Newest studies

Spatial memory and hippocampal volume in humans with unilateral vestibular deafferentation

43/100 ✓ Peer-reviewed Hippocampus size on brain scans Hippocampus

Key finding: Patients with acquired chronic bilateral vestibular loss were recently found to have a significant impairment in spatial memory and navigation when tested with a virtual Morris water task. +3 more findings

• Brain Scans

Full summary, score breakdown and related studies → Original source

Dying in hospital of terminal heart failure or severe dementia: the circumstances associated with death and the opinions of caregivers

49/100 ✓ Peer-reviewed End-of-life care Palliative medicine

Key finding: Our results suggest that some aspects of the palliative care provided to elderly patients with end-stage chronic diseases, admitted to acute care hospitals, could be improved. +1 more finding

• End-of-Life Care
• Caregiving
• Care Services

Full summary, score breakdown and related studies → Original source

Nurses' perceptions around providing palliative care for long-term care residents with dementia

38/100 ✓ Peer-reviewed End-of-life care Journal of palliative care

Key finding: Nurses appraise residents' general deterioration as a main factor in deciding that a resident is palliative. +4 more findings

• End-of-Life Care
• Care Services

Full summary, score breakdown and related studies → Original source

Dysphagia in patients with frontotemporal lobar dementia

43/100 ✓ Peer-reviewed Clinical safety Archives of neurology

Key finding: When assessed via instrumentation, swallowing abnormalities are found in many patients with FTLD. +1 more finding

• Other Dementias

Full summary, score breakdown and related studies → Original source

Heart failure and cognitive impairment: challenges and opportunities

40/100 ✓ Peer-reviewed Clinical safety Clinical interventions in aging

Key finding: HF is associated with ICF, manifested primarily as delirium in hospitalized patients, or as mild cognitive impairment or dementia in otherwise stable outpatients. +4 more findings

Full summary, score breakdown and related studies → Original source

Progression of tremor and ataxia in male carriers of the FMR1 premutation

52/100 ✓ Peer-reviewed Clinical safety Movement disorders : official journal of the Movement Disorder Society

Key finding: The natural history of FXTAS is largely unknown. +4 more findings

Full summary, score breakdown and related studies → Original source

Nutritional status determinants and cognition in the elderly

36/100 ✓ Peer-reviewed Prevention trials Archives of gerontology and geriatrics

Key finding: High dietary intake of antioxidants and omega-3 fatty acids lower the risk of Alzheimer disease (AD). +4 more findings

• Prevention
• Lifestyle
• Risk Factors

Full summary, score breakdown and related studies → Original source

Super Value Grocery Store: The Bahamian Super Market

11/100 ⚠ Preprint — not yet peer-reviewed Risk factors Not indexed

Key finding: Marketing and promotional efforts to improve sales failed to yield any positive results. +2 more findings

Full summary, score breakdown and related studies → Original source

Role of the toll-like receptor 4 in neuroinflammation in Alzheimer's disease

48/100 ✓ Peer-reviewed Inflammation and the immune system Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology

Key finding: The innate immune receptor Toll-like-receptor 4 (TLR4), localized on the surface of microglia, is a first-line host defense receptor against invading microorganisms. +3 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source

Microglial activation and its implications in the brain diseases

47/100 ✓ Peer-reviewed Inflammation and the immune system Current medicinal chemistry

Key finding: The inflammatory response is mediated by the activated microglia, the resident immune cells of the CNS, which normally respond to neuronal damage and remove the damaged cells by phagocytosis. +3 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source

Alpha-lipoic acid as a new treatment option for Alzheimer's disease--a 48 months follow-up analysis

50/100 ✓ Peer-reviewed Cognitive tests and assessment Journal of neural transmission. Supplementum

Key finding: It is therefore conceivable that pro-energetic and antioxidant drugs such as alpha-lipoic acid might delay the onset or slow down the progression of the disease. +3 more findings

• Treatments
• Clinical Trials

Full summary, score breakdown and related studies → Original source

Effectiveness of a cognitive rehabilitation program in mild dementia (MD) and mild cognitive impairment (MCI): a case control study

41/100 ✓ Peer-reviewed Mild cognitive impairment Archives of gerontology and geriatrics

Key finding: Our results demonstrate that a systematic rehabilitation, that provides a computerized cognitive program training, produces an improvement in cognitive and affective status of patients with MCI and MD, while a rehabilitation program not providing a punctual stimulation of cognitive functions, does not have significant effects.

