Newest studies

Data-driven subtypes of type 2 diabetes and risk of dementia, stroke, and brain structural changes in the UK Biobank

43/100 ✓ Peer-reviewed Long-term cohort studies Diabetes Research and Clinical Practice

Key finding: Three subtypes emerged: severe obesity-related inflammatory diabetes (SOID), mild metabolic diabetes (MMD, reference), and mild age-related hypertension-predominant diabetes (MARD-H). +4 more findings

• Risk Factors

Full summary, score breakdown and related studies → Original source

Emergency Departments Leading the Transformation of Alzheimer's and Dementia Care

44/100 ✓ Peer-reviewed End-of-life care Journal of the American Geriatrics Society

Key finding: More than 50% of older adults with AD/ADRD visit the emergency department (ED) each year [3, 4] and those who do are seriously ill, have significant healthcare costs (e.g., hospital admissions, repeat ED visits) and mortality [4-6]. +4 more findings

• Care Services
• Policy

Full summary, score breakdown and related studies → Original source

A randomised controlled trial of physical activity and cognitive training in older adults: the PhABHeaD study

58/100 ✓ Peer-reviewed Prevention trials Trials

Key finding: If a substantial synergetic effect is detected, it may lead to the use of more widespread concurrent physical and cognitive training and the potential development of methods to make concurrent training practical. +3 more findings

• Clinical Trials
• Lifestyle

Full summary, score breakdown and related studies → Original source

Early syndecan-4 upregulation predicts cognitive and pathological trajectories in Alzheimer disease

55/100 ✓ Peer-reviewed Biomarkers Alzheimer s Research & Therapy

Key finding: CSF SDC4 levels were elevated in AD, including the earliest preclinical stages, compared to controls and were closely associated with CSF and imaging biomarkers of amyloid and tau, and CSF biomarkers of neuronal and synaptic injury, astrocytic reactivity and microglial dysregulation.

• Biomarkers
• Brain Biology

Full summary, score breakdown and related studies → Original source

Circadian Rest-Activity Rhythms, Cognition, and Alzheimer Disease Dementia in Adults With Down Syndrome

56/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Neurology

Key finding: Of 115 participants (mean age 40.0 ± 9.2 years; 43.5% female), higher interdaily stability was associated with higher DSMSE scores B = 20.6 (95% CI 5.0-36.2). +3 more findings

• Down Syndrome

Full summary, score breakdown and related studies → Original source

How effective is cognitive training as a preventive intervention for cognitive decline in individuals at risk of Alzheimer's disease?

41/100 ✓ Peer-reviewed Prevention trials Zenodo (CERN European Organization for Nuclear Research)

Key finding: Cognitive training appears effective in improving cognitive functions and delaying cognitive decline in people at risk of Alzheimer's disease but requires more standardized research for conclusive evidence.

• Risk Factors
• Lifestyle

Full summary, score breakdown and related studies → Original source

How effective is cognitive training as a preventive intervention for cognitive decline in individuals at risk of Alzheimer's disease?

28/100 ✓ Peer-reviewed Prevention trials Zenodo (CERN European Organization for Nuclear Research)

Key finding: Cognitive training appears effective in improving cognitive functions and delaying cognitive decline in people at risk of Alzheimer's disease but requires more standardized research for conclusive evidence.

• Risk Factors
• Lifestyle

Full summary, score breakdown and related studies → Original source

What is the effectiveness of cognitive training in preventing cognitive decline in individuals at risk for Alzheimer's disease?

28/100 ✓ Peer-reviewed Prevention trials Zenodo (CERN European Organization for Nuclear Research)

Key finding: Cognitive training shows potential in preventing cognitive decline in individuals at risk for Alzheimer's disease, especially as part of multimodal interventions, though current evidence varies in quality and clarity.

• Prevention
• Lifestyle

Full summary, score breakdown and related studies → Original source

What is the effectiveness of cognitive training in preventing cognitive decline in individuals at risk for Alzheimer's disease?

