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Comorbidities of epilepsy: current concepts and future perspectives
Keezer MR, Sisodiya SM, Sander JW.. The Lancet. Neurology, 2015-11-06
Topic: Risk, prevention and care in population studies
The burden of comorbidity in people with epilepsy is high. Several diseases, including depression, anxiety, dementia, migraine, heart disease, peptic ulcers, and arthritis are up to eight times more common in people with epilepsy than in the general population. Several mechanisms explain how epilepsy and comorbidities are associated, including shared risk factors and bidirectional relations. There is a pressing need for new and validated screening instruments and guidelines to help with the early detection and treatment of comorbid conditions. Preliminary evidence suggests that some conditions, such as depression and migraine, negatively affect seizure outcome and quality of life. Further investigation is needed to explore these relations and the effects of targeted interventions. Future advances in the investigation of the comorbidities of epilepsy will strengthen our understanding of epilepsy and could play an important part in stratification for genetic studies.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Keezer, M. R., Sisodiya, S. M., & Sander, J. W. (2016). Comorbidities of epilepsy: current concepts and future perspectives. The Lancet. Neurology. https://doi.org/10.1016/s1474-4422(15)00225-2
Vancouver
Keezer MR, Sisodiya SM, Sander JW. Comorbidities of epilepsy: current concepts and future perspectives. The Lancet. Neurology. 2016. doi:10.1016/s1474-4422(15)00225-2. PMID: 26549780.
BibTeX
@article{keezer2016-26549780,
author = {Keezer, M. R. and Sisodiya, S. M. and Sander, J. W.},
title = {{Comorbidities of epilepsy: current concepts and future perspectives}},
journal = {The Lancet. Neurology},
year = {2016},
doi = {10.1016/s1474-4422(15)00225-2},
pmid = {26549780},
url = {https://doi.org/10.1016/s1474-4422(15)00225-2}
}
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Key findings
- Preliminary evidence suggests that some conditions, such as depression and migraine, negatively affect seizure outcome and quality of life.
Why it matters
This review notes that dementia is more common in people with epilepsy and that preliminary evidence suggests some conditions such as depression and migraine negatively affect seizure outcome and quality of life. It does not test any treatment, cure, or prevention for Alzheimer's disease.
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Study details
- Evidence strengthLow
How this study scored 56/100
Published in a leading specialty journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 9 / 10 | Tier 2 — leading specialty journal (The Lancet. Neurology) |
| Journal's citation record | 3 / 4 | The Lancet Neurology: journal h-index 457 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2016 — within 20 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 6 / 7 | Cited 785 times (OpenAlex, 2026-10-10) |
| Citations per year | 5 / 5 | 65.4 citations a year over 12 year(s) since 2016 |
| Impact for its field and year | 5 / 6 | Cited 20.8× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 2 / 6 | Cited by 3 other studies in this library |
| Still being cited | 4 / 4 | Cited 307 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 4 / 4 | Last-listed author Josemir W. A. S. Sander: h-index 122 (OpenAlex, whole career) |
| Institution's track record | 2 / 3 | University College London: institution h-index 2,029 (OpenAlex) |
| Multi-centre collaboration | 2 / 3 | OpenAlex lists 6 institution(s) in 2 countries |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 26549780) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 56 / 100 | — |
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Read the original
- DOI: 10.1016/s1474-4422(15)00225-2
- PubMed: 26549780
- Original source →
- Free full text: UCL Discovery (University College London) →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
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