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63/100

✓ Peer-reviewed alzhub usefulness score 63 out of 100. Disparities

Topic: Risk, prevention and care in population studies

Objective To determine whether birth in 9 high stroke mortality states (HSMSs) is associated with dementia in a diverse cohort of individuals living in Northern California. Results Of the 7423 persons included in the analysis, 4049 (54.5%) were women; 1354 (18.2%) were black. Overall, birth in an HSMS was associated with a 28% higher risk of dementia (adjusted hazard ratio [aHR], 1.28; 95% CI, 1.13-1.46) adjusted for age, sex, and race. Compared with nonblack persons born outside of an HSMS, black individuals born in an HSMS had the highest dementia risk (aHR, 1.67; 95% CI, 1.48-1.88), followed by black individuals not born in an HSMS (aHR, 1.48; 95% CI, 1.28-1.72), and nonblack persons born in an HSMS had a 46% increased risk (aHR, 1.46; 95% CI, 1.23-1.74). Conclusions and relevance To our knowledge, this is the first study to date of place of birth and incident dementia and shows increased risk for individuals born in an HSMS, even though all participants subsequently resided in California.

Cite this study APA, Vancouver, BibTeX · download .bib or .ris

APA 7th

Gilsanz, P., Mayeda, E. R., Glymour, M. M., Quesenberry, C. P., & Whitmer, R. A. (2017). Association Between Birth in a High Stroke Mortality State, Race, and Risk of Dementia. JAMA neurology. https://doi.org/10.1001/jamaneurol.2017.1553

Vancouver

Gilsanz P, Mayeda ER, Glymour MM, Quesenberry CP, Whitmer RA. Association Between Birth in a High Stroke Mortality State, Race, and Risk of Dementia. JAMA neurology. 2017. doi:10.1001/jamaneurol.2017.1553. PMID: 28759663.

BibTeX

@article{gilsanz2017-28759663,
  author  = {Gilsanz, P. and Mayeda, E. R. and Glymour, M. M. and Quesenberry, C. P. and Whitmer, R. A.},
  title   = {{Association Between Birth in a High Stroke Mortality State, Race, and Risk of Dementia}},
  journal = {JAMA neurology},
  year    = {2017},
  doi     = {10.1001/jamaneurol.2017.1553},
  pmid    = {28759663},
  url     = {https://doi.org/10.1001/jamaneurol.2017.1553}
}

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Key findings

Objective To determine whether birth in 9 high stroke mortality states (HSMSs) is associated with dementia in a diverse cohort of individuals living in Northern California.
Results Of the 7423 persons included in the analysis, 4049 (54.5%) were women; 1354 (18.2%) were black.
Overall, birth in an HSMS was associated with a 28% higher risk of dementia (adjusted hazard ratio [aHR], 1.28; 95% CI, 1.13-1.46) adjusted for age, sex, and race.
Compared with nonblack persons born outside of an HSMS, black individuals born in an HSMS had the highest dementia risk (aHR, 1.67; 95% CI, 1.48-1.88), followed by black individuals not born in an HSMS (aHR, 1.48; 95% CI, 1.28-1.72), and nonblack persons born in an HSMS had a 46% increased risk (aHR, 1.46; 95% CI, 1.23-1.74).
Conclusions and relevance To our knowledge, this is the first study to date of place of birth and incident dementia and shows increased risk for individuals born in an HSMS, even though all participants subsequently resided in California.

Why it matters

In 7,423 adults who all later lived in Northern California, those born in one of 9 US states with high stroke death rates had a 28% higher risk of developing dementia (adjusted hazard ratio 1.28), even after accounting for age, sex and race. Compared with nonblack people born elsewhere, Black people born in those states had the highest risk (aHR 1.67); the authors describe it as the first study of place of birth and incident dementia. It shows an association only — it does not explain why, and it tests no treatment or prevention.

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Study details

Study designcohort study
Participants7,423
Effect size54.5%; 18.2%; 30.4%
Evidence strengthModerate

How this study scored 63/100

Published in a leading specialty journal, and it is a cohort study following people over time. Scored zero for randomised / blinded because the record does not state it.

Component	Points	Why
Journal tier	9 / 10	Tier 2 — leading specialty journal (JAMA neurology)
Journal's citation record	2 / 4	JAMA Neurology: journal h-index 235 (OpenAlex, 2026-10-29)
Study design	7 / 12	A cohort study following people over time
Strength of evidence	3 / 5	Rated “moderate” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	2 / 5	2017 — within 10 year(s) of the newest study here
Sample size	3 / 4	7,423 participants
Effect reported	2 / 3	Effect reported as a number, without an interval or test
Studied in people	3 / 3	Studied in people (participant count stated)
Randomised / blinded	0 / 2	No randomisation or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	4 / 7	Cited 84 times (OpenAlex, 2026-10-10)
Citations per year	2 / 5	7.6 citations a year over 11 year(s) since 2017
Impact for its field and year	3 / 6	Cited 4.8× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	2 / 6	Cited by 7 other studies in this library
Still being cited	2 / 4	Cited 26 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	3 / 4	Last-listed author Rachel A. Whitmer: h-index 63 (OpenAlex, whole career)
Institution's track record	2 / 3	University of California, Los Angeles: institution h-index 1,923 (OpenAlex)
Multi-centre collaboration	2 / 3	OpenAlex lists 4 institution(s) in 1 country
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 28759663)
Free to read	0 / 2	Behind a paywall — scores zero
Total	63 / 100	—

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