• Early Stage

Full summary, score breakdown and related studies → Original source

Qualitative estimates of medial temporal atrophy as a predictor of progression from mild cognitive impairment to dementia

63/100 ✓ Peer-reviewed Mild cognitive impairment Archives of neurology

Key finding: Adjusted estimates of MTA were associated with significantly increased risk of developing dementia within 3 years, suggesting that obtaining a magnetic resonance image during the evaluation of MCI may offer additional independent information about the risk of progression to dementia. +1 more finding

• Early Stage
• Clinical Trials

Full summary, score breakdown and related studies → Original source

Expression of Nrf2 in neurodegenerative diseases

47/100 ✓ Peer-reviewed Lewy body dementia Journal of neuropathology and experimental neurology

Key finding: By immunoblotting, we observed a significant decrease in nuclear Nrf2 levels in AD cases. +1 more finding

• Other Dementias
• Brain Biology

Full summary, score breakdown and related studies → Original source

Cognitive impairment and pain management: review of issues and challenges

38/100 ✓ Peer-reviewed Digital health tools Journal of rehabilitation research and development

Key finding: Disorders affecting cognition include neurodegenerative, vascular, toxic, anoxic, and infectious processes. +4 more findings

Full summary, score breakdown and related studies → Original source

The many faces of corticobasal degeneration

43/100 ✓ Peer-reviewed Digital health tools Parkinsonism & related disorders

Key finding: Dementia, progressive non-fluent aphasia, speech apraxia, progressive supranuclear palsy (PSP)-like syndrome and posterior cortical atrophy syndrome are other presentations of CBD. +4 more findings

Full summary, score breakdown and related studies → Original source

Oxidative stress and the pathogenesis of neurodegenerative disorders

48/100 ✓ Peer-reviewed How common it is International review of neurobiology

Key finding: The detrimental effects of oxidative stress in the brain and nervous system are primarily a result of the diminished capacity of the central nervous system to prevent ongoing oxidative damage. +1 more finding

• Brain Biology

Full summary, score breakdown and related studies → Original source

Conversion from subtypes of mild cognitive impairment to Alzheimer dementia

60/100 ✓ Peer-reviewed How common it is Neurology

Key finding: Patients with mild cognitive impairment (MCI) showed a high probability to be diagnosed with Alzheimer dementia (AD) after 30 months.

• Early Stage
• Other Dementias

Full summary, score breakdown and related studies → Original source

A systematic review of the effectiveness and cost-effectiveness of different models of community-based respite care for frail older people and their carers

16/100 ⚠ Report — not peer-reviewed Disparities Health technology assessment (Winchester, England)

Key finding: Twenty-two primary studies were included. +3 more findings

• Caregiving
• Policy

Scored 42 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

Full summary, score breakdown and related studies → Original source

Antihypertensive medication adherence in the Department of Veterans Affairs

53/100 ✓ Peer-reviewed Disparities The American journal of medicine

Key finding: We studied 40,492 hypertensive patients taking at least one antihypertensive drug class.

• Health Equity
• Treatments

Full summary, score breakdown and related studies → Original source

Nicotinic acetylcholine receptors and nicotinic cholinergic mechanisms of the central nervous system

48/100 ✓ Peer-reviewed Disparities Annual review of pharmacology and toxicology

Key finding: Subtypes of neuronal nicotinic acetylcholine receptors (nAChRs) are constructed from numerous subunit combinations that compose channel-receptor complexes with varied functional and pharmacological characteristics. +4 more findings

• Other Dementias

Full summary, score breakdown and related studies → Original source

Perinatal iron deficiency results in altered developmental expression of genes mediating energy metabolism and neuronal morphogenesis in hippocampus

42/100 ✓ Peer-reviewed Brain scans and imaging Hippocampus

Key finding: All 25 genes showed altered expression during the period of ID (P7, 15, and 30); 10 had changes on P65 after iron repletion. +4 more findings

• Genetics

Full summary, score breakdown and related studies → Original source

Diffusion tensor imaging of cingulum fibers in mild cognitive impairment and Alzheimer disease

59/100 ✓ Peer-reviewed Brain scans and imaging Neurology

Key finding: Assessment of the cingulum fibers using diffusion tensor imaging may aid early diagnosis of Alzheimer disease. +3 more findings

• Brain Scans
• Early Stage

Full summary, score breakdown and related studies → Original source

The cognitive correlates of functional status: a review from the Committee on Research of the American Neuropsychiatric Association

45/100 ✓ Peer-reviewed Getting a diagnosis The Journal of neuropsychiatry and clinical neurosciences

Key finding: What literature is available suggests that 1) the variance in functional status that can be specifically attributed to cognition is surprisingly modest; 2) some cognitive domains may be more relevant to functional capacity than others; 3) some measures of executive control function are relatively strong correlates of functional capacities, particularly medical or financial decision-making; and 4) "general" cognitive screening tests are surprisingly strong correlates of functional status. +1 more finding

• Diagnosis

Full summary, score breakdown and related studies → Original source

Recommendations for the diagnosis and management of Alzheimer's disease and other disorders associated with dementia: EFNS guideline

67/100 ✓ Peer-reviewed Getting a diagnosis European journal of neurology

Key finding: The recommendations for clinical diagnosis, blood tests, neuroimaging, electroencephalography (EEG), cerebrospinal fluid (CSF) analysis, genetic testing, tissue biopsy, disclosure of diagnosis, treatment of Alzheimer's disease, and counselling and support for caregivers were all revised when compared with the previous EFNS guideline.

• Diagnosis
• Biomarkers
• Other Dementias

Full summary, score breakdown and related studies → Original source