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Newest studies

Every summary in our library, newest first, as a dated timeline.

What "newest" means here

The most recent study in this library is dated 2026-11-01 (Paths of Aging Minds: Health Journeys of Older Adults with Mild Cognitive Impairment). This is our summary library, not a news wire — it is added to in batches, so the newest entry may not be the newest paper published anywhere.

Entries are sorted strictly by publication date, newest first. 26489 of the 27380 entries carry a full day-level date. 65 have no date recorded at all and are placed by publication year, at the start of that year; those are marked "no date recorded" below so you can see where the ordering is a best effort rather than a fact.

Prefer a reader? Subscribe to the Atom feed. Want them sorted by subject or by score instead? Browse the research library.

Showing 16,401–16,425 of 27,380 studies, newest first · page 657 of 1096.

January 2016 25

  1. 2016-01-01

    Metabolic connectomics targeting brain pathology in dementia with Lewy bodies

    ✓ Peer-reviewed Brain tissue and pathology Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism

    Key finding: To gain an overview of brain systems affected by neurodegeneration, we characterized the [18F]FDG-PET metabolic connectivity in 42 dementia with Lewy bodies patients, as compared to 42 healthy controls, using sparse inverse covariance estimation method and graph theory. +3 more findings

    Full summary, score breakdown and related studies → Original source

  2. 2016 year only

    Multi-Nutrient Dietary Intervention Approach to the Management of Alzheimer's Disease - A Mini-Review

    ✓ Peer-reviewed Prevention and risk Current Alzheimer research

    Key finding: The findings of this review study indicate that multi-nutrient intervention seem to bring many benefits for AD patients such as the delay of cognitive decline, non-invasive and less costly treatment or none or fewer side effects.

    Full summary, score breakdown and related studies → Original source

  3. 2016 year only

    Metformin Facilitates Amyloid-β Generation by β- and γ-Secretases via Autophagy Activation

    ✓ Peer-reviewed Drug development Journal of Alzheimer's disease : JAD

    Key finding: Contrary to suggestions that anti-diabetes drugs may have potential for treating AD, we demonstrate here that the insulin sensitizing anti-diabetes drug metformin (Glucophage®) increased the generation of amyloid-β (Aβ), one of the major pathological hallmarks of AD, by promoting β- and γ-secretase-mediated cleavage of amyloid-β protein precursor (AβPP) in SH-SY5Y cells. +3 more findings

    Full summary, score breakdown and related studies → Original source

  4. 2016 year only

    Tau-directed approaches for the treatment of Alzheimer's disease: focus on leuco-methylthioninium

    ✓ Peer-reviewed Drug development Expert review of neurotherapeutics

    Key finding: This trial failed to show significant positive effects of MT in the overall patient population.

    Full summary, score breakdown and related studies → Original source

  5. 2016 year only

    Cerebral Amyloid Angiopathy-Related Inflammation Biomarkers: Where are we Now?

    ✓ Peer-reviewed Treatments Journal of Alzheimer's disease : JAD

    Key finding: Cerebral amyloid angiopathy- related inflammation (CAA-ri) is an aggressive disease subtype of CAA with characteristic clinical and radiological findings. +4 more findings

    Full summary, score breakdown and related studies → Original source

  6. 2016 year only

    Diagnostic Impact of Cerebrospinal Fluid Biomarker (Pre-)Analytical Variability in Alzheimer's Disease

    ✓ Peer-reviewed Tau biomarkers Journal of Alzheimer's disease : JAD

    Key finding: In conclusion, induced shifts of ±20% in only one of the three biomarkers has limited impact on the clinical accuracy of AD CSF biomarkers in MCI and autopsy-confirmed AD patients when using the IWG-2 criteria.

    Full summary, score breakdown and related studies → Original source

  7. 2016 year only

    Differential Diagnosis of Dementia with High Levels of Cerebrospinal Fluid Tau Protein

    ✓ Peer-reviewed Tau biomarkers Journal of Alzheimer's disease : JAD

    Key finding: Patients were diagnosed with AD (n = 148, 73.2%), mixed dementia (n = 38, 18.8%), CJD, vascular dementia (n = 4, 2.0% for each), Lewy body dementia, and frontotemporal dementia (n = 3, 1.5% for each). +4 more findings

    Full summary, score breakdown and related studies → Original source

  8. 2016 year only

    Plasma Proteomics Biomarkers in Alzheimer's Disease: Latest Advances and Challenges

    ✓ Peer-reviewed Biomarkers Methods in molecular biology (Clifton, N.J.)

