Newest studies

Occurrence of neuropathological changes and dementia of Alzheimer's disease in Down's syndrome

56/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Annals of Neurology

Key finding: The brains of the patients with DS who also had clinical dementia had more than twenty plaques or plaques and tangles per 1.5 X 10(6) micron 2 of cortex. +4 more findings

• Down Syndrome
• Brain Biology

Full summary, score breakdown and related studies → Original source

A Perspective on Training for Academic Leadership in Geriatrics*

31/100 ✓ Peer-reviewed Health systems and care delivery Journal of the American Geriatrics Society

Key finding: Overall, these numbers amount to a goal of approximately 1,300 physician faculty members in clinical departments and 1,300 other faculty for all of our nation's medical schools. +4 more findings

Full summary, score breakdown and related studies → Original source

Aphasia in dementia of the Alzheimer type

51/100 ✓ Peer-reviewed Digital health tools Neurology

Key finding: Speech and language assessment in 30 patients with dementia of the Alzheimer type and in 70 normal controls revealed that all Alzheimer patients were aphasic.

Full summary, score breakdown and related studies → Original source

The Ways of Coping Checklist: Revision and Psychometric Properties

36/100 ✓ Peer-reviewed Risk factors Multivariate behavioral research

Key finding: This study examined the psychometric properties of the "original" seven factored scales derived by Aldwin et al. from Folkman and Lazarus' Ways of Coping Checklist (WCCL) versus a revised set of scales. +1 more finding

Full summary, score breakdown and related studies → Original source

Elevated concentrations of CSF corticotropin-releasing factor-like immunoreactivity in depressed patients

41/100 ✓ Peer-reviewed Tau biomarkers Science (New York, N.Y.)

Key finding: When compared to the controls and the other diagnostic groups, the patients with major depression showed significantly increased cerebrospinal fluid concentrations of CRF-like immunoreactivity; in 11 of the 23 depressed patients this immunoreactivity was greater than the highest value in the normal controls. +1 more finding

• Biomarkers

Full summary, score breakdown and related studies → Original source

Senile dementia: public policy and adequate institutional care

38/100 ✓ Peer-reviewed Health systems and care delivery American Journal of Public Health

Key finding: Because such patients require heavy care and are the ones most likely to be Medicaid-dependent, nursing homes are being provided with incentives to prevent admissions. +4 more findings

• Care Services
• Policy

Full summary, score breakdown and related studies → Original source

A new rating scale for Alzheimer's disease

54/100 ✓ Peer-reviewed Cognitive tests and assessment American Journal of Psychiatry

Key finding: Twenty-one items with significant intraclass correlation coefficients for interrater reliability (range, .650-.989) and significant Spearman rank-order correlation coefficients for test-retest reliability (range, .514-1) constitute the final scale. +1 more finding

Full summary, score breakdown and related studies → Original source

Alzheimer's Disease: Cell-Specific Pathology Isolates the Hippocampal Formation

54/100 ✓ Peer-reviewed Brain tissue and pathology Science

Examination of temporal lobe structures from Alzheimer patients reveals a specific cellular pattern of pathology of the subiculum of the hippocampal formation and layers II and IV of the entorhinal cortex.

Full summary, score breakdown and related studies → Original source

Intrusions and perseverations

36/100 ✓ Peer-reviewed Digital health tools Brain and language

Key finding: Thus, we have confirmed prior suggestions that perseveration can occur in the absence of frontal lobe injury. +2 more findings

Full summary, score breakdown and related studies → Original source

Psychiatric illness in residential homes for the elderly: a survey in one London borough

39/100 ✓ Peer-reviewed Disparities Age and ageing

Key finding: Depression was associated with the presence of visual handicap and incontinence, and was commoner when the resident had been admitted from his own home or belonged to a minority religion. +2 more findings

Full summary, score breakdown and related studies → Original source

Subcortical dementia. Review of an emerging concept

36/100 ✓ Peer-reviewed Clinical safety Archives of neurology

Key finding: Subcortical dementia is a clinical syndrome characterized by slowness of mental processing, forgetfulness, impaired cognition, apathy, and depression. +4 more findings

Full summary, score breakdown and related studies → Original source

Alzheimer's disease and Down's syndrome: Sharing of a unique cerebrovascular amyloid fibril protein

47/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Biochemical and Biophysical Research Communications

• Down Syndrome

Full summary, score breakdown and related studies → Original source

Cerebral blood flow changes in benign aging and cerebrovascular disease

59/100 ✓ Peer-reviewed Vascular contributions Neurology

Key finding: Cross-sectional analysis of CBF values was carried out among 668 volunteers and patients. +4 more findings

