Newest studies

Prospective Associations between Single Foods, Alzheimer's Dementia and Memory Decline in the Elderly

61/100 ✓ Peer-reviewed Genetics Nutrients

Key finding: Only higher red wine intake was associated with a lower incidence of AD ( HR = 0.92; P = 0.045). +3 more findings

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Neurodegeneration, synaptic dysfunction, and gliosis are phenotypic of Alzheimer dementia

55/100 ✓ Peer-reviewed Biomarkers Neurology

Key finding: These results provide evidence that, in the absence of significant neurodegenerative processes, individuals who harbor AD neuropathology may remain cognitively unimpaired. +3 more findings

• Biomarkers
• Brain Biology

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Chronic depressive symptomatology and CSF amyloid beta and tau levels in mild cognitive impairment

46/100 ✓ Peer-reviewed Tau biomarkers International journal of geriatric psychiatry

Key finding: As compared to the non-SSD group, the SSD group displayed lower CSF Aβ1-42 levels (β = -24.293, S.E. = 6.345, P < 0.001). +4 more findings

• Biomarkers
• Early Stage

Full summary, score breakdown and related studies → Original source

Neurofilament relates to white matter microstructure in older adults

46/100 ✓ Peer-reviewed Tau biomarkers Neurobiology of aging

Key finding: To study whether NFL is associated with diffusion tensor imaging (DTI) measurements of white matter (WM) microstructure, Vanderbilt Memory & Aging Project participants with normal cognition (n = 77), early mild cognitive impairment (n = 15), and MCI (n = 55) underwent lumbar puncture to obtain CSF and 3T brain MRI. +1 more finding

• Biomarkers
• Brain Scans

Full summary, score breakdown and related studies → Original source

Clinical Research on Alzheimer's Disease: Progress and Perspectives

38/100 ✓ Peer-reviewed Brain scans and imaging Neuroscience bulletin

Key finding: During the past year, significant progress has been made in clinical research on the diagnosis, prevention, and treatment of AD.

• Brain Scans
• Treatments

Full summary, score breakdown and related studies → Original source

On the way to precision formulation additives: 2D-screening to select solubilizers with tailored host and release capabilities

36/100 ✓ Peer-reviewed Tau biomarkers Journal of controlled release : official journal of the Controlled Release Society

Key finding: The identified sequences are conjugated with poly(ethylene glycol) (PEG) to obtain peptide-PEG conjugates that proved to be valuable as solubilizers for small organic molecule drugs to overcome limitations of poor water-solubility and low bio-availability. +3 more findings

• Diagnosis

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Age-related shift in LTD is dependent on neuronal adenosine A2A receptors interplay with mGluR5 and NMDA receptors

45/100 ✓ Peer-reviewed Hippocampus size on brain scans Molecular psychiatry

Key finding: We report, for the first time, a significant overexpression of A 2A R in hippocampal neurons of aged humans, which is aggravated in AD patients.

• Brain Biology

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Making Neighborhood-Disadvantage Metrics Accessible — The Neighborhood Atlas

59/100 ✓ Peer-reviewed Disparities New England Journal of Medicine

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iPSC-derived familial Alzheimer's PSEN2 N141I cholinergic neurons exhibit mutation-dependent molecular pathology corrected by insulin signaling

39/100 ✓ Peer-reviewed Risk genes beyond APOE Molecular neurodegeneration

Key finding: We report herein that wildtype, PSEN2 N141I and CRISPR/Cas9-corrected iPSC-derived BFCNs (and their precursors) show indistinguishable insulin signaling profiles as determined by the phosphorylation of canonical insulin signaling pathway molecules. +4 more findings

• Genetics

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Comparing post-acute rehabilitation use, length of stay, and outcomes experienced by Medicare fee-for-service and Medicare Advantage beneficiaries with hip fracture in the United States: A secondary analysis of administrative data

58/100 ✓ Peer-reviewed Health systems and care delivery PLoS Medicine

Key finding: This was a retrospective cohort study to examine differences in health service utilization and outcomes between FFS and MA patients in SNFs following hip fracture hospitalization during the period January 1, 2011, to June 30, 2015, and followed up until December 31, 2015. +4 more findings

• Care Services
• Policy

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Combined neuropathological pathways account for age-related risk of dementia

56/100 ✓ Peer-reviewed Disparities Annals of neurology

Key finding: Age-related increases in dementia risk can be attributed to accumulation of multiple pathologies, each of which contributes to dementia risk.

