Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 16,801–16,825 of 27,380 studies, newest first · page 673 of 1096.
July 2015 25
-
2015-07-21
Medical costs of Alzheimer's disease misdiagnosis among US Medicare beneficiaries
41/100 ✓ Peer-reviewed Costs and economics Alzheimer's & dementia : the journal of the Alzheimer's Association
Key finding: Patients with prior AD diagnosis used substantially more medical services every year until their VD/PD diagnosis, resulting in incremental annual medical costs of approximately $9,500-$14,000. +3 more findings
Full summary, score breakdown and related studies → Original source
-
2015-07-21
Bioinformatics methods in drug repurposing for Alzheimer's disease
38/100 ✓ Peer-reviewed Drug development Briefings in bioinformatics
Key finding: We found a list of 27 potential anti-Alzheimer agents that were additionally processed with regard to molecular similarity, pathway/ontology enrichment and network analysis.
Full summary, score breakdown and related studies → Original source
-
2015-07-21
Evidence that the rab5 effector APPL1 mediates APP-βCTF-induced dysfunction of endosomes in Down syndrome and Alzheimer's disease
43/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Molecular psychiatry
Key finding: Endosomes are highly active APP processing sites, and endosome anomalies associated with upregulated expression of early endosomal regulator, rab5, are the earliest known disease-specific neuronal response in AD. +1 more finding
Full summary, score breakdown and related studies → Original source
-
2015-07-21
Olfactory deposition of inhaled nanoparticles in humans
40/100 ✓ Peer-reviewed Risk factors Inhalation toxicology
Key finding: In humans, olfactory dose of inhaled nanoparticles is highest for 1-2 nm particles with ∼1% of inhaled particles depositing in the olfactory region. +2 more findings
Full summary, score breakdown and related studies → Original source
-
2015-07-21
Clearance systems in the brain-implications for Alzheimer disease
56/100 ✓ Peer-reviewed Brain tissue and pathology Nature reviews. Neurology
Key finding: Aβ accumulation has been hypothesized to result from an imbalance between Aβ production and clearance; indeed, Aβ clearance seems to be impaired in both early and late forms of AD. +3 more findings
Full summary, score breakdown and related studies → Original source
-
2015-07-21
White matter hyperintensity burden in elderly cohort studies: The Sunnybrook Dementia Study, Alzheimer's Disease Neuroimaging Initiative, and Three-City Study
52/100 ✓ Peer-reviewed Long-term cohort studies Alzheimer's & dementia : the journal of the Alzheimer's Association
Key finding: Using white matter hyperintensities (WMH) as a biomarker of cerebrovascular disease, we compared WMH burden between the Sunnybrook Dementia Study, the Alzheimer's Disease Neuroimaging Initiative (ADNI-1), the Three-City Study, and various other studies around the world. +3 more findings
Full summary, score breakdown and related studies → Original source
-
2015-07-21
De novo deleterious genetic variations target a biological network centered on Aβ peptide in early-onset Alzheimer disease
47/100 ✓ Peer-reviewed Risk genes beyond APOE Molecular psychiatry
Key finding: We investigated 14 sporadic EOAD trios first by array-comparative genomic hybridization. +3 more findings
Full summary, score breakdown and related studies → Original source
-
2015-07-21
Anosognosia in Alzheimer disease: Disconnection between memory and self-related brain networks
47/100 ✓ Peer-reviewed Brain scans and imaging Annals of neurology
Key finding: Anosognosia in AD is due not only to functional changes within cortical midline structures involved in self-referential processes (OFC, PCC), but also to disconnection between these regions as well as with the medial temporal lobe. +2 more findings
Full summary, score breakdown and related studies → Original source
-
2015-07-21
The potential for prevention of dementia across two decades: the prospective, population-based Rotterdam Study
60/100 ✓ Peer-reviewed Prevention and risk BMC medicine
Key finding: A substantial part of dementia cases could be prevented if modifiable risk factors would be eliminated.
Full summary, score breakdown and related studies → Original source
-
2015-07-20
Prophylactic liraglutide treatment prevents amyloid plaque deposition, chronic inflammation and memory impairment in APP/PS1 mice
36/100 ✓ Peer-reviewed Drug development Behavioural brain research
Key finding: Previously, we have shown that the diabetes drug liraglutide is protective in middle aged and in old APP/PS1 mice. +1 more finding
Full summary, score breakdown and related studies → Original source
-
2015-07-17
Mediterranean diet and preserved brain structural connectivity in older subjects
50/100 ✓ Peer-reviewed Prevention and risk Alzheimer's & dementia : the journal of the Alzheimer's Association
Key finding: In multivariate voxel-by-voxel analyses, adherence to the MeDi was significantly associated with preserved white matter microstructure in extensive areas, a gain in structural connectivity that was related to strong cognitive benefits. +3 more findings
Full summary, score breakdown and related studies → Original source
-
2015-07-17
Trends in Psychotropic Dispensing Among Older Adults with Dementia Living in Long-Term Care Facilities: 2004-2013
52/100 ✓ Peer-reviewed Digital health tools The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry
Key finding: Utilization patterns of psychotropic drugs in institutionalized patients with dementia have changed over the past decade. +3 more findings
Full summary, score breakdown and related studies → Original source
-
2015-07-16
Factors associated with rushed and missed resident care in western Canadian nursing homes: a cross-sectional survey of health care aides
52/100 ✓ Peer-reviewed Disparities Journal of clinical nursing
Key finding: Health care aides frequently report care that is rushed and tasks omitted due to lack of time. +3 more findings
Full summary, score breakdown and related studies → Original source
-
2015-07-16
Role of apolipoprotein E in neurodegenerative diseases
45/100 ✓ Peer-reviewed Prevention and risk Neuropsychiatric disease and treatment
Key finding: APOE binds to cell-surface receptors to deliver lipids and to the hydrophobic amyloid-β peptide, regulating amyloid-β aggregations and clearances in the brain. +4 more findings
Full summary, score breakdown and related studies → Original source
-
2015-07-15
Role of RAGE in Alzheimer's Disease
36/100 ✓ Peer-reviewed Disease mechanisms Cellular and molecular neurobiology
Key finding: Compelling evidence suggests that RAGE acts as both an inflammatory intermediary and a critical inducer of oxidative stress, underlying RAGE-induced Alzheimer-like pathophysiological changes that drive the process of Alzheimer's disease (AD).
