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EEG characteristics in "eyes-open" versus "eyes-closed" conditions: Small-world network architecture in healthy aging and age-related brain degeneration
Miraglia F, Vecchio F, Bramanti P, Rossini PM.. Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 2015-09-25
Topic: Risk, prevention and care in population studies
Objective Applying graph theory, we investigated how cortical sources small worldness (SW) of resting EEG in eyes-closed/open (EC/EO) differs in amnestic mild cognitive impairment (aMCI) and Alzheimer's disease (AD) subjects with respect to normal elderly (Nold). Methods EEG was recorded in 30 Nold, 30 aMCI, and 30 AD during EC and EO. Undirected and weighted cortical brain network was built to evaluate graph core measures. eLORETA lagged linear connectivity was used to weight the network. Results In Nold, in EO condition, the brain network is characterized by more SW (higher SW) in alpha bands and less SW (lower SW) in beta2 and gamma bands. In aMCI, SW has the same trend, except for delta and theta bands where the network shows less small worldness. AD shows a similar trend of Nold, but with less fluctuations between EO/EC conditions. Furthermore, in both conditions, aMCI SW architecture presents midway properties between AD and Nold. At low frequencies (delta e theta bands) in EC, aMCI group presents network's architecture similar to Nold, while in EO aMCI, SW is superimposable to AD ones. Conclusions In resting state condition, aMCI small-world architecture presents midway topological properties between AD subjects and healthy controls, confirming the hypothesis that aMCI is an intermediate step along the disease progression. Significance We proposed the application of graph theory to EEG in reactivity to EO in order to find a marker of diagnosis that - in association with other techniques of neuroimaging - could be sensitive to the progression of MCI or conversion into AD.
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APA 7th
Miraglia, F., Vecchio, F., Bramanti, P., & Rossini, P. M. (2016). EEG characteristics in "eyes-open" versus "eyes-closed" conditions: Small-world network architecture in healthy aging and age-related brain degeneration. Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology. https://doi.org/10.1016/j.clinph.2015.07.040
Vancouver
Miraglia F, Vecchio F, Bramanti P, Rossini PM. EEG characteristics in "eyes-open" versus "eyes-closed" conditions: Small-world network architecture in healthy aging and age-related brain degeneration. Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology. 2016. doi:10.1016/j.clinph.2015.07.040. PMID: 26603651.
BibTeX
@article{miraglia2016-26603651,
author = {Miraglia, F. and Vecchio, F. and Bramanti, P. and Rossini, P. M.},
title = {{EEG characteristics in "eyes-open" versus "eyes-closed" conditions: Small-world network architecture in healthy aging and age-related brain degeneration}},
journal = {Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology},
year = {2016},
doi = {10.1016/j.clinph.2015.07.040},
pmid = {26603651},
url = {https://doi.org/10.1016/j.clinph.2015.07.040}
}
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Key findings
- Results In Nold, in EO condition, the brain network is characterized by more SW (higher SW) in alpha bands and less SW (lower SW) in beta2 and gamma bands.
Why it matters
This study found that people with amnestic mild cognitive impairment had brain network properties that fell between those of healthy older adults and people with Alzheimer's disease. The findings describe brain changes associated with disease progression but do not test any treatment or prevention.
Study details
- Evidence strengthLow
How this study scored 44/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology) |
| Journal's citation record | 2 / 4 | Clinical Neurophysiology: journal h-index 247 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2016 — within 20 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 5 / 7 | Cited 151 times (OpenAlex, 2026-10-10) |
| Citations per year | 3 / 5 | 12.6 citations a year over 12 year(s) since 2016 |
| Impact for its field and year | 4 / 6 | Cited 8.9× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 2 / 6 | Cited by 6 other studies in this library |
| Still being cited | 2 / 4 | Cited 27 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 4 / 4 | Last-listed author Paolo Maria Rossini: h-index 121 (OpenAlex, whole career) |
| Institution's track record | 0 / 3 | Istituti di Ricovero e Cura a Carattere Scientifico: institution h-index 487 (OpenAlex) |
| Multi-centre collaboration | 1 / 3 | OpenAlex lists 3 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 26603651) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 44 / 100 | — |
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