41/100 ✓ Peer-reviewed Prevention trials Zenodo (CERN European Organization for Nuclear Research)

Key finding: Cognitive training shows potential in preventing cognitive decline in individuals at risk for Alzheimer's disease, especially as part of multimodal interventions, though current evidence varies in quality and clarity.

• Prevention
• Lifestyle

Full summary, score breakdown and related studies → Original source

What is the evidence for cognitive training in preventing cognitive decline in Alzheimer's disease?

41/100 ✓ Peer-reviewed Prevention trials Zenodo (CERN European Organization for Nuclear Research)

Key finding: The evidence for cognitive training in preventing cognitive decline in Alzheimer's disease is varied, with some studies indicating cognitive benefits but showing limited impact on functional outcomes or disease progression.

• Prevention
• Lifestyle

Full summary, score breakdown and related studies → Original source

What is the evidence for cognitive training in preventing cognitive decline in Alzheimer's disease?

28/100 ✓ Peer-reviewed Prevention trials Zenodo (CERN European Organization for Nuclear Research)

Key finding: The evidence for cognitive training in preventing cognitive decline in Alzheimer's disease is varied, with some studies indicating cognitive benefits but showing limited impact on functional outcomes or disease progression.

• Prevention
• Lifestyle

Full summary, score breakdown and related studies → Original source

Combining EEG, event-related potentials, and MRI biomarkers for detection of mild cognitive impairment: A machine learning approach

44/100 ✓ Peer-reviewed Mild cognitive impairment Clinical Neurophysiology

Key finding: EEG/ERP analysis suggested differences in frontal alpha asymmetry, power ratio, and ERP components between the MCI and CN groups. +4 more findings

• Early Stage
• Digital Tools
• Biomarkers

Full summary, score breakdown and related studies → Original source

Alzheimer's Disease: Silent Erosion of Memory - From Discovery to Modern Crisis and the Quest for a Cure

28/100 ✓ Peer-reviewed Treatments Current Alzheimer Research

Key finding: First described by Alois Alzheimer in 1906, AD continues to pose significant global health and socioeconomic challenges, with incidence anticipated to exceed 14 million cases by 2060.

• Treatments
• Brain Biology

Full summary, score breakdown and related studies → Original source

Recomendaciones de uso de donanemab

28/100 ✓ Peer-reviewed Treatments Acta neurológica colombiana

Key finding: El texto analiza también aspectos de seguridad, especialmente las anomalías de imagen relacionadas con amiloide (ARIA), que presentan mayor incidencia en pacientes tratados, particularmente en portadores del genotipo APOE ε4 homocigoto. +4 more findings

• Treatments

Full summary, score breakdown and related studies → Original source

A Transferable Health Economic Evaluation Framework for Alzheimer’s Disease-Modifying Therapies

16/100 ⚠ Preprint — not yet peer-reviewed Costs and economics Research Square

Key finding: Base-case incremental cost-effectiveness ratios (ICERs) for lecanemab versus standard of care were €296,506 per QALY gained, and €371,299 per QALY for donanemab, from the HSE payer perspective under HIQA guidelines. +4 more findings

• Treatments
• Policy

Scored 24 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

Full summary, score breakdown and related studies → Original source

Demyelination in Vascular Dementia: Focus on Oligodendrocytes, Microglia, and Their Interaction

30/100 ✓ Peer-reviewed Inflammation and the immune system Current Neuropharmacology

Key finding: Vascular dementia (VaD), a primary cognitive disorder caused by cerebrovascular pathology, features significant white matter damage from chronic cerebral hypoperfusion strongly correlated with cognitive decline.

