Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 22,901–22,925 of 27,380 studies, newest first · page 917 of 1096.
November 2006 14
-
2006-11-01
Effects of rivastigmine in patients with and without visual hallucinations in dementia associated with Parkinson's disease
65/100 ✓ Peer-reviewed Treatments Movement disorders : official journal of the Movement Disorder Society
Key finding: This was a 24-week double-blind placebo-controlled study. +3 more findings
Full summary, score breakdown and related studies → Original source
-
2006-11-01
Progression of mild cognitive impairment to dementia: a challenge to current thinking
44/100 ✓ Peer-reviewed Mild cognitive impairment The British journal of psychiatry : the journal of mental science
Key finding: Further long-term studies are needed to examine the time-dependent evolution from mild cognitive impairment to dementia and to establish age-specific conversion rates during lifetime.
Full summary, score breakdown and related studies → Original source
-
2006-11-01
Vitamin B12, folic acid, and the nervous system
50/100 ✓ Peer-reviewed Lewy body dementia The Lancet. Neurology
Key finding: There are many reasons for reviewing the neurology of vitamin-B12 and folic-acid deficiencies together, including the intimate relation between the metabolism of the two vitamins, their morphologically indistinguishable megaloblastic anaemias, and their overlapping neuropsychiatric syndromes and neuropathology, including their related inborn errors of metabolism. +2 more findings
Full summary, score breakdown and related studies → Original source
-
2006-11-01
Effectiveness of nonpharmacological interventions for the management of neuropsychiatric symptoms in patients with dementia: a systematic review
57/100 ✓ Peer-reviewed Disparities Archives of internal medicine
Key finding: Three randomized controlled trials (RCTs) and 6 single-case designs (SCDs; N of 1 trials) met inclusion criteria. +3 more findings
Full summary, score breakdown and related studies → Original source
-
2006-11-01
Dementia care: mental health effects, intervention strategies, and clinical implications
48/100 ✓ Peer-reviewed Caregiving The Lancet. Neurology
Key finding: Caring for elderly people with dementia is associated with well-documented increases in burden, distress, and decrements in mental health and wellbeing. +1 more finding
Full summary, score breakdown and related studies → Original source
-
2006-11-01
The effect of a disease management intervention on quality and outcomes of dementia care: a randomized, controlled trial
68/100 ✓ Peer-reviewed Caregiving Annals of internal medicine
Key finding: A dementia guideline-based disease management program led to substantial improvements in quality of care for patients with dementia.
Full summary, score breakdown and related studies → Original source
-
2006-11-01
Proteome-based plasma biomarkers for Alzheimer's disease
66/100 ✓ Peer-reviewed Getting a diagnosis Brain : a journal of neurology
Key finding: These findings suggest that blood may be a rich source for biomarkers of Alzheimer's disease and that CFH, together with other proteins such as alpha-2M may be a specific markers of this illness.
Full summary, score breakdown and related studies → Original source
-
2006-11-01
Comparison of the Saint Louis University mental status examination and the mini-mental state examination for detecting dementia and mild neurocognitive disorder--a pilot study
54/100 ✓ Peer-reviewed Getting a diagnosis The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry
Key finding: These results suggest that the SLUMS and MMSE have comparable sensitivities, specificities, and area under the curve in detecting dementia. +2 more findings
Full summary, score breakdown and related studies → Original source
-
2006-11-01
The Addenbrooke's Cognitive Examination Revised (ACE-R): a brief cognitive test battery for dementia screening
59/100 ✓ Peer-reviewed Getting a diagnosis International journal of geriatric psychiatry
Key finding: Reliability of the ACE-R was very good (alpha coefficient=0.8). +1 more finding
Full summary, score breakdown and related studies → Original source
-
2006-11-01
Plasma phosphatidylcholine docosahexaenoic acid content and risk of dementia and Alzheimer disease: the Framingham Heart Study
56/100 ✓ Peer-reviewed Prevention and risk Archives of neurology
Key finding: Ninety-nine new cases of dementia (including 71 of Alzheimer disease) occurred during the follow-up. +3 more findings
Full summary, score breakdown and related studies → Original source
-
2006-11-01
Design of Depression in Alzheimer's Disease Study-2
59/100 ✓ Peer-reviewed Treatments The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry
Key finding: The authors believe these design elements are important features to be included in trials of depression and other neuropsychiatric disturbances in Alzheimer disease. +3 more findings
Full summary, score breakdown and related studies → Original source
-
2006-11-01
The GuidAge study: methodological issues. A 5-year double-blind randomized trial of the efficacy of EGb 761 for prevention of Alzheimer disease in patients over 70 with a memory complaint
65/100 ✓ Peer-reviewed Treatments Neurology
Key finding: The GuidAge study is the largest study carried out in Europe on the prevention of AD. +1 more finding
Full summary, score breakdown and related studies → Original source
-
2006-11-01
Improving caregiver well-being delays nursing home placement of patients with Alzheimer disease
73/100 ✓ Peer-reviewed Treatments Neurology
Key finding: Greater access to effective programs of counseling and support could yield considerable benefits for caregivers, patients with Alzheimer disease, and society. +1 more finding
Full summary, score breakdown and related studies → Original source
-
2006-11-01
Enhancing the quality of life of dementia caregivers from different ethnic or racial groups: a randomized, controlled trial
61/100 ✓ Peer-reviewed Treatments Annals of internal medicine
Key finding: A structured multicomponent intervention adapted to individual risk profiles can increase the quality of life of ethnically diverse dementia caregivers.
