate or "hold" the inevitable and often unresolvable uncertainties of providing and receiving care in these settings. +1 more finding
Full summary, score breakdown and related studies → Original source
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2015-09-17
Cerebrospinal fluid VILIP-1 and YKL-40, candidate biomarkers to diagnose, predict and monitor Alzheimer's disease in a memory clinic cohort
57/100 ✓ Peer-reviewed Mild cognitive impairment Alzheimer's research & therapy
Key finding: CSF levels of YKL-40 may have utility for discriminating between cognitively normal individuals and patients with MCI or AD. +1 more finding
Full summary, score breakdown and related studies → Original source
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2015-09-16
Computerised cognitive testing of individuals with Down's syndrome and Alzheimer's disease
61/100 ✓ Peer-reviewed Cognitive tests and assessment Journal of intellectual disability research : JIDR
Key finding: Mean scaled scores in this longitudinal study were evaluated with repeated measures analysis of variance. +3 more findings
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2015-09-16
Exenatide reduces TNF-α expression and improves hippocampal neuron numbers and memory in streptozotocin treated rats
40/100 ✓ Peer-reviewed Drug development European journal of pharmacology
Key finding: While the brain TNF-α levels were significantly high in the saline-treated STZ group, exenatide treatment suppressed the increase in TNF-α levels. +4 more findings
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2015-09-16
Health care professionals' perspectives of advance care planning for people with dementia living in long-term care settings: A narrative review of the literature
38/100 ✓ Peer-reviewed End-of-life care Dementia (London, England)
Key finding: A systematic literature search identified 14 papers for inclusion. +4 more findings
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2015-09-16
Eating behavior in frontotemporal dementia: Peripheral hormones vs hypothalamic pathology
43/100 ✓ Peer-reviewed Brain scans and imaging Neurology
Key finding: In bvFTD, they are in part related to hypothalamic degeneration, with potential disintegration of the network connections between the hypothalamus and orbitofrontal cortex/reward pathways.
Full summary, score breakdown and related studies → Original source
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2015-09-15
Cerebrospinal fluid neurogranin: relation to cognition and neurodegeneration in Alzheimer's disease
62/100 ✓ Peer-reviewed Disease mechanisms Brain : a journal of neurology
Key finding: Cerebrospinal fluid neurogranin was increased in patients with Alzheimer's disease dementia (P < 0.001), progressive mild cognitive impairment (P < 0.001) and stable mild cognitive impairment (P < 0.05) compared with controls, and in Alzheimer's disease dementia (P < 0.01) and progressive mild cognitive impairment (P < 0.05) compared with stable mild cognitive impairment. +1 more finding
Full summary, score breakdown and related studies → Original source
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2015-09-15
Quantitative analysis and clinico-pathological correlations of different dipeptide repeat protein pathologies in C9ORF72 mutation carriers
51/100 ✓ Peer-reviewed Caregiving Acta neuropathologica
Key finding: While previous studies focusing on poly-GA pathology have failed to detect any clinico-pathological correlations in C9ORF72 mutation cases, recent data from animal and cell culture models suggested that it may be only specific DPR species that are toxic and only when accumulated in certain intracellular compartments. +3 more findings
Full summary, score breakdown and related studies → Original source
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2015-09-15
Multidomain Lifestyle Interventions for the Prevention of Cognitive Decline After Ischemic Stroke: Randomized Trial
64/100 ✓ Peer-reviewed Treatments Stroke
Key finding: This trial found no benefit of 24-month multidomain intervention with focus on improvement in lifestyle and vascular risk factors on the incidence of poststroke cognitive decline in comparison with standard stroke care.
Full summary, score breakdown and related studies → Original source
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2015-09-15
The Triggering Receptor Expressed on Myeloid Cells 2 Binds Apolipoprotein E
50/100 ✓ Peer-reviewed Genetics The Journal of biological chemistry
Key finding: These findings reveal a link between two Alzheimer disease risk factors and may provide important clues to the pathogenesis of Nasu-Hakola disease and other neurodegenerative disorders.
Full summary, score breakdown and related studies → Original source
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2015-09-15
Apolipoprotein E Is a Ligand for Triggering Receptor Expressed on Myeloid Cells 2 (TREM2)
54/100 ✓ Peer-reviewed Genetics The Journal of biological chemistry
Key finding: Using a biochemical assay, we demonstrated high-affinity binding of apoE to human TREM2.
Full summary, score breakdown and related studies → Original source
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2015-09-14
Family physicians' role in palliative care throughout the care continuum: stakeholder perspectives
36/100 ✓ Peer-reviewed End-of-life care Family practice
Key finding: Our results help to elucidate the tasks and roles required of FPs to make integration of a palliative care approach into the care continuum possible. +1 more finding
Full summary, score breakdown and related studies → Original source
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2015-09-14
Potentials and limits to enhance cognitive functions in healthy and pathological aging by tDCS
47/100 ✓ Peer-reviewed Prevention trials Frontiers in cellular neuroscience
Key finding: Although promising short-term results have been reported, evidence from randomized controlled trials (RCTs) with sufficient sample sizes is scarce.
Full summary, score breakdown and related studies → Original source
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