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34/100

✓ Peer-reviewed alzhub usefulness score 34 out of 100. Risk factors

Topic: Risk, prevention and care in population studies

Clinical and population-based epidemiological studies report variation in the observed prevalence and incidence of dementia with Lewy bodies (DLB). Although validated diagnostic criteria and clinical biomarkers support detection of DLB in clinical populations, it is estimated that only around one in three cases of DLB might be correctly identified in routine care. However, clear evidence that this is the case is lacking, and whether variability between studies reflects true geographical variation, or diagnostic differences, is unknown. We screened consecutive clinical case records of patients with dementia seen at nine memory clinics and dementia services, located across two distinct geographical areas, over an 18-month period. DLB cases identified during this process were approached for detailed retrospective case note review. Non-DLB controls, identified as the next consecutive patient diagnosed with a non-DLB dementia, matched for age, gender and Mini-Mental State Examination score, were also recruited. Diagnostic pathway, symptom profiles and all visits and treatments were recorded for DLB cases and non-DLB controls. Case notes of 9 410 individual patients, of whom 52.4% had a diagnosis of dementia, were reviewed. Patients with DLB made up 4.2% (95% CI 3.7–4.8%) of all dementia cases. Significant variation was observed between services, with DLB prevalence ranging from 1.8% to 5.9% (χ=24.3, p<0.01). DLB was significantly more prevalent in men (χ=20.45, p<0.01) and was negatively correlated with age (χ=8.2, p<0.01). DLB diagnostic rates in secondary care were considerably lower than would be expected based on previous neuropathological studies. Importantly, there was significant variation noted across services and regions. This variation, combined with the frequent diagnostic revision for DLB, suggests suboptimal recognition of core and suggestive features of the disease in some services, though the possibility of real differences in DLB prevalence cannot be entirely excluded.

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APA 7th

Kane, J. P. M., Surendranathan, A., Barker, S. H., Bentley, A., Allan, L. M., Taylor, J., et al. (2017). [P2–526]: GEOGRAPHICAL VARIATIONS IN DIAGNOSTIC RATES FOR DEMENTIA WITH LEWY BODIES IN CLINICAL SERVICES. Alzheimer s & Dementia. https://doi.org/10.1016/j.jalz.2017.06.1184

Vancouver

Kane JPM, Surendranathan A, Barker SH, Bentley A, Allan LM, Taylor J, et al. [P2–526]: GEOGRAPHICAL VARIATIONS IN DIAGNOSTIC RATES FOR DEMENTIA WITH LEWY BODIES IN CLINICAL SERVICES. Alzheimer s & Dementia. 2017. doi:10.1016/j.jalz.2017.06.1184.

BibTeX

@article{kane2017-f15b63ca,
  author  = {Kane, Joseph P. M. and Surendranathan, Ajenthan and Barker, Sally H. and Bentley, Alison and Allan, Louise M. and Taylor, John‐Paul and James, Peter W and Burn, David John and others},
  title   = {{[P2–526]: GEOGRAPHICAL VARIATIONS IN DIAGNOSTIC RATES FOR DEMENTIA WITH LEWY BODIES IN CLINICAL SERVICES}},
  journal = {Alzheimer s \& Dementia},
  year    = {2017},
  doi     = {10.1016/j.jalz.2017.06.1184},
  url     = {https://doi.org/10.1016/j.jalz.2017.06.1184}
}

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Key findings

Significant variation was observed between services, with DLB prevalence ranging from 1.8% to 5.9% (χ=24.3, p<0.01).
DLB was significantly more prevalent in men (χ=20.45, p<0.01) and was negatively correlated with age (χ=8.2, p<0.01).
Importantly, there was significant variation noted across services and regions.

Why it matters

This study found that the proportion of dementia cases diagnosed as dementia with Lewy bodies varied significantly between memory clinics and regions. It does not test any treatment, cure or prevention, and the authors note it is unclear whether this variation reflects true differences or differences in diagnosis.

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Study details

Effect size52.4%; 4.2%; 4.8%
Evidence strengthLow

How this study scored 34/100

Published in a peer-reviewed journal. Scored zero for study design, sample size, studied in people and randomised / blinded because the record does not state it.

Component	Points	Why
Journal tier	7 / 10	Tier 3 — peer-reviewed journal (Alzheimer s & Dementia)
Journal's citation record	2 / 4	Alzheimer s & Dementia: journal h-index 228 (OpenAlex, 2026-10-29)
Study design	0 / 12	No study design recorded — scores zero, not guessed (not stated in the record — scored 0)
Strength of evidence	1 / 5	Rated “low” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	2 / 5	2017 — within 10 year(s) of the newest study here
Sample size	0 / 4	Participant count not stated — scores zero (not stated in the record — scored 0)
Effect reported	2 / 3	Effect reported as a number, without an interval or test
Studied in people	0 / 3	Not stated whether this was studied in people — scores zero (not stated in the record — scored 0)
Randomised / blinded	0 / 2	No randomisation or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	0 / 7	Cited 0 times (OpenAlex, 2026-10-10)
Citations per year	0 / 5	0.0 citations a year over 11 year(s) since 2017
Impact for its field and year	0 / 6	Cited 0.0× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	0 / 6	No other study in this library cites it
Still being cited	0 / 4	Cited 0 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	4 / 4	Last-listed author John Tiernan O'Brien: h-index 140 (OpenAlex, whole career)
Institution's track record	2 / 3	University of Cambridge: institution h-index 1,973 (OpenAlex)
Multi-centre collaboration	1 / 3	OpenAlex lists 2 institution(s) in 1 country
Indexed in PubMed	1 / 2	Not in PubMed, but has a DOI
Free to read	2 / 2	Free to read
Total	34 / 100	—

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