    Key finding: Blood plasma is easily accessible and contains a large number of proteins related to cerebral processes. +4 more findings

    Full summary, score breakdown and related studies → Original source

  9. 2016 year only

    Greater specificity for cerebrospinal fluid P-tau231 over P-tau181 in the differentiation of healthy controls from Alzheimer's disease

    ✓ Peer-reviewed Biomarkers Journal of Alzheimer's disease : JAD

    Key finding: Logistic regression modeling demonstrated that the P-tau231 was superior to the P-tau181 in the diagnostic classifications. +4 more findings

    Full summary, score breakdown and related studies → Original source

  10. 2016-01-01

    Linguistic Features Identify Alzheimer's Disease in Narrative Speech

    ✓ Peer-reviewed Digital health tools Journal of Alzheimer's disease : JAD

    Key finding: Modern machine learning and linguistic analysis will be increasingly useful in assessment and clustering of suspected AD.

    Full summary, score breakdown and related studies → Original source

  11. 2016-01-01

    Emergency Department Use Among Older Adults With Dementia

    ✓ Peer-reviewed Costs and economics Alzheimer disease and associated disorders

    Key finding: Patients with dementia visited the ED more frequently, were hospitalized more often than patients without dementia, and had an increased odds of returning to the ED within 30 days of an index ED visit compared with persons who never had a dementia diagnosis (odds ratio, 2.29; P<0.001). +3 more findings

    Full summary, score breakdown and related studies → Original source

  12. 2016-01-01

    Gut microbiota in autism and mood disorders

    ✓ Peer-reviewed Disease mechanisms World journal of gastroenterology

    Key finding: The application of therapeutic modulators of gut microbiota to autism and mood disorders has been experienced only in experimental settings to date, with few but promising results.

    Full summary, score breakdown and related studies → Original source

  13. 2016-01-01

    Moderate-to-High Intensity Physical Exercise in Patients with Alzheimer's Disease: A Randomized Controlled Trial

    ✓ Peer-reviewed Prevention trials Journal of Alzheimer's disease : JAD

    Key finding: This is the first randomized controlled trial with supervised moderate-to-high intensity exercise in patients with mild AD. +3 more findings

    Full summary, score breakdown and related studies → Original source

  14. 2016-01-01

    Metformin in Amnestic Mild Cognitive Impairment: Results of a Pilot Randomized Placebo Controlled Clinical Trial

    ✓ Peer-reviewed Drug development Journal of Alzheimer's disease : JAD

    Key finding: After adjusting for baseline ADAS-cog, changes in total recall of the SRT favored the metformin group (9.7±8.5 versus 5.3±8.5; p = 0.02). +1 more finding

    Full summary, score breakdown and related studies → Original source

  15. 2016-01-01

    Neuroprotective effects of glucose-dependent insulinotropic polypeptide in Alzheimer's disease

    ✓ Peer-reviewed Drug development Reviews in the neurosciences

    Key finding: Novel dual agonist peptides that activate the GIP receptor and another incretin receptor, glucagon-like peptide -1 (GLP-1), are under development that show superior effects in diabetic patients compared to single GLP-1 agonists.

    Full summary, score breakdown and related studies → Original source

  16. 2016-01-01

    A Randomized, Double-Blind, Phase 2 Study of the Effects of the Vaccine Vanutide Cridificar with QS-21 Adjuvant on Immunogenicity, Safety and Amyloid Imaging in Patients with Mild to Moderate Alzheimer's Disease

    ✓ Peer-reviewed Treatments The journal of prevention of Alzheimer's disease

    Key finding: Primary biomarker efficacy endpoints were not statistically significant in either dose group. +4 more findings

    Full summary, score breakdown and related studies → Original source

  17. 2016-01-01

    Accelerated pericyte degeneration and blood-brain barrier breakdown in apolipoprotein E4 carriers with Alzheimer's disease

    ✓ Peer-reviewed Genetics Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism

    Key finding: Our data suggest that APOE4 leads to accelerated pericyte loss and enhanced activation of LRP1-dependent CypA–MMP-9 BBB-degrading pathway in pericytes and endothelial cells, which can mediate a greater BBB damage in AD APOE4 compared with AD APOE3 carriers.

