Newest studies

Current Role for Biomarkers in Clinical Diagnosis of Alzheimer Disease and Frontotemporal Dementia

34/100 ✓ Peer-reviewed Biomarkers Current treatment options in neurology

Key finding: Alzheimer's disease (AD) and frontotemporal dementia can often be diagnosed accurately with careful clinical history, cognitive testing, neurological examination, and structural brain MRI.

• Biomarkers
• Diagnosis
• Brain Scans

Full summary, score breakdown and related studies → Original source

Prognostic value of amyloid PET scan in normal pressure hydrocephalus

52/100 ✓ Peer-reviewed Brain scans and imaging Journal of neurology

Key finding: FBB PET scans and the tap test were performed in 31 patients with clinically suspected iNPH, and amyloid positive (iNPH/FBB+) and negative (iNPH/FBB-) groups were compared with respect to clinical characteristics. +3 more findings

• Brain Scans

Full summary, score breakdown and related studies → Original source

Computerized cognitive training for older diabetic adults at risk of dementia: Study protocol for a randomized controlled trial

52/100 ✓ Peer-reviewed Cognitive tests and assessment Alzheimer's & dementia (New York, N. Y.)

Key finding: This pilot study is the first trial evaluating the potential benefits of home-based tailored and adaptive CCT in relation to cognitive and disease self-management in older diabetic adults. +3 more findings

• Clinical Trials
• Risk Factors

Full summary, score breakdown and related studies → Original source

Pathways of cellular proteostasis in aging and disease

41/100 ✓ Peer-reviewed Disease mechanisms The Journal of cell biology

Key finding: Here we discuss the major proteostasis pathways in light of recent research suggesting that their age-dependent failure can both contribute to and result from disease.

Full summary, score breakdown and related studies → Original source

Optimizing the preclinical Alzheimer's cognitive composite with semantic processing: The PACC5

71/100 ✓ Peer-reviewed Brain scans and imaging Alzheimer's & dementia (New York, N. Y.)

Key finding: Addition of CAT to the PACC provides unique information about early cognitive decline not currently captured by the episodic memory, executive function, and global cognition components and may therefore improve detection of early Aβ-related cognitive decline.

• Brain Scans
• Early Stage

Full summary, score breakdown and related studies → Original source

General Practice Clinical Data Help Identify Dementia Hotspots: A Novel Geospatial Analysis Approach

45/100 ✓ Peer-reviewed Risk factors Journal of Alzheimer s Disease

Key finding: To shed light on these important questions, this study aimed to compute a dementia risk score for individuals to assess spatial variation of dementia risk, identify significant clusters (hotspots), and explore their association with socioeconomic status. +4 more findings

• Risk Factors

Full summary, score breakdown and related studies → Original source

YKL-40 in the brain and cerebrospinal fluid of neurodegenerative dementias

61/100 ✓ Peer-reviewed Inflammation and the immune system Molecular neurodegeneration

Key finding: YKL-40 (also known as Chitinase 3-like 1) is a glycoprotein produced by inflammatory, cancer and stem cells. +3 more findings

• Biomarkers

Full summary, score breakdown and related studies → Original source

Near infrared light decreases synaptic vulnerability to amyloid beta oligomers

39/100 ✓ Peer-reviewed Disease mechanisms Scientific reports

Key finding: We found that Aβ oligomer binding to CNS synaptosomes isolated from wild type (wt) mice treated with NIR light was significantly reduced and the resulting suppression of long term potentiation (LTP) by Aβ oligomers was prevented. +1 more finding

• Brain Biology

Full summary, score breakdown and related studies → Original source

Neurodegeneration and the ordered assembly of α-synuclein

39/100 ✓ Peer-reviewed Brain tissue and pathology Cell and tissue research

Key finding: In 2017, it was 200 years since James Parkinson published 'An Essay on the Shaking Palsy' and 20 years since α-synuclein aggregation came to the fore. +3 more findings

• Other Dementias

Full summary, score breakdown and related studies → Original source

Blood pressure from mid- to late life and risk of incident dementia

67/100 ✓ Peer-reviewed Risk factors Neurology

Key finding: Elevated blood pressure during midlife, persistence of elevated blood pressure into late life, and, among nonhypertensives, a steep decline in blood pressure during mid- to late life were associated with an increased dementia risk in a community-based cohort. +4 more findings

• Risk Factors

Full summary, score breakdown and related studies → Original source

Alzheimer's Disease-Related Dementias Summit 2016: National research priorities

51/100 ✓ Peer-reviewed Disparities Neurology

Key finding: Goal 1 of the National Plan to Address Alzheimer's Disease is to prevent and effectively treat Alzheimer disease and Alzheimer disease-related dementias by 2025. +2 more findings

Full summary, score breakdown and related studies → Original source

Speed of processing training results in lower risk of dementia

88/100 ✓ Peer-reviewed Prevention trials Alzheimer's & dementia (New York, N. Y.)

Key finding: Initially, healthy older adults randomized to speed of processing cognitive training had a 29% reduction in their risk of dementia after 10 years of follow-up compared to the untreated control group. +4 more findings

• Risk Factors
• Clinical Trials
• Prevention

Full summary, score breakdown and related studies → Original source

Cerebral blood flow in normal aging adults: cardiovascular determinants, clinical implications, and aerobic fitness

46/100 ✓ Peer-reviewed Prevention and risk Journal of neurochemistry

Key finding: Mounting evidence indicates that the presence of cardiovascular disease and risk factors elevates the incidence of both vascular cognitive impairment and Alzheimer's disease (AD).

