Newest studies

CHMP2B p.Ala30Ser Variant in Biomarker-Confirmed Early-Onset Alzheimer Disease: A Potential Endolysosomal Disease Modifier

30/100 ✓ Peer-reviewed Tau biomarkers Alzheimer disease and associated disorders

Key finding: The charged multivesicular body protein 2B (CHMP2B) gene encodes a component of the endosomal sorting complexes required for transport (ESCRT-III), which regulates endosomal trafficking, multivesicular body formation, and autophagosome-lysosome fusion. +3 more findings

• Biomarkers
• Genetics

Full summary, score breakdown and related studies → Original source

AETA peptide contributes to Alzheimer's disease signature of synapse dysfunction

48/100 ✓ Peer-reviewed Disease mechanisms Acta neuropathologica

Key finding: Post-mortem analyses of human hippocampal and prefrontal cortex tissues revealed significantly elevated AETA levels in AD patients, particularly in females. +2 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source

Diagnostic performance of plasma p-Tau217, p-Tau181, and p-Tau231 across the Alzheimer's disease continuum: a network meta-analysis

84/100 ✓ Peer-reviewed Biomarkers Frontiers in aging neuroscience

Key finding: A total of 18 high-quality studies comprising 24 independent datasets and 4,736 participants were included. +4 more findings

• Biomarkers
• Diagnosis

Full summary, score breakdown and related studies → Original source

Cryptic splicing in synaptic and membrane excitability genes links TDP-43 loss to neuronal dysfunction

51/100 ✓ Peer-reviewed Brain tissue and pathology Science Translational Medicine

Key finding: Using human stem cell-derived neurons, we show that TDP-43 reduction induces cryptic splicing and downregulation of these genes, resulting in impaired excitability and synaptic transmission.

• Brain Biology
• Genetics

Full summary, score breakdown and related studies → Original source

Influence of Cardiometabolic and Alzheimer Disease Genetics on Cognitive-Related Outcomes in a Diverse Population

41/100 ✓ Peer-reviewed Genetics Neurology

Key finding: While the APOE ɛ4 allele is the strongest genetic risk factor of Alzheimer disease (AD), polygenic risk factors also play a significant role.

• Genetics
• Health Equity

Full summary, score breakdown and related studies → Original source

ApoE4 lowers the ptau217 threshold for tau aggregation and spread in an allele dose-dependent manner

60/100 ✓ Peer-reviewed Laboratory science Brain

Key finding: We found that ApoE4 did not facilitate amyloid-PET-associated ptau increases, suggesting that amyloid-related ptau secretion is not altered by ApoE4 carriage. +3 more findings

• Brain Biology
• Biomarkers
• Genetics

Full summary, score breakdown and related studies → Original source

Ultraprocessed Foods and the Risk of Cognitive Impairment and Dementia in Older US Adults: 2013-2020 Health and Retirement Study

53/100 ✓ Peer-reviewed Prevention and risk American Journal of Public Health

Key finding: Increased UPF consumption is associated with higher risks of dementia, CIND, and CIND or dementia among US older adults. +3 more findings

Full summary, score breakdown and related studies → Original source

Dynamic Imaging Markers of ARIA-H Risk in the A4 Study: A Person-Interval Analysis of Current Lesion Burden and Recent Microhaemorrhage Activity

16/100 ⚠ Preprint — not yet peer-reviewed Treatments medRxiv

Key finding: Temporal imaging variables may provide independent prognostic information beyond baseline risk, supporting a dynamic model of haemorrhagic risk in Alzheimer’s disease. +1 more finding

• Side Effects
• Treatments
• Brain Scans

Scored 35 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

Full summary, score breakdown and related studies → Original source

Gain-of-function Modulation of TREM2 and its Impact on Amyloid-β and Tau Pathologies in Alzheimer's Disease: A Systematic Review and Meta-analysis of Animal Studies

50/100 ✓ Peer-reviewed TREM2 and immune genetics Molecular neurobiology

Key finding: A total of 12 studies were included, with overall moderate risk of bias, mainly due to inadequate randomization and blinding. +2 more findings

• Genetics
• Brain Biology

Full summary, score breakdown and related studies → Original source

Multi-Dimensional Transcriptomics Reveals the Prominent Role of Neuroinflammation in Alzheimer’s Disease

38/100 ✓ Peer-reviewed Inflammation and the immune system International Journal of Molecular Sciences

Key finding: These approaches have revealed state-specific transitions in microglia and astrocytes, including shifts in transcriptional programs, metabolic reprogramming, and pro-inflammatory polarization across disease stages.

• Brain Biology

Full summary, score breakdown and related studies → Original source

Transcriptome-informed metabolic modeling reveals astrocyte-specific vulnerabilities in mild cognitive impairment and Alzheimer’s disease progression

36/100 ✓ Peer-reviewed Mild cognitive impairment Frontiers in Bioinformatics

Key finding: The analyses supported stage-dependent remodeling of astrocyte-associated transcriptional and metabolic programs during disease progression. +4 more findings

• Early Stage
• Brain Biology

Full summary, score breakdown and related studies → Original source

NOVEL DRUG DELIVERY SYSTEM: A PANDORA BOX FOR THE MANAGE MENT OF ALZHEIMER NOVEL DRUG DELIVERY IN ALZHEIMER

27/100 ✓ Peer-reviewed Genetics Genetics and Molecular Research

Key finding: With an estimated 40 million affected worldwide, the number is expected to increase significantly as the population ages, resulting in significant medical, social, and financial problems.