    Full summary, score breakdown and related studies → Original source

  18. 2016-01-01

    Hello Harlie: Enabling Speech Monitoring Through Chat-Bot Conversations

    ✓ Peer-reviewed Cognitive tests and assessment Studies in health technology and informatics

    Key finding: This paper presents initial testing of an artificial conversational agent, called Harlie. +4 more findings

    Full summary, score breakdown and related studies → Original source

  19. 2016-01-01

    Hypertension enhances Aβ-induced neurovascular dysfunction, promotes β-secretase activity, and leads to amyloidogenic processing of APP

    ✓ Peer-reviewed Biomarkers Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism

    Key finding: We conclude that HTN enhances amyloidogenic APP processing, effects that may contribute to the pathogenic interaction between HTN and AD.

    Full summary, score breakdown and related studies → Original source

  20. 2016-01-01

    Cerebrospinal Fluid Markers of Alzheimer's Disease Pathology and Microglial Activation are Associated with Altered White Matter Microstructure in Asymptomatic Adults at Risk for Alzheimer's Disease

    ✓ Peer-reviewed Biomarkers Journal of Alzheimer's disease : JAD

    Key finding: Inflammation may play a role in neural damage in preclinical AD. +3 more findings

    Full summary, score breakdown and related studies → Original source

  21. 2016-01-01

    Live Discharge from Hospice and the Grief Experience of Dementia Caregivers

    ✓ Peer-reviewed End-of-life care Journal of social work in end-of-life & palliative care

    Key finding: When an individual has dementia, family members are involved in many care transitions in their roles as caregivers.

    Full summary, score breakdown and related studies → Original source

  22. 2016-01-01

    Palliative Care Teams' Cost-Saving Effect Is Larger For Cancer Patients With Higher Numbers Of Comorbidities

    ✓ Peer-reviewed End-of-life care Health affairs (Project Hope)

    Key finding: Such spending is projected to continue to grow substantially as a result of increased insurance eligibility, the ever-rising cost of care, the continued use of nonbeneficial high-intensity treatments at the end of life, and demographic changes. +2 more findings

    Full summary, score breakdown and related studies → Original source

  23. 2016-01-01

    A Personalized 12-week "Brain Fitness Program" for Improving Cognitive Function and Increasing the Volume of Hippocampus in Elderly with Mild Cognitive Impairment

    ✓ Peer-reviewed Prevention trials The journal of prevention of Alzheimer's disease

    Key finding: The post-program testing showed 84% of the patients experienced statistically significant improvements in their cognitive function (p< 0.05).

    Full summary, score breakdown and related studies → Original source

  24. 2016-01-01

    Altered Intrinsic Pyramidal Neuron Properties and Pathway-Specific Synaptic Dysfunction Underlie Aberrant Hippocampal Network Function in a Mouse Model of Tauopathy

    ✓ Peer-reviewed Disease mechanisms The Journal of neuroscience : the official journal of the Society for Neuroscience

    Key finding: In vitro recordings revealed shifted theta-frequency resonance properties of CA1 pyramidal neurons, deficits in synaptic transmission at Schaffer collateral synapses, and blunted plasticity and imbalanced inhibition at temporoammonic synapses. +3 more findings

    Full summary, score breakdown and related studies → Original source

  25. 2016-01-01

    Characterization of Early Pathological Tau Conformations and Phosphorylation in Chronic Traumatic Encephalopathy

    ✓ Peer-reviewed Disease mechanisms Journal of neuropathology and experimental neurology

    Key finding: Several lines of evidence in other tauopathies suggest that tau oligomer formation induces neurotoxicity and that tau oligomer-mediated neurotoxicity involves induction of axonal dysfunction through exposure of an N-terminal motif in tau, the phosphatase-activating domain (PAD). +1 more finding

    Full summary, score breakdown and related studies → Original source

Browse the library by subject, with the full score breakdown →