• Brain Biology
• Risk Factors

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Hospital outcomes of older people with cognitive impairment: An integrative review

49/100 ✓ Peer-reviewed Caregiving International journal of geriatric psychiatry

Key finding: Older people with cognitive impairment have a higher risk of a variety of negative outcomes in hospital. +3 more findings

• Care Services

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A decade in psychiatric GWAS research

43/100 ✓ Peer-reviewed Genetics Molecular psychiatry

Key finding: The SNPs rs2075650 and rs4420638 were linked to the most replications within a single reclassified phenotype or very similar reclassified phenotypes; both were associated with Alzheimer's disease (AD). +4 more findings

• Genetics
• Risk Factors

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Genome-wide association meta-analysis in 269,867 individuals identifies new genetic and functional links to intelligence

81/100 ✓ Peer-reviewed Genetics Nature genetics

Key finding: We confirm previous strong genetic correlations with multiple health-related outcomes, and Mendelian randomization analysis results suggest protective effects of intelligence for Alzheimer's disease and ADHD and bidirectional causation with pleiotropic effects for schizophrenia. +1 more finding

• Genetics

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Prevalence and Risk Factors for Fecal Incontinence in Home Hospice

70/100 ✓ Peer-reviewed End-of-life care The American journal of hospice & palliative care

Key finding: Further studies are needed to identify modifiable risk factors for FI detection and its symptom management in this patient population. +4 more findings

• Risk Factors
• End-of-Life Care

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Working definitions, subjective and objective assessments and experimental paradigms in a study exploring social withdrawal in schizophrenia and Alzheimer's disease

38/100 ✓ Peer-reviewed Cognitive tests and assessment Neuroscience and biobehavioral reviews

Key finding: The Psychiatric Ratings using Intermediate Stratified Markers (PRISM) project focusses on the shared and unique neurobiological basis of social withdrawal in schizophrenia, Alzheimer and depression. +4 more findings

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Dementia Care at End of Life: Current Approaches

39/100 ✓ Peer-reviewed End-of-life care Current psychiatry reports

Key finding: Improved and earlier advanced care planning for persons with dementia and their caregivers can help delineate goals of care and prepare for the inevitable complications of end-stage dementia.

• End-of-Life Care

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The Gut Microbiome Alterations and Inflammation-Driven Pathogenesis of Alzheimer's Disease-a Critical Review

41/100 ✓ Peer-reviewed Disease mechanisms Molecular neurobiology

Key finding: Scientists suggest that human gut microflora may even act as the "second brain" and be responsible for neurodegenerative disorders like Alzheimer's disease (AD). +1 more finding

• Brain Biology

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Potential Utility of Retinal Imaging for Alzheimer's Disease: A Review

39/100 ✓ Peer-reviewed Brain scans and imaging Frontiers in aging neuroscience

Key finding: As a projection of the central nervous system (CNS), the retina has been described as a "window to the brain" and a novel marker for AD. +4 more findings

• Brain Scans
• Diagnosis
• Biomarkers

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Overview of the clinical implementation of a study exploring social withdrawal in patients with schizophrenia and Alzheimer's disease

45/100 ✓ Peer-reviewed Cognitive tests and assessment Neuroscience and biobehavioral reviews

Key finding: Thus we will explore both differentiation and cross-diagnostic overlap in the biomarkers associated with different levels of social withdrawal in SZ and AD.

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Hospitalization and Emergency Department Visits for Severe Hypoglycemia among U.S. Adults with Diabetes and Serious Comorbid Conditions

38/100 ✓ Peer-reviewed Health systems and care delivery Diabetes

Key finding: Diabetes care guidelines recommend more relaxed glycemic targets for patients with specific chronic conditions because they are thought to have an increased risk of hypoglycemia, limited life expectancy, and/or high clinical complexity. +2 more findings

• Care Services
• Risk Factors
• Policy

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High-Risk Medication Use to Achieve Tight Glycemic Control among U.S. Adults with Serious Chronic Conditions

41/100 ✓ Peer-reviewed Health systems and care delivery Diabetes

Key finding: The plurality of patients in each disease cohort was treated insulin and/or sulfonylurea, including 66.9% of patients with hypoglycemia, 54.4% with ESRD, 51.9% with CKD, 51.1% with cirrhosis, 46.8% with MI, 48% with HF, and 43% with dementia. +4 more findings

• Treatments
• Care Services
• Policy

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The association between "Brain-Age Score" (BAS) and traditional neuropsychological screening tools in Alzheimer's disease

41/100 ✓ Peer-reviewed Long-term cohort studies Brain and behavior

Key finding: We present the Brain-Age Score (BAS) as a magnetic resonance imaging (MRI)-based index for Alzheimer's disease (AD). +3 more findings

• Brain Scans

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Multiscale Analysis of Independent Alzheimer's Cohorts Finds Disruption of Molecular, Genetic, and Clinical Networks by Human Herpesvirus

38/100 ✓ Peer-reviewed Risk genes beyond APOE Neuron

Key finding: We observed increased human herpesvirus 6A (HHV-6A) and human herpesvirus 7 (HHV-7) from subjects with AD compared with controls. +2 more findings

• Genetics

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Advance care planning in dementia: recommendations for healthcare professionals

48/100 ✓ Peer-reviewed End-of-life care BMC palliative care

Key finding: No high-quality guidelines are available for ACP in dementia care.

• End-of-Life Care

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