Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 26,551–26,575 of 27,380 studies, newest first · page 1063 of 1096.
March 1995 12
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1995-03-01
Depression and memory impairment: a meta-analysis of the association, its pattern, and specificity
57/100 ✓ Peer-reviewed Risk factors Psychological bulletin
Key finding: The purpose of this investigation was to determine whether depression is associated with memory impairment, whether moderator variables determine the extent of this association, and whether any obtained association is unique to depression. +1 more finding
Full summary, score breakdown and related studies → Original source
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1995-03-01
Amyloid beta protein (A beta) in Alzheimer's disease brain. Biochemical and immunocytochemical analysis with antibodies specific for forms ending at A beta 40 or A beta 42(43)
36/100 ✓ Peer-reviewed Tau biomarkers The Journal of biological chemistry
Key finding: Immunocytochemical analysis with monoclonal antibodies selective for A beta s ending at A beta 42(43) or A beta 40 confirmed that, in brains with minimal congophilic angiopathy, virtually all A beta is A beta ending at A beta 42(43) and showed that this A beta is deposited in senile plaques of all types. +1 more finding
Full summary, score breakdown and related studies → Original source
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1995-03-01
The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part X. Neuropathology confirmation of the clinical diagnosis of Alzheimer's disease
49/100 ✓ Peer-reviewed Brain tissue and pathology Neurology
Key finding: In 92 (87%) of the 106 cases, neuropathologists confirmed Alzheimer's disease (AD) as the primary dementing illness. +3 more findings
Full summary, score breakdown and related studies → Original source
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1995-03-01
Long-term estrogen replacement therapy in female patients with dementia of the Alzheimer type: 7 case reports
42/100 ✓ Peer-reviewed Cognitive tests and assessment Dementia (Basel, Switzerland)
Key finding: Five of the 7 patients were cases who had responded well to short-term ERT with 1.25 mg/day of conjugated equine estrogens (CEE) for 6 weeks. +3 more findings
Full summary, score breakdown and related studies → Original source
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1995-03-01
HIV Dementia Scale: a rapid screening test
43/100 ✓ Peer-reviewed Cognitive tests and assessment Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association
Key finding: Accurate and early diagnosis of HIV dementia can lead to optimized therapeutic and management decisions. +3 more findings
Full summary, score breakdown and related studies → Original source
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1995-03-01
Dephosphorylation of Alzheimer paired helical filaments by protein phosphatase-2A and -2B
45/100 ✓ Peer-reviewed Tau biomarkers The Journal of biological chemistry
Key finding: In this study the dephosphorylation of sparingly soluble PHF, PHF II-tau by brain protein phosphatase (PP)-2A1 and PP-2B, and the resulting biochemical, biological, and structural alterations were investigated. +3 more findings
Full summary, score breakdown and related studies → Original source
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1995-03-01
Muscarinic regulation of Alzheimer's disease amyloid precursor protein secretion and amyloid beta-protein production in human neuronal NT2N cells
45/100 ✓ Peer-reviewed Risk genes beyond APOE The Journal of biological chemistry
Key finding: Recent studies have shown that cells can secrete carboxyl terminus truncated APP derivatives (APP-S) in response to physiological stimulus. +3 more findings
Full summary, score breakdown and related studies → Original source
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1995-03-01
Inflammatory processes induce beta-amyloid precursor protein changes in mouse brain
45/100 ✓ Peer-reviewed Risk genes beyond APOE Proceedings of the National Academy of Sciences of the United States of America
Key finding: Factors such as head injury or acute infection that trigger inflammatory processes may play a crucial role in development of the disease. +3 more findings
Full summary, score breakdown and related studies → Original source
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1995-03-01
Progressive multifocal leukoencephalopathy: the evolution of a disease once considered rare
36/100 ✓ Peer-reviewed Caregiving Journal of neurovirology
Key finding: The clinical features of the disorder in patients with acquired immunodeficiency syndrome do not appear to be significantly different from progressive multifocal leukoencephalopathy occurring in association with other immunosuppressive disorders. +2 more findings
Full summary, score breakdown and related studies → Original source
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1995-03-01
Documentation and evaluation of cognitive impairment in elderly primary care patients
67/100 ✓ Peer-reviewed Getting a diagnosis Annals of internal medicine
Key finding: Cognitive impairment is associated with increased use of health services and increased mortality. +3 more findings
Full summary, score breakdown and related studies → Original source
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1995-03-01
A severe loss of choline acetyltransferase in the frontal cortex of Alzheimer patients carrying apolipoprotein epsilon 4 allele
42/100 ✓ Peer-reviewed Genetics Neuroscience letters
Key finding: The ChAT values were significantly lower for the AD patients with 2 epsilon 4 alleles than for those with 0 epsilon 4 (ANOVA, P < 0.05). +3 more findings
Full summary, score breakdown and related studies → Original source
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1995-03-01
Apolipoprotein E type 4 allele and cerebral glucose metabolism in relatives at risk for familial Alzheimer disease
65/100 ✓ Peer-reviewed Genetics JAMA
Key finding: These results suggest that the inheritance of APOE epsilon 4 is associated with reduced cerebral parietal metabolism and increased asymmetry in non-demented relatives at risk for probable AD. +3 more findings
Full summary, score breakdown and related studies → Original source
