Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 26,476–26,500 of 27,380 studies, newest first · page 1060 of 1096.
October 1995 11
-
1995-10-01
Reduction of beta-amyloid peptide42 in the cerebrospinal fluid of patients with Alzheimer's disease
40/100 ✓ Peer-reviewed Tau biomarkers Annals of neurology
Key finding: It is interesting that CSF A beta 42 levels were found to be significantly lower in AD patients relative to controls, whereas total A beta levels were not. +1 more finding
Full summary, score breakdown and related studies → Original source
-
1995-10-01
Spatial learning with a minislab in the dorsal hippocampus
36/100 ✓ Peer-reviewed Hippocampus size on brain scans Proceedings of the National Academy of Sciences of the United States of America
Key finding: We have determined the volume and location of hippocampal tissue required for normal acquisition of a spatial memory task. +4 more findings
Full summary, score breakdown and related studies → Original source
-
1995-10-01
AIDS dementia complex and HIV-1 brain infection: clinical-virological correlations
45/100 ✓ Peer-reviewed Inflammation and the immune system Annals of neurology
Key finding: In a subset of 40 of these patients who had undergone antemortem neurological evaluation of the AIDS dementia complex (ADC), we analyzed the relation between the severities of the viral infection and clinical dysfunction. +3 more findings
Full summary, score breakdown and related studies → Original source
-
1995-10-01
Regulated formation of Golgi secretory vesicles containing Alzheimer beta-amyloid precursor protein
45/100 ✓ Peer-reviewed Risk genes beyond APOE The Journal of biological chemistry
Key finding: The molecular and cellular bases of PKC-regulated beta-APP cleavage are poorly understood. +2 more findings
Full summary, score breakdown and related studies → Original source
-
1995-10-01
Glutamate as a hippocampal neuron survival factor: an inherited defect in the trisomy 16 mouse
38/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Proceedings of the National Academy of Sciences of the United States of America
Key finding: Blockade of kainate/AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid) glutamate receptors increased the rate of neuron death, suggesting that endogenous glutamate in the cultures promotes survival. +2 more findings
Full summary, score breakdown and related studies → Original source
-
1995-10-01
A mouse model for Down syndrome exhibits learning and behaviour deficits
54/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Nature genetics
Key finding: The reproducibility of this phenotype among Ts65Dn mice indicates that dosage imbalance for a gene or genes in this region contributes to this impairment.
Full summary, score breakdown and related studies → Original source
-
1995-10-01
Epidemiology of do-not-resuscitate orders. Disparity by age, diagnosis, gender, race, and functional impairment
44/100 ✓ Peer-reviewed Disparities Archives of internal medicine
Key finding: Sickness at admission and functional impairment do not explain the increase in DNR orders with age or the disparity across diagnosis.
Full summary, score breakdown and related studies → Original source
-
1995-10-01
Clinical spectrum of CADASIL: a study of 7 families. Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy
57/100 ✓ Peer-reviewed Getting a diagnosis Lancet (London, England)
Key finding: Genetic analysis showed strong linkage to the CADASIL locus for all seven families, suggesting genetic homogeneity. +4 more findings
Full summary, score breakdown and related studies → Original source
-
1995-10-01
Association of apolipoprotein E genotype with brain levels of apolipoprotein E and apolipoprotein J (clusterin) in Alzheimer disease
43/100 ✓ Peer-reviewed Genetics Brain research. Molecular brain research
Key finding: This study examines the relationship between the levels of apolipoprotein E (apoE) and apolipoprotein J (apoJ, also designated as clusterin) as a function of apoE genotype in the hippocampus and cortex of Alzheimer disease (AD) subjects. +1 more finding
Full summary, score breakdown and related studies → Original source
-
1995-10-01
Low density lipoprotein receptor-related protein mediates apolipoprotein E-dependent neurite outgrowth in a central nervous system-derived neuronal cell line
47/100 ✓ Peer-reviewed Genetics Proceedings of the National Academy of Sciences of the United States of America
Key finding: The epsilon 4 allele of apolipoprotein E (apoE) is a major risk factor for Alzheimer disease, suggesting that apoE may directly influence neurons in the aging brain. +1 more finding
Full summary, score breakdown and related studies → Original source
-
1995-10-01
Fas antigen expression in brains of patients with Alzheimer-type dementia
40/100 ✓ Peer-reviewed Biomarkers Brain research
Key finding: Doubly labeled astrocytes were also found around senile plaques, suggesting that the Fas immunoreactivity in senile plaques was derived from astrocytic membranes. +1 more finding
Full summary, score breakdown and related studies → Original source
September 1995 11
-
1995-09 month only
Tau protein concentrations in cerebrospinal fluid of patients with dementia of the Alzheimer type
45/100 ✓ Peer-reviewed Tau biomarkers Journal of neurology, neurosurgery, and psychiatry
Key finding: Tau protein concentrations were significantly higher in patients with DAT than in controls (P < 0.001) and patients with MID (P < 0.001). +1 more finding
Full summary, score breakdown and related studies → Original source
-
1995-09-01
The Behavior Rating Scale for Dementia of the Consortium to Establish a Registry for Alzheimer's Disease. The Behavioral Pathology Committee of the Consortium to Establish a Registry for Alzheimer's Disease
46/100 ✓ Peer-reviewed Clinical safety The American journal of psychiatry
Key finding: The Behavior Rating Scale for Dementia provides a standardized, reliable measure that can be administered to caregivers of demented subjects.