• Risk Factors
• Lifestyle

Full summary, score breakdown and related studies → Original source

Using Retinal Imaging to Study Dementia

39/100 ✓ Peer-reviewed Brain scans and imaging Journal of visualized experiments : JoVE

Key finding: This protocol aims to describe a method of quantifying and analyzing retinal vasculature and neuronal structure, which are potentially associated with dementia.

• Brain Scans

Full summary, score breakdown and related studies → Original source

Tau PET imaging predicts cognition in atypical variants of Alzheimer's disease

39/100 ✓ Peer-reviewed Brain scans and imaging Human brain mapping

Key finding: Accumulation of paired helical filament tau contributes to neurodegeneration in Alzheimer's disease (AD). 18 F-flortaucipir is a positron emission tomography (PET) radioligand sensitive to tau in AD, but its clinical utility will depend in part on its ability to predict cognitive symptoms in diverse dementia phenotypes associated with selective, regional uptake. +3 more findings

• Brain Scans

Full summary, score breakdown and related studies → Original source

Low Serum Phosphorus Correlates with Cerebral Aβ Deposition in Cognitively Impaired Subjects: Results from the KBASE Study

39/100 ✓ Peer-reviewed Biomarkers Frontiers in aging neuroscience

Key finding: Recent studies also have shown that the serum level of phosphorus correlates to the risk of incident dementia. +3 more findings

• Brain Scans
• Brain Biology

Full summary, score breakdown and related studies → Original source

Adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP): Integrating the literature on hereditary diffuse leukoencephalopathy with spheroids (HDLS) and pigmentary orthochromatic leukodystrophy (POLD)

56/100 ✓ Peer-reviewed Inflammation and the immune system Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia

Key finding: Antemortem diagnoses of autopsy-confirmed ALSP vary significantly, and include primary progressive multiple sclerosis, frontotemporal dementia, Alzheimer disease, atypical cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), corticobasal syndrome, and atypical Parkinson disease, suggesting that ALSP may be significantly underdiagnosed.

• Brain Biology
• Genetics

Full summary, score breakdown and related studies → Original source

Effect of aerobic exercise on hippocampal volume in humans: A systematic review and meta-analysis

74/100 ✓ Peer-reviewed Hippocampus size on brain scans NeuroImage

Key finding: A random-effects meta-analysis showed no significant effect of aerobic exercise on total hippocampal volume across the 737 participants. +2 more findings

• Brain Scans
• Lifestyle

Full summary, score breakdown and related studies → Original source

Brains with sporadic Creutzfeldt-Jakob disease and copathology showed a prolonged end-stage of disease

45/100 ✓ Peer-reviewed Brain tissue and pathology Journal of clinical pathology

Key finding: Copathology was significantly associated with survival in brains with CJD (4.2±1.2 vs 9.2±1.9; P=0.019) and in brains with MM1/MV1 CJD (2.1±1.0 vs 6.7±2.8; P=0.012). +4 more findings

Full summary, score breakdown and related studies → Original source

Race modifies the relationship between cognition and Alzheimer's disease cerebrospinal fluid biomarkers

50/100 ✓ Peer-reviewed Hippocampus size on brain scans Alzheimer's research & therapy

Key finding: We hypothesized that cerebrospinal fluid (CSF) biomarkers of amyloid, neurodegeneration, and endothelial dysfunction would differ between older African Americans and Caucasians with normal cognition and cognitive impairment associated with AD. +2 more findings

• Biomarkers

Full summary, score breakdown and related studies → Original source

High TREM2 expression correlates with poor prognosis in gastric cancer

39/100 ✓ Peer-reviewed TREM2 and immune genetics Human pathology

Key finding: Gastric cancer (GC) is one of the most common human cancers in the world. +3 more findings

• Genetics

Full summary, score breakdown and related studies → Original source

Applications of Resting-State Functional Connectivity to Neurodegenerative Disease

39/100 ✓ Peer-reviewed Brain scans and imaging Neuroimaging clinics of North America

Key finding: Neurodegenerative diseases target specific large-scale neuronal networks, leading to distinct behavioral and cognitive dysfunctions. +4 more findings

• Brain Scans

Full summary, score breakdown and related studies → Original source

iPSC-Based Compound Screening and In Vitro Trials Identify a Synergistic Anti-amyloid β Combination for Alzheimer's Disease

38/100 ✓ Peer-reviewed Treatments Cell reports

Key finding: Finally, using neurons from familial and sporadic AD patients, we found that the cocktail showed a significant and potent anti-Aβ effect on patient cells.

• Treatments
• Brain Biology

Full summary, score breakdown and related studies → Original source

Preparedness for Death: How Caregivers of Elders With Dementia Define and Perceive its Value

38/100 ✓ Peer-reviewed End-of-life care The Gerontologist

Key finding: Only one third (n = 10) of caregivers interviewed were prepared for the death, and the majority who were prepared were enrolled in hospice. +2 more findings

• Caregiving

Full summary, score breakdown and related studies → Original source

Poor Performance on a Preoperative Cognitive Screening Test Predicts Postoperative Complications in Older Orthopedic Surgical Patients

47/100 ✓ Peer-reviewed Clinical safety Anesthesiology

Key finding: Many older elective orthopedic surgical patients have probable cognitive impairment preoperatively. +3 more findings

• Diagnosis

Full summary, score breakdown and related studies → Original source