Full summary, score breakdown and related studies → Original source
-
2015-07-15
Mixed pathology is more likely in black than white decedents with Alzheimer dementia
65/100 ✓ Peer-reviewed Caregiving Neurology
Key finding: Black decedents with AD dementia are more likely to have mixed brain pathologies compared with age-, sex-, education-, and cognition-matched white decedents with AD dementia. +1 more finding
Full summary, score breakdown and related studies → Original source
-
2015-07-15
Multiple pathologies are common and related to dementia in the oldest-old: The 90+ Study
68/100 ✓ Peer-reviewed Caregiving Neurology
Key finding: In the oldest-old, the presence of multiple pathologies is associated with increased likelihood and severity of dementia. +3 more findings
Full summary, score breakdown and related studies → Original source
-
2015-07-15
Amyloid precursor protein metabolism and inflammation markers in preclinical Alzheimer disease
56/100 ✓ Peer-reviewed Genetics Neurology
Key finding: Our findings suggest that inflammation in the CNS increases in normal aging and is intimately related to markers of neurodegeneration in the preclinical stages of AD and SNAP. sAPPβ and β-secretase activity are not useful diagnostic or staging markers in preclinical AD. +1 more finding
Full summary, score breakdown and related studies → Original source
-
2015-07-14
The cerebrospinal fluid biomarker profile in an HIV-infected subject with Alzheimer's disease
38/100 ✓ Peer-reviewed Tau biomarkers AIDS research and therapy
Key finding: Here we describe a 63 year old HIV-infected woman who had a history, neuropsychological test result, and PET examination consistent with characteristic Alzheimer's disease (AD).
Full summary, score breakdown and related studies → Original source
-
2015-07-14
Baseline and longitudinal grey matter changes in newly diagnosed Parkinson's disease: ICICLE-PD study
68/100 ✓ Peer-reviewed Mild cognitive impairment Brain : a journal of neurology
Key finding: Mild cognitive impairment in Parkinson's disease is associated with progression to dementia (Parkinson's disease dementia) in a majority of patients. +4 more findings
Full summary, score breakdown and related studies → Original source
-
2015-07-14
New suggestive genetic loci and biological pathways for attention function in adult attention-deficit/hyperactivity disorder
41/100 ✓ Peer-reviewed Genetics American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
Key finding: However, the specific genetic variants that may be associated with attention function in adult ADHD remain largely unknown. +4 more findings
Full summary, score breakdown and related studies → Original source
-
2015-07-10
Combined Liver X Receptor/Peroxisome Proliferator-activated Receptor γ Agonist Treatment Reduces Amyloid β Levels and Improves Behavior in Amyloid Precursor Protein/Presenilin 1 Mice
44/100 ✓ Peer-reviewed Genetics The Journal of biological chemistry
Key finding: Agonists of LXRs have been demonstrated previously to reduce Aβ levels and improve cognitive deficits in AD mouse models by inducing the transcription and lipidation of apolipoprotein E (apoE). +4 more findings
Full summary, score breakdown and related studies → Original source
-
2015-07-09
Gender differences in risk factors for transition from mild cognitive impairment to Alzheimer's disease: A CREDOS study
60/100 ✓ Peer-reviewed Mild cognitive impairment Comprehensive psychiatry
Key finding: Risk factors for progression from MCI to probable AD differed in men and women. +4 more findings
Full summary, score breakdown and related studies → Original source
-
2015-07-08
Occupational Complexity and Cognitive Reserve in a Middle-Aged Cohort at Risk for Alzheimer's Disease
46/100 ✓ Peer-reviewed Risk factors Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists
Key finding: Higher occupational attainment has previously been associated with increased Alzheimer's disease (AD) neuropathology when individuals are matched for cognitive function, indicating occupation could provide cognitive reserve. +2 more findings
Full summary, score breakdown and related studies → Original source
-
2015-07-07
Traffic-Related Air Pollution and Parkinson's Disease in Denmark: A Case-Control Study
59/100 ✓ Peer-reviewed Risk factors Environmental health perspectives
Key finding: Our findings raise concerns about potential effects of air pollution from traffic and other sources on the risk of PD, particularly in populations with high or increasing exposures. +2 more findings
Full summary, score breakdown and related studies → Original source
Browse the library by subject, with the full score breakdown →