Newest studies

A novel dual GLP-1 and GIP receptor agonist is neuroprotective in the MPTP mouse model of Parkinson's disease by increasing expression of BNDF

36/100 ✓ Peer-reviewed Drug development Brain research

Key finding: The results demonstrate that DA-JC1 shows promise as a novel treatment for PD.

• Brain Biology
• Treatments
• Other Dementias

Full summary, score breakdown and related studies → Original source

Interaction between variants in CLU and MS4A4E modulates Alzheimer's disease risk

54/100 ✓ Peer-reviewed TREM2 and immune genetics Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: We replicated the CLU-MS4A4E interaction in a large case-control series and observed APOE ε4 and possible dominant effect.

• Genetics

Full summary, score breakdown and related studies → Original source

Spectrum of cognition short of dementia: Framingham Heart Study and Mayo Clinic Study of Aging

47/100 ✓ Peer-reviewed Long-term cohort studies Neurology

Key finding: We quantitated risk of progression to dementia in elderly persons without dementia from 2 population-based studies, the Framingham Heart Study (FHS) and Mayo Clinic Study of Aging (MCSA), aged 70 to 89 years at enrollment. +3 more findings

Full summary, score breakdown and related studies → Original source

Varieties of semantic 'access' deficit in Wernicke's aphasia and semantic aphasia

46/100 ✓ Peer-reviewed Digital health tools Brain : a journal of neurology

Key finding: Comprehension deficits are common in stroke aphasia, including in cases with (i) semantic aphasia, characterized by poor executive control of semantic processing across verbal and non-verbal modalities; and (ii) Wernicke's aphasia, associated with poor auditory-verbal comprehension and repetition, plus fluent speech with jargon. +1 more finding

Full summary, score breakdown and related studies → Original source

Neuroprotective Effects of Clostridium butyricum against Vascular Dementia in Mice via Metabolic Butyrate

40/100 ✓ Peer-reviewed Disease mechanisms BioMed research international

Key finding: The results showed that C. butyricum significantly attenuated the cognitive dysfunction and histopathological changes in VaD mice. +1 more finding

• Brain Biology
• Other Dementias

Full summary, score breakdown and related studies → Original source

Treatment of Symptoms of the Menopause: An Endocrine Society Clinical Practice Guideline

69/100 ✓ Peer-reviewed Prevention and risk The Journal of clinical endocrinology and metabolism

Key finding: Menopausal hormone therapy (MHT) is the most effective treatment for vasomotor symptoms and other symptoms of the climacteric. +4 more findings

• Treatments

Full summary, score breakdown and related studies → Original source

Ocular Fundus Photography as a Tool to Study Stroke and Dementia

38/100 ✓ Peer-reviewed Brain scans and imaging Seminars in neurology

Key finding: Recent clinic- and population-based studies have demonstrated a close link between retinal vascular changes seen on fundus photography and stroke and dementia, suggesting that ocular fundus photography may provide insights to the contribution of microvascular disease to stroke and dementia. +1 more finding

Full summary, score breakdown and related studies → Original source

Imaging β-amyloid using [(18)F]flutemetamol positron emission tomography: from dosimetry to clinical diagnosis

38/100 ✓ Peer-reviewed Brain scans and imaging European journal of nuclear medicine and molecular imaging

Key finding: In Alzheimer's disease (AD), the deposition of β-amyloid (Aβ) is hypothesized to result in a series of secondary neurodegenerative processes, leading ultimately to synaptic dysfunction and neuronal loss.

• Brain Scans
• Brain Biology

Full summary, score breakdown and related studies → Original source

Aberrant intra- and inter-network connectivity architectures in Alzheimer's disease and mild cognitive impairment

47/100 ✓ Peer-reviewed Mild cognitive impairment Scientific reports

Key finding: For this purpose, we explored altered functional connectivities based on previously well-defined brain areas that comprise the five key functional systems [the default mode network (DMN), dorsal attention network (DAN), control network (CON), salience network (SAL), sensorimotor network (SMN)] in 35 with AD and 27 with mild cognitive impairment (MCI) subjects, compared with 27 normal cognitive subjects. +3 more findings

• Early Stage

Full summary, score breakdown and related studies → Original source

Depletion of microglia and inhibition of exosome synthesis halt tau propagation

61/100 ✓ Peer-reviewed Inflammation and the immune system Nature Neuroscience

Key finding: Depleting microglia dramatically suppressed the propagation of tau and reduced excitability in the dentate gyrus in this mouse model +1 more finding

• Brain Biology

Full summary, score breakdown and related studies → Original source

Medicare's Annual Wellness Visit in a Large Health Care Organization: Who Is Using It?

47/100 ✓ Peer-reviewed Health systems and care delivery Annals of Internal Medicine

Key finding: This benefit is being offered at no cost to eligible Medicare recipients; however, recent reports suggest that few persons are taking advantage of it (1–3) and who is using it is unclear. +1 more finding

• Care Services
• Policy

Full summary, score breakdown and related studies → Original source

Genetics ignite focus on microglial inflammation in Alzheimer's disease

47/100 ✓ Peer-reviewed TREM2 and immune genetics Molecular neurodegeneration

Key finding: Analyses of these risk factors have focused attention upon the role of immune processes in AD, specifically microglial function. +3 more findings

• Genetics
• Brain Biology

Full summary, score breakdown and related studies → Original source

MDS research criteria for prodromal Parkinson's disease

36/100 ✓ Peer-reviewed Mild cognitive impairment Movement disorders : official journal of the Movement Disorder Society

Key finding: This diagnostic information combines estimates of background risk (from environmental risk factors and genetic findings) and results of diagnostic marker testing.

