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41/100

✓ Peer-reviewed alzhub usefulness score 41 out of 100. Risk factors

Topic: Amyloid, tau and blood-test diagnosis

Neighborhood disadvantage is associated with education, health behaviors and mortality. Higher levels of neighborhood disadvantage were associated with worse baseline cognitive outcomes, especially within the most disadvantaged neighborhood decile (p<0.0001). After adjustment for age and education, those within the most disadvantaged decile demonstrated worse cognitive performance across all domains (beta [95% confidence interval] and p-value by domain: working memory: -0.45 [-0.62, -0.28], <0.0001; immediate memory: -0.34 [-0.52, -0.17], <0.0001; speed/flexibility: -0.62 [-0.78, -0.45], <0.0001; verbal learning: -0.44 [-0.61, -0.27], <0.0001). These early data suggest that neighborhood disadvantage may account for some of the observed disparities in prevalence of dementia. Given the urgent need to reduce dementia and AD disparities, the current results suggest that neighborhood disadvantage deserves additional study.

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APA 7th

Kind, A., Bendlin, B. B., Kim, A. J., Koscik, R. L., Buckingham, W. R., Gleason, C. E., et al. (2017). [O1–04–03]: NEIGHBORHOOD SOCIOECONOMIC CONTEXTUAL DISADVANTAGE, BASELINE COGNITION AND ALZHEIMER's DISEASE BIOMARKERS IN THE WISCONSIN REGISTRY FOR ALZHEIMER's PREVENTION (WRAP) STUDY. Alzheimer s & Dementia. https://doi.org/10.1016/j.jalz.2017.07.054

Vancouver

Kind A, Bendlin BB, Kim AJ, Koscik RL, Buckingham WR, Gleason CE, et al. [O1–04–03]: NEIGHBORHOOD SOCIOECONOMIC CONTEXTUAL DISADVANTAGE, BASELINE COGNITION AND ALZHEIMER's DISEASE BIOMARKERS IN THE WISCONSIN REGISTRY FOR ALZHEIMER's PREVENTION (WRAP) STUDY. Alzheimer s & Dementia. 2017. doi:10.1016/j.jalz.2017.07.054.

BibTeX

@article{kind2017-4fec9d5a,
  author  = {Kind, Amy and Bendlin, Barbara B. and Kim, Alice J. and Koscik, Rebecca L. and Buckingham, William R. and Gleason, Carey Elizabeth and Blennow, Kaj and Zetterberg, Henrik and others},
  title   = {{[O1–04–03]: NEIGHBORHOOD SOCIOECONOMIC CONTEXTUAL DISADVANTAGE, BASELINE COGNITION AND ALZHEIMER's DISEASE BIOMARKERS IN THE WISCONSIN REGISTRY FOR ALZHEIMER's PREVENTION (WRAP) STUDY}},
  journal = {Alzheimer s \& Dementia},
  year    = {2017},
  doi     = {10.1016/j.jalz.2017.07.054},
  url     = {https://doi.org/10.1016/j.jalz.2017.07.054}
}

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Key findings

Neighborhood disadvantage is associated with education, health behaviors and mortality.
Higher levels of neighborhood disadvantage were associated with worse baseline cognitive outcomes, especially within the most disadvantaged neighborhood decile (p<0.0001).
After adjustment for age and education, those within the most disadvantaged decile demonstrated worse cognitive performance across all domains (beta [95% confidence interval] and p-value by domain: working memory: -0.45 [-0.62, -0.28], <0.0001; immediate memory: -0.34 [-0.52, -0.17], <0.0001; speed/flexibility: -0.62 [-0.78, -0.45], <0.0001; verbal learning: -0.44 [-0.61, -0.27], <0.0001).
These early data suggest that neighborhood disadvantage may account for some of the observed disparities in prevalence of dementia.
Given the urgent need to reduce dementia and AD disparities, the current results suggest that neighborhood disadvantage deserves additional study.

Why it matters

This study found that higher neighborhood disadvantage was linked to worse baseline cognitive performance, especially in the most disadvantaged neighborhood decile. It is early data on social context and cognition, not about treating, curing or preventing Alzheimer's disease.

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Study details

Participants1,479
Evidence strengthModerate

How this study scored 41/100

Published in a peer-reviewed journal. Scored zero for study design, effect reported and randomised / blinded because the record does not state it.

Component	Points	Why
Journal tier	7 / 10	Tier 3 — peer-reviewed journal (Alzheimer s & Dementia)
Journal's citation record	2 / 4	Alzheimer s & Dementia: journal h-index 228 (OpenAlex, 2026-10-29)
Study design	0 / 12	No study design recorded — scores zero, not guessed (not stated in the record — scored 0)
Strength of evidence	3 / 5	Rated “moderate” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	2 / 5	2017 — within 10 year(s) of the newest study here
Sample size	3 / 4	1,479 participants
Effect reported	0 / 3	No effect size reported — scores zero (not stated in the record — scored 0)
Studied in people	3 / 3	Studied in people (participant count stated)
Randomised / blinded	0 / 2	No randomisation or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	1 / 7	Cited 2 times (OpenAlex, 2026-10-10)
Citations per year	0 / 5	0.2 citations a year over 11 year(s) since 2017
Impact for its field and year	1 / 6	Cited 0.2× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	0 / 6	No other study in this library cites it
Still being cited	0 / 4	Cited 0 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	4 / 4	Last-listed author Sterling C. Johnson: h-index 112 (OpenAlex, whole career)
Institution's track record	2 / 3	University College London: institution h-index 2,029 (OpenAlex)
Multi-centre collaboration	2 / 3	OpenAlex lists 6 institution(s) in 3 countries
Indexed in PubMed	1 / 2	Not in PubMed, but has a DOI
Free to read	0 / 2	Behind a paywall — scores zero
Total	41 / 100	—

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