• Brain Biology
• Other Dementias

Full summary, score breakdown and related studies → Original source

Multimorbidity and Associations with Cognition and Alzheimer's Disease Biomarkers

59/100 ✓ Peer-reviewed Biomarkers Annals of neurology

Key finding: Greater multimorbidity burden was associated with worse cognition and biomarkers of AD (PET amyloid standardized uptake value ratios and positivity, p-tau181, and p-tau217), neurodegeneration (neurofilament light, total tau, cortical thickness, and hippocampal volume), and SVD (white matter hyperintensity volume and presence of lacune and cerebral microbleeds). +2 more findings

• Biomarkers
• Brain Scans

Full summary, score breakdown and related studies → Original source

Cerebral Amyloid Angiopathy and Risk of Dementia in Patients With Cognitive Complaint

63/100 ✓ Peer-reviewed Brain tissue and pathology Neurology

Key finding: Of 2,323 MEMENTO participants, 2,136 (92%) were included in this study. +4 more findings

• Risk Factors

Full summary, score breakdown and related studies → Original source

What Does a Positive Alzheimer Disease Blood-Based Biomarker Result Mean in People With Mild Cognitive Impairment?

44/100 ✓ Peer-reviewed Mild cognitive impairment Neurology

Key finding: Limited data are available to guide clinicians on when to test, how to counsel patients with MCI and a positive AD BBM result about their risk of dementia progression, or which evidence-based dementia prevention strategies or treatments to recommend.

• Biomarkers
• Early Stage

Full summary, score breakdown and related studies → Original source

Indices of Arterial Stiffness and the Alzheimer’s Disease Biomarker, p-tau217, in Non-Demented Midlife Women

42/100 ✓ Peer-reviewed Biomarkers Pulse

Key finding: Among 871 participants (mean age: 62.80 ± 6.02 years), every SD increase in AIx and RI scores was both associated with 0.010 pg/mL (95% CI: 0.003–0.017, p = 0.004) higher blood p-tau217 levels after adjustment for age, employment status, BMI, mild cognitive impairment, hypertension, cholesterol-HDL ratio, renal function, and ApoE4 carrier status. +4 more findings

• Biomarkers

Full summary, score breakdown and related studies → Original source

Disease Burden and Direct Health-Care Spending on Brain Conditions in Switzerland: Findings from the Global Burden of Disease 2023 Study for the Implementation of the Swiss Brain Health Plan

16/100 ⚠ Preprint — not yet peer-reviewed Costs and economics medRxiv

Key finding: In fixed-effects panel models that accounted for spending persistence, lagged DALYs were not statistically associated with subsequent spending. +3 more findings

• Policy

Scored 35 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

Full summary, score breakdown and related studies → Original source

Delirium and incident nursing home admission among people with and without dementia

73/100 ✓ Peer-reviewed Health systems and care delivery Age and ageing

Key finding: Delirium was associated with a higher risk of nursing home admission in participants without dementia (SHR 1.23, 95% CI 1.14-1.34) and with pre-existing dementia (SHR 1.22, 95% CI 1.07-1.38). +4 more findings

• Care Services

Full summary, score breakdown and related studies → Original source

Comorbid neuropathologies but not Braak stage influence cognitive impairment in primary age-related tauopathy

50/100 ✓ Peer-reviewed Disease mechanisms Journal of Neuropathology & Experimental Neurology

Key finding: It is unclear whether there is any significant cognitive effect of "isolated" or "pure" PART, as opposed to ADNC, in which cognitive decline mirrors pathologic progression. +2 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source

Association Between ICD ‐Coded Delirium and Health Determinants in The Atherosclerosis Risk in Communities Study

55/100 ✓ Peer-reviewed Risk factors Journal of the American Geriatrics Society

Key finding: In this analytic cohort of 4130 participants, 486 (11.8%) experienced at least one hospitalization with delirium. +4 more findings

Full summary, score breakdown and related studies → Original source

The Alzheimer’s disease Burden in China (ABC) study: protocol for a nationwide multicentre cross-sectional and prospective cohort study

16/100 ⚠ Preprint — not yet peer-reviewed Costs and economics medRxiv

Key finding: Previous studies have shown that AD-related costs are mainly driven by long-term informal care. +1 more finding

Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

Full summary, score breakdown and related studies → Original source