alzhub.org
Get help now — free helplines

You can call any of these for free. You do not need a diagnosis, an appointment, or a crisis to call — questions and plain exhaustion are reasons enough.

  • Alzheimer's Association 24/7 Helpline 800-272-3900 24 hours a day, 365 days a year Free, confidential support and information for people with dementia, caregivers, families and the public. Master's-level clinicians. Also Spanish.
  • 988 Suicide & Crisis Lifeline 988 24/7 Call or text 988, or chat at 988lifeline.org. For anyone in emotional distress or a mental-health crisis, including caregivers.
  • Alzheimer's Foundation of America (AFA) Helpline 866-232-8484 9:00 am - 9:00 pm ET, seven days a week Licensed social workers providing support, info and referrals. Also text message and web chat. Text: 646-586-5283

In a medical emergency, call 911. More numbers, and what each line does, on the help page.

Newest studies

Every summary in our library, newest first, as a dated timeline.

What "newest" means here

The most recent study in this library is dated 2026-11-01 (Paths of Aging Minds: Health Journeys of Older Adults with Mild Cognitive Impairment). This is our summary library, not a news wire — it is added to in batches, so the newest entry may not be the newest paper published anywhere.

Entries are sorted strictly by publication date, newest first. 26489 of the 27380 entries carry a full day-level date. 65 have no date recorded at all and are placed by publication year, at the start of that year; those are marked "no date recorded" below so you can see where the ordering is a best effort rather than a fact.

Prefer a reader? Subscribe to the Atom feed. Want them sorted by subject or by score instead? Browse the research library.

Showing 17,426–17,450 of 27,380 studies, newest first · page 698 of 1096.

December 2014 25

  1. 2014-12-23

    Mobile technologies in the early detection of cognitive decline

    ✓ Peer-reviewed Disparities PloS one

    Key finding: Whereas imaging markers were unrelated to traditional neuropsychological test scores, they were significantly associated with mobile assessments of semantic memory performance. +1 more finding

    Full summary, score breakdown and related studies → Original source

  2. 2014-12-22

    Cognitive training in Parkinson's disease reduces cognitive decline in the long term

    ✓ Peer-reviewed Prevention trials European journal of neurology

    Key finding: This study gives evidence that cognitive training may be effective to prevent cognitive decline and onset of MCI in PD patients. +2 more findings

    Full summary, score breakdown and related studies → Original source

  3. 2014-12-20

    Convergent genetic and expression data implicate immunity in Alzheimer's disease

    ✓ Peer-reviewed Genetics Alzheimer's & dementia : the journal of the Alzheimer's Association

    Key finding: The immune response, regulation of endocytosis, cholesterol transport, and protein ubiquitination represent prime targets for AD therapeutics. +1 more finding

    Full summary, score breakdown and related studies → Original source

  4. 2014-12-20

    Identification of diabetes-related dementia: Longitudinal perfusion SPECT and amyloid PET studies

    ✓ Peer-reviewed Biomarkers Journal of the neurological sciences

    Key finding: A subset of a dementia subgroup with characteristics predominantly associated with DM-related factors may underlie a pathophysiology different from AD, although these patients were clinically diagnosed as having AD. +3 more findings

    Full summary, score breakdown and related studies → Original source

  5. 2014-12-19

    Effects of Physical Exercise on Neuroinflammation, Neuroplasticity, Neurodegeneration, and Behavior: What We Can Learn From Animal Models in Clinical Settings

    ✓ Peer-reviewed Inflammation and the immune system Neurorehabilitation and neural repair

    Key finding: In this narrative review, we discuss the beneficial effects of exercise performed in animal models of neurodegenerative disorders and how the results from animal studies can be used in clinical settings.

