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[Late life depression - Diagnosis, pathophysiology and therapeutic strategies]
Forugh S Dafsari, Frank Jessen. Fortschritte der Neurologie-Psychiatrie, 2018-04-24
Topic: Drug trials: efficacy and safety
Late-life depression is a frequent and severe mental disorder. It is characterized by alterations in mood as well as cognitive deficits and somatic symptoms. LLD is associated with various adverse outcomes, such as reduced quality of life, negative impact on physical comorbidities, functional impairments, increased suicide and non-suicide mortality. Moreover, LLD serves as a risk factor for developing all-cause dementia, including Alzheimer´s disease. It leads to a frequent use of health care services and remains a serious public health concern. Unfortunately, LLD is often misinterpreted as a physiological aging process and thus remains underdiagnosed and undertreated for years. With a view towards the demographic change LLD is one of the major diagnostic and therapeutic challenges of the aging society. Nevertheless, psychotherapy, pharmacological interventions as well as ECT are effective treatment options. The goal of any treatment for LLD is to ensure full remission, functional recovery and social reintegration.
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APA 7th
Dafsari, F. S., & Jessen, F. (2018). [Late life depression - Diagnosis, pathophysiology and therapeutic strategies]. Fortschritte der Neurologie-Psychiatrie. https://doi.org/10.1055/s-0043-119799
Vancouver
Dafsari FS, Jessen F. [Late life depression - Diagnosis, pathophysiology and therapeutic strategies]. Fortschritte der Neurologie-Psychiatrie. 2018. doi:10.1055/s-0043-119799. PMID: 29689582.
BibTeX
@article{dafsari2018-29689582,
author = {Dafsari, Forugh S and Jessen, Frank},
title = {{[Late life depression - Diagnosis, pathophysiology and therapeutic strategies]}},
journal = {Fortschritte der Neurologie-Psychiatrie},
year = {2018},
doi = {10.1055/s-0043-119799},
pmid = {29689582},
url = {https://doi.org/10.1055/s-0043-119799}
}
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Key findings
- LLD is associated with various adverse outcomes, such as reduced quality of life, negative impact on physical comorbidities, functional impairments, increased suicide and non-suicide mortality.
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Study details
- Evidence strengthLow
How this study scored 39/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record, multi-centre collaboration and free to read, so those were left out: it earned 22 of the 56 points we could judge it on, which is 39 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Fortschritte der Neurologie-Psychiatrie) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 2 / 5 | 2018 — within 10 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 29689582) |
| Free to read | — / 2 | Access not recorded — left out of this score |
| Points | 22 / 56 | Scored on 10 of 20 parts. We have no data for the rest, so they are left out: 22 of the 56 points we could judge it on is 39 out of 100. |
| Total | 39 / 100 | — |
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