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Automated Imaging Differentiation for Dementia
Robin Chen, Shannon Chiu, Jesse C. DeSimone, Wei Wang, Angelos Barmpoutis, Corey T. McMillan, Hamsanandini Radhakrishnan, David John Irwin et al.. Neurology Open Access, 2026-04-13
Topic: Risk, prevention and care in population studies
Differentiation of Alzheimer disease dementia (ADD) and dementia with Lewy bodies (DLB) remains a challenge. Free-water (FW) imaging has been investigated in neurodegenerative diseases and was found to be associated with neurodegeneration and neuroinflammation. This retrospective cohort study tested whether Automated Imaging Differentiation for Dementia (AIDD), combining diffusion free-water imaging (FWI) and support vector machine, predicts ADD vs DLB with high accuracy.
Key findings
- Free-water (FW) imaging has been investigated in neurodegenerative diseases and was found to be associated with neurodegeneration and neuroinflammation.
Why it matters
This study tested whether combining free-water imaging with a machine learning method could tell Alzheimer's disease dementia apart from dementia with Lewy bodies. It concerns diagnosis, not treating, curing or preventing Alzheimer's disease.
Study details
- Study designcohort study
- Evidence strengthModerate
How this study scored 46/100
Published in a peer-reviewed journal, and it is a cohort study following people over time. Scored zero for sample size, effect reported, studied in people and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Neurology Open Access) |
| Journal's citation record | 0 / 4 | Neurology Open Access: journal h-index 5 (OpenAlex, 2026-10-29) |
| Study design | 7 / 12 | A cohort study following people over time |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 5 / 5 | 2026 — within 1 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 1 / 7 | Cited 1 times (OpenAlex, 2026-10-10) |
| Citations per year | 0 / 5 | 0.5 citations a year over 2 year(s) since 2026 |
| Impact for its field and year | 3 / 6 | Cited 4.7× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 0 / 4 | Cited 1 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 3 / 4 | Last-listed author David E. Vaillancourt: h-index 68 (OpenAlex, whole career) |
| Institution's track record | 2 / 3 | University of Pennsylvania: institution h-index 1,859 (OpenAlex) |
| Multi-centre collaboration | 2 / 3 | OpenAlex lists 4 institution(s) in 1 country |
| Indexed in PubMed | 1 / 2 | Not in PubMed, but has a DOI |
| Free to read | 2 / 2 | Free to read |
| Total | 46 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.
APA 7th
Chen, R., Chiu, S., DeSimone, J. C., Wang, W., Barmpoutis, A., McMillan, C. T., et al. (2026). Automated Imaging Differentiation for Dementia. Neurology Open Access. https://doi.org/10.1212/wn9.0000000000000093
Vancouver
Chen R, Chiu S, DeSimone JC, Wang W, Barmpoutis A, McMillan CT, et al. Automated Imaging Differentiation for Dementia. Neurology Open Access. 2026. doi:10.1212/wn9.0000000000000093.
BibTeX
@article{chen2026-dd40034c,
author = {Chen, Robin and Chiu, Shannon and DeSimone, Jesse C. and Wang, Wei and Barmpoutis, Angelos and McMillan, Corey T. and Radhakrishnan, Hamsanandini and Irwin, David John and others},
title = {{Automated Imaging Differentiation for Dementia}},
journal = {Neurology Open Access},
year = {2026},
doi = {10.1212/wn9.0000000000000093},
url = {https://doi.org/10.1212/wn9.0000000000000093}
}
Studies this one cites
Referenced by this study and also in the alzhub library, so you can read them here.