February 1995 6
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1995-02-01
The precursor protein of non-A beta component of Alzheimer's disease amyloid is a presynaptic protein of the central nervous system
36/100 ✓ Peer-reviewed Disease mechanisms Neuron
Key finding: Confocal laser microscopy analysis revealed that anti-NACP immunostaining was colocalized with synaptophysin-immunoreactive presynaptic terminals. +2 more findings
Full summary, score breakdown and related studies → Original source
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1995-02-01
Anterior hippocampal volume deficits in nonamnesic, aging chronic alcoholics
43/100 ✓ Peer-reviewed Hippocampus size on brain scans Alcoholism, clinical and experimental research
Key finding: The results of this cross-sectional study showed that the anterior, but not the posterior, portions of the hippocampus in both hemispheres were significantly smaller in the alcoholic than the healthy control group. +3 more findings
Full summary, score breakdown and related studies → Original source
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1995-02-01
Alzheimer-type neuropathology in transgenic mice overexpressing V717F beta-amyloid precursor protein
59/100 ✓ Peer-reviewed Risk genes beyond APOE Nature
Key finding: AD brains contain numerous amyloid plaques surrounded by dystrophic neurites, and show profound synaptic loss, neurofibrillary tangle formation and gliosis. +3 more findings
Full summary, score breakdown and related studies → Original source
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1995-02-01
[Alzheimer-type dementia and Down syndrome]
26/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Ugeskrift for laeger
Key finding: Dementia is seen earlier and more often in patients with Down syndrome (DS) than in the general population. +4 more findings
Full summary, score breakdown and related studies → Original source
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1995-02-01
Neurochemical correlates of dementia severity in Alzheimer's disease: relative importance of the cholinergic deficits
51/100 ✓ Peer-reviewed How common it is Journal of neurochemistry
Key finding: Levels of choline acetyltransferase, acetylcholinesterase, somatostatin, corticotropin-releasing factor, serotonin, and 5-hydroxyindoleacetic acid were significantly reduced in AD versus controls. +2 more findings
Full summary, score breakdown and related studies → Original source
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1995-02-01
Prevalence and subtypes of dementia in Taiwan: a community survey of 5297 individuals
49/100 ✓ Peer-reviewed Disparities Journal of the American Geriatrics Society
Key finding: The prevalence rate of dementia was low in this Chinese population. +2 more findings
Full summary, score breakdown and related studies → Original source
January 1995 7
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1995-01-01
Autosomal dominant cerebellar phenotypes
40/100 ✓ Peer-reviewed Brain scans and imaging Neurology
Key finding: For these reasons, I suggested in 1990 [1] that for the autosomal dominant phenotypes, the genotype would be required to settle the issue of disease assignment and classification. +4 more findings
Full summary, score breakdown and related studies → Original source
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1995-01-01
Hypomethylation of the amyloid precursor protein gene in the brain of an Alzheimer's disease patient
36/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Journal of molecular neuroscience : MN
Key finding: Southern-blot analysis revealed the absence of methylation at a site in the APP gene of an Alzheimer's disease subject. +1 more finding
Full summary, score breakdown and related studies → Original source
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1995-01-01
Corticotropin-releasing factor receptors: physiology, pharmacology, biochemistry and role in central nervous system and immune disorders
36/100 ✓ Peer-reviewed Disease mechanisms Psychoneuroendocrinology
Key finding: In addition to a physiological role for CRF in integrating the responses of the brain, endocrine and immune systems to physiological, psychological and immunological stimuli, recent clinical data implicate CRF in the etiology and pathophysiology of various endocrine, psychiatric, neurologic and inflammatory illnesses. +4 more findings
Full summary, score breakdown and related studies → Original source
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1995-01-01
Immunoreactivity against tau, amyloid precursor protein, and beta-amyloid in the human retina
43/100 ✓ Peer-reviewed Drug development Investigative ophthalmology & visual science
Key finding: The proteins investigated in this study are present in the human retina.
Full summary, score breakdown and related studies → Original source
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1995-01-01
Oxidative stress: the paradox of aerobic life
36/100 ✓ Peer-reviewed Brain scans and imaging Biochemical Society symposium
Key finding: Alternatively, compounds found in certain foods may be able to significantly bolster biological resistance against oxidants.
Full summary, score breakdown and related studies → Original source
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1995-01-01
Alzheimer disease, attention, and the cholinergic system
36/100 ✓ Peer-reviewed Cognitive tests and assessment Alzheimer disease and associated disorders
Key finding: Recent neuropsychological studies suggest that, in addition to prominent mnemonic dysfunction, attentional impairments are a core feature of Alzheimer disease (AD). +2 more findings
Full summary, score breakdown and related studies → Original source
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1995-01-01
Access to hospice programs in end-stage dementia: a national survey of hospice programs
36/100 ✓ Peer-reviewed End-of-life care Journal of the American Geriatrics Society
Key finding: A national survey of hospices revealed that few patients with primary dementia are currently treated by these programs, unless they have other terminal illnesses. +4 more findings
Full summary, score breakdown and related studies → Original source
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