• Early Stage
• Other Dementias

Full summary, score breakdown and related studies → Original source

The Disproportionate Impact Of Dementia On Family And Unpaid Caregiving To Older Adults

36/100 ✓ Peer-reviewed Health systems and care delivery Health affairs (Project Hope)

Key finding: We found that among family and unpaid caregivers to older noninstitutionalized adults, one-third of caregivers, and 41 percent of the hours of help they provide, help people with dementia, who account for about 10 percent of older noninstitutionalized adults.

• Caregiving
• Care Services

Full summary, score breakdown and related studies → Original source

Depression as a microglial disease

36/100 ✓ Peer-reviewed Risk factors Trends in neurosciences

Key finding: Recent studies indicate that impairment of the normal structure and function of microglia, caused by either intense inflammatory activation (e.g., following infections, trauma, stroke, short-term stress, autoimmune or neurodegenerative diseases) or by decline and senescence of these cells (e.g., during aging, Alzheimer's disease, or chronic unpredictable stress exposure), can lead to depression and associated impairments in neuroplasticity and neurogenesis.

• Brain Biology

Full summary, score breakdown and related studies → Original source

Hippocampal sharp wave-ripple: A cognitive biomarker for episodic memory and planning

40/100 ✓ Peer-reviewed Risk factors Hippocampus

Key finding: SPW-Rs occur during "off-line" states of the brain, associated with consummatory behaviors and non-REM sleep, and are influenced by numerous neurotransmitters and neuromodulators.

Full summary, score breakdown and related studies → Original source

MDS clinical diagnostic criteria for Parkinson's disease

57/100 ✓ Peer-reviewed Getting a diagnosis Movement Disorders

This document presents the Movement Disorder Society Clinical Diagnostic Criteria for Parkinson's disease (PD).

• Diagnosis
• Other Dementias

Full summary, score breakdown and related studies → Original source

Quantifying the prevalence of frailty in English hospitals

45/100 ✓ Peer-reviewed Risk factors BMJ Open

Key finding: A rising trend of admission spells was noted from January 2005 to March 2013 (daily average admissions for month rising from over 2000 to over 4000). +4 more findings

• Care Services

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Vascular dementia

59/100 ✓ Peer-reviewed Lewy body dementia Lancet (London, England)

Key finding: Vascular dementia is one of the most common causes of dementia after Alzheimer's disease, causing around 15% of cases. +4 more findings

• Other Dementias

Full summary, score breakdown and related studies → Original source

Plasma Exosomal miRNAs in Persons with and without Alzheimer Disease: Altered Expression and Prospects for Biomarkers

56/100 ✓ Peer-reviewed Getting a diagnosis PloS one

Key finding: Samples from 35 persons with a clinical diagnosis of AD dementia were compared to 35 age and sex matched controls. +3 more findings

• Diagnosis
• Biomarkers

Full summary, score breakdown and related studies → Original source

Lewy body dementias

58/100 ✓ Peer-reviewed Getting a diagnosis Lancet (London, England)

Key finding: However, dementia with Lewy bodies and Parkinson's disease dementia, now called Lewy body dementias, are the second most common type of degenerative dementia in patients older than 65 years. +4 more findings

• Diagnosis
• Other Dementias

Full summary, score breakdown and related studies → Original source

Frontotemporal dementia

59/100 ✓ Peer-reviewed Getting a diagnosis Lancet (London, England)

Key finding: The disease can mimic many psychiatric disorders because of the prominent behavioural features. +4 more findings

• Other Dementias

Full summary, score breakdown and related studies → Original source

Effects of Physical Exercise on Health and Well-Being of Individuals Living With a Dementia in Nursing Homes: A Systematic Review

60/100 ✓ Peer-reviewed Prevention and risk Journal of the American Medical Directors Association

Key finding: There is emerging evidence that physical exercise significantly benefits individuals living with a dementia in nursing homes. +1 more finding

• Lifestyle
• Care Services

Full summary, score breakdown and related studies → Original source

Cerebrospinal fluid profiles with increasing number of cerebral microbleeds in a continuum of cognitive impairment

52/100 ✓ Peer-reviewed Tau biomarkers Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism

Key finding: Increasing number of CMBs were independently associated with low Aβ42 levels, in the whole cohort, Alzheimer's disease and mild cognitive impairment (p < 0.05). +3 more findings

• Biomarkers

Full summary, score breakdown and related studies → Original source

Different definitions of neurodegeneration produce similar amyloid/neurodegeneration biomarker group findings

50/100 ✓ Peer-reviewed Hippocampus size on brain scans Brain : a journal of neurology

Key finding: We recently demonstrated that the frequencies of biomarker groups defined by the presence or absence of both amyloidosis (A+) and neurodegeneration (N+) changed dramatically by age in cognitively non-impaired subjects. +3 more findings

• Biomarkers

Full summary, score breakdown and related studies → Original source