    Full summary, score breakdown and related studies → Original source

  6. 2014-12-19

    Age of dementia diagnosis in community dwelling bilingual and monolingual Hispanic Americans

    ✓ Peer-reviewed Disparities Cortex; a journal devoted to the study of the nervous system and behavior

    Key finding: It involved a secondary analysis of the subset of 81 bi/monolingual dementia cases identified at yearly follow-up (1998 through 2008) using neuropsychological test results and objective diagnostic criteria from the Sacramento Area Latino Study on Aging that involved a random sampling of community dwelling Hispanic Americans (N = 1789). +3 more findings

    Full summary, score breakdown and related studies → Original source

  7. 2014-12-19

    Cerebrospinal fluid levels of the synaptic protein neurogranin correlates with cognitive decline in prodromal Alzheimer's disease

    ✓ Peer-reviewed Getting a diagnosis Alzheimer's & dementia : the journal of the Alzheimer's Association

    Key finding: Synaptic dysfunction is an early event in Alzheimer's disease (AD) pathogenesis and directly related to cognitive impairment.

    Full summary, score breakdown and related studies → Original source

  8. 2014-12-18

    NFκB-activated astroglial release of complement C3 compromises neuronal morphology and function associated with Alzheimer's disease

    ✓ Peer-reviewed Disease mechanisms Neuron

    Key finding: Abnormal NFκB activation has been implicated in Alzheimer's disease (AD). +4 more findings

    Full summary, score breakdown and related studies → Original source

  9. 2014-12-18

    Serum IgG antibody levels to periodontal microbiota are associated with incident Alzheimer disease

    ✓ Peer-reviewed Disease mechanisms PloS one

    Key finding: Serum IgG levels to common periodontal microbiota are associated with risk for developing incident AD. +4 more findings

    Full summary, score breakdown and related studies → Original source

  10. 2014-12-18

    Global, regional, and national age-sex specific all-cause and cause-specific mortality for 240 causes of death, 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013

    ✓ Peer-reviewed Risk factors Lancet (London, England)

    Key finding: We used the results to assess whether there is epidemiological convergence across countries. +1 more finding

    Full summary, score breakdown and related studies → Original source

  11. 2014-12-18

    International variation in place of death of older people who died from dementia in 14 European and non-European countries

    ✓ Peer-reviewed End-of-life care Journal of the American Medical Directors Association

    Key finding: Place of death of older people who died from a dementia-related disease differs substantially between countries, which might point to organizational differences in end-of-life care provision. +2 more findings

    Full summary, score breakdown and related studies → Original source

  12. 2014-12-18

    Spontaneous white matter damage, cognitive decline and neuroinflammation in middle-aged hypertensive rats: an animal model of early-stage cerebral small vessel disease

    ✓ Peer-reviewed Disparities Acta neuropathologica communications

    Key finding: Our results indicate that SHR share behavioral and neuropathological characteristics with human cSVD patients and further undergird the relevance of immune responses for the initiation and progression of cSVD. +3 more findings

    Full summary, score breakdown and related studies → Original source

  13. 2014-12-17

    Tau, amyloid, and hypometabolism in a patient with posterior cortical atrophy

    ✓ Peer-reviewed Brain scans and imaging Annals of neurology

    Key finding: Determining the relative contribution of amyloid plaques and neurofibrillary tangles to brain dysfunction in Alzheimer disease is critical for therapeutic approaches, but until recently could only be assessed at autopsy. +3 more findings

    Full summary, score breakdown and related studies → Original source

  14. 2014-12-15

    A double-blind randomized placebo-controlled withdrawal trial comparing memantine and antipsychotics for the long-term treatment of function and neuropsychiatric symptoms in people with Alzheimer's disease (MAIN-AD)

    ✓ Peer-reviewed Treatments Journal of the American Medical Directors Association

    Key finding: This study indicates no benefits for memantine in the long-term treatment and prophylaxis of clinically significant neuropsychiatric symptoms. +4 more findings

    Full summary, score breakdown and related studies → Original source

  15. 2014-12-14

    Priority setting partnership to identify the top 10 research priorities for the management of Parkinson's disease

    ✓ Peer-reviewed Clinical safety BMJ open

    Key finding: These research priorities identify crucial gaps in the existing evidence to address everyday practicalities in the management of the complexities of PD.

