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Cerebral amyloid angiopathy and cognitive outcomes in community-based older persons
Boyle PA, Yu L, Nag S, Leurgans S, Wilson RS, Bennett DA, Schneider JA.. Neurology, 2015-11-04
Topic: Amyloid, tau and blood-test diagnosis
Objective We tested the hypothesis that cerebral amyloid angiopathy (CAA) is related to Alzheimer disease (AD) dementia and decline in multiple cognitive systems in old age, independent of AD plaque and tangle pathology and other common age-related neuropathologies. Methods Participants (n = 1,113) came from 2 longitudinal clinical-pathologic studies of aging, the Rush Memory and Aging Project and the Religious Orders Study. All underwent annual clinical evaluations including detailed cognitive testing for a mean of 7.1 years before death.
Key findings
- Methods Participants (n = 1,113) came from 2 longitudinal clinical-pathologic studies of aging, the Rush Memory and Aging Project and the Religious Orders Study.
- All underwent annual clinical evaluations including detailed cognitive testing for a mean of 7.1 years before death.
- Clinical diagnoses of AD were established after reviewing all clinical data, blinded to neuropathologic information.
- Neuropathologic examinations provided measures of CAA, AD pathology, macroscopic infarcts, microinfarcts, and neocortical Lewy bodies.
Why it matters
This longitudinal study tested whether cerebral amyloid angiopathy is related to Alzheimer's disease dementia and decline in multiple cognitive systems in old age, independent of AD plaque and tangle pathology. It followed 1,113 participants from two longitudinal clinical-pathologic studies of aging with annual cognitive testing for a mean of 7.1 years before death.
Study details
- Study designlongitudinal study
- Participants1,113
- Effect size78.9%
- Evidence strengthModerate
How this study scored 70/100
Published in a leading specialty journal, and it is a longitudinal study following the same people over time.
| Component | Points | Why |
|---|---|---|
| Journal tier | 9 / 10 | Tier 2 — leading specialty journal (Neurology) |
| Journal's citation record | 4 / 4 | Neurology: journal h-index 525 (OpenAlex, 2026-10-29) |
| Study design | 7 / 12 | A longitudinal study following the same people over time |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2015 — within 20 year(s) of the newest study here |
| Sample size | 3 / 4 | 1,113 participants |
| Effect reported | 2 / 3 | Effect reported as a number, without an interval or test |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 1 / 2 | Blinded or placebo-controlled (as stated in the record) |
| Times cited | 6 / 7 | Cited 423 times (OpenAlex, 2026-10-10) |
| Citations per year | 4 / 5 | 32.5 citations a year over 13 year(s) since 2015 |
| Impact for its field and year | 4 / 6 | Cited 17.4× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 4 / 6 | Cited by 30 other studies in this library |
| Still being cited | 3 / 4 | Cited 159 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 4 / 4 | Last-listed author Julie A. Schneider: h-index 151 (OpenAlex, whole career) |
| Institution's track record | 0 / 3 | Rush University Medical Center: institution h-index 670 (OpenAlex) |
| Multi-centre collaboration | 0 / 3 | OpenAlex lists 1 institution(s) in 1 country — scores zero (affiliation lists can be incomplete) |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 26537052) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 70 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record names 7 authors; APA and Vancouver show the first six, BibTeX and the downloads carry all of them. Check the citation against the original before you use it.
APA 7th
Boyle, P. A., Yu, L., Nag, S., Leurgans, S., Wilson, R. S., Bennett, D. A., et al. (2015). Cerebral amyloid angiopathy and cognitive outcomes in community-based older persons. Neurology. https://doi.org/10.1212/wnl.0000000000002175
Vancouver
Boyle PA, Yu L, Nag S, Leurgans S, Wilson RS, Bennett DA, et al. Cerebral amyloid angiopathy and cognitive outcomes in community-based older persons. Neurology. 2015. doi:10.1212/wnl.0000000000002175. PMID: 26537052.
BibTeX
@article{boyle2015-26537052,
author = {Boyle, P. A. and Yu, L. and Nag, S. and Leurgans, S. and Wilson, R. S. and Bennett, D. A. and Schneider, J. A.},
title = {{Cerebral amyloid angiopathy and cognitive outcomes in community-based older persons}},
journal = {Neurology},
year = {2015},
doi = {10.1212/wnl.0000000000002175},
pmid = {26537052},
url = {https://doi.org/10.1212/wnl.0000000000002175}
}
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