Full summary, score breakdown and related studies → Original source
-
1995-09-01
Aging, energy, and oxidative stress in neurodegenerative diseases
40/100 ✓ Peer-reviewed Disease mechanisms Annals of neurology
Key finding: Mitochondrial DNA is particularly susceptible to oxidative stress, and there is evidence of age-dependent damage and deterioration of respiratory enzyme activities with normal aging. +4 more findings
Full summary, score breakdown and related studies → Original source
-
1995-09-01
Facilitation of lin-12-mediated signalling by sel-12, a Caenorhabditis elegans S182 Alzheimer's disease gene
41/100 ✓ Peer-reviewed Drug development Nature
Key finding: The high degree of sequence conservation suggests that the function of the SEL-12 and S182 proteins may also be conserved.
Full summary, score breakdown and related studies → Original source
-
1995-09-01
Glycogen synthase kinase-3 beta phosphorylates tau protein at multiple sites in intact cells
36/100 ✓ Peer-reviewed Drug development Neuroscience letters
Key finding: Hyperphosphorylation of tau is believed to be the critical event that leads to filament assembly. +4 more findings
Full summary, score breakdown and related studies → Original source
-
1995-09-01
Anterior hippocampal volume reductions predict frontal lobe dysfunction in first episode schizophrenia
36/100 ✓ Peer-reviewed Hippocampus size on brain scans Schizophrenia research
Key finding: Decreased volume selectively in the anterior hippocampal formation was associated with lower scores on measures of executive and motor functions usually considered sensitive to the integrity of frontal lobe systems. +1 more finding
Full summary, score breakdown and related studies → Original source
-
1995-09-01
Abundant expression of HIV Nef and Rev proteins in brain astrocytes in vivo is associated with dementia
42/100 ✓ Peer-reviewed Inflammation and the immune system AIDS (London, England)
Key finding: Formalin-fixed postmortem brain tissue from 14 HIV-infected adult patients, with previous repeated neurological and neuroradiological examinations, was studied by immunohistochemical and molecular biological methods. +3 more findings
Full summary, score breakdown and related studies → Original source
-
1995-09-01
The inflammatory response system of brain: implications for therapy of Alzheimer and other neurodegenerative diseases
51/100 ✓ Peer-reviewed Inflammation and the immune system Brain research. Brain research reviews
Key finding: They constitute the endogenous immune response system of brain. +3 more findings
Full summary, score breakdown and related studies → Original source
-
1995-09-01
Genetic dissection of Alzheimer disease, a heterogeneous disorder
42/100 ✓ Peer-reviewed Risk genes beyond APOE Proceedings of the National Academy of Sciences of the United States of America
Key finding: Mutations in the amyloid precursor protein gene (APP) can cause early-onset autosomal dominant AD. +3 more findings
Full summary, score breakdown and related studies → Original source
-
1995-09-01
Familial non-specific dementia maps to chromosome 3
40/100 ✓ Peer-reviewed Disparities Human molecular genetics
Key finding: A significant minority of degenerative dementias lack distinctive inclusion bodies, plagues or tangles on pathological examination.
Full summary, score breakdown and related studies → Original source
-
1995-09-01
Pallidal lesions in patients with liver cirrhosis: clinical and MRI evaluation
39/100 ✓ Peer-reviewed Brain scans and imaging Metabolic brain disease
Key finding: The vast majority of the patients with liver cirrhosis (92%) present with bilateral symmetric pallidal hyperintensities in the T1-weighted MR spin echo sequence, while the T2-weighted images are normal. +4 more findings
Full summary, score breakdown and related studies → Original source
August 1995 3
-
1995-08-18
A Familial Alzheimer's Disease Locus on Chromosome 1
41/100 ✓ Peer-reviewed Risk genes beyond APOE Science
Key finding: Significant evidence for linkage to AD in these families was obtained with D1S479 and there was also positive evidence for linkage with other markers in the region.
Full summary, score breakdown and related studies → Original source
-
1995-08-18
Candidate Gene for the Chromosome 1 Familial Alzheimer's Disease Locus
60/100 ✓ Peer-reviewed Risk genes beyond APOE Science
A candidate gene for the chromosome 1 Alzheimer's disease (AD) locus was identified (STM2).
Full summary, score breakdown and related studies → Original source
-
1995-08-01
The Predictive Value of Cerebrospinal Fluid Dynamic Tests in Patients With the Idiopathic Adult Hydrocephalus Syndrome
43/100 ✓ Peer-reviewed Digital health tools Archives of Neurology
Key finding: Gait was improved in 25 (72%) of the 35 patients, whereas the Bartel index remained unchanged. +4 more findings
Full summary, score breakdown and related studies → Original source
Browse the library by subject, with the full score breakdown →