    Full summary, score breakdown and related studies → Original source

  16. 2014-12-12

    Down syndrome and Alzheimer's disease: Common pathways, common goals

    ✓ Peer-reviewed Down syndrome and Alzheimer's Alzheimer's & dementia : the journal of the Alzheimer's Association

    Key finding: In the United States, estimates indicate there are between 250,000 and 400,000 individuals with Down syndrome (DS), and nearly all will develop Alzheimer's disease (AD) pathology starting in their 30s. +3 more findings

    Full summary, score breakdown and related studies → Original source

  17. 2014-12-12

    Vascular contributions to cognitive impairment and dementia including Alzheimer's disease

    ✓ Peer-reviewed Vascular contributions Alzheimer's & dementia : the journal of the Alzheimer's Association

    Key finding: Scientific evidence continues to demonstrate the linkage of vascular contributions to cognitive impairment and dementia such as Alzheimer's disease. +2 more findings

    Full summary, score breakdown and related studies → Original source

  18. 2014-12-12

    Target risk factors for dementia prevention: a systematic review and Delphi consensus study on the evidence from observational studies

    ✓ Peer-reviewed Prevention and risk International journal of geriatric psychiatry

    Key finding: Out of 3127 abstracts, 291 were included in the review.

    Full summary, score breakdown and related studies → Original source

  19. 2014-12-10

    Rare variant testing of imputed data: an analysis pipeline typified

    ✓ Peer-reviewed Genetics Human heredity

    Key finding: Further, we show that our pipeline leads to valid significance testing procedures with controlled type I error rates. +4 more findings

    Full summary, score breakdown and related studies → Original source

  20. 2014-12-09

    Biomarkers of Alzheimer's disease and mild cognitive impairment: a current perspective

    ✓ Peer-reviewed Tau biomarkers Advances in medical sciences

    Key finding: A growing body of evidence supports the application of the neurochemical dementia diagnostics (NDD) biomarkers for the diagnosis of dementing conditions. +4 more findings

    Full summary, score breakdown and related studies → Original source

  21. 2014-12-09

    Disturbed mitochondrial dynamics and neurodegenerative disorders

    ✓ Peer-reviewed Risk genes beyond APOE Nature reviews. Neurology

    Key finding: Pathogenic mutations that disrupt these two pro-fusion proteins cause autosomal dominant optic atrophy and axonal Charcot-Marie-Tooth disease type 2A, respectively. +4 more findings

    Full summary, score breakdown and related studies → Original source

  22. 2014-12-09

    Melatonin attenuates D-galactose-induced memory impairment, neuroinflammation and neurodegeneration via RAGE/NF-K B/JNK signaling pathway in aging mouse model

    ✓ Peer-reviewed Biomarkers Journal of pineal research

    Key finding: Our behavioral (Morris water maze and Y-maze test) results revealed that chronic melatonin treatment alleviated D-galactose-induced memory impairment. +2 more findings

    Full summary, score breakdown and related studies → Original source

  23. 2014-12-09

    Post-stroke cognitive decline: an update and perspectives for clinical research

    ✓ Peer-reviewed Vascular contributions European journal of neurology

    Key finding: Both neurodegenerative and vascular mechanisms are activated and probably result in overlapping processes within the neurovascular unit.

    Full summary, score breakdown and related studies → Original source

  24. 2014-12-09

    Mediterranean diet and cognitive decline over time in an elderly Mediterranean population

    ✓ Peer-reviewed Prevention trials European journal of nutrition

    Key finding: Closer adherence to the traditional MD is highly likely to protect against cognitive decline in this elderly Mediterranean population. +4 more findings

    Full summary, score breakdown and related studies → Original source

  25. 2014-12-09

    The triggering receptor expressed on myeloid cells 2 (TREM2) is associated with enhanced inflammation, neuropathological lesions and increased risk for Alzheimer's dementia

    ✓ Peer-reviewed TREM2 and immune genetics Alzheimer's & dementia : the journal of the Alzheimer's Association

    Key finding: The TREM2 variant is associated with: (i) AD (odds ratio: 4.76; P = .014); (ii) increased density of amyloid plaques and neurofibrillary tangles in multiple brain regions; (iii) increased TREM2 (P = .041) and TYROBP (P = .006) gene expression; (iv) decreased TREM2 protein levels (P = .016); and (v) upregulation of proinflammatory cytokines (regulated on activation, norma +2 more findings

    Full summary, score breakdown and related studies → Original source

Browse the library by subject, with the full score breakdown →