Full summary, score breakdown and related studies → Original source

Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease

58/100 ✓ Peer-reviewed Getting a diagnosis Neurology

Key finding: There are no motor, sensory, or coordination deficits early in the disease. +4 more findings

• Diagnosis

Full summary, score breakdown and related studies → Original source

Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein

54/100 ✓ Peer-reviewed Disease mechanisms Biochemical and Biophysical Research Communications

Key finding: A purified protein derived from the twisted beta-pleated sheet fibrils in cerebrovascular amyloidosis associated with Alzheimer's disease has been isolated by Sephadex G-100 column chromatography with 5 M guanidine-HC1 in 1 N acetic acid and by high performance liquid chromatography. +2 more findings

Full summary, score breakdown and related studies → Original source

Alzheimer's disease: a study of epidemiological aspects

64/100 ✓ Peer-reviewed Prevention and risk Annals of neurology

Key finding: No significant differences were found between patients and control subjects in toxic environmental exposures, animal contacts, smoking, drinking, or unusual dietary habits. +3 more findings

Full summary, score breakdown and related studies → Original source

Clinical application of the P3 component of event-related potentials. II. Dementia, depression and schizophrenia

45/100 ✓ Peer-reviewed Getting a diagnosis Electroencephalography and clinical neurophysiology

Key finding: The patient groups were compared to age normative predictions derived from a large control sample for a number of ERP and behavioral variables. +4 more findings

Full summary, score breakdown and related studies → Original source

Neurochemical characteristics of early and late onset types of Alzheimer's disease

52/100 ✓ Peer-reviewed Brain tissue and pathology British medical journal (Clinical research ed.)

Key finding: The Alzheimer group exhibited noticeably reduced activity of the cholinergic marker enzyme choline acetyltransferase in the cerebral cortex, but cortical concentrations of noradrenaline, gamma-aminobutyric acid, and somatostatin were also significantly reduced. +3 more findings

Full summary, score breakdown and related studies → Original source

Familial Alzheimer Dementia: a prevalent disorder with specific clinical features

42/100 ✓ Peer-reviewed Health systems and care delivery Psychological Medicine

Key finding: Since pedigree studies had suggested that FAD is an autosomal dominant genetic disorder, we hypothesized that the first-degree relatives of language-disordered or apractic AD probands would show at least 50% lifetime risks of dementia. +1 more finding

• Genetics

Full summary, score breakdown and related studies → Original source

Neuropeptides in Alzheimer type dementia

36/100 ✓ Peer-reviewed Disease mechanisms Journal of the neurological sciences

Key finding: The distribution and magnitude of the reduction in SRIF were less than that of CAT activity and the temporal cortex was the only region in which there was a significant relationship between CAT and SRIF deficits. +1 more finding

Full summary, score breakdown and related studies → Original source

Gait and balance in senile dementia of Alzheimer's type

36/100 ✓ Peer-reviewed Clinical safety Age and ageing

Key finding: Valid results were obtained in nine pairs. +1 more finding

Full summary, score breakdown and related studies → Original source

Transient cognitive disorders (delirium, acute confusional states) in the elderly

44/100 ✓ Peer-reviewed Getting a diagnosis The American journal of psychiatry

Key finding: Delirium is a common feature of physical illness or drug intoxication in elderly patients and requires prompt medical attention. +4 more findings

Full summary, score breakdown and related studies → Original source

Senile dementia of the Alzheimer type

48/100 ✓ Peer-reviewed Getting a diagnosis Annals of neurology

Key finding: Down's syndrome in adults is often associated with Alzheimer changes. +1 more finding

• Brain Biology

Full summary, score breakdown and related studies → Original source

Regional cerebral metabolic alterations in dementia of the Alzheimer type: positron emission tomography with [18F]fluorodeoxyglucose

46/100 ✓ Peer-reviewed Getting a diagnosis Journal of computer assisted tomography

Key finding: This diminished uptake was due to lowered rates of FDG use and suggests that the metabolic effects of Alzheimer disease are most concentrated in the temporoparietal cortex.

• Brain Scans

Full summary, score breakdown and related studies → Original source

The Hospital Anxiety and Depression Scale

49/100 ✓ Peer-reviewed Cognitive tests and assessment Acta Psychiatrica Scandinavica

A self-assessment scale has been developed and found to be a reliable instrument for detecting states of depression and anxiety in the setting of an hospital medical outpatient clinic.

• Care Services

Full summary, score breakdown and related studies → Original source