Newest studies

Clinical Spectrum of Tauopathies

59/100 ✓ Peer-reviewed Digital health tools Frontiers in neurology

Key finding: Here, we discuss clinical syndromes associated with various primary tauopathies and their distinguishing clinical features and new biomarkers becoming available to improve in vivo diagnosis.

• Other Dementias

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Associations between dementia diagnosis and end-of-life care utilization

61/100 ✓ Peer-reviewed Disparities Journal of the American Geriatrics Society

Key finding: 54% of Medicare decedents were female, 85% non-Hispanic White, 8% non-Hispanic Black, and 4% Hispanic. +4 more findings

• Health Equity
• Diagnosis
• End-of-Life Care

Full summary, score breakdown and related studies → Original source

Polygenic score for Alzheimer's disease identifies differential atrophy in hippocampal subfield volumes

52/100 ✓ Peer-reviewed Genetics PloS one

Key finding: Hippocampal subfield atrophy is a prime structural change in the brain, associated with cognitive aging and neurodegenerative diseases such as Alzheimer's disease. +2 more findings

• Genetics
• Early Stage

Full summary, score breakdown and related studies → Original source

Relational Care, Dementia, and Communication Challenges in Long-Term Care: A Meta-Ethnography

41/100 ✓ Peer-reviewed Health systems and care delivery Canadian journal on aging = La revue canadienne du vieillissement

Key finding: We identified five translatable concepts across the six studies: (1) doing with versus doing for, (2) staff responsiveness, (3) resident agency, (4) inclusive communication, and (5) time.

• Care Services

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Particulate matter and Alzheimer's disease: an intimate connection

41/100 ✓ Peer-reviewed Risk factors Trends in molecular medicine

Key finding: The environmental role in disease progression has been appreciated for decades; however, understanding how airborne toxicant exposure can affect organs beyond the lungs is an underappreciated area of scientific inquiry. +4 more findings

Full summary, score breakdown and related studies → Original source

Development of the CogDrisk tool to assess risk factors for dementia

73/100 ✓ Peer-reviewed Risk factors Alzheimer's & dementia (Amsterdam, Netherlands)

Key finding: Seventeen risk/protective factors met criteria for the algorithm to estimate risk for any dementia including age, sex, education, hypertension, midlife obesity, midlife high cholesterol, diabetes, insufficient physical activity, depression, traumatic brain injury, atrial fibrillation, smoking, social engagement, cognitive engagement, fish consumption (diet), stroke, and insomnia. +4 more findings

• Risk Factors
• Lifestyle

Full summary, score breakdown and related studies → Original source

Hepatic and renal function impact concentrations of plasma biomarkers of neuropathology

54/100 ✓ Peer-reviewed Biomarkers Alzheimer's & dementia (Amsterdam, Netherlands)

Key finding: p-tau181, NfL, t-tau, and UCHL1 were increased 2- to 4-fold in cirrhosis, whereas GFAP was not increased. +2 more findings

• Biomarkers
• Brain Biology

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Pathobiology of the Klotho Antiaging Protein and Therapeutic Considerations

43/100 ✓ Peer-reviewed Drug development Frontiers in aging

Key finding: Lack of Klotho or FGF23 results in hyperphosphatemia and hypervitaminosis D.

• Treatments

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Comparative analytical performance of multiple plasma Aβ42 and Aβ40 assays and their ability to predict positron emission tomography amyloid positivity

43/100 ✓ Peer-reviewed Biomarkers Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: Measurement of Aβ in plasma contributes to addressing the amyloid component of the ATN (amyloid/tau/neurodegeneration) framework and could be a first step before or in place of a PET or cerebrospinal fluid screening study. +1 more finding

• Biomarkers
• Brain Scans
• Genetics

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TDP-43 Pathology Exacerbates Cognitive Decline in Primary Age-Related Tauopathy

52/100 ✓ Peer-reviewed Brain tissue and pathology Annals of neurology

Key finding: Concomitant LATE-NC and vascular pathology were equally common, and cognition was equally impaired, in PART (Mini-Mental State Examination [MMSE] = 24.8 ± 6.9) and ADNC (MMSE = 24.2 ± 6.0). +4 more findings

• Brain Biology
• Diagnosis

Full summary, score breakdown and related studies → Original source

Automated semi-quantitative amyloid PET analysis technique without MR images for Alzheimer's disease

45/100 ✓ Peer-reviewed Brain scans and imaging Annals of nuclear medicine

Key finding: SUVr calculated by our method and CortexID were highly correlated (R2 = 0.9657). +4 more findings

• Brain Scans

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Mechanisms of Short-Chain Fatty Acids Derived from Gut Microbiota in Alzheimer's Disease

43/100 ✓ Peer-reviewed Disease mechanisms Aging and disease

Key finding: Recent studies on gut-brain interaction have shown that SCFAs are important mediators of gut-brain interactions and are involved in the occurrence and development of many neurodegenerative diseases, including Alzheimer's disease.