• Treatments
• Genetics
• Brain Biology

Full summary, score breakdown and related studies → Original source

Associations of Anthropometry Measures Across 35 Years With Late-Life Plasma P-tau217 and Dementia

51/100 ✓ Peer-reviewed Biomarkers Neurology

Key finding: The final study sample comprised 8,797 participants (53.5% women, mean age at HUNT4 77.8 [SD 6.2]). +4 more findings

• Biomarkers
• Risk Factors

Full summary, score breakdown and related studies → Original source

Evaluating the accuracy and reliability of telephone-derived Clinical Dementia Rating scores: A comparative analysis with in-person assessments

63/100 ✓ Peer-reviewed Cognitive tests and assessment Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: Agreement for the global CDR was moderate (κ = 0.53, 95% CI: 0.47-0.59). +4 more findings

Full summary, score breakdown and related studies → Original source

Remote, self-administered, smartphone cognitive testing in a registry-based cohort: Feasibility, reliability, and validity findings

66/100 ✓ Peer-reviewed Cognitive tests and assessment Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: Adherence was high (82.2%) and usability favorable. +3 more findings

• Diagnosis
• Digital Tools

Full summary, score breakdown and related studies → Original source

Scalable biological-cognitive profiling for Alzheimer's disease in the population

64/100 ✓ Peer-reviewed Cognitive tests and assessment Brain communications

Key finding: Higher plasma phosphorylated tau217 levels were associated with lower scores on telephone-administered cognitive tests. +1 more finding

• Diagnosis

Full summary, score breakdown and related studies → Original source

Plasma p-tau markers, vascular factors, and cognitive decline in the CIMA-Q cohort

64/100 ✓ Peer-reviewed Biomarkers Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: Higher plasma p-tau levels were associated with worse cognition at baseline and over time, with the strongest effect observed with p-tau217 in cognitively impaired individuals (β = -0.49, p < 0.001). +3 more findings

• Biomarkers
• Early Stage

Full summary, score breakdown and related studies → Original source

Donanemab treatment effect by baseline tau burden and disease severity: Observations from the TRAILBLAZER-ALZ 2 trial

75/100 ✓ Peer-reviewed Biomarkers Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: Donanemab-mediated slowing of disease progression occurred across baseline tau PET and plasma P-tau217 levels. +4 more findings

• Treatments
• Biomarkers
• Clinical Trials

Full summary, score breakdown and related studies → Original source

Perceptions of Dementia Threats and Related Advance Care Planning among Adults in Central Vietnam

31/100 ✓ Peer-reviewed End-of-life care VNU Journal of Social Sciences and Humanities

Key finding: Understanding dementia beliefs among Vietnamese people is crucial for the development of evidence-based interventions to promote positive help-seeking behaviors when facing the risk of dementia for themselves and their relatives. +2 more findings

• End-of-Life Care

Full summary, score breakdown and related studies → Original source

Clinical checklists of multicomponent non-pharmacological interventions for delirium management in adult patients in non-ICU inpatient healthcare settings: a rapid review

48/100 ✓ Peer-reviewed Clinical safety BMJ Open

Key finding: From the database searches, 4796 records were identified. +4 more findings

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From FINGER to World-Wide FINGERS - multidomain interventions for risk reduction and prevention of dementia

28/100 ✓ Peer-reviewed Prevention trials European Psychiatry

Key finding: At present, there is no cure for dementia. +4 more findings

• Prevention

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Effect of a Multicomponent Program on the Prevention of Cognitive Decline and Dementia

35/100 ✓ Peer-reviewed Prevention trials European Psychiatry

Key finding: The program was effective, as evidenced by the multidimensional health gains achieved. +3 more findings

• Prevention

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Differences in the prevalence and patterns of dementia risk factors across 14 countries and regions: a harmonised cross-national analysis

43/100 ✓ Peer-reviewed Prevention trials The Lancet Healthy Longevity

Key finding: Data on 214 251 respondents were included in the study. +4 more findings

• Risk Factors

Full summary, score breakdown and related studies → Original source

Distinct and combined interferon-ɑ/β-receptor-1 loss in neurons and astrocytes disrupt brain energy metabolism and drive Parkinsonian dementia

38/100 ✓ Peer-reviewed Inflammation and the immune system Journal of Biomedical Science

Key finding: IFNAR1 plays a crucial role in brain and mitochondrial homeostasis, loss of which results in neurodegeneration and neuropathology resembling PDD. +2 more findings

• Brain Biology
• Other Dementias

Full summary, score breakdown and related studies → Original source

Single-cell atlas reveals pathological amplification of aging programs and proteostasis collapse in microglia of Alzheimer′s disease mice

30/100 ✓ Peer-reviewed Risk genes beyond APOE DOAJ (DOAJ: Directory of Open Access Journals)

Key finding: The pathological activation of AD microglia significantly amplifies endogenous aging characteristics. +3 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source