Full summary, score breakdown and related studies → Original source
October 2006 11
-
2006-10-30
TDP-43 is a component of ubiquitin-positive tau-negative inclusions in frontotemporal lobar degeneration and amyotrophic lateral sclerosis
56/100 ✓ Peer-reviewed Lewy body dementia Biochemical and biophysical research communications
Key finding: Dephosphorylation treatment of the sarkosyl insoluble fraction has shown that abnormal phosphorylation takes place in accumulated TDP-43. +1 more finding
Full summary, score breakdown and related studies → Original source
-
2006-10-29
Rare earth nanoparticles prevent retinal degeneration induced by intracellular peroxides
36/100 ✓ Peer-reviewed Brain scans and imaging Nature nanotechnology
Key finding: These data indicate that the nanoceria particles may be effective in inhibiting the progression of ROI-induced cell death, which is thought to be involved in macular degeneration, retinitis pigmentosa and other blinding diseases, as well as the ROI-induced death of other cell types in diabetes, Alzheimer's disease, atherosclerosis, stroke and so on. +1 more finding
Full summary, score breakdown and related studies → Original source
-
2006-10-27
Alzheimer disease, the two-hit hypothesis: an update
36/100 ✓ Peer-reviewed Drug development Biochimica et biophysica acta
Key finding: Given the relative modality of single-insult models to accurately reflect Alzheimer disease pathogenesis, based on studies on mitogenic and oxidative stress signaling pathways, we proposed a two-hit hypothesis 2 years ago stating that both oxidative stress and mitogenic dysregulation are necessary and sufficient to cause the disease and suggested that it may be a common mechanism for other neurodegenerative diseases as well (X.
Full summary, score breakdown and related studies → Original source
-
2006-10-24
Chronic lithium administration to FTDP-17 tau and GSK-3beta overexpressing mice prevents tau hyperphosphorylation and neurofibrillary tangle formation, but pre-formed neurofibrillary tangles do not revert
36/100 ✓ Peer-reviewed Disease mechanisms Journal of neurochemistry
Key finding: We used this transgenic model to address two issues: first, whether chronic lithium treatment is able to prevent the formation of aberrant tau aggregates that result from the overexpression of FTDP-17 tau and GSK-3beta; second, whether lithium is able to change back already formed NFTs in aged animals. +2 more findings
Full summary, score breakdown and related studies → Original source
-
2006-10-24
Mutations of presenilin genes in dilated cardiomyopathy and heart failure
45/100 ✓ Peer-reviewed Risk genes beyond APOE American journal of human genetics
Key finding: Heart failure usually results from dilated cardiomyopathy (DCM). +3 more findings
Full summary, score breakdown and related studies → Original source
-
2006-10-24
A multidisciplinary, multifactorial intervention program reduces postoperative falls and injuries after femoral neck fracture
64/100 ✓ Peer-reviewed Prevention and risk Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
Key finding: A team applying comprehensive geriatric assessment and rehabilitation, including prevention, detection, and treatment of fall risk factors, can successfully prevent inpatient falls and injuries, even in patients with dementia. +1 more finding
Full summary, score breakdown and related studies → Original source
-
2006-10-20
Modeling behavioral and neuronal symptoms of Alzheimer's disease in mice: a role for intraneuronal amyloid
36/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Neuroscience and biobehavioral reviews
Key finding: More recently, emerging evidence indicates that intraneuronal accumulation of Abeta may also contribute to the cascade of neurodegenerative events and strongly suggest that it is an early, pathological biomarker for the onset of AD and associated cognitive and other behavioral deficits.
Full summary, score breakdown and related studies → Original source
-
2006-10-20
Reduction of soluble Abeta and tau, but not soluble Abeta alone, ameliorates cognitive decline in transgenic mice with plaques and tangles
36/100 ✓ Peer-reviewed Disease mechanisms The Journal of biological chemistry
Key finding: Our results show that Abeta immunotherapy reduces soluble tau and ameliorates behavioral deficit in old transgenic mice.
Full summary, score breakdown and related studies → Original source
-
2006-10-18
Cdk5 is involved in NFT-like tauopathy induced by transient cerebral ischemia in female rats
36/100 ✓ Peer-reviewed Disease mechanisms Biochimica et biophysica acta
Key finding: As a potential underlying mechanism, we were able to determine that transient ischemia induced tau hyperphosphorylation and NFT-like conformations are associated with aberrant activation of cyclin dependent kinase 5 (Cdk5) and can be rescued by delivery of a potent, but non-specific cyclin dependent kinase inhibitor, roscovitine to the brain. +2 more findings
Full summary, score breakdown and related studies → Original source
-
2006-10-18
Inflammatory changes parallel the early stages of Alzheimer disease
45/100 ✓ Peer-reviewed Inflammation and the immune system Neurobiology of aging
Key finding: To determine changes in the AD brain that may mediate the transition into dementia, the gene expression of approximately 10,000 full-length genes was compared in mild/moderate dementia cases to non-demented controls that exhibited high AD pathology. +3 more findings
Full summary, score breakdown and related studies → Original source
-
2006-10-16
Subjective memory complaints and cognitive impairment in older people
47/100 ✓ Peer-reviewed Getting a diagnosis Dementia and geriatric cognitive disorders
Key finding: In conclusion, the determinants of SMCs are complex.
Full summary, score breakdown and related studies → Original source
Browse the library by subject, with the full score breakdown →