• Brain Biology

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Aptamer-Functionalized Carbon Nanotube Field-Effect Transistor Biosensors for Alzheimer's Disease Serum Biomarker Detection

40/100 ✓ Peer-reviewed Biomarkers ACS sensors

Key finding: The adsorption of biological substrates to the sensor was significantly reduced by multiple blocking steps, resulting in selectivity ratios of up to 730% (Aβ 40 ) and 800% (Aβ 42 ).

• Biomarkers

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Determining Vascular Risk Factors for Dementia and Dementia Risk Prediction Across Mid- to Later Life: The Framingham Heart Study

63/100 ✓ Peer-reviewed Long-term cohort studies Neurology

Key finding: The association between vascular risk factors and dementia varies with age, making generalizability of dementia risk prediction rules to individuals of different ages challenging. +3 more findings

• Risk Factors

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TREM2-induced activation of microglia contributes to synaptic integrity in cognitively intact aged individuals with Alzheimer's neuropathology

45/100 ✓ Peer-reviewed TREM2 and immune genetics Brain pathology (Zurich, Switzerland)

Key finding: Exposed phosphatidylserine (ePS) represents a neuronal "eat-me" signal involved in microglial-mediated phagocytosis of damaged synapses. +3 more findings

• Brain Biology
• Genetics

Full summary, score breakdown and related studies → Original source

Associations of Social Isolation and Loneliness With Later Dementia

77/100 ✓ Peer-reviewed Prevention and risk Neurology

Key finding: Then, voxel-wise brainwide association analyses were used to identify gray matter volumes (GMVs) associated with social isolation and with loneliness. +4 more findings

• Lifestyle
• Risk Factors

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Plasma Neurofilament Light and p-tau181 and Risk of Psychosis in Parkinson’s Disease

55/100 ✓ Peer-reviewed Biomarkers Journal of Parkinson's Disease

Key finding: Baseline plasma NfL was a significant predictor of psychotic symptoms longitudinally across the study adjusted for age, Hoehn and Yahr stage, duration of follow up, duration of disease, baseline levodopa and dopamine agonist medication, and baseline cognition: (OR 8.15 [95% CI 1.40–47.4], p = 0.020). +4 more findings

• Biomarkers

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Cerebrospinal Fluid Cortisol and Dehydroepiandrosterone Sulfate, Alzheimer's Disease Pathology, and Cognitive Decline

50/100 ✓ Peer-reviewed Tau biomarkers Frontiers in aging neuroscience

Key finding: Higher CSF cortisol was associated with poorer global cognitive performance and higher disease severity at baseline. +4 more findings

• Biomarkers

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Decreased Frontal Gamma Activity in Alzheimer Disease Patients

47/100 ✓ Peer-reviewed Disease mechanisms Annals of neurology

Key finding: Our data provide novel evidence that frontal lobe gamma activity is dampened in AD patients. +1 more finding

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Automated detection of mild cognitive impairment and dementia from voice recordings: A natural language processing approach

55/100 ✓ Peer-reviewed Digital health tools Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: The proposed approach offers a fully automated identification of MCI and dementia based on a recorded neuropsychological test, providing an opportunity to develop a remote screening tool that could be adapted easily to any language.

• Early Stage

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Trans-Anethole Alleviates Trimethyltin Chloride-Induced Impairments in Long-Term Potentiation

41/100 ✓ Peer-reviewed Disease mechanisms Pharmaceutics

Key finding: These results revealed that trans-anethole enhances NMDA receptor-dependent and -independent LTP and alleviates TMT-induced LTP impairment. +1 more finding

• Brain Biology

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Molecular landscapes of human hippocampal immature neurons across lifespan

45/100 ✓ Peer-reviewed Genetics Nature

Key finding: Finally, we demonstrated the capacity for neurogenesis in the adult human hippocampus with the presence of rare dentate granule cell fate-specific proliferating neural progenitors and with cultured surgical specimens. +1 more finding

• Brain Biology

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Which components of the Mediterranean diet are associated with dementia? A UK Biobank cohort study

76/100 ✓ Peer-reviewed Prevention trials GeroScience

Key finding: Cohort studies suggest that the Mediterranean diet is associated with better global cognition in older adults, slower cognitive decline and lower risk of dementia. +4 more findings

• Lifestyle
• Risk Factors

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Association of Pace of Aging Measured by Blood-Based DNA Methylation With Age-Related Cognitive Impairment and Dementia

70/100 ✓ Peer-reviewed Long-term cohort studies Neurology

Key finding: DNA methylation algorithms are increasingly used to estimate biological aging; however, how these proposed measures of whole-organism biological aging relate to aging in the brain is not known. +3 more findings

• Biomarkers

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Single-cell roadmap of human gonadal development

62/100 ✓ Peer-reviewed TREM2 and immune genetics Nature

Key finding: Historically, limited tissue accessibility, a lack of reliable in vitro models and critical differences between humans and mice have hampered our knowledge of human gonadogenesis, despite its importance in gonadal conditions and infertility. +3 more findings

Full summary, score breakdown and related studies → Original source