Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 15,926–15,950 of 27,380 studies, newest first · page 638 of 1096.
July 2016 25
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2016-07-16
Tract-specific white matter hyperintensities disrupt neural network function in Alzheimer's disease
50/100 ✓ Peer-reviewed Brain scans and imaging Alzheimer's & dementia : the journal of the Alzheimer's Association
Key finding: WMH volume within the inferior fronto-occipital fasciculus (IFOF) was the highest among all tract ROIs and associated with reduced FC in IFOF-connected DMN areas, independently of global AV-45 PET. +2 more findings
Full summary, score breakdown and related studies → Original source
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2016-07-16
Increased DNA methylation near TREM2 is consistently seen in the superior temporal gyrus in Alzheimer's disease brain
57/100 ✓ Peer-reviewed TREM2 and immune genetics Neurobiology of aging
Key finding: Here, we present data demonstrating increased DNA methylation in the superior temporal gyrus in Alzheimer's disease brain at a CpG site located 289 bp upstream of the transcription start site of the TREM2 gene in 3 independent study cohorts using 2 different technologies (Illumina Infinium 450K methylation beadchip and pyrosequencing). +2 more findings
Full summary, score breakdown and related studies → Original source
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2016-07-15
Long-Term Treatment with Liraglutide, a Glucagon-Like Peptide-1 (GLP-1) Receptor Agonist, Has No Effect on β-Amyloid Plaque Load in Two Transgenic APP/PS1 Mouse Models of Alzheimer’s Disease
40/100 ✓ Peer-reviewed Drug development PLoS ONE
Key finding: Compared to vehicle-dosed transgenic controls, liraglutide treatment had no effect on the plaque levels in hAPPLon/PS1A246E and hAPPSwe/PS1ΔE9 mice. +1 more finding
Full summary, score breakdown and related studies → Original source
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2016-07-15
The blood-brain barrier in Alzheimer's disease
41/100 ✓ Peer-reviewed Vascular contributions Neurobiology of disease
Key finding: In transgenic animals with AD-like pathology, recent studies have shown that circulating leukocytes migrate through the activated brain endothelium when certain adhesion molecules are expressed, penetrating into the brain parenchyma, interacting with the NVU components and potentially affecting their structural integrity and functionality.
Full summary, score breakdown and related studies → Original source
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2016-07-15
Barriers to and facilitators for implementing quality improvements in palliative care - results from a qualitative interview study in Norway
40/100 ✓ Peer-reviewed End-of-life care BMC palliative care
Key finding: When planning an improvement project in PC, services should pay particular attention to factors associated with their chosen implementation strategy. +1 more finding
Full summary, score breakdown and related studies → Original source
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2016-07-15
Chronic Conditions and Self-Reported Health in a Medicare Advantage Plan Population
28/100 ✓ Peer-reviewed Health systems and care delivery Population Health Management
Key finding: This study explored how one MA plan's survey of participants' responses regarding changes in physical and mental health is associated with a set of chronic conditions as well as sociodemographic characteristics. +3 more findings
Full summary, score breakdown and related studies → Original source
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2016-07-14
Atomic Resolution Structure of Monomorphic Aβ42 Amyloid Fibrils
36/100 ✓ Peer-reviewed Risk genes beyond APOE Journal of the American Chemical Society
Key finding: The outer surface of the monomers presents hydrophilic side chains to the solvent. +4 more findings
Full summary, score breakdown and related studies → Original source
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2016-07-14
Sleep Apnea, Sleep Duration and Brain MRI Markers of Cerebral Vascular Disease and Alzheimer's Disease: The Atherosclerosis Risk in Communities Study (ARIC)
46/100 ✓ Peer-reviewed Long-term cohort studies PloS one
Key finding: A growing body of literature has suggested that obstructive sleep apnea (OSA) and habitual short sleep duration are linked to poor cognitive function. +3 more findings
Full summary, score breakdown and related studies → Original source
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2016-07-14
Prestroke Vascular Pathology and the Risk of Recurrent Stroke and Poststroke Dementia
51/100 ✓ Peer-reviewed Long-term cohort studies Stroke
Key finding: Improved short-term survival after stroke has necessitated quantifying risk and risk factors of long-term sequelae after stroke (ie, recurrent stroke and dementia). +3 more findings
Full summary, score breakdown and related studies → Original source
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2016-07-14
Cerebrospinal fluid sTREM2 levels are associated with gray matter volume increases and reduced diffusivity in early Alzheimer's disease
51/100 ✓ Peer-reviewed TREM2 and immune genetics Alzheimer's & dementia : the journal of the Alzheimer's Association
Key finding: A soluble fragment (sTREM2) is often found abnormally increased in cerebrospinal fluid (CSF) in Alzheimer's disease (AD). +3 more findings
Full summary, score breakdown and related studies → Original source
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2016-07-13
Advance Care Planning in Dementia: Do Family Carers Know the Treatment Preferences of People with Early Dementia?
47/100 ✓ Peer-reviewed End-of-life care PloS one
Key finding: In interviews PWD were able to indicate their treatment preferences across all three scenarios. +1 more finding
Full summary, score breakdown and related studies → Original source
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2016-07-12
[Nutrition and cognitive impairment]
38/100 ✓ Peer-reviewed Prevention and risk Nutricion hospitalaria
Key finding: Better results are achieved when complete diets have been studied and considered over specific nutrients separately.
Full summary, score breakdown and related studies → Original source
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2016-07-11
Neurotrophic factor small-molecule mimetics mediated neuroregeneration and synaptic repair: emerging therapeutic modality for Alzheimer's disease
40/100 ✓ Peer-reviewed Disease mechanisms Molecular neurodegeneration
Key finding: P021 is a small molecular weight, BBB permeable compound with suitable pharmacokinetics for oral administration, and without adverse effects associated with native CNTF or BDNF molecule.
Full summary, score breakdown and related studies → Original source
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2016-07-11
Circulating biosignatures of late-life depression (LLD): Towards a comprehensive, data-driven approach to understanding LLD pathophysiology
41/100 ✓ Peer-reviewed Digital health tools Journal of psychiatric research
Key finding: Machine learning analysis was applied to the combined dataset to determine the accuracy with which specific proteins could correctly discriminate LLD versus control participants. +4 more findings
Full summary, score breakdown and related studies → Original source
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2016-07-09
Cost of Dementia and Its Correlation With Dependence
38/100 ✓ Peer-reviewed Costs and economics Journal of aging and health
Key finding: Average annual cost among patients diagnosed with dementia was €43,259, primarily incurred by accommodation. +3 more findings
Full summary, score breakdown and related studies → Original source
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2016-07-08
Hearing Impairment Affects Dementia Incidence. An Analysis Based on Longitudinal Health Claims Data in Germany
72/100 ✓ Peer-reviewed Digital health tools PloS one
Key finding: Recent research has revealed an association between hearing impairment and dementia. +3 more findings
Full summary, score breakdown and related studies → Original source
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2016-07-08
Can Ketones Help Rescue Brain Fuel Supply in Later Life? Implications for Cognitive Health during Aging and the Treatment of Alzheimer's Disease
43/100 ✓ Peer-reviewed Mild cognitive impairment Frontiers in molecular neuroscience
Key finding: These observations point to a brain fuel deficit which appears to be specific to glucose, precedes cognitive decline associated with AD, and becomes more severe as MCI progresses toward AD. +2 more findings
Full summary, score breakdown and related studies → Original source
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2016-07-08
In vivo cortical spreading pattern of tau and amyloid in the Alzheimer disease spectrum
57/100 ✓ Peer-reviewed Mild cognitive impairment Annals of neurology
Key finding: Our PET study replicated postmortem spreading patterns of tau and amyloid-β pathologies.
Full summary, score breakdown and related studies → Original source
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2016-07-08
Noggin Along with a Self-Assembling Peptide Nanofiber Containing Long Motif of Laminin Induces Tyrosine Hydroxylase Gene Expression
38/100 ✓ Peer-reviewed Biomarkers Molecular neurobiology
Key finding: The results indicated that neuroblastoma cell and hEnSC viability is in good agreement with the level of Bcl2 and β-tubulin III gene expression; however, -BMHP-1 and -laminin nanofibers exhibited significantly higher cell viability eventually through Wnt/β-catenin signaling pathway as compared to others, respectively. +2 more findings
Full summary, score breakdown and related studies → Original source
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2016-07-07
Analgesic prescribing in care home residents: how epidemiological studies may inform clinical practice
38/100 ✓ Peer-reviewed Health systems and care delivery Pain management
Key finding: Care home residents are often frail with multiple comorbidities and cognitive impairment, most commonly caused by dementia. +3 more findings
Full summary, score breakdown and related studies → Original source
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2016-07-07
An ethnographic study of strategies to support discussions with family members on end-of-life care for people with advanced dementia in nursing homes
41/100 ✓ Peer-reviewed End-of-life care BMC palliative care
Key finding: The Interdisciplinary Care Leader role offers a promising method for supporting and improving end-of-life care discussions between families of people with advanced dementia and nursing home staff.
Full summary, score breakdown and related studies → Original source
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2016-07-07
Sex Differences in Hip Fracture Surgery: Preoperative Risk Factors for Delirium and Postoperative Outcomes
64/100 ✓ Peer-reviewed Clinical safety Journal of the American Geriatrics Society
Key finding: Men are at higher risk of postoperative delirium after hip fracture repair than women and have more postoperative surgical complications. +4 more findings
Full summary, score breakdown and related studies → Original source
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2016-07-07
Pittsburgh compound B imaging and cerebrospinal fluid amyloid-β in a multicentre European memory clinic study
59/100 ✓ Peer-reviewed Disparities Brain : a journal of neurology
Key finding: Pittsburgh compound B standardized uptake value ratio results were scaled using the Centiloid method. +2 more findings
Full summary, score breakdown and related studies → Original source
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2016-07-06
Polygenic risk of Alzheimer disease is associated with early- and late-life processes
60/100 ✓ Peer-reviewed Genetics Neurology
Key finding: The influence of this genetic risk may begin in early life and make an individual more susceptible to cognitive impairment in late life.
Full summary, score breakdown and related studies → Original source
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2016-07-05
Interrelationship between Changes in the Amyloid β 42/40 Ratio and Presenilin 1 Conformation
38/100 ✓ Peer-reviewed Biomarkers Molecular medicine (Cambridge, Mass.)
Key finding: The enzyme exists in a dynamic equilibrium of the conformational states, with so-called "close" conformation associated with the shift of the γ-secretase cleavage towards the production of longer, neurotoxic Aβ species. +2 more findings
Full summary, score